Hmdb loader
Survey
Identification
HMDB Protein ID HMDBP09323
Secondary Accession Numbers
  • 15159
Name Ubiquitin-protein ligase E3B
Synonyms Not Available
Gene Name UBE3B
Protein Type Enzyme
Biological Properties
General Function Involved in acid-amino acid ligase activity
Specific Function E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates
Pathways Not Available
Reactions Not Available
GO Classification
Component
cell part
intracellular
Function
catalytic activity
ligase activity
ligase activity, forming carbon-nitrogen bonds
acid-amino acid ligase activity
Process
metabolic process
macromolecule metabolic process
macromolecule modification
protein modification process
Cellular Location Not Available
Gene Properties
Chromosome Location Chromosome:1
Locus 12q24.11
SNPs UBE3B
Gene Sequence
>3207 bp
ATGTTCACCCTGTCTCAGACCTCGAGAGCATGGTTCATCGATAGAGCCCGTCAGGCACGA
GAAGAAAGGCTTGTGCAGAAGGAACGGGAGCGGGCAGCTGTTGTGATCCAGGCCCATGTC
CGGAGTTTTCTCTGTCGGAGTCGACTGCAGAGAGATATCAGGAGAGAGATTGATGACTTT
TTTAAAGCAGATGACCCTGAGTCCACTAAAAGAAGTGCACTTTGTATTTTCAAGATTGCC
AGGAAACTGCTGTTCCTATTCAGAATCAAAGAGGATAATGAGAGATTTGAGAAGTTGTGT
CGCAGCATCCTGAGCAGCATGGATGCTGAGAATGAGCCTAAGGTGTGGTATGTGTCCCTG
GCTTGTTCTAAGGACCTCACCCTCCTTTGGATTCAACAGATCAAGAACATTTTGTGGTAC
TGCTGTGATTTTCTCAAGCAGCTCAAGCCTGAAATCCTGCAGGACTCCCGACTCATCACC
CTGTACCTCACGATGCTTGTCACCTTCACAGACACTTCAACGTGGAAAATTCTTCGGGGA
AAAGGTGAAAGTCTTCGACCAGCGATGAACCACATTTGTGCAAATATAATGGGACATCTC
AACCAGCATGGATTTTATTCTGTGCTGCAGATATTGTTAACCCGTGGCCTGGCAAGACCC
CGTCCTTGTCTATCCAAAGGCACTTTAACAGCAGCTTTTTCTCTAGCGTTACGCCCTGTG
ATTGCTGCACAGTTCTCAGACAATCTGATTCGGCCGTTCCTCATCCACATCATGTCTGTG
CCTGCTCTGGTGACTCATCTCAGCACAGTGACCCCTGAGCGCCTCACTGTTTTAGAATCC
CATGACATGCTTCGTAAATTCATCATATTTTTAAGAGACCAAGATCGATGCCGTGATGTA
TGTGAAAGTTTAGAAGGATGCCATACGCTTTGTCTAATGGGCAACCTCCTACACTTGGGC
TCCCTCAGCCCCAGAGTGTTAGAGGAGGAGACAGATGGGTTCGTGAGTTTGCTCACCCAG
ACGCTGTGCTACTGTCGGAAGTATGTGTCTCAGAAGAAGTCCAACCTGACCCACTGGCAT
CCTGTCCTTGGCTGGTTCTCCCAATCTGTGGATTATGGCCTTAACGAGTCAATGCACTTG
ATCACCAAACAGCTGCAGTTCTTGTGGGGGGTGCCTCTGATCCGGATCTTCTTCTGTGAC
ATCCTGAGCAAGAAGCTACTGGAGAGCCAGGAGCCAGCCCACGCACAGCCAGCATCCCCT
CAGAATGTGCTCCCAGTGAAGAGTCTCCTAAAGCGTGCTTTTCAAAAGTCGGCATCAGTC
CGGAATATTCTCAGGCCTGTCGGGGGTAAACGGGTCGACTCTGCAGAAGTCCAGAAGGTT
TGCAACATCTGTGTCCTCTACCAGACCTCGCTGACAACTCTCACACAGATTCGGCTGCAG
ATACTCACAGGTCTCACTTACCTTGATGACCTGCTTCCCAAACTGTGGGCATTTATCTGT
GAGCTCGGGCCCCACGGAGGGTTAAAGCTCTTCTTGGAATGCCTGAACAATGACACTGAA
GAGTCCAAGCAACTCTTGGCCATGCTGATGCTGTTCTGTGACTGTTCGCGGCACCTCATC
ACAATCCTTGATGACATTGAAGTTTATGAAGAACAGATTTCATTCAAACTGGAAGAGCTG
GTCACTATCTCCTCTTTCCTGAATTCTTTTGTGTTTAAGATGATCTGGGATGGAATTGTA
GAGAACGCCAAGGGTGAGACCTTGGAGCTGTTCCAGTCTGTCCACGGGTGGCTTATGGTG
CTGTACGAGCGGGACTGCCGGCGGCGCTTCACCCCCGAGGACCACTGGCTGCGAAAGGAT
CTCAAACCTAGCGTGCTCTTCCAAGAACTCGACAGGGACAGAAAACGGGCACAGTTGATC
CTGCAGTACATCCCACATGTCATCCCTCACAAAAACAGAGTTCTACTGTTTCGAACCATG
GTTACCAAGGAGAAGGAGAAACTGGGGCTGGTGGAAACCAGCTCTGCCTCCCCGCATGTC
ACTCACATCACCATCCGCCGGTCCAGGATGCTGGAGGACGGCTACGAGCAGCTTAGGCAG
CTCTCCCAGCACGCCATGAAGGGGGTCATCCGTGTGAAGTTTGTCAATGACCTCGGGGTG
GACGAAGCAGGGATTGATCAAGACGGTGTTTTTAAGGAGTTCTTGGAAGAGATCATCAAG
AGAGTTTTTGACCCAGCACTCAATCTGTTCAAGACAACCAGTGGGGATGAGAGGCTGTAC
CCCTCACCCACATCCTACATCCATGAGAATTACCTGCAGCTCTTCGAGTTTGTGGGGAAG
ATGCTGGGGAAGGCTGTGTATGAGGGAATTGTGGTGGACGTGCCATTTGCATCCTTCTTC
CTGAGCCAACTGCTTGGGCACCACCACAGCGTCTTCTATAGCTCGGTGGATGAACTGCCT
TCTCTGGACTCCGAGTTCTATAAAAACCTCACCTCCATCAAGCGCTATGATGGGGACATC
ACTGACCTGGGCCTGACGCTGTCTTACGACGAGGACGTCATGGGTCAGCTTGTTTGCCAT
GAACTGATTCCTGGAGGGAAGACCATTCCTGTTACAAATGAAAATAAAATTAGCTACATC
CATCTGATGGCACATTTTCGAATGCACACTCAAATAAAAAACCAAACAGCTGCCCTCATT
AGCGGATTCCGTTCCATTATCAAACCCGAGTGGATCCGAATGTTCTCAACTCCTGAACTG
CAGCGTCTCATCTCTGGCGACAATGCTGAGATTGATCTGGAAGATTTAAAGAAGCACACA
GTCTACTACGGTGGTTTCCATGGAAGTCACAGAGTCATCATCTGGCTCTGGGATATTCTG
GCCTCCGACTTCACACCGGATGAGAGAGCTATGTTTCTGAAGTTCGTGACCAGCTGCTCC
AGACCCCCGCTCCTGGGATTCGCCTACCTCAAGCCTCCATTCTCCATCCGCTGCGTGGAG
GTGTCGGACGATCAGGACACCGGGGACACTCTGGGCAGCGTCCTCCGGGGCTTCTTCACC
ATCCGCAAGCGGGAGCCAGGCGGCCGCCTGCCCACCTCCTCCACCTGCTTCAACCTGCTC
AAGCTGCCCAACTACAGCAAGAAGAGCGTCCTCCGCGAGAAGCTGCGCTACGCCATCAGC
ATGAACACGGGCTTTGAACTCTCCTAG
Protein Properties
Number of Residues 1068
Molecular Weight 123096.7
Theoretical pI 8.27
Pfam Domain Function
Signals
  • None
Transmembrane Regions
  • None
Protein Sequence
>Ubiquitin-protein ligase E3B
MFTLSQTSRAWFIDRARQAREERLVQKERERAAVVIQAHVRSFLCRSRLQRDIRREIDDF
FKADDPESTKRSALCIFKIARKLLFLFRIKEDNERFEKLCRSILSSMDAENEPKVWYVSL
ACSKDLTLLWIQQIKNILWYCCDFLKQLKPEILQDSRLITLYLTMLVTFTDTSTWKILRG
KGESLRPAMNHICANIMGHLNQHGFYSVLQILLTRGLARPRPCLSKGTLTAAFSLALRPV
IAAQFSDNLIRPFLIHIMSVPALVTHLSTVTPERLTVLESHDMLRKFIIFLRDQDRCRDV
CESLEGCHTLCLMGNLLHLGSLSPRVLEEETDGFVSLLTQTLCYCRKYVSQKKSNLTHWH
PVLGWFSQSVDYGLNESMHLITKQLQFLWGVPLIRIFFCDILSKKLLESQEPAHAQPASP
QNVLPVKSLLKRAFQKSASVRNILRPVGGKRVDSAEVQKVCNICVLYQTSLTTLTQIRLQ
ILTGLTYLDDLLPKLWAFICELGPHGGLKLFLECLNNDTEESKQLLAMLMLFCDCSRHLI
TILDDIEVYEEQISFKLEELVTISSFLNSFVFKMIWDGIVENAKGETLELFQSVHGWLMV
LYERDCRRRFTPEDHWLRKDLKPSVLFQELDRDRKRAQLILQYIPHVIPHKNRVLLFRTM
VTKEKEKLGLVETSSASPHVTHITIRRSRMLEDGYEQLRQLSQHAMKGVIRVKFVNDLGV
DEAGIDQDGVFKEFLEEIIKRVFDPALNLFKTTSGDERLYPSPTSYIHENYLQLFEFVGK
MLGKAVYEGIVVDVPFASFFLSQLLGHHHSVFYSSVDELPSLDSEFYKNLTSIKRYDGDI
TDLGLTLSYDEDVMGQLVCHELIPGGKTIPVTNENKISYIHLMAHFRMHTQIKNQTAALI
SGFRSIIKPEWIRMFSTPELQRLISGDNAEIDLEDLKKHTVYYGGFHGSHRVIIWLWDIL
ASDFTPDERAMFLKFVTSCSRPPLLGFAYLKPPFSIRCVEVSDDQDTGDTLGSVLRGFFT
IRKREPGGRLPTSSTCFNLLKLPNYSKKSVLREKLRYAISMNTGFELS
GenBank ID Protein 35493959
UniProtKB/Swiss-Prot ID Q7Z3V4
UniProtKB/Swiss-Prot Entry Name UBE3B_HUMAN
PDB IDs Not Available
GenBank Gene ID NM_130466.2
GeneCard ID UBE3B
GenAtlas ID UBE3B
HGNC ID HGNC:13478
References
General References
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  2. Daub H, Olsen JV, Bairlein M, Gnad F, Oppermann FS, Korner R, Greff Z, Keri G, Stemmann O, Mann M: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. Mol Cell. 2008 Aug 8;31(3):438-48. doi: 10.1016/j.molcel.2008.07.007. [PubMed:18691976 ]
  3. Scherer SE, Muzny DM, Buhay CJ, Chen R, Cree A, Ding Y, Dugan-Rocha S, Gill R, Gunaratne P, Harris RA, Hawes AC, Hernandez J, Hodgson AV, Hume J, Jackson A, Khan ZM, Kovar-Smith C, Lewis LR, Lozado RJ, Metzker ML, Milosavljevic A, Miner GR, Montgomery KT, Morgan MB, Nazareth LV, Scott G, Sodergren E, Song XZ, Steffen D, Lovering RC, Wheeler DA, Worley KC, Yuan Y, Zhang Z, Adams CQ, Ansari-Lari MA, Ayele M, Brown MJ, Chen G, Chen Z, Clerc-Blankenburg KP, Davis C, Delgado O, Dinh HH, Draper H, Gonzalez-Garay ML, Havlak P, Jackson LR, Jacob LS, Kelly SH, Li L, Li Z, Liu J, Liu W, Lu J, Maheshwari M, Nguyen BV, Okwuonu GO, Pasternak S, Perez LM, Plopper FJ, Santibanez J, Shen H, Tabor PE, Verduzco D, Waldron L, Wang Q, Williams GA, Zhang J, Zhou J, Allen CC, Amin AG, Anyalebechi V, Bailey M, Barbaria JA, Bimage KE, Bryant NP, Burch PE, Burkett CE, Burrell KL, Calderon E, Cardenas V, Carter K, Casias K, Cavazos I, Cavazos SR, Ceasar H, Chacko J, Chan SN, Chavez D, Christopoulos C, Chu J, Cockrell R, Cox CD, Dang M, Dathorne SR, David R, Davis CM, Davy-Carroll L, Deshazo DR, Donlin JE, D'Souza L, Eaves KA, Egan A, Emery-Cohen AJ, Escotto M, Flagg N, Forbes LD, Gabisi AM, Garza M, Hamilton C, Henderson N, Hernandez O, Hines S, Hogues ME, Huang M, Idlebird DG, Johnson R, Jolivet A, Jones S, Kagan R, King LM, Leal B, Lebow H, Lee S, LeVan JM, Lewis LC, London P, Lorensuhewa LM, Loulseged H, Lovett DA, Lucier A, Lucier RL, Ma J, Madu RC, Mapua P, Martindale AD, Martinez E, Massey E, Mawhiney S, Meador MG, Mendez S, Mercado C, Mercado IC, Merritt CE, Miner ZL, Minja E, Mitchell T, Mohabbat F, Mohabbat K, Montgomery B, Moore N, Morris S, Munidasa M, Ngo RN, Nguyen NB, Nickerson E, Nwaokelemeh OO, Nwokenkwo S, Obregon M, Oguh M, Oragunye N, Oviedo RJ, Parish BJ, Parker DN, Parrish J, Parks KL, Paul HA, Payton BA, Perez A, Perrin W, Pickens A, Primus EL, Pu LL, Puazo M, Quiles MM, Quiroz JB, Rabata D, Reeves K, Ruiz SJ, Shao H, Sisson I, Sonaike T, Sorelle RP, Sutton AE, Svatek AF, Svetz LA, Tamerisa KS, Taylor TR, Teague B, Thomas N, Thorn RD, Trejos ZY, Trevino BK, Ukegbu ON, Urban JB, Vasquez LI, Vera VA, Villasana DM, Wang L, Ward-Moore S, Warren JT, Wei X, White F, Williamson AL, Wleczyk R, Wooden HS, Wooden SH, Yen J, Yoon L, Yoon V, Zorrilla SE, Nelson D, Kucherlapati R, Weinstock G, Gibbs RA: The finished DNA sequence of human chromosome 12. Nature. 2006 Mar 16;440(7082):346-51. [PubMed:16541075 ]
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  5. Gong TW, Huang L, Warner SJ, Lomax MI: Characterization of the human UBE3B gene: structure, expression, evolution, and alternative splicing. Genomics. 2003 Aug;82(2):143-52. [PubMed:12837265 ]