Human Metabolome Database: Showing Protein Thiamine transporter THTR-1 (HMDBP10779)

Identification Biological properties Gene properties Protein properties External links References XML Show 1 metabolite

Identification

HMDB Protein ID

HMDBP10779

Secondary Accession Numbers

17048

Name

Thiamine transporter THTR-1

Synonyms

Not Available

Gene Name

SLC19A2

Protein Type

Unknown

Biological Properties

General Function

Involved in folic acid binding

Specific Function

Not Available

Pathways

Not Available

Reactions

Not Available

GO Classification

Component
membrane
cell part
Function
active transmembrane transporter activity
binding
transmembrane transporter activity
folic acid binding
carboxylic acid binding
amino acid binding
transporter activity
secondary active transmembrane transporter activity
reduced folate carrier activity
Process
establishment of localization
transport

Cellular Location

Not Available

Gene Properties

Chromosome Location

Chromosome:1

Locus

1q23.3

SNPs

SLC19A2

Gene Sequence

>204 bp
ATGGATGTGCCCGGCCCGGTGTCTCGGCGGGCGGCGGCGGCGGCGGCCACTGTGCTCCTG
CGGACCGCTCGGGTCCGTCGCGAATGCTGGTTCTTGCCGACCGCGCTGCTCTGCGCCTAC
GGCTTCTTCGCCAGCCTCAGGCCGTCCGAGCTCTTCCTGACCCCGTACCTGCTGGGGCCG
GACAAGAACCTGACCGAGAGGGAG

Protein Properties

Number of Residues

Molecular Weight

7567.7

Theoretical pI

9.39

Pfam Domain Function

Folate_carrier (PF01770 )

Signals

None

Transmembrane Regions

None

Protein Sequence

>Thiamine transporter THTR-1
MDVPGPVSRRAAAAAATVLLRTARVRRECWFLPTALLCAYGFFASLRPSELFLTPYLLGP
DKNLTERE

External Links

GenBank ID Protein

30962027

UniProtKB/Swiss-Prot ID

Q7Z7J1

UniProtKB/Swiss-Prot Entry Name

Q7Z7J1_HUMAN

PDB IDs

Not Available

GenBank Gene ID

GeneCard ID

GenAtlas ID

HGNC ID

References

General References

Lagarde WH, Underwood LE, Moats-Staats BM, Calikoglu AS: Novel mutation in the SLC19A2 gene in an African-American female with thiamine-responsive megaloblastic anemia syndrome. Am J Med Genet A. 2004 Mar 15;125A(3):299-305. [PubMed:14994241 ]