Identification |
HMDB Protein ID
| HMDBP12339 |
Secondary Accession Numbers
| None |
Name
| 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase |
Synonyms
|
- MTA/SAH nucleosidase
- MTAN
- 5'-deoxyadenosine nucleosidase
- 5'-methylthioadenosine nucleosidase
- S-adenosylhomocysteine nucleosidase
- DOA nucleosidase
- dAdo nucleosidase
- MTA nucleosidase
- AdoHcy nucleosidase
- SAH nucleosidase
- SRH nucleosidase
|
Gene Name
| MTNN |
Protein Type
| Unknown |
Biological Properties |
General Function
| Not Available |
Specific Function
| Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively. Also cleaves 5'-deoxyadenosine, a toxic by-product of radical S-adenosylmethionine (SAM) enzymes, into 5-deoxyribose and adenine. Thus, is required for in vivo function of the radical SAM enzymes biotin synthase and lipoic acid synthase, that are inhibited by 5'-deoxyadenosine accumulation. |
Pathways
|
- Biosynthesis of amino acids
- Cysteine and methionine metabolism
- L-methionine biosynthesis via salvage pathway
|
Reactions
| Not Available |
GO Classification
|
Biological Process |
L-methionine salvage from methylthioadenosine |
L-methionine salvage from S-adenosylmethionine |
purine deoxyribonucleoside catabolic process |
Molecular Function |
adenosylhomocysteine nucleosidase activity |
methylthioadenosine nucleosidase activity |
|
Cellular Location
|
Not Available
|
Gene Properties |
Chromosome Location
| Not Available |
Locus
| Not Available |
SNPs
| Not Available |
Gene Sequence
|
Not Available
|
Protein Properties |
Number of Residues
| 232 |
Molecular Weight
| 24353.725 |
Theoretical pI
| 5.246 |
Pfam Domain Function
|
|
Signals
|
Not Available
|
Transmembrane Regions
|
Not Available
|
Protein Sequence
|
Not Available
|
External Links |
GenBank ID Protein
| Not Available |
UniProtKB/Swiss-Prot ID
| A1A7K5 |
UniProtKB/Swiss-Prot Entry Name
| MTNN_ECOK1 |
PDB IDs
|
Not Available |
GenBank Gene ID
| Not Available |
GeneCard ID
| Not Available |
GenAtlas ID
| Not Available |
HGNC ID
| Not Available |
References |
General References
| - Johnson TJ, Kariyawasam S, Wannemuehler Y, Mangiamele P, Johnson SJ, Doetkott C, Skyberg JA, Lynne AM, Johnson JR, Nolan LK: The genome sequence of avian pathogenic Escherichia coli strain O1:K1:H7 shares strong similarities with human extraintestinal pathogenic E. coli genomes. J Bacteriol. 2007 Apr;189(8):3228-36. doi: 10.1128/JB.01726-06. Epub 2007 Feb 9. [PubMed:17293413 ]
|