Hmdb loader
Identification
HMDB Protein ID HMDBP10121
Secondary Accession Numbers
  • 16077
Name Ubiquitin carboxyl-terminal hydrolase 46
Synonyms
  1. Deubiquitinating enzyme 46
  2. Ubiquitin thiolesterase 46
  3. Ubiquitin-specific-processing protease 46
Gene Name USP46
Protein Type Enzyme
Biological Properties
General Function Involved in ubiquitin thiolesterase activity
Specific Function Deubiquitinating enzyme that plays a role in behavior, possibly by regulating GABA action. May act by mediating the deubiquitination of GAD1/GAD67. Has almost no deubiquitinating activity by itself and requires the interaction with WDR48 to have a high activity. Not involved in deubiquitination of monoubiquitinated FANCD2
Pathways Not Available
Reactions Not Available
GO Classification
Function
hydrolase activity, acting on ester bonds
catalytic activity
hydrolase activity
ubiquitin thiolesterase activity
thiolester hydrolase activity
Process
metabolic process
catabolic process
macromolecule catabolic process
cellular macromolecule catabolic process
modification-dependent macromolecule catabolic process
modification-dependent protein catabolic process
ubiquitin-dependent protein catabolic process
Cellular Location
  1. Cytoplasmic
Gene Properties
Chromosome Location Chromosome:4
Locus 4q12
SNPs USP46
Gene Sequence
>1101 bp
ATGACTGTCCGAAACATCGCCTCCATCTGTAATATGGGCACCAATGCCTCTGCTCTGGAA
AAAGACATTGGTCCAGAGCAGTTTCCAATCAATGAACACTATTTCGGATTGGTCAATTTT
GGAAACACATGCTACTGTAACTCCGTGCTTCAGGCATTGTACTTCTGCCGTCCATTCCGG
GAGAATGTGTTGGCATACAAGGCCCAGCAAAAGAAGAAGGAAAACTTGCTGACGTGCCTG
GCGGACCTTTTCCACAGCATTGCCACACAGAAGAAGAAGGTTGGCGTCATCCCACCAAAG
AAGTTCATTTCAAGGCTGAGAAAAGAGAATGATCTCTTTGATAACTACATGCAGCAGGAT
GCTCATGAATTTTTAAATTATTTGCTAAACACTATTGCGGACATCCTTCAGGAGGAGAAG
AAACAGGAAAAACAAAATGGAAAATTAAAAAATGGCAACATGAACGAACCTGCGGAAAAT
AATAAACCAGAACTCACCTGGGTCCATGAGATTTTTCAGGGAACGCTTACCAATGAAACT
CGATGCTTGAACTGTGAAACTGTTAGTAGCAAAGATGAAGATTTTCTTGACCTTTCTGTT
GATGTGGAGCAGAATACATCCATTACCCACTGTCTAAGAGACTTCAGCAACACAGAAACA
CTGTGTAGTGAACAAAAATATTATTGTGAAACATGCTGCAGCAAACAAGAAGCCCAGAAA
AGGATGAGGGTAAAAAAGCTGCCCATGGTCTTGGCCCTGCACCTAAAGCGGTTCAAGTAC
ATGGAGCAGCTGCGCAGATACACCAAGCTGTCTTACCGTGTGGTCTTCCCTCTGGAACTC
CGGCTCTTCAACACCTCCAGTGATGCAGTGAACCTGGACCGCATGTATGACTTGGTTGCG
GTGGTCGTTCACTGTGGCAGTGGTCCTAATCGTGGGCATTATATCACTATTGTGAAAAGT
CACGGCTTCTGGCTTTTGTTTGATGATGACATTGTAGAGAAAATAGATGCTCAAGCTATT
GAAGAATTCTATGGCCTGACGTCAGATATATCAAAAAATTCAGAATCTGGATATATTTTA
TTCTATCAGTCAAGAGAGTAA
Protein Properties
Number of Residues 366
Molecular Weight 42442.1
Theoretical pI 6.82
Pfam Domain Function
Signals
  • None
Transmembrane Regions
  • None
Protein Sequence
>Ubiquitin carboxyl-terminal hydrolase 46
MTVRNIASICNMGTNASALEKDIGPEQFPINEHYFGLVNFGNTCYCNSVLQALYFCRPFR
ENVLAYKAQQKKKENLLTCLADLFHSIATQKKKVGVIPPKKFISRLRKENDLFDNYMQQD
AHEFLNYLLNTIADILQEEKKQEKQNGKLKNGNMNEPAENNKPELTWVHEIFQGTLTNET
RCLNCETVSSKDEDFLDLSVDVEQNTSITHCLRDFSNTETLCSEQKYYCETCCSKQEAQK
RMRVKKLPMILALHLKRFKYMEQLHRYTKLSYRVVFPLELRLFNTSSDAVNLDRMYDLVA
VVVHCGSGPNRGHYITIVKSHGFWLLFDDDIVEKIDAQAIEEFYGLTSDISKNSESGYIL
FYQSRE
GenBank ID Protein 10434108
UniProtKB/Swiss-Prot ID P62068
UniProtKB/Swiss-Prot Entry Name UBP46_HUMAN
PDB IDs Not Available
GenBank Gene ID AK022614
GeneCard ID USP46
GenAtlas ID USP46
HGNC ID HGNC:20075
References
General References
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  2. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [PubMed:15489334 ]
  3. Quesada V, Diaz-Perales A, Gutierrez-Fernandez A, Garabaya C, Cal S, Lopez-Otin C: Cloning and enzymatic analysis of 22 novel human ubiquitin-specific proteases. Biochem Biophys Res Commun. 2004 Jan 30;314(1):54-62. [PubMed:14715245 ]
  4. Cohn MA, Kee Y, Haas W, Gygi SP, D'Andrea AD: UAF1 is a subunit of multiple deubiquitinating enzyme complexes. J Biol Chem. 2009 Feb 20;284(8):5343-51. doi: 10.1074/jbc.M808430200. Epub 2008 Dec 15. [PubMed:19075014 ]