Hmdb loader
Identification
HMDB Protein ID HMDBP10898
Secondary Accession Numbers
  • 17198
Name Hyaluronan and proteoglycan link protein 1
Synonyms
  1. Cartilage-link protein
  2. Cartilage-linking protein 1
  3. Proteoglycan link protein
Gene Name HAPLN1
Protein Type Unknown
Biological Properties
General Function Involved in binding
Specific Function Stabilizes the aggregates of proteoglycan monomers with hyaluronic acid in the extracellular cartilage matrix
Pathways Not Available
Reactions Not Available
GO Classification
Function
binding
pattern binding
polysaccharide binding
glycosaminoglycan binding
hyaluronic acid binding
Process
cell adhesion
cellular process
Cellular Location
  1. Secreted
  2. extracellular space
  3. extracellular matrix
Gene Properties
Chromosome Location Chromosome:5
Locus 5q14.3
SNPs HAPLN1
Gene Sequence
>1065 bp
ATGAAGAGTCTACTTCTTCTGGTGCTGATTTCAATCTGCTGGGCTGATCATCTTTCAGAC
AACTATACTCTGGATCATGACAGAGCTATTCACATCCAAGCAGAAAATGGCCCCCATCTA
CTTGTGGAAGCAGAGCAAGCCAAGGTGTTTTCACACAGAGGTGGCAATGTTACACTGCCA
TGTAAATTTTATCGAGACCCTACAGCATTTGGCTCAGGAATCCATAAAATCCGAATTAAG
TGGACCAAGCTAACTTCGGATTACCTCAAGGAAGTGGATGTTTTTGTTTCCATGGGATAC
CACAAAAAAACCTATGGAGGCTACCAGGGTAGAGTGTTTCTGAAGGGAGGCAGTGATAGT
GATGCTTCTCTGGTCATCACAGACCTCACTCTGGAAGATTATGGGAGATATAAGTGTGAG
GTGATTGAAGGATTAGAAGATGATACTGTTGTGGTAGCACTGGACTTACAAGGTGTGGTA
TTCCCTTACTTTCCACGACTGGGGCGCTACAATCTCAATTTTCACGAGGCGCAGCAGGCG
TGTCTGGACCAGGATGCTGTGATCGCCTCCTTCGACCAGCTGTACGACGCCTGGCGGGGC
GGGCTGGACTGGTGCAATGCCGGCTGGCTCAGTGATGGCTCTGTGCAATATCCCATCACA
AAGCCCAGAGAGCCCTGTGGGGGCCAGAACACAGTGCCCGGAGTCAGGAACTACGGATTT
TGGGATAAAGATAAAAGCAGATATGATGTTTTCTGTTTTACATCCAATTTCAATGGCCGT
TTTTACTATCTGATCCACCCCACCAAACTGACCTATGATGAAGCGGTGCAAGCTTGTCTC
AATGATGGTGCTCAGATTGCAAAAGTGGGCCAGATATTTGCTGCCTGGAAAATTCTCGGA
TATGACCGCTGTGATGCGGGCTGGTTGGCGGATGGCAGCGTCCGCTACCCCATCTCTAGG
CCAAGAAGGCGCTGCAGTCCTACTGAGGCTGCAGTGCGCTTCGTGGGTTTCCCAGATAAA
AAGCATAAGCTGTATGGTGTCTACTGCTTCAGAGCATACAACTGA
Protein Properties
Number of Residues 354
Molecular Weight 40165.2
Theoretical pI 7.45
Pfam Domain Function
Signals
  • None
Transmembrane Regions
  • None
Protein Sequence
>Hyaluronan and proteoglycan link protein 1
MKSLLLLVLISICWADHLSDNYTLDHDRAIHIQAENGPHLLVEAEQAKVFSHRGGNVTLP
CKFYRDPTAFGSGIHKIRIKWTKLTSDYLKEVDVFVSMGYHKKTYGGYQGRVFLKGGSDS
DASLVITDLTLEDYGRYKCEVIEGLEDDTVVVALDLQGVVFPYFPRLGRYNLNFHEAQQA
CLDQDAVIASFDQLYDAWRGGLDWCNAGWLSDGSVQYPITKPREPCGGQNTVPGVRNYGF
WDKDKSRYDVFCFTSNFNGRFYYLIHPTKLTYDEAVQACLNDGAQIAKVGQIFAAWKILG
YDRCDAGWLADGSVRYPISRPRRRCSPTEAAVRFVGFPDKKHKLYGVYCFRAYN
GenBank ID Protein 189053949
UniProtKB/Swiss-Prot ID P10915
UniProtKB/Swiss-Prot Entry Name HPLN1_HUMAN
PDB IDs Not Available
GenBank Gene ID AK313713
GeneCard ID HAPLN1
GenAtlas ID HAPLN1
HGNC ID HGNC:2380
References
General References
  1. Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S: Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat Genet. 2004 Jan;36(1):40-5. Epub 2003 Dec 21. [PubMed:14702039 ]
  2. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [PubMed:15489334 ]
  3. Sjoblom T, Jones S, Wood LD, Parsons DW, Lin J, Barber TD, Mandelker D, Leary RJ, Ptak J, Silliman N, Szabo S, Buckhaults P, Farrell C, Meeh P, Markowitz SD, Willis J, Dawson D, Willson JK, Gazdar AF, Hartigan J, Wu L, Liu C, Parmigiani G, Park BH, Bachman KE, Papadopoulos N, Vogelstein B, Kinzler KW, Velculescu VE: The consensus coding sequences of human breast and colorectal cancers. Science. 2006 Oct 13;314(5797):268-74. Epub 2006 Sep 7. [PubMed:16959974 ]
  4. Dudhia J, Hardingham TE: The primary structure of human cartilage link protein. Nucleic Acids Res. 1990 Mar 11;18(5):1292. [PubMed:2320422 ]
  5. Dudhia J, Hardingham TE: The primary structure of human cartilage link protein. Nucleic Acids Res. 1990 Apr 25;18(8):2214. [PubMed:2336413 ]
  6. Osborne-Lawrence SL, Sinclair AK, Hicks RC, Lacey SW, Eddy RL Jr, Byers MG, Shows TB, Duby AD: Complete amino acid sequence of human cartilage link protein (CRTL1) deduced from cDNA clones and chromosomal assignment of the gene. Genomics. 1990 Nov;8(3):562-7. [PubMed:2286376 ]
  7. Rhodes C, Savagner P, Line S, Sasaki M, Chirigos M, Doege K, Yamada Y: Characterization of the promoter for the rat and human link protein gene. Nucleic Acids Res. 1991 Apr 25;19(8):1933-9. [PubMed:2030970 ]
  8. Hirakawa S, Oohashi T, Su WD, Yoshioka H, Murakami T, Arata J, Ninomiya Y: The brain link protein-1 (BRAL1): cDNA cloning, genomic structure, and characterization as a novel link protein expressed in adult brain. Biochem Biophys Res Commun. 2000 Oct 5;276(3):982-9. [PubMed:11027579 ]
  9. Spicer AP, Joo A, Bowling RA Jr: A hyaluronan binding link protein gene family whose members are physically linked adjacent to chondroitin sulfate proteoglycan core protein genes: the missing links. J Biol Chem. 2003 Jun 6;278(23):21083-91. Epub 2003 Mar 27. [PubMed:12663660 ]