| Identification |
|---|
| HMDB Protein ID
| HMDBP13527 |
| Secondary Accession Numbers
| None |
| Name
| Thrombin-like enzyme BJ-48 |
| Synonyms
|
- SVTLE BJ-48
- Fibrinogen-clotting enzyme
- Snake venom serine protease
- SVSP
|
| Gene Name
| Not Available |
| Protein Type
| Unknown |
| Biological Properties |
|---|
| General Function
| Not Available |
| Specific Function
| Thrombin-like serine protease which cleaves specifically the Aalpha chain of human fibrinogen (FGA) to release fibrinopeptide A. Also cleaves rapidly the Bbeta chain of human fibrinogen (FGB). Is selective for Arg over Lys at position 1 of the tripeptide substrates. |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
| Cellular Component |
| extracellular region |
| Molecular Function |
| toxin activity |
| serine-type peptidase activity |
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Not Available |
| Locus
| Not Available |
| SNPs
| Not Available |
| Gene Sequence
|
Not Available
|
| Protein Properties |
|---|
| Number of Residues
| Not Available |
| Molecular Weight
| 2467.855 |
| Theoretical pI
| Not Available |
| Pfam Domain Function
|
Not Available |
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
Not Available
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| P0DJF0 |
| UniProtKB/Swiss-Prot Entry Name
| VSP48_BOTJR |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| Not Available |
| GeneCard ID
| Not Available |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| - Silva-Junior FP, Guedes HL, Garvey LC, Aguiar AS, Bourguignon SC, Di Cera E, Giovanni-De-Simone S: BJ-48, a novel thrombin-like enzyme from the Bothrops jararacussu venom with high selectivity for Arg over Lys in P1: Role of N-glycosylation in thermostability and active site accessibility. Toxicon. 2007 Jul;50(1):18-31. doi: 10.1016/j.toxicon.2007.02.018. Epub 2007 Mar 7. [PubMed:17433397 ]
- De-Simone SG, Correa-Netto C, Antunes OA, De-Alencastro RB, Silva FP Jr: Biochemical and molecular modeling analysis of the ability of two p-aminobenzamidine-based sorbents to selectively purify serine proteases (fibrinogenases) from snake venoms. J Chromatogr B Analyt Technol Biomed Life Sci. 2005 Aug 5;822(1-2):1-9. doi: 10.1016/j.jchromb.2005.04.018. [PubMed:15994137 ]
- Guedes HL, Silva FP Jr, Netto CC, de Salles CM, Alexandre G, Oliveira CL, Torriani I, De Simone SG: Structural characterization and low-resolution model of BJ-48, a thrombin-like enzyme from Bothrops jararacussu venom. Biophys Chem. 2008 Feb;132(2-3):159-64. doi: 10.1016/j.bpc.2007.11.002. Epub 2007 Nov 17. [PubMed:18069115 ]
|
