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Showing Protein DNA repair protein complementing XP-A cells (HMDBP12799)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 1 metabolite
Identification
HMDB Protein ID HMDBP12799
Secondary Accession Numbers None
Name DNA repair protein complementing XP-A cells
Synonyms
  1. Xeroderma pigmentosum group A-complementing protein
Gene Name XPA
Protein Type Unknown
Biological Properties
General Function Not Available
Specific Function Involved in DNA excision repair. Initiates repair by binding to damaged sites with various affinities, depending on the photoproduct and the transcriptional state of the region. Required for UV-induced CHEK1 phosphorylation and the recruitment of CEP164 to cyclobutane pyrimidine dimmers (CPD), sites of DNA damage after UV irradiation.
Pathways
  • Nucleotide excision repair
  • Platinum drug resistance
Reactions Not Available
GO Classification
Biological Process
transcription-coupled nucleotide-excision repair
DNA repair
global genome nucleotide-excision repair
nucleotide-excision repair, DNA damage recognition
nucleotide-excision repair, preincision complex assembly
response to auditory stimulus
nucleotide-excision repair involved in interstrand cross-link repair
nucleotide-excision repair, DNA incision, 3'-to lesion
nucleotide-excision repair, DNA incision, 5'-to lesion
nucleotide-excision repair, preincision complex stabilization
nucleotide-excision repair, DNA incision
nucleotide-excision repair, DNA duplex unwinding
UV-damage excision repair
base-excision repair
UV protection
protein localization to nucleus
Cellular Component
cytoplasm
nucleus
nucleoplasm
nucleotide-excision repair factor 1 complex
intercellular bridge
Molecular Function
metal ion binding
protein homodimerization activity
damaged DNA binding
protein domain specific binding
sequence-specific double-stranded DNA binding
Cellular Location Not Available
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues 273
Molecular Weight 31367.71
Theoretical pI 6.731
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence Not Available
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID P23025
UniProtKB/Swiss-Prot Entry Name XPA_HUMAN
PDB IDs
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID Not Available
References
General References
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  22. Satokata I, Tanaka K, Yuba S, Okada Y: Identification of splicing mutations of the last nucleotides of exons, a nonsense mutation, and a missense mutation of the XPAC gene as causes of group A xeroderma pigmentosum. Mutat Res. 1992 Mar;273(2):203-12. doi: 10.1016/0921-8777(92)90081-d. [PubMed:1372103 ]
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