Hmdb loader
Identification
HMDB Protein ID HMDBP13426
Secondary Accession Numbers None
Name GRB2-associated-binding protein 1
Synonyms
  1. GRB2-associated binder 1
  2. Growth factor receptor bound protein 2-associated protein 1
Gene Name GAB1
Protein Type Unknown
Biological Properties
General Function Not Available
Specific Function Adapter protein that plays a role in intracellular signaling cascades triggered by activated receptor-type kinases. Plays a role in FGFR1 signaling. Probably involved in signaling by the epidermal growth factor receptor (EGFR) and the insulin receptor (INSR). Involved in the MET/HGF-signaling pathway (PubMed:29408807).
Pathways
  • Bacterial invasion of epithelial cells
  • EGFR tyrosine kinase inhibitor resistance
  • ErbB signaling pathway
  • Gastric cancer
  • Hepatocellular carcinoma
  • Neurotrophin signaling pathway
  • Phospholipase D signaling pathway
  • Proteoglycans in cancer
  • Ras signaling pathway
  • Renal cell carcinoma
Reactions Not Available
GO Classification
Biological Process
insulin receptor signaling pathway
angiogenesis
positive regulation of angiogenesis
axon guidance
positive regulation of protein kinase B signaling cascade
actin cytoskeleton reorganization
endothelial cell chemotaxis to vascular endothelial growth factor
positive regulation of cell migration by vascular endothelial growth factor signaling pathway
response to hepatocyte growth factor
vascular endothelial growth factor signaling pathway
ERBB2 signaling pathway
positive regulation of phosphatidylinositol 3-kinase cascade
epidermal growth factor receptor signaling pathway
Cellular Component
cytosol
cell-cell junction
Cellular Location Not Available
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues 694
Molecular Weight 76615.475
Theoretical pI 5.959
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence Not Available
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID Q13480
UniProtKB/Swiss-Prot Entry Name GAB1_HUMAN
PDB IDs
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID Not Available
References
General References
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