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Showing Protein Guanine nucleotide-binding protein G(k) subunit alpha (HMDBP11461)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 3 metabolites
Identification
HMDB Protein ID HMDBP11461
Secondary Accession Numbers
  • 17808
Name Guanine nucleotide-binding protein G(k) subunit alpha
Synonyms
  1. G(i) alpha-3
Gene Name GNAI3
Protein Type Unknown
Biological Properties
General Function Involved in signal transducer activity
Specific Function Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. G(k) is the stimulatory G protein of receptor- regulated K(+) channels
Pathways Not Available
Reactions Not Available
GO Classification
Function
purine nucleotide binding
binding
nucleotide binding
guanyl nucleotide binding
guanyl ribonucleotide binding
gtp binding
molecular transducer activity
signal transducer activity
Process
biological regulation
regulation of biological process
regulation of cellular process
signal transduction
signaling
signaling pathway
cell surface receptor linked signaling pathway
g-protein coupled receptor protein signaling pathway
Cellular Location Not Available
Gene Properties
Chromosome Location Chromosome:1
Locus 1p13
SNPs GNAI3
Gene Sequence 
>1065 bp
ATGGGCTGCACGTTGAGCGCCGAAGACAAGGCGGCAGTGGAGCGAAGCAAGATGATCGAC
CGCAACTTACGGGAGGACGGGGAAAAAGCGGCCAAAGAAGTGAAGCTGCTGCTACTCGGT
GCTGGAGAATCTGGTAAAAGCACCATTGTGAAACAGATGAAAATCATTCATGAGGATGGC
TATTCAGAGGATGAATGTAAACAATATAAAGTAGTTGTCTACAGCAATACTATACAGTCC
ATCATTGCAATCATAAGAGCCATGGGACGGCTAAAGATTGACTTTGGGGAAGCTGCCAGG
GCAGATGATGCCCGGCAATTATTTGTTTTAGCTGGCAGTGCTGAAGAAGGAGTCATGACT
CCAGAACTAGCAGGAGTGATTAAACGGTTATGGCGAGATGGTGGGGTACAAGCTTGCTTC
AGCAGATCCAGGGAATATCAGCTCAATGATTCTGCTTCATATTATCTAAATGATCTGGAT
AGAATATCCCAGTCTAACTACATTCCAACTCAGCAAGATGTTCTTCGGACGAGAGTGAAG
ACCACAGGCATTGTAGAAACACATTTCACCTTCAAAGACCTATACTTCAAGATGTTTGAT
GTAGGTGGCCAAAGATCAGAACGAAAAAAGTGGATTCACTGTTTTGAGGGAGTGACAGCA
ATTATCTTCTGTGTGGCCCTCAGTGATTATGACCTTGTTCTGGCTGAGGACGAGGAGATG
AACCGAATGCATGAAAGCATGAAACTGTTTGACAGCATTTGTAATAACAAATGGTTTACA
GAAACTTCAATCATTCTCTTCCTTAACAAGAAAGACCTTTTTGAGGAAAAAATAAAGAGG
AGTCCGTTAACTATCTGTTATCCAGAATACACAGGTTCCAATACATATGAAGAGGCAGCT
GCCTATATTCAATGCCAGTTTGAAGATCTGAACAGAAGAAAAGATACCAAGGAGATCTAT
ACTCACTTCACCTGTGCCACAGACACGAAGAATGTGCAGTTTGTTTTTGATGCTGTTACA
GATGTCATCATTAAAAACAACTTAAAGGAATGTGGACTTTATTGA
Protein Properties
Number of Residues 354
Molecular Weight 40531.8
Theoretical pI 5.37
Pfam Domain Function
Signals
  • None
Transmembrane Regions
  • None
Protein Sequence 
>Guanine nucleotide-binding protein G(k) subunit alpha
MGCTLSAEDKAAVERSKMIDRNLREDGEKAAKEVKLLLLGAGESGKSTIVKQMKIIHEDG
YSEDECKQYKVVVYSNTIQSIIAIIRAMGRLKIDFGEAARADDARQLFVLAGSAEEGVMT
PELAGVIKRLWRDGGVQACFSRSREYQLNDSASYYLNDLDRISQSNYIPTQQDVLRTRVK
TTGIVETHFTFKDLYFKMFDVGGQRSERKKWIHCFEGVTAIIFCVALSDYDLVLAEDEEM
NRMHESMKLFDSICNNKWFTETSIILFLNKKDLFEEKIKRSPLTICYPEYTGSNTYEEAA
AYIQCQFEDLNRRKDTKEIYTHFTCATDTKNVQFVFDAVTDVIIKNNLKECGLY
GenBank ID Protein 20147707
UniProtKB/Swiss-Prot ID P08754
UniProtKB/Swiss-Prot Entry Name GNAI3_HUMAN
PDB IDs
GenBank Gene ID AF493907
GeneCard ID GNAI3
GenAtlas ID GNAI3
HGNC ID HGNC:4387
References
General References
  1. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [PubMed:15489334 ]
  2. Rikova K, Guo A, Zeng Q, Possemato A, Yu J, Haack H, Nardone J, Lee K, Reeves C, Li Y, Hu Y, Tan Z, Stokes M, Sullivan L, Mitchell J, Wetzel R, Macneill J, Ren JM, Yuan J, Bakalarski CE, Villen J, Kornhauser JM, Smith B, Li D, Zhou X, Gygi SP, Gu TL, Polakiewicz RD, Rush J, Comb MJ: Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer. Cell. 2007 Dec 14;131(6):1190-203. [PubMed:18083107 ]
  3. Heibeck TH, Ding SJ, Opresko LK, Zhao R, Schepmoes AA, Yang F, Tolmachev AV, Monroe ME, Camp DG 2nd, Smith RD, Wiley HS, Qian WJ: An extensive survey of tyrosine phosphorylation revealing new sites in human mammary epithelial cells. J Proteome Res. 2009 Aug;8(8):3852-61. doi: 10.1021/pr900044c. [PubMed:19534553 ]
  4. Itoh H, Toyama R, Kozasa T, Tsukamoto T, Matsuoka M, Kaziro Y: Presence of three distinct molecular species of Gi protein alpha subunit. Structure of rat cDNAs and human genomic DNAs. J Biol Chem. 1988 May 15;263(14):6656-64. [PubMed:2834384 ]
  5. Didsbury JR, Snyderman R: Molecular cloning of a new human G protein. Evidence for two Gi alpha-like protein families. FEBS Lett. 1987 Jul 13;219(1):259-63. [PubMed:3109953 ]
  6. Beals CR, Wilson CB, Perlmutter RM: A small multigene family encodes Gi signal-transduction proteins. Proc Natl Acad Sci U S A. 1987 Nov;84(22):7886-90. [PubMed:3120178 ]
  7. Codina J, Olate J, Abramowitz J, Mattera R, Cook RG, Birnbaumer L: Alpha i-3 cDNA encodes the alpha subunit of Gk, the stimulatory G protein of receptor-regulated K+ channels. J Biol Chem. 1988 May 15;263(14):6746-50. [PubMed:2452165 ]
  8. Kim SY, Ang SL, Bloch DB, Bloch KD, Kawahara Y, Tolman C, Lee R, Seidman JG, Neer EJ: Identification of cDNA encoding an additional alpha subunit of a human GTP-binding protein: expression of three alpha i subtypes in human tissues and cell lines. Proc Natl Acad Sci U S A. 1988 Jun;85(12):4153-7. [PubMed:3132707 ]
  9. Suki WN, Abramowitz J, Mattera R, Codina J, Birnbaumer L: The human genome encodes at least three non-allellic G proteins with alpha i-type subunits. FEBS Lett. 1987 Aug 10;220(1):187-92. [PubMed:2440724 ]