| Identification |
|---|
| HMDB Protein ID
| HMDBP13528 |
| Secondary Accession Numbers
| None |
| Name
| Venom plasminogen activator LV-PA |
| Synonyms
|
- LMUT0402S
- Plasminogen activating proteinase
- Snake venom serine protease
- SVSP
|
| Gene Name
| Not Available |
| Protein Type
| Unknown |
| Biological Properties |
|---|
| General Function
| Not Available |
| Specific Function
| Snake venom serine protease that activates plasminogen. Weakly hydrolyzes the alpha chain of human fibrinogen without releasing fibrinopeptide A. Does not hydrolyze plasma kallikrein or factor Xa. Does not clot fibrinogen. Does not affect platelet function. Induces hypotensive effects on rats. Shows a preferential cleavage at Lys-|-Xaa over Arg-|-Xaa bonds. |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
| Biological Process |
| regulation of blood pressure |
| Cellular Component |
| extracellular region |
| Molecular Function |
| toxin activity |
| serine-type endopeptidase activity |
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Not Available |
| Locus
| Not Available |
| SNPs
| Not Available |
| Gene Sequence
|
Not Available
|
| Protein Properties |
|---|
| Number of Residues
| Not Available |
| Molecular Weight
| 28061.795 |
| Theoretical pI
| Not Available |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
Not Available
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| Q27J47 |
| UniProtKB/Swiss-Prot Entry Name
| VSPPA_LACMU |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| Not Available |
| GeneCard ID
| Not Available |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| - Sanchez EF, Felicori LF, Chavez-Olortegui C, Magalhaes HB, Hermogenes AL, Diniz MV, Junqueira-de-Azevedo IL, Magalhaes A, Richardson M: Biochemical characterization and molecular cloning of a plasminogen activator proteinase (LV-PA) from bushmaster snake venom. Biochim Biophys Acta. 2006 Dec;1760(12):1762-71. doi: 10.1016/j.bbagen.2006.08.023. Epub 2006 Sep 6. [PubMed:17034951 ]
- Junqueira-de-Azevedo IL, Ching AT, Carvalho E, Faria F, Nishiyama MY Jr, Ho PL, Diniz MR: Lachesis muta (Viperidae) cDNAs reveal diverging pit viper molecules and scaffolds typical of cobra (Elapidae) venoms: implications for snake toxin repertoire evolution. Genetics. 2006 Jun;173(2):877-89. doi: 10.1534/genetics.106.056515. Epub 2006 Apr 2. [PubMed:16582429 ]
- Sanchez EF, Santos CI, Magalhaes A, Diniz CR, Figueiredo S, Gilroy J, Richardson M: Isolation of a proteinase with plasminogen-activating activity from Lachesis muta muta (bushmaster) snake venom. Arch Biochem Biophys. 2000 Jun 1;378(1):131-41. doi: 10.1006/abbi.2000.1781. [PubMed:10871053 ]
|
