Hmdb loader
Identification
HMDB Protein ID HMDBP14133
Secondary Accession Numbers None
Name F-BAR and double SH3 domains protein 2
Synonyms
  1. Carom
  2. Protein nervous wreck 1
  3. SH3 multiple domains protein 3
  4. NWK1
Gene Name FCHSD2
Protein Type Unknown
Biological Properties
General Function Not Available
Specific Function Adapter protein that plays a role in endocytosis via clathrin-coated pits. Contributes to the internalization of cell surface receptors, such as integrin ITGB1 and transferrin receptor (PubMed:29887380). Promotes endocytosis of EGFR in cancer cells, and thereby contributes to the down-regulation of EGFR signaling (PubMed:30249660). Recruited to clathrin-coated pits during a mid-to-late stage of assembly, where it is required for normal progress from U-shaped intermediate stage pits to terminal, omega-shaped pits (PubMed:29887380). Binds to membranes enriched in phosphatidylinositol 3,4-bisphosphate or phosphatidylinositol 3,4,5-trisphosphate (PubMed:29887380). When bound to membranes, promotes actin polymerization via its interaction with WAS and/or WASL which leads to the activation of the Arp2/3 complex. Does not promote actin polymerisation in the absence of membranes (PubMed:29887380).
Pathways Not Available
Reactions Not Available
GO Classification
Biological Process
protein transport
neuromuscular synaptic transmission
positive regulation of actin filament polymerization
positive regulation of Arp2/3 complex-mediated actin nucleation
regulation of actin filament polymerization
clathrin-dependent endocytosis
Cellular Component
plasma membrane
neuromuscular junction
coated pit
recycling endosome
stereocilium shaft
Molecular Function
phosphatidylinositol-3,4,5-trisphosphate binding
phosphatidylinositol-3,4-bisphosphate binding
Cellular Location Not Available
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues 740
Molecular Weight 84275.745
Theoretical pI 5.768
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence Not Available
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID O94868
UniProtKB/Swiss-Prot Entry Name FCSD2_HUMAN
PDB IDs
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID Not Available
References
General References
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  3. Bechtel S, Rosenfelder H, Duda A, Schmidt CP, Ernst U, Wellenreuther R, Mehrle A, Schuster C, Bahr A, Blocker H, Heubner D, Hoerlein A, Michel G, Wedler H, Kohrer K, Ottenwalder B, Poustka A, Wiemann S, Schupp I: The full-ORF clone resource of the German cDNA Consortium. BMC Genomics. 2007 Oct 31;8:399. [PubMed:17974005 ]
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  9. Almeida-Souza L, Frank RAW, Garcia-Nafria J, Colussi A, Gunawardana N, Johnson CM, Yu M, Howard G, Andrews B, Vallis Y, McMahon HT: A Flat BAR Protein Promotes Actin Polymerization at the Base of Clathrin-Coated Pits. Cell. 2018 Jul 12;174(2):325-337.e14. doi: 10.1016/j.cell.2018.05.020. Epub 2018 Jun 7. [PubMed:29887380 ]
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