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Identification
HMDB Protein ID HMDBP12770
Secondary Accession Numbers None
Name Glutathione S-transferase theta-2
Synonyms
  1. GST 12-12
  2. GST class-theta-2
  3. Glutathione S-transferase 12
  4. Glutathione S-transferase Yrs-Yrs
Gene Name GSTT2
Protein Type Unknown
Biological Properties
General Function Not Available
Specific Function Catalyzes the inactivation of reactive sulfate esters in carcinogenic arylmethanols. Highest activity towards ethacrynic acid and cumene hydroperoxide.
Pathways
  • Chemical carcinogenesis - DNA adducts
  • Chemical carcinogenesis - reactive oxygen species
  • Chemical carcinogenesis - receptor activation
  • Drug metabolism - cytochrome P450
  • Drug metabolism - other enzymes
  • Fluid shear stress and atherosclerosis
  • Glutathione metabolism
  • Hepatocellular carcinoma
  • Metabolism of xenobiotics by cytochrome P450
  • Platinum drug resistance
Reactions Not Available
GO Classification
Biological Process
cellular response to leukemia inhibitory factor
glutathione metabolic process
response to salicylic acid
Cellular Component
cytosol
cytoplasm
nucleus
Molecular Function
glutathione peroxidase activity
glutathione transferase activity
Cellular Location Not Available
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues 244
Molecular Weight 27438.755
Theoretical pI 7.92
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence Not Available
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID P30713
UniProtKB/Swiss-Prot Entry Name GSTT2_RAT
PDB IDs Not Available
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID Not Available
References
General References
  1. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [PubMed:15489334 ]
  2. Meyer DJ, Coles B, Pemble SE, Gilmore KS, Fraser GM, Ketterer B: Theta, a new class of glutathione transferases purified from rat and man. Biochem J. 1991 Mar 1;274 ( Pt 2):409-14. [PubMed:1848757 ]
  3. Mainwaring GW, Williams SM, Foster JR, Tugwood J, Green T: The distribution of theta-class glutathione S-transferases in the liver and lung of mouse, rat and human. Biochem J. 1996 Aug 15;318 ( Pt 1):297-303. [PubMed:8761485 ]
  4. Ogura K, Nishiyama T, Okada T, Kajital J, Narihata H, Watabe T, Hiratsuka A, Watabe T: Molecular cloning and amino acid sequencing of rat liver class theta glutathione S-transferase Yrs-Yrs inactivating reactive sulfate esters of carcinogenic arylmethanols. Biochem Biophys Res Commun. 1991 Dec 31;181(3):1294-300. doi: 10.1016/0006-291x(91)92079-y. [PubMed:1764080 ]
  5. Ogura K, Nishiyama T, Hiratsuka A, Watabe T, Watabe T: Isolation and characterization of the gene encoding rat class theta glutathione S-transferase subunit yrs. Biochem Biophys Res Commun. 1994 Dec 15;205(2):1250-6. doi: 10.1006/bbrc.1994.2799. [PubMed:7802657 ]
  6. Hiratsuka A, Sebata N, Kawashima K, Okuda H, Ogura K, Watabe T, Satoh K, Hatayama I, Tsuchida S, Ishikawa T, et al.: A new class of rat glutathione S-transferase Yrs-Yrs inactivating reactive sulfate esters as metabolites of carcinogenic arylmethanols. J Biol Chem. 1990 Jul 15;265(20):11973-81. [PubMed:2114406 ]