| Identification |
|---|
| HMDB Protein ID
| HMDBP14458 |
| Secondary Accession Numbers
| None |
| Name
| Mu-theraphotoxin-Os1a |
| Synonyms
|
- Mu-TRTX-Os1a
- Cyriotoxin-1a
- Mu-theraphotoxin-Cs1a
- CyrTx-1a
|
| Gene Name
| Not Available |
| Protein Type
| Unknown |
| Biological Properties |
|---|
| General Function
| Not Available |
| Specific Function
| Potently and reversibly inhibits some human voltage-gated sodium channels (Nav1.1/SCN1A (IC(50)=72.0 nM), Nav1.2/SCN2A (IC(50)=75.5 nM), Nav1.6/SCN8A (IC(50)=115.0 nM), Nav1.7/SCN9A (IC(50)=52.7-129.5 nM), Nav1.3/SCN3A (IC(50)=306.6 nM)) (PubMed:30784059). The hNav1.7/SCN9A channel inhibition occurs without any change in steady-state inactivation- and conductance-voltage relationships (PubMed:30784059). On adult mouse DRG neurons, this toxin is approximately 1000-fold more efficient to inhibit tetrodotoxin (TTX)-sensitive than TTX-resistant sodium currents (PubMed:30784059). In vivo, this toxin exhibits analgesic effects in mice pain models (PubMed:30784059). |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
| Biological Process |
| pathogenesis |
| Cellular Component |
| extracellular region |
| Molecular Function |
| ion channel inhibitor activity |
| toxin activity |
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Not Available |
| Locus
| Not Available |
| SNPs
| Not Available |
| Gene Sequence
|
Not Available
|
| Protein Properties |
|---|
| Number of Residues
| Not Available |
| Molecular Weight
| 3588.25 |
| Theoretical pI
| Not Available |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
Not Available
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| A0A4V8GZX0 |
| UniProtKB/Swiss-Prot Entry Name
| TXNA1_OMOSC |
| PDB IDs
|
|
| GenBank Gene ID
| Not Available |
| GeneCard ID
| Not Available |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| - Goncalves TC, Benoit E, Kurz M, Lucarain L, Fouconnier S, Combemale S, Jaquillard L, Schombert B, Chambard JM, Boukaiba R, Hessler G, Bohme A, Bialy L, Hourcade S, Beroud R, De Waard M, Servent D, Partiseti M: From identification to functional characterization of cyriotoxin-1a, an antinociceptive toxin from the spider Cyriopagopus schioedtei. Br J Pharmacol. 2019 May;176(9):1298-1314. doi: 10.1111/bph.14628. Epub 2019 Apr 9. [PubMed:30784059 ]
|
