Hmdb loader
Identification
HMDB Protein ID HMDBP13638
Secondary Accession Numbers None
Name Neuropeptide Y receptor type 5
Synonyms
  1. NPY5-R
  2. NPY-Y5 receptor
  3. NPYY5-R
  4. Y5 receptor
Gene Name NPY5R
Protein Type Unknown
Biological Properties
General Function Not Available
Specific Function Receptor for neuropeptide Y and peptide YY. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity. Seems to be associated with food intake. Could be involved in feeding disorders.
Pathways
  • Neuroactive ligand-receptor interaction
Reactions Not Available
GO Classification
Biological Process
negative regulation of apoptotic process
G-protein coupled receptor signaling pathway
positive regulation of ERK1 and ERK2 cascade
negative regulation of synaptic transmission, GABAergic
outflow tract morphogenesis
cardiac left ventricle morphogenesis
aging
generation of ovulation cycle rhythm
negative regulation of acute inflammatory response to antigenic stimulus
negative regulation of glutamate secretion
positive regulation of acute inflammatory response
eating behavior
positive regulation of smooth muscle cell proliferation
synaptic transmission
Cellular Component
cytoplasm
plasma membrane
synapse
membrane
neuron projection
integral to plasma membrane
Molecular Function
pancreatic polypeptide receptor activity
peptide YY receptor activity
neuropeptide Y receptor activity
Cellular Location Not Available
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues 445
Molecular Weight 50725.99
Theoretical pI 8.72
Pfam Domain Function
Signals Not Available
Transmembrane Regions
  • 43-63;78-98;118-138;157-177;209-229;370-390;408-428;
Protein Sequence Not Available
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID Q15761
UniProtKB/Swiss-Prot Entry Name NPY5R_HUMAN
PDB IDs
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID Not Available
References
General References
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  2. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [PubMed:15489334 ]
  3. Hu Y, Bloomquist BT, Cornfield LJ, DeCarr LB, Flores-Riveros JR, Friedman L, Jiang P, Lewis-Higgins L, Sadlowski Y, Schaefer J, Velazquez N, McCaleb ML: Identification of a novel hypothalamic neuropeptide Y receptor associated with feeding behavior. J Biol Chem. 1996 Oct 18;271(42):26315-9. [PubMed:8824284 ]
  4. Gerald C, Walker MW, Criscione L, Gustafson EL, Batzl-Hartmann C, Smith KE, Vaysse P, Durkin MM, Laz TM, Linemeyer DL, Schaffhauser AO, Whitebread S, Hofbauer KG, Taber RI, Branchek TA, Weinshank RL: A receptor subtype involved in neuropeptide-Y-induced food intake. Nature. 1996 Jul 11;382(6587):168-71. doi: 10.1038/382168a0. [PubMed:8700207 ]
  5. Herzog H, Darby K, Ball H, Hort Y, Beck-Sickinger A, Shine J: Overlapping gene structure of the human neuropeptide Y receptor subtypes Y1 and Y5 suggests coordinate transcriptional regulation. Genomics. 1997 May 1;41(3):315-9. doi: 10.1006/geno.1997.4684. [PubMed:9169127 ]