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Showing Protein Epoxide hydrolase 1 (HMDBP12314)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 1 metabolite
Identification
HMDB Protein ID HMDBP12314
Secondary Accession Numbers None
Name Epoxide hydrolase 1
Synonyms
  1. Epoxide hydratase
  2. Microsomal epoxide hydrolase
  3. mEH
Gene Name EPHX1
Protein Type Unknown
Biological Properties
General Function Not Available
Specific Function Biotransformation enzyme that catalyzes the hydrolysis of arene and aliphatic epoxides to less reactive and more water soluble dihydrodiols by the trans addition of water. May play a role in the metabolism of endogenous lipids such as epoxide-containing fatty acids. Metabolizes the abundant endocannabinoid 2-arachidonoylglycerol (2-AG) to free arachidonic acid (AA) and glycerol (By similarity).
Pathways
  • Bile secretion
  • Chemical carcinogenesis - DNA adducts
  • Chemical carcinogenesis - reactive oxygen species
  • Chemical carcinogenesis - receptor activation
  • Metabolism of xenobiotics by cytochrome P450
Reactions Not Available
GO Classification
Biological Process
aromatic compound catabolic process
cellular response to organic substance
diol biosynthetic process
epoxide metabolic process
liver development
cellular aromatic compound metabolic process
arachidonic acid metabolic process
cellular response to glucocorticoid stimulus
response to toxin
response to organic cyclic compound
Cellular Component
endoplasmic reticulum membrane
plasma membrane
membrane
intracellular membrane-bounded organelle
integral to membrane
Molecular Function
cis-stilbene-oxide hydrolase activity
epoxide hydrolase activity
enzyme binding
Cellular Location Not Available
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues 455
Molecular Weight 52581.21
Theoretical pI 8.507
Pfam Domain Function
Signals Not Available
Transmembrane Regions
  • 1-21;
Protein Sequence Not Available
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID P07687
UniProtKB/Swiss-Prot Entry Name HYEP_RAT
PDB IDs Not Available
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID Not Available
References
General References
  1. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [PubMed:15489334 ]
  2. Falany CN, McQuiddy P, Kasper CB: Structure and organization of the microsomal xenobiotic epoxide hydrolase gene. J Biol Chem. 1987 Apr 25;262(12):5924-30. [PubMed:3032949 ]
  3. Porter TD, Beck TW, Kasper CB: Complementary DNA and amino acid sequence of rat liver microsomal, xenobiotic epoxide hydrolase. Arch Biochem Biophys. 1986 Jul;248(1):121-9. doi: 10.1016/0003-9861(86)90408-x. [PubMed:3755318 ]
  4. Holler R, Arand M, Mecky A, Oesch F, Friedberg T: The membrane anchor of microsomal epoxide hydrolase from human, rat, and rabbit displays an unexpected membrane topology. Biochem Biophys Res Commun. 1997 Jul 30;236(3):754-9. doi: 10.1006/bbrc.1997.7044. [PubMed:9245728 ]
  5. Arand M, Muller F, Mecky A, Hinz W, Urban P, Pompon D, Kellner R, Oesch F: Catalytic triad of microsomal epoxide hydrolase: replacement of Glu404 with Asp leads to a strongly increased turnover rate. Biochem J. 1999 Jan 1;337 ( Pt 1):37-43. [PubMed:9854022 ]
  6. Wu CC, MacCoss MJ, Mardones G, Finnigan C, Mogelsvang S, Yates JR 3rd, Howell KE: Organellar proteomics reveals Golgi arginine dimethylation. Mol Biol Cell. 2004 Jun;15(6):2907-19. doi: 10.1091/mbc.e04-02-0101. Epub 2004 Mar 26. [PubMed:15047867 ]