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Showing Protein Small t antigen (HMDBP12776)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 1 metabolite
Identification
HMDB Protein ID HMDBP12776
Secondary Accession Numbers None
Name Small t antigen
Synonyms
  1. ST
  2. ST-AG
Gene Name Not Available
Protein Type Unknown
Biological Properties
General Function Not Available
Specific Function Promotes efficient viral genome replication by accelerating both G1 and S phase progression of the cell cycle. Inhibits host PP2A by binding to the A subunit, thereby displacing lower affinity regulatory B subunit. Inactivation of PP2A in turn results in the transactivation of cyclin A and cyclin D1 promoters. Late during the infection cycle, ST may induce dephosphorylation of host MTOR, leading to the inhibition of cap-dependent translation. May establish and maintain high levels of viral genomes during persistent infection in cell culture.
Pathways Not Available
Reactions Not Available
GO Classification
Biological Process
viral reproduction
Cellular Component
host cell cytoplasm
host cell nucleus
Molecular Function
metal ion binding
Cellular Location Not Available
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues Not Available
Molecular Weight 20453.795
Theoretical pI Not Available
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence Not Available
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID P15000
UniProtKB/Swiss-Prot Entry Name ST_POVBA
PDB IDs Not Available
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID Not Available
References
General References
  1. Tavis JE, Walker DL, Gardner SD, Frisque RJ: Nucleotide sequence of the human polyomavirus AS virus, an antigenic variant of BK virus. J Virol. 1989 Feb;63(2):901-11. doi: 10.1128/JVI.63.2.901-911.1989. [PubMed:2536111 ]