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Showing Protein Aminoacyl tRNA synthase complex-interacting multifunctional protein 1 (HMDBP13586)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 2 metabolites
Identification
HMDB Protein ID HMDBP13586
Secondary Accession Numbers None
Name Aminoacyl tRNA synthase complex-interacting multifunctional protein 1
Synonyms
  1. Multisynthase complex auxiliary component p43
Gene Name AIMP1
Protein Type Unknown
Biological Properties
General Function Not Available
Specific Function Non-catalytic component of the multisynthase complex. Stimulates the catalytic activity of cytoplasmic arginyl-tRNA synthase (PubMed:10358004). Binds tRNA. Possesses inflammatory cytokine activity (PubMed:11306575). Negatively regulates TGF-beta signaling through stabilization of SMURF2 by binding to SMURF2 and inhibiting its SMAD7-mediated degradation (By similarity). Involved in glucose homeostasis through induction of glucagon secretion at low glucose levels (By similarity). Promotes dermal fibroblast proliferation and wound repair (PubMed:16472771). Regulates KDELR1-mediated retention of HSP90B1/gp96 in the endoplasmic reticulum (By similarity). Plays a role in angiogenesis by inducing endothelial cell migration at low concentrations and endothelian cell apoptosis at high concentrations (PubMed:12237313). Induces maturation of dendritic cells and monocyte cell adhesion (PubMed:11818442). Modulates endothelial cell responses by degrading HIF-1A through interaction with PSMA7 (PubMed:19362550).
Pathways Not Available
Reactions Not Available
GO Classification
Biological Process
cell-cell signaling
apoptotic process
leukocyte migration
inflammatory response
positive regulation of glucagon secretion
angiogenesis
defense response to virus
negative regulation of endothelial cell proliferation
tRNA aminoacylation for protein translation
Cellular Component
cytosol
cell surface
endoplasmic reticulum
Golgi apparatus
nucleus
aminoacyl-tRNA synthetase multienzyme complex
extracellular space
membrane
Molecular Function
protein homodimerization activity
cytokine activity
GTPase binding
tRNA binding
Cellular Location Not Available
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues 312
Molecular Weight 34352.445
Theoretical pI 8.425
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence Not Available
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID Q12904
UniProtKB/Swiss-Prot Entry Name AIMP1_HUMAN
PDB IDs
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID Not Available
References
General References
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