Identification |
HMDB Protein ID
| HMDBP13522 |
Secondary Accession Numbers
| None |
Name
| Thrombin-like enzyme BpirSP41 |
Synonyms
|
- SVTLE
- Fibrinogen-clotting enzyme
- Snake venom serine protease
- SVSP
|
Gene Name
| Not Available |
Protein Type
| Unknown |
Biological Properties |
General Function
| Not Available |
Specific Function
| Snake venom serine protease that interferes with the hemostatic system of the prey. It almost completely degrades both Aalpha (FGA) and Bbeta (FGB) chains of fibrinogen. It presents a higher ability to degrade fibrin clots than BpirSP27. It hydrolyzes chromogenic substrates S-2238 (used for testing thrombin activity), S-2222 (factor Xa), S-2266 (glandular kallikrein and factor XIa), and S-2302 (plasma kallikrein, factor XIa and XIIa). It shows a decrease in the clotting time of human plasma in the presence of increasing doses of the enzyme. Its minimum coagulant dose (MCD) is 20 ug. It promotes platelet aggregation with a maximum of aggregation of 20%, regardless of the concentration increase or the presence of calcium. It also shows 40% inhibition of the hemolytic activity promoted by the complement pathways and possess only a minor role in the induction of edema and pain in rat. |
Pathways
|
Not Available
|
Reactions
| Not Available |
GO Classification
|
Cellular Component |
extracellular region |
Molecular Function |
toxin activity |
serine-type endopeptidase activity |
|
Cellular Location
|
Not Available
|
Gene Properties |
Chromosome Location
| Not Available |
Locus
| Not Available |
SNPs
| Not Available |
Gene Sequence
|
Not Available
|
Protein Properties |
Number of Residues
| Not Available |
Molecular Weight
| 5835.635 |
Theoretical pI
| Not Available |
Pfam Domain Function
|
|
Signals
|
Not Available
|
Transmembrane Regions
|
Not Available
|
Protein Sequence
|
Not Available
|
External Links |
GenBank ID Protein
| Not Available |
UniProtKB/Swiss-Prot ID
| P0DL27 |
UniProtKB/Swiss-Prot Entry Name
| VSP41_BOTPI |
PDB IDs
|
Not Available |
GenBank Gene ID
| Not Available |
GeneCard ID
| Not Available |
GenAtlas ID
| Not Available |
HGNC ID
| Not Available |
References |
General References
| - Menaldo DL, Bernardes CP, Santos-Filho NA, Moura Lde A, Fuly AL, Arantes EC, Sampaio SV: Biochemical characterization and comparative analysis of two distinct serine proteases from Bothrops pirajai snake venom. Biochimie. 2012 Dec;94(12):2545-58. doi: 10.1016/j.biochi.2012.07.007. Epub 2012 Jul 17. [PubMed:22819993 ]
- Menaldo DL, Bernardes CP, Pereira JC, Silveira DS, Mamede CC, Stanziola L, Oliveira Fd, Pereira-Crott LS, Faccioli LH, Sampaio SV: Effects of two serine proteases from Bothrops pirajai snake venom on the complement system and the inflammatory response. Int Immunopharmacol. 2013 Apr;15(4):764-71. doi: 10.1016/j.intimp.2013.02.023. Epub 2013 Mar 15. [PubMed:23499645 ]
|