| Identification |
|---|
| HMDB Protein ID
| HMDBP11531 |
| Secondary Accession Numbers
| |
| Name
| Putative lipoyltransferase 2, mitochondrial |
| Synonyms
|
- Lipoate-protein ligase B
- Lipoyl/octanoyl transferase
- Octanoyl-[acyl-carrier-protein]-protein N-octanoyltransferase
|
| Gene Name
| LIPT2 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in catalytic activity |
| Specific Function
| Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
| Component |
| cell part |
| intracellular part |
| cytoplasm |
| Function |
| catalytic activity |
| transferase activity |
| transferase activity, transferring acyl groups |
| transferase activity, transferring acyl groups other than amino-acyl groups |
| acyltransferase activity |
| octanoyltransferase activity |
| Process |
| metabolic process |
| lipoic acid metabolic process |
| lipoic acid biosynthetic process |
| lipoate biosynthetic process |
| macromolecule metabolic process |
| cellular metabolic process |
| macromolecule modification |
| protein modification process |
| cofactor metabolic process |
| coenzyme metabolic process |
|
| Cellular Location
|
- Mitochondrion (Potential)
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 11q13.4 |
| SNPs
| LIPT2 |
| Gene Sequence
|
>696 bp
ATGCGGCAACCCGCCGTTCGGTTGGTGCGCCTGGGTCGGGTGCCGTACGCCGAGCTACTG
GGGCTGCAGGACCGCTGGCTGCGGCGGCTGCAGGCCGAGCCAGGCATTGAGGCCCCGTCG
GGGACTGAGGCGGGCGCGCTCCTGCTCTGCGAGCCCGCGGGGCCCGTGTATACGGCCGGG
CTGCGCGGCGGCCTGACGCCCGAGGAAACTGCGCGGCTACGGGCCTTGGGCGCCGAGGTG
CGCGTCACAGGCCGCGGTGGCCTGGCCACCTTCCACGGCCCGGGCCAGCTGCTTTGCCAC
CCGGTACTCGACCTGCGGCGTCTCGGCCTGCGCTTGCGCATGCACGTAGCGTCGCTGGAG
GCGTGCGCCGTGCGCCTGTGCGAGCTCCAGGGCCTGCAGGACGCCCGCGCGCGGCCCCCG
CCCTACACTGGCGTCTGGCTAGACGATCGCAAGATCTGCGCGATCGGAGTCCGCTGTGGA
AGGCACATCACATCCCACGGCCTGGCTCTCAACTGCTCTACCGACCTCACGTGGTTTGAG
CACATCGTGCCCTGTGGACTGGTTGGGACAGGCGTCACTTCCTTGAGTAAGGAGCTCCAG
AGGCACGTCACCGTGGAAGAAGTAATGCCACCTTTCCTTGTGGCCTTTAAGGAGATCTAC
AAGTGCACACTGATCTCAGAGGACAGCCCCAACTGA
|
| Protein Properties |
|---|
| Number of Residues
| 231 |
| Molecular Weight
| 25195.1 |
| Theoretical pI
| 8.34 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Putative lipoyltransferase 2, mitochondrial
MRQPAVRLVRLGRVPYAELLGLQDRWLRRLQAEPGIEAPSGTEAGALLLCEPAGPVYTAG
LRGGLTPEETARLRALGAEVRVTGRGGLATFHGPGQLLCHPVLDLRRLGLRLRMHVASLE
ACAVRLCELQGLQDARARPPPYTGVWLDDRKICAIGVRCGRHITSHGLALNCSTDLTWFE
HIVPCGLVGTGVTSLSKELQRHVTVEEVMPPFLVAFKEIYKCTLISEDSPN
|
| External Links |
|---|
| GenBank ID Protein
| 221554520 |
| UniProtKB/Swiss-Prot ID
| A6NK58 |
| UniProtKB/Swiss-Prot Entry Name
| LIPT2_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| NM_001144869.1 |
| GeneCard ID
| LIPT2 |
| GenAtlas ID
| LIPT2 |
| HGNC ID
| HGNC:37216 |
| References |
|---|
| General References
| - Taylor TD, Noguchi H, Totoki Y, Toyoda A, Kuroki Y, Dewar K, Lloyd C, Itoh T, Takeda T, Kim DW, She X, Barlow KF, Bloom T, Bruford E, Chang JL, Cuomo CA, Eichler E, FitzGerald MG, Jaffe DB, LaButti K, Nicol R, Park HS, Seaman C, Sougnez C, Yang X, Zimmer AR, Zody MC, Birren BW, Nusbaum C, Fujiyama A, Hattori M, Rogers J, Lander ES, Sakaki Y: Human chromosome 11 DNA sequence and analysis including novel gene identification. Nature. 2006 Mar 23;440(7083):497-500. [PubMed:16554811 ]
|
