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Showing Protein Leukocyte immunoglobulin-like receptor subfamily A member 2 (HMDBP13819)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 1 metabolite
Identification
HMDB Protein ID HMDBP13819
Secondary Accession Numbers None
Name Leukocyte immunoglobulin-like receptor subfamily A member 2
Synonyms
  1. CD85 antigen-like family member H
  2. Immunoglobulin-like transcript 1
  3. Leukocyte immunoglobulin-like receptor 7
  4. ILT-1
  5. LIR-7
Gene Name LILRA2
Protein Type Unknown
Biological Properties
General Function Not Available
Specific Function Part of the innate immune responses against microbial infection (PubMed:12529506, PubMed:27572839). Specifically recognizes a set of N-terminally truncated immunoglobulins that are produced via cleavage by proteases from a range of pathogenic bacteria and fungi, including L.pneumophila, M.hyorhinis, S.pneumoniae, S.aureus and C.albicans (PubMed:27572839). Recognizes epitopes that are in part in the variable region of the immunoglobulin light chains, but requires also the constant region for signaling (PubMed:27572839). Binds to a subset of cleaved IgM, IgG3 and IgG4 molecules, but does not bind cleaved IgA1 (PubMed:27572839). Binding of N-terminally truncated immunoglobulins mediates activation of neutrophils (PubMed:27572839). In monocytes, activation leads to the release of CSF2, CF3, IL6, CXCL8 and CCL3 and down-regulates responses to bacterial lipopolysaccharide (LPS), possibly via down-regulation of TLR4 expression and reduced signaling via TLR4 (PubMed:22479404). In eosinophils, activation by ligand binding leads to the release of RNASE2, IL4 and leukotriene C4 (PubMed:12529506). Does not bind class I MHC antigens (PubMed:19230061).
Pathways
  • B cell receptor signaling pathway
  • Osteoclast differentiation
Reactions Not Available
GO Classification
Biological Process
signal transduction
negative regulation of lipopolysaccharide-mediated signaling pathway
positive regulation of interleukin-8 production
negative regulation of toll-like receptor 4 signaling pathway
innate immune response activating cell surface receptor signaling pathway
neutrophil activation involved in immune response
positive regulation of cell activation
positive regulation of granulocyte colony-stimulating factor production
innate immune response
positive regulation of calcium ion transport
positive regulation of granulocyte macrophage colony-stimulating factor production
positive regulation of tumor necrosis factor production
positive regulation of interleukin-1 beta production
positive regulation of interleukin-6 production
defense response
Cellular Component
extracellular region
integral to plasma membrane
Molecular Function
IgM binding
antigen binding
signaling receptor activity
Cellular Location Not Available
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues 483
Molecular Weight 52991.33
Theoretical pI 6.919
Pfam Domain Function
Signals
  • 1-23;
Transmembrane Regions
  • 450-470;
Protein Sequence Not Available
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID Q8N149
UniProtKB/Swiss-Prot Entry Name LIRA2_HUMAN
PDB IDs
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID Not Available
References
General References
  1. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [PubMed:15489334 ]
  2. Borges L, Hsu ML, Fanger N, Kubin M, Cosman D: A family of human lymphoid and myeloid Ig-like receptors, some of which bind to MHC class I molecules. J Immunol. 1997 Dec 1;159(11):5192-6. [PubMed:9548455 ]
  3. Jones DC, Roghanian A, Brown DP, Chang C, Allen RL, Trowsdale J, Young NT: Alternative mRNA splicing creates transcripts encoding soluble proteins from most LILR genes. Eur J Immunol. 2009 Nov;39(11):3195-206. doi: 10.1002/eji.200839080. [PubMed:19658091 ]
  4. Tedla N, Bandeira-Melo C, Tassinari P, Sloane DE, Samplaski M, Cosman D, Borges L, Weller PF, Arm JP: Activation of human eosinophils through leukocyte immunoglobulin-like receptor 7. Proc Natl Acad Sci U S A. 2003 Feb 4;100(3):1174-9. doi: 10.1073/pnas.0337567100. Epub 2003 Jan 14. [PubMed:12529506 ]
  5. Lu HK, Mitchell A, Endoh Y, Hampartzoumian T, Huynh O, Borges L, Geczy C, Bryant K, Tedla N: LILRA2 selectively modulates LPS-mediated cytokine production and inhibits phagocytosis by monocytes. PLoS One. 2012;7(3):e33478. doi: 10.1371/journal.pone.0033478. Epub 2012 Mar 30. [PubMed:22479404 ]
  6. Hirayasu K, Saito F, Suenaga T, Shida K, Arase N, Oikawa K, Yamaoka T, Murota H, Chibana H, Nakagawa I, Kubori T, Nagai H, Nakamaru Y, Katayama I, Colonna M, Arase H: Microbially cleaved immunoglobulins are sensed by the innate immune receptor LILRA2. Nat Microbiol. 2016 Apr 25;1(6):16054. doi: 10.1038/nmicrobiol.2016.54. [PubMed:27572839 ]
  7. Chen Y, Gao F, Chu F, Peng H, Zong L, Liu Y, Tien P, Gao GF: Crystal structure of myeloid cell activating receptor leukocyte Ig-like receptor A2 (LILRA2/ILT1/LIR-7) domain swapped dimer: molecular basis for its non-binding to MHC complexes. J Mol Biol. 2009 Feb 27;386(3):841-53. doi: 10.1016/j.jmb.2009.01.006. [PubMed:19230061 ]