| Identification |
|---|
| HMDB Protein ID
| HMDBP09262 |
| Secondary Accession Numbers
| |
| Name
| TGIF-interacting ubiquitin ligase 1 |
| Synonyms
|
Not Available
|
| Gene Name
| Not Available |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in acid-amino acid ligase activity |
| Specific Function
| Not Available |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
| Component |
| cell part |
| intracellular |
| Function |
| binding |
| catalytic activity |
| ligase activity |
| protein binding |
| ligase activity, forming carbon-nitrogen bonds |
| acid-amino acid ligase activity |
| Process |
| metabolic process |
| macromolecule metabolic process |
| macromolecule modification |
| protein modification process |
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Not Available |
| Locus
| Not Available |
| SNPs
| Not Available |
| Gene Sequence
|
>2769 bp
ATGGCCACTGCTTCACCAAGGTCTGATACTAGTAATAACCACAGTGGAAGGTTGCAGTTA
CAGGTAACTGTTTCTAGTGCCAAACTTAAAAGAAAAAAGAACTGGTTCGGAACAGCAATA
TATACAGAAGTAGTTGTAGATGGAGAAATTACGAAAACAGCAAAATCCAGTAGTTCTTCT
AATCCAAAATGGGATGAACAGCTAACTGTAAATGTTACGCCACAGACTACATTGGAATTT
CAAGTTTGGAGCCATCGCACTTTAAAAGCAGATGCTTTATTAGGAAAAGCAACGATAGAT
TTGAAACAAGCTCTGTTGATACACAATAGAAAATTGGAAAGAGTGAAAGAACAATTAAAA
CTTTCCTTGGAAAACAAGAATGGCATAGCACAAACTGGTGAATTGACAGTTGTGCTTGAT
GGATTGGTGATTGAGCAAGAAAATATAACAAACTGCAGCTCATCTCCAACCATAGAAATA
CAGGAAAATGGTGATGCCTTACATGAAAATGGAGAGCCTTCAGCAAGGACAACTGCCAGG
TTGGCTGTTGAAGGCACGAATGGAATAGATAATCATGTACCTACAAGCACTCTAGTCCAA
AACTCATGCTGCTCGTATGTAGTTAATGGAGACAACACACCTTCATCTCCGTCTCAGGTT
GCTGCCAGACCCAAAAATACACCAGCTCCAAAACCACTCGCATCTGAGCCTGCCGATGAC
ACTGTTAATGGAGAATCATCCTCATTTGCACCAACTGATAATGCGTCTGTCACGGGTACT
CCAGTAGTGTCTGAAGAAAATGCCTTGTCTCCAAATTGCACTAGTACTACTGTTGAAGAT
CCTCCAGTTCAAGAAATACTGACTTCCTCAGAAAACAATGAATGTATTCCTTCTACCAGT
GCAGAATTGGAATCTGAAGCTAGAAGTATATTAGAGCCTGACACCTCTAATTCTAGAAGT
AGTTCTGCTTTTGAAGCAGCCAAATCAAGACAGCCAGATGGGTGTATGGATCCTGTACGG
CAGCAGTCTGGGAATGCCAACACAGAAACCTTGCCATCAGGGTGGGAACAAAGAAAAGAT
CCTCATGGTAGAACCTATTATGTGGATCATAATACTCGAACTACCACATGGGAGAGACCA
CAACCTTTACCTCCAGGTTGGGAAAGAAGAGTTGATGATCGTAGAAGAGTTTATTATGTG
GATCATAACACCAGAACAACAACGTGGCAGCGGCCTACCATGGAATCTGTCCGAAATTTT
GAACAGTGGCAATCTCAGCGGAACCAATTGCAGGGAGCTATGCAACAGTTTAACCAACGA
TACCTCTATTCGGCTTCAATGTTAGCTGCAGAAAATGACCCTTATGGACCTTTGCCACCA
GGCTGGGAAAAAAGAGTGGATTCAACAGACAGGGTTTACTTTGTGAATCATAACACAAAA
ACAACCCAGTGGGAAGATCCAAGAACTCAAGGCTTACAGAATGAAGAACCCCTGCCAGAA
GGCTGGGAAATTAGATATACTCGTGAAGGTGTAAGGTACTTTGTTGATCATAACACAAGA
ACAACAACATTCAAAGATCCTCGCAATGGGAAGTCATCTGTAACTAAAGGTGGTCCACAA
ATTGCTTATGAACGCGGCTTTAGGTGGAAGCTTGCTCACTTCCGTTATTTGTGCCAGTCT
AATGCACTACCTAGTCATGTAAAGATCAATGTGTCCCGGCAGACATTGTTTGAAGATTCC
TTCCAACAGATTATGGCATTAAAACCCTATGACTTGAGGAGGCGCTTATATGTAATATTT
AGAGGAGAAGAAGGACTTGATTATGGTGGCCTAGCGAGAGAATGGTTTTTCTTGCTTTCA
CATGAAGTTTTGAACCCAATGTATTGCTTATTTGAGTATGCGGGCAAGAACAACTATTGT
CTGCAGATAAATCCAGCATCAACCATTAATCCAGACCATCTTTCATACTTCTGTTTCATT
GGTCGTTTTATTGCCATGGCACTATTTCATGGAAAGTTTATCGATACTGGTTTCTCTTTA
CCATTCTACAAGCGTATGTTAAGTAAAAAACTTACTATTAAGGATTTGGAATCTATTGAT
ACTGAATTTTATAACTCCCTTATCTGGATAAGAGATAACAACATTGAAGAATGTGGCTTA
GAAATGTACTTTTCTGTTGACATGGAGATTTTGGGAAAAGTTACTTCACATGACCTGAAG
TTGGGAGGTTCCAATATTCTGGTGACTGAGGAGAACAAAGATGAATATATTGGTTTAATG
ACAGAATGGCGTTTTTCTCGAGGAGTACAAGAACAGACCAAAGCTTTCCTTGATGGTTTT
AATGAAGTTGTTCCTCTTCAGTGGCTACAGTACTTCGATGAAAAAGAATTAGAGGTTATG
TTGTGTGGCATGCAGGAGGTTGACTTGGCAGATTGGCAGAGAAATACTGTTTATCGACAT
TATACAAGAAACAGCAAGCAAATCATTTGGTTTTGGCAGTTTGTGAAAGAGACAGACAAT
GAAGTAAGAATGCGACTATTGCAGTTCGTCACTGGAACCTGCCGTTTACCTCTAGGAGGA
TTTGCTGAGCTCATGGGAAGTAATGGGCCTCAAAAGTTTTGCATTGAAAAAGTTGGCAAA
GACACTTGGTTACCAAGAAGCCATACATGTTTTAATCGCTTGGATCTACCACCATATAAG
AGTTATGAACAACTAAAGGAAAAACTTCTTTTTGCAATAGAAGAGACAGAGGGATTTGGA
CAAGAATGA
|
| Protein Properties |
|---|
| Number of Residues
| 922 |
| Molecular Weight
| 105201.0 |
| Theoretical pI
| 5.71 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>TGIF-interacting ubiquitin ligase 1
MATASPRSDTSNNHSGRLQLQVTVSSAKLKRKKNWFGTAIYTEVVVDGEITKTAKSSSSS
NPKWDEQLTVNVTPQTTLEFQVWSHRTLKADALLGKATIDLKQALLIHNRKLERVKEQLK
LSLENKNGIAQTGELTVVLDGLVIEQENITNCSSSPTIEIQENGDALHENGEPSARTTAR
LAVEGTNGIDNHVPTSTLVQNSCCSYVVNGDNTPSSPSQVAARPKNTPAPKPLASEPADD
TVNGESSSFAPTDNASVTGTPVVSEENALSPNCTSTTVEDPPVQEILTSSENNECIPSTS
AELESEARSILEPDTSNSRSSSAFEAAKSRQPDGCMDPVRQQSGNANTETLPSGWEQRKD
PHGRTYYVDHNTRTTTWERPQPLPPGWERRVDDRRRVYYVDHNTRTTTWQRPTMESVRNF
EQWQSQRNQLQGAMQQFNQRYLYSASMLAAENDPYGPLPPGWEKRVDSTDRVYFVNHNTK
TTQWEDPRTQGLQNEEPLPEGWEIRYTREGVRYFVDHNTRTTTFKDPRNGKSSVTKGGPQ
IAYERGFRWKLAHFRYLCQSNALPSHVKINVSRQTLFEDSFQQIMALKPYDLRRRLYVIF
RGEEGLDYGGLAREWFFLLSHEVLNPMYCLFEYAGKNNYCLQINPASTINPDHLSYFCFI
GRFIAMALFHGKFIDTGFSLPFYKRMLSKKLTIKDLESIDTEFYNSLIWIRDNNIEECGL
EMYFSVDMEILGKVTSHDLKLGGSNILVTEENKDEYIGLMTEWRFSRGVQEQTKAFLDGF
NEVVPLQWLQYFDEKELEVMLCGMQEVDLADWQRNTVYRHYTRNSKQIIWFWQFVKETDN
EVRMRLLQFVTGTCRLPLGGFAELMGSNGPQKFCIEKVGKDTWLPRSHTCFNRLDLPPYK
SYEQLKEKLLFAIEETEGFGQE
|
| External Links |
|---|
| GenBank ID Protein
| 33590476 |
| UniProtKB/Swiss-Prot ID
| Q9H0M0 |
| UniProtKB/Swiss-Prot Entry Name
| Q5YLC1_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| AY345857 |
| GeneCard ID
| Not Available |
| GenAtlas ID
| Not Available |
| HGNC ID
| HGNC:17004 |
| References |
|---|
| General References
| - Seo SR, Lallemand F, Ferrand N, Pessah M, L'Hoste S, Camonis J, Atfi A: The novel E3 ubiquitin ligase Tiul1 associates with TGIF to target Smad2 for degradation. EMBO J. 2004 Oct 1;23(19):3780-92. Epub 2004 Sep 9. [PubMed:15359284 ]
|
