| Identification |
|---|
| HMDB Protein ID
| HMDBP13619 |
| Secondary Accession Numbers
| None |
| Name
| Transcriptional regulator LovE |
| Synonyms
|
- Lovastatin biosynthesis cluster protein E
|
| Gene Name
| LOVE |
| Protein Type
| Unknown |
| Biological Properties |
|---|
| General Function
| Not Available |
| Specific Function
| Transcription factor that regulates the expression of the he gene cluster that mediates the biosynthesis of lovastatin (also known as mevinolin, mevacor or monacolin K), a hypolipidemic inhibitor of (3S)-hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR). |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
| Cellular Component |
| nucleus |
| Molecular Function |
| zinc ion binding |
| DNA-binding transcription factor activity, RNA polymerase II-specific |
| DNA binding |
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Not Available |
| Locus
| Not Available |
| SNPs
| Not Available |
| Gene Sequence
|
Not Available
|
| Protein Properties |
|---|
| Number of Residues
| Not Available |
| Molecular Weight
| 55426.62 |
| Theoretical pI
| Not Available |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
Not Available
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| Q9Y7D3 |
| UniProtKB/Swiss-Prot Entry Name
| LOVE_ASPTE |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| Not Available |
| GeneCard ID
| Not Available |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| - Kennedy J, Auclair K, Kendrew SG, Park C, Vederas JC, Hutchinson CR: Modulation of polyketide synthase activity by accessory proteins during lovastatin biosynthesis. Science. 1999 May 21;284(5418):1368-72. doi: 10.1126/science.284.5418.1368. [PubMed:10334994 ]
- Alberts AW, Chen J, Kuron G, Hunt V, Huff J, Hoffman C, Rothrock J, Lopez M, Joshua H, Harris E, Patchett A, Monaghan R, Currie S, Stapley E, Albers-Schonberg G, Hensens O, Hirshfield J, Hoogsteen K, Liesch J, Springer J: Mevinolin: a highly potent competitive inhibitor of hydroxymethylglutaryl-coenzyme A reductase and a cholesterol-lowering agent. Proc Natl Acad Sci U S A. 1980 Jul;77(7):3957-61. doi: 10.1073/pnas.77.7.3957. [PubMed:6933445 ]
- Chen MC, Tsai YC, Tseng JH, Liou JJ, Horng S, Wen HC, Fan YC, Zhong WB, Hsu SP: Simvastatin Inhibits Cell Proliferation and Migration in Human Anaplastic Thyroid Cancer. Int J Mol Sci. 2017 Dec 13;18(12). pii: ijms18122690. doi: 10.3390/ijms18122690. [PubMed:29236027 ]
- Zhong WB, Tsai YC, Chin LH, Tseng JH, Tang LW, Horng S, Fan YC, Hsu SP: A Synergistic Anti-Cancer Effect of Troglitazone and Lovastatin in a Human Anaplastic Thyroid Cancer Cell Line and in a Mouse Xenograft Model. Int J Mol Sci. 2018 Jun 22;19(7). pii: ijms19071834. doi: 10.3390/ijms19071834. [PubMed:29932104 ]
- Huang X, Li HM: Cloning and bioinformatic analysis of lovastatin biosynthesis regulatory gene lovE. Chin Med J (Engl). 2009 Aug 5;122(15):1800-5. [PubMed:19781329 ]
- Barrios-Gonzalez J, Banos JG, Covarrubias AA, Garay-Arroyo A: Lovastatin biosynthetic genes of Aspergillus terreus are expressed differentially in solid-state and in liquid submerged fermentation. Appl Microbiol Biotechnol. 2008 May;79(2):179-86. doi: 10.1007/s00253-008-1409-2. [PubMed:18414850 ]
|
