Identification |
HMDB Protein ID
| HMDBP12698 |
Secondary Accession Numbers
| None |
Name
| 1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial |
Synonyms
|
- 24-OHase
- Vitamin D(3) 24-hydroxylase
- Cytochrome P450 24A1
- Cytochrome P450-CC24
|
Gene Name
| CYP24A1 |
Protein Type
| Unknown |
Biological Properties |
General Function
| Not Available |
Specific Function
| A cytochrome P450 monooxygenase with a key role in vitamin D catabolism and calcium homeostasis. Via C24-oxidation pathway, catalyzes the inactivation of both the vitamin D precursor calcidiol (25-hydroxyvitamin D(3)) and the active hormone calcitriol (1-alpha,25-dihydroxyvitamin D(3)). With initial hydroxylation at C-24 (via C24-oxidation pathway), performs a sequential 6-step oxidation of calcitriol leading to the formation of the biliary metabolite calcitroic acid. Hydroxylates at C-24 or C-25 other vitamin D active metabolites, such as CYP11A1-derived secosteroids 20S-hydroxycholecalciferol and 20S,23-dihydroxycholecalciferol. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via FDXR/adrenodoxin reductase and FDX1/adrenodoxin. |
Pathways
|
- MicroRNAs in cancer
- Parathyroid hormone synthesis, secretion and action
- Steroid biosynthesis
|
Reactions
| Not Available |
GO Classification
|
Biological Process |
fatty acid omega-oxidation |
vitamin D metabolic process |
osteoblast differentiation |
vitamin D catabolic process |
response to vitamin D |
Cellular Component |
mitochondrion |
nucleoplasm |
Molecular Function |
vitamin D 24-hydroxylase activity |
1-alpha,25-dihydroxyvitamin D3 23-hydroxylase activity |
25-hydroxycholecalciferol-23-hydroxylase activity |
vitamin D 25-hydroxylase activity |
iron ion binding |
1-alpha,25-dihydroxyvitamin D3 24-hydroxylase activity |
25-hydroxycholecalciferol-24-hydroxylase activity |
heme binding |
|
Cellular Location
|
Not Available
|
Gene Properties |
Chromosome Location
| Not Available |
Locus
| Not Available |
SNPs
| Not Available |
Gene Sequence
|
Not Available
|
Protein Properties |
Number of Residues
| 514 |
Molecular Weight
| 59452.655 |
Theoretical pI
| 9.031 |
Pfam Domain Function
|
|
Signals
|
Not Available
|
Transmembrane Regions
|
Not Available
|
Protein Sequence
|
Not Available
|
External Links |
GenBank ID Protein
| Not Available |
UniProtKB/Swiss-Prot ID
| Q64441 |
UniProtKB/Swiss-Prot Entry Name
| CP24A_MOUSE |
PDB IDs
|
Not Available |
GenBank Gene ID
| Not Available |
GeneCard ID
| Not Available |
GenAtlas ID
| Not Available |
HGNC ID
| Not Available |
References |
General References
| - Tsujikawa H, Kurotaki Y, Fujimori T, Fukuda K, Nabeshima Y: Klotho, a gene related to a syndrome resembling human premature aging, functions in a negative regulatory circuit of vitamin D endocrine system. Mol Endocrinol. 2003 Dec;17(12):2393-403. Epub 2003 Oct 3. [PubMed:14528024 ]
- Akeno N, Saikatsu S, Kawane T, Horiuchi N: Mouse vitamin D-24-hydroxylase: molecular cloning, tissue distribution, and transcriptional regulation by 1alpha,25-dihydroxyvitamin D3. Endocrinology. 1997 Jun;138(6):2233-40. [PubMed:9165006 ]
- Itoh S, Yoshimura T, Iemura O, Yamada E, Tsujikawa K, Kohama Y, Mimura T: Molecular cloning of 25-hydroxyvitamin D-3 24-hydroxylase (Cyp-24) from mouse kidney: its inducibility by vitamin D-3. Biochim Biophys Acta. 1995 Oct 17;1264(1):26-8. doi: 10.1016/0167-4781(95)00147-9. [PubMed:7578252 ]
|