Identification |
HMDB Protein ID
| HMDBP12437 |
Secondary Accession Numbers
| None |
Name
| Potassium channel toxin alpha-KTx 6.13 |
Synonyms
|
- Spinoxin
|
Gene Name
| Not Available |
Protein Type
| Unknown |
Biological Properties |
General Function
| Not Available |
Specific Function
| Antagonist of Kv1/KCNA potassium channels (Ref.1, Ref.2). Shows a weak interaction with muscle-type nicotinic acetylcholine receptors (nAChR), since it inhibits alpha-bungarotoxin binding to both muscle-type nAChR from T.californica (IC(50)=490 nM) (PubMed:31276191). This suggests it probably weakly inhibits nAChR (PubMed:31276191). |
Pathways
|
Not Available
|
Reactions
| Not Available |
GO Classification
|
Biological Process |
pathogenesis |
Cellular Component |
extracellular region |
Molecular Function |
ion channel inhibitor activity |
toxin activity |
|
Cellular Location
|
Not Available
|
Gene Properties |
Chromosome Location
| Not Available |
Locus
| Not Available |
SNPs
| Not Available |
Gene Sequence
|
Not Available
|
Protein Properties |
Number of Residues
| Not Available |
Molecular Weight
| 3709.325 |
Theoretical pI
| Not Available |
Pfam Domain Function
|
|
Signals
|
Not Available
|
Transmembrane Regions
|
Not Available
|
Protein Sequence
|
Not Available
|
External Links |
GenBank ID Protein
| Not Available |
UniProtKB/Swiss-Prot ID
| P84094 |
UniProtKB/Swiss-Prot Entry Name
| KAX6D_HETSP |
PDB IDs
|
Not Available |
GenBank Gene ID
| Not Available |
GeneCard ID
| Not Available |
GenAtlas ID
| Not Available |
HGNC ID
| Not Available |
References |
General References
| - Kasheverov IE, Oparin PB, Zhmak MN, Egorova NS, Ivanov IA, Gigolaev AM, Nekrasova OV, Serebryakova MV, Kudryavtsev DS, Prokopev NA, Hoang AN, Tsetlin VI, Vassilevski AA, Utkin YN: Scorpion toxins interact with nicotinic acetylcholine receptors. FEBS Lett. 2019 Oct;593(19):2779-2789. doi: 10.1002/1873-3468.13530. Epub 2019 Jul 18. [PubMed:31276191 ]
- Abdel-Mottaleb Y, Corzo G, Martin-Eauclaire MF, Satake H, Ceard B, Peigneur S, Nambaru P, Bougis PE, Possani LD, Tytgat J: A common "hot spot" confers hERG blockade activity to alpha-scorpion toxins affecting K+ channels. Biochem Pharmacol. 2008 Sep 15;76(6):805-15. doi: 10.1016/j.bcp.2008.07.008. Epub 2008 Jul 18. [PubMed:18687312 ]
|