| Identification |
|---|
| HMDB Protein ID
| HMDBP13346 |
| Secondary Accession Numbers
| None |
| Name
| Probable flavin mononucleotide-dependent alkene reductase |
| Synonyms
|
- Flavin mononucleotide-dependent nitroreductase
- NTR2
|
| Gene Name
| (REFSEQ) PUTATIVE NADH:FLAVIN OXIDOREDUCTASE/NADH OXIDASE |
| Protein Type
| Unknown |
| Biological Properties |
|---|
| General Function
| Not Available |
| Specific Function
| May function as a flavin mononucleotide (FMN)-dependent alkene reductase on substrates carrying alpha,beta-unsaturated carbonyl groups (ketones, aldehydes, carboxylic acids, esters, lactones or cyclic imides). The catalysis depends on NAD(P)H, which acts as hydride donor for the reduction. Seems to be involved in metabolic pathways required for efficient replication of amastigotes within macrophages.Acts as a FMN-dependent nitroreductase that activates anti-leishmanial bicyclic nitroaromatic prodrugs including delamanid, DNDI-VL-2098 and (R)-PA-824, forming toxic products that kill the parasites. |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
| Cellular Component |
| cytosol |
| Molecular Function |
| FMN binding |
| oxidoreductase activity, acting on NAD(P)H, nitrogenous group as acceptor |
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Not Available |
| Locus
| Not Available |
| SNPs
| Not Available |
| Gene Sequence
|
Not Available
|
| Protein Properties |
|---|
| Number of Residues
| 365 |
| Molecular Weight
| 39451.09 |
| Theoretical pI
| 6.139 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
Not Available
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| E9AGH7 |
| UniProtKB/Swiss-Prot Entry Name
| NTR2_LEIIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| Not Available |
| GeneCard ID
| Not Available |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| - Peacock CS, Seeger K, Harris D, Murphy L, Ruiz JC, Quail MA, Peters N, Adlem E, Tivey A, Aslett M, Kerhornou A, Ivens A, Fraser A, Rajandream MA, Carver T, Norbertczak H, Chillingworth T, Hance Z, Jagels K, Moule S, Ormond D, Rutter S, Squares R, Whitehead S, Rabbinowitsch E, Arrowsmith C, White B, Thurston S, Bringaud F, Baldauf SL, Faulconbridge A, Jeffares D, Depledge DP, Oyola SO, Hilley JD, Brito LO, Tosi LR, Barrell B, Cruz AK, Mottram JC, Smith DF, Berriman M: Comparative genomic analysis of three Leishmania species that cause diverse human disease. Nat Genet. 2007 Jul;39(7):839-47. doi: 10.1038/ng2053. Epub 2007 Jun 17. [PubMed:17572675 ]
- Wyllie S, Roberts AJ, Norval S, Patterson S, Foth BJ, Berriman M, Read KD, Fairlamb AH: Activation of Bicyclic Nitro-drugs by a Novel Nitroreductase (NTR2) in Leishmania. PLoS Pathog. 2016 Nov 3;12(11):e1005971. doi: 10.1371/journal.ppat.1005971. eCollection 2016 Nov. [PubMed:27812217 ]
|
