Hmdb loader
Identification
HMDB Protein ID HMDBP09075
Secondary Accession Numbers
  • 14819
Name Sodium-dependent neutral amino acid transporter SLC6A17
Synonyms
  1. Solute carrier family 6 member 17
  2. Sodium-dependent neurotransmitter transporter NTT4
Gene Name SLC6A17
Protein Type Unknown
Biological Properties
General Function Involved in neurotransmitter:sodium symporter activity
Specific Function Functions as a sodium-dependent vesicular transporter selective for proline, glycine, leucine and alanine. In contrast to other members of this neurotransmitter transporter family, does not appear to be chloride-dependent (By similarity).
Pathways Not Available
Reactions Not Available
GO Classification
Biological Process
leucine transport
proline transport
alanine transport
glycine transport
Cellular Component
cell junction
synaptic vesicle
integral to plasma membrane
synaptic vesicle membrane
Component
integral to plasma membrane
membrane
cell part
membrane part
intrinsic to membrane
integral to membrane
Function
neurotransmitter transporter activity
neurotransmitter:sodium symporter activity
transmembrane transporter activity
transporter activity
Molecular Function
neurotransmitter:sodium symporter activity
Process
establishment of localization
transport
neurotransmitter transport
Cellular Location
  1. Membrane
  2. Multi-pass membrane protein
Gene Properties
Chromosome Location 1
Locus 1p13.3
SNPs SLC6A17
Gene Sequence
>2184 bp
ATGCCGAAGAACAGCAAAGTGACCCAGCGTGAGCACAGCAGTGAGCATGTCACTGAGTCC
GTGGCCGACCTGCTGGCCCTCGAGGAGCCTGTGGACTATAAGCAGAGTGTACTGAATGTG
GCTGGTGAGGCAGGCGGCAAGCAGAAGGCGGTGGAGGAGGAGCTGGATGCAGAGGACCGG
CCGGCCTGGAACAGTAAGCTGCAGTACATCCTGGCCCAGATTGGCTTCTCTGTGGGCCTC
GGCAACATCTGGAGGTTCCCCTACCTGTGCCAGAAAAATGGAGGAGGTGCTTACCTGGTG
CCCTACCTGGTGCTGCTGATCATCATCGGGATCCCCCTCTTCTTCCTGGAGCTGGCTGTG
GGTCAGAGGATCCGCCGCGGCAGCATCGGTGTGTGGCACTATATATGTCCCCGCCTGGGG
GGCATCGGCTTCTCCAGCTGCATAGTCTGTCTCTTTGTGGGGCTGTATTATAATGTGATC
ATCGGGTGGAGCATCTTCTATTTCTTCAAGTCCTTCCAGTACCCGCTGCCCTGGAGTGAA
TGTCCTGTCGTCAGGAATGGGAGCGTGGCAGTGGTGGAGGCAGAGTGTGAAAAGAGCTCA
GCCACTACCTACTTCTGGTACCGAGAGGCCTTGGACATCTCTGACTCCATCTCGGAGAGT
GGGGGCCTCAACTGGAAGATGACCCTGTGCCTCCTCGTGGCCTGGAGCATCGTGGGGATG
GCTGTCGTTAAGGGCATCCAGTCCTCGGGGAAGGTGATGTATTTCAGCTCCCTCTTCCCC
TACGTGGTGCTGGCCTGCTTCCTGGTCCGGGGGCTGTTGCTGCGAGGGGCAGTTGATGGC
ATCCTACACATGTTCACTCCCAAGCTGGACAAGATGCTGGACCCCCAGGTGTGGCGGGAG
GCAGCTACCCAGGTCTTCTTTGCCTTGGGCCTGGGCTTTGGTGGTGTCATTGCCTTCTCC
AGCTACAATAAGCAGGACAACAACTGCCACTTCGATGCCGCCCTGGTGTCCTTCATCAAC
TTCTTCACGTCAGTGTTGGCCACCCTCGTGGTGTTTGCTGTGCTGGGCTTCAAGGCCAAC
ATCATGAATGAGAAGTGTGTGGTCGAGAATGCTGAGAAAATCCTAGGGTACCTTAACACC
AACGTCCTGAGCCGGGACCTCATCCCACCCCACGTCAACTTCTCCCACCTGACCACAAAG
GACTACATGGAGATGTACAATGTCATCATGACCGTGAAGGAGGACCAGTTCTCAGCCCTG
GGCCTTGACCCCTGCCTTCTGGAGGACGAGCTGGACAAGTCCGTGCAGGGCACAGGCCTG
GCCTTCATCGCCTTCACTGAGGCCATGACGCACTTCCCCGCCTCCCCGTTCTGGTCCGTC
ATGTTCTTCTTGATGCTTATCAACCTGGGCCTGGGCAGCATGATCGGGACCATGGCAGGC
ATCACCACGCCCATCATCGACACCTTCAAGGTGCCCAAGGAGATGTTCACAGTGGGCTGC
TGTGTCTTTGCATTCCTCGTGGGGCTGTTGTTCGTCCAGCGCTCCGGAAACTACTTTGTC
ACCATGTTCGATGACTACTCGGCCACCCTGCCACTCACTCTCATCGTCATCCTTGAGAAC
ATCGCTGTGGCCTGGATTTATGGAACCAAGAAGTTCATGCAGGAGCTGACGGAGATGCTG
GGCTTCCGCCCCTACCGCTTCTATTTCTACATGTGGAAGTTCGTGTCTCCACTATGCATG
GCTGTGCTCACCACAGCCAGCATCATCCAGCTGGGGGTCACGCCCCCGGGCTACAGCGCC
TGGATCAAGGAGGAGGCTGCCGAGCGCTACCTGTATTTCCCCAACTGGGCCATGGCACTC
CTGATCACCCTCATCGTCGTGGCGACGCTGCCCATCCCTGTGGTGTTCGTCCTGCGGCAC
TTCCACCTGCTCTCTGATGGCTCCAACACCCTCTCCGTGTCCTACAAGAAGGGCCGCATG
ATGAAGGACATCTCCAACCTGGAGGAGAACGATGAGACCCGCTTCATCCTCAGCAAGGTG
CCCAGTGAGGCACCTTCCCCCATGCCCACTCACCGTTCCTATCTGGGGCCCGGCAGCACA
TCACCCCTGGAGACCAGCGGTAACCCCAATGGACGCTATGGGAGCGGCTACCTGCTGGCC
AGCACCCCTGAGTCGGAGCTGTGA
Protein Properties
Number of Residues 727
Molecular Weight 81000.71
Theoretical pI 5.981
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence
>Orphan sodium- and chloride-dependent neurotransmitter transporter NTT4
MPKNSKVTQREHSSEHVTESVADLLALEEPVDYKQSVLNVAGEAGGKQKAVEEELDAEDR
PAWNSKLQYILAQIGFSVGLGNIWRFPYLCQKNGGGAYLVPYLVLLIIIGIPLFFLELAV
GQRIRRGSIGVWHYICPRLGGIGFSSCIVCLFVGLYYNVIIGWSIFYFFKSFQYPLPWSE
CPVVRNGSVAVVEAECEKSSATTYFWYREALDISDSISESGGLNWKMTLCLLVAWSIVGM
AVVKGIQSSGKVMYFSSLFPYVVLACFLVRGLLLRGAVDGILHMFTPKLDKMLDPQVWRE
AATQVFFALGLGFGGVIAFSSYNKQDNNCHFDAALVSFINFFTSVLATLVVFAVLGFKAN
IMNEKCVVENAEKILGYLNTNVLSRDLIPPHVNFSHLTTKDYMEMYNVIMTVKEDQFSAL
GLDPCLLEDELDKSVQGTGLAFIAFTEAMTHFPASPFWSVMFFLMLINLGLGSMIGTMAG
ITTPIIDTFKVPKEMFTVGCCVFAFLVGLLFVQRSGNYFVTMFDDYSATLPLTLIVILEN
IAVAWIYGTKKFMQELTEMLGFRPYRFYFYMWKFVSPLCMAVLTTASIIQLGVTPPGYSA
WIKEEAAERYLYFPNWAMALLITLIVVATLPIPVVFVLRHFHLLSDGSNTLSVSYKKGRM
MKDISNLEENDETRFILSKVPSEAPSPMPTHRSYLGPGSTSPLETSGNPNGRYGSGYLLA
STPESEL
GenBank ID Protein 56204187
UniProtKB/Swiss-Prot ID Q9H1V8
UniProtKB/Swiss-Prot Entry Name S6A17_HUMAN
PDB IDs Not Available
GenBank Gene ID AL137790
GeneCard ID SLC6A17
GenAtlas ID SLC6A17
HGNC ID HGNC:31399
References
General References
  1. Gregory SG, Barlow KF, McLay KE, Kaul R, Swarbreck D, Dunham A, Scott CE, Howe KL, Woodfine K, Spencer CC, Jones MC, Gillson C, Searle S, Zhou Y, Kokocinski F, McDonald L, Evans R, Phillips K, Atkinson A, Cooper R, Jones C, Hall RE, Andrews TD, Lloyd C, Ainscough R, Almeida JP, Ambrose KD, Anderson F, Andrew RW, Ashwell RI, Aubin K, Babbage AK, Bagguley CL, Bailey J, Beasley H, Bethel G, Bird CP, Bray-Allen S, Brown JY, Brown AJ, Buckley D, Burton J, Bye J, Carder C, Chapman JC, Clark SY, Clarke G, Clee C, Cobley V, Collier RE, Corby N, Coville GJ, Davies J, Deadman R, Dunn M, Earthrowl M, Ellington AG, Errington H, Frankish A, Frankland J, French L, Garner P, Garnett J, Gay L, Ghori MR, Gibson R, Gilby LM, Gillett W, Glithero RJ, Grafham DV, Griffiths C, Griffiths-Jones S, Grocock R, Hammond S, Harrison ES, Hart E, Haugen E, Heath PD, Holmes S, Holt K, Howden PJ, Hunt AR, Hunt SE, Hunter G, Isherwood J, James R, Johnson C, Johnson D, Joy A, Kay M, Kershaw JK, Kibukawa M, Kimberley AM, King A, Knights AJ, Lad H, Laird G, Lawlor S, Leongamornlert DA, Lloyd DM, Loveland J, Lovell J, Lush MJ, Lyne R, Martin S, Mashreghi-Mohammadi M, Matthews L, Matthews NS, McLaren S, Milne S, Mistry S, Moore MJ, Nickerson T, O'Dell CN, Oliver K, Palmeiri A, Palmer SA, Parker A, Patel D, Pearce AV, Peck AI, Pelan S, Phelps K, Phillimore BJ, Plumb R, Rajan J, Raymond C, Rouse G, Saenphimmachak C, Sehra HK, Sheridan E, Shownkeen R, Sims S, Skuce CD, Smith M, Steward C, Subramanian S, Sycamore N, Tracey A, Tromans A, Van Helmond Z, Wall M, Wallis JM, White S, Whitehead SL, Wilkinson JE, Willey DL, Williams H, Wilming L, Wray PW, Wu Z, Coulson A, Vaudin M, Sulston JE, Durbin R, Hubbard T, Wooster R, Dunham I, Carter NP, McVean G, Ross MT, Harrow J, Olson MV, Beck S, Rogers J, Bentley DR, Banerjee R, Bryant SP, Burford DC, Burrill WD, Clegg SM, Dhami P, Dovey O, Faulkner LM, Gribble SM, Langford CF, Pandian RD, Porter KM, Prigmore E: The DNA sequence and biological annotation of human chromosome 1. Nature. 2006 May 18;441(7091):315-21. [PubMed:16710414 ]