Hmdb loader

Showing Protein Zinc metalloproteinase/disintegrin (HMDBP13524)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 1 metabolite
Identification
HMDB Protein ID HMDBP13524
Secondary Accession Numbers None
Name Zinc metalloproteinase/disintegrin
Synonyms Not Available
Gene Name Not Available
Protein Type Unknown
Biological Properties
General Function Not Available
Specific Function non-hemorrhagic proteinase that activates prothrombin (F2) calcium-independently. Activates factor X (F10) and hydrolyzes the Aalpha-chain and more slowly the Bbeta-chain of fibrin and fibrinogen without affecting the gamma chain. It induces neither detachment nor apoptosis of human endothelial cells and is also not able to trigger an endothelial proinflammatory cell response. Nitric oxide and prostacyclin levels released by endothelial cells are significantly increased after treatment with insularinase A.inhibits platelet aggregation induced by ADP, thrombin, platelet-activating factor and collagen. Acts by inhibiting fibrinogen interaction with platelet receptors GPIIb/GPIIIa (ITGA2B/ITGB3) (By similarity).
Pathways Not Available
Reactions Not Available
GO Classification
Cellular Component
extracellular region
Molecular Function
metal ion binding
peptidase activator activity
toxin activity
metalloendopeptidase activity
Cellular Location Not Available
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues Not Available
Molecular Weight 53312.555
Theoretical pI Not Available
Pfam Domain Function
Signals
  • 1-20;
Transmembrane Regions Not Available
Protein Sequence Not Available
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID Q5XUW8
UniProtKB/Swiss-Prot Entry Name VM2IA_BOTIN
PDB IDs Not Available
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID Not Available
References
General References
  1. Modesto JC, Junqueira-de-Azevedo IL, Neves-Ferreira AG, Fritzen M, Oliva ML, Ho PL, Perales J, Chudzinski-Tavassi AM: Insularinase A, a prothrombin activator from Bothrops insularis venom, is a metalloprotease derived from a gene encoding protease and disintegrin domains. Biol Chem. 2005 Jun;386(6):589-600. doi: 10.1515/BC.2005.069. [PubMed:16006246 ]
  2. Junqueira-de-Azevedo Ide L, Ho PL: A survey of gene expression and diversity in the venom glands of the pitviper snake Bothrops insularis through the generation of expressed sequence tags (ESTs). Gene. 2002 Oct 16;299(1-2):279-91. doi: 10.1016/s0378-1119(02)01080-6. [PubMed:12459276 ]