Hmdb loader
Survey

Showing Protein Cbp/p300-interacting transactivator 1 (HMDBP14507)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 1 metabolite
Identification
HMDB Protein ID HMDBP14507
Secondary Accession Numbers None
Name Cbp/p300-interacting transactivator 1
Synonyms
  1. Melanocyte-specific protein 1
Gene Name CITED1
Protein Type Unknown
Biological Properties
General Function Not Available
Specific Function Transcriptional coactivator of the p300/CBP-mediated transcription complex. Enhances SMAD-mediated transcription by strengthening the functional link between the DNA-binding SMAD transcription factors and the p300/CBP transcription coactivator complex. Stimulates estrogen-dependent transactivation activity mediated by estrogen receptors signaling; stabilizes the interaction of estrogen receptor ESR1 and histone acetyltransferase EP300. Positively regulates TGF-beta signaling through its association with the SMAD/p300/CBP-mediated transcriptional coactivator complex. Induces transcription from estrogen-responsive promoters and protection against cell death. Potentiates EGR2-mediated transcriptional activation activity from the ERBB2 promoter. Acts as an inhibitor of osteoblastic mineralization through a cAMP-dependent parathyroid hormone receptor signaling. May play a role in pigmentation of melanocytes. Associates with chromatin to the estrogen-responsive TGF-alpha promoter region in a estrogen-dependent manner.
Pathways Not Available
Reactions Not Available
GO Classification
Biological Process
labyrinthine layer development
response to interleukin-1
response to interleukin-6
apoptotic process
negative regulation of neuron apoptotic process
response to lipopolysaccharide
SMAD protein signal transduction
response to insulin stimulus
melanin biosynthetic process
embryonic axis specification
melanocyte differentiation
negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis
nucleocytoplasmic transport
response to interferon-gamma
response to interleukin-11
response to interleukin-2
negative regulation of transcription, DNA-dependent
response to interleukin-4
positive regulation of transcription, DNA-dependent
response to interleukin-9
response to parathyroid hormone
spongiotrophoblast layer development
brain development
positive regulation of transcription from RNA polymerase II promoter
regulation of apoptotic process
vasculogenesis
negative regulation of osteoblast differentiation
response to transforming growth factor beta
pigmentation
transforming growth factor beta receptor signaling pathway
positive regulation of gene expression
placenta development
response to cytokine stimulus
response to cAMP
response to estrogen stimulus
Cellular Component
cytosol
cytoplasm
nucleus
nucleoplasm
Molecular Function
protein C-terminus binding
co-SMAD binding
LBD domain binding
transcription coactivator activity
chromatin binding
protein homodimerization activity
Cellular Location Not Available
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues 203
Molecular Weight 20800.05
Theoretical pI 4.667
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence Not Available
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID P97769
UniProtKB/Swiss-Prot Entry Name CITE1_MOUSE
PDB IDs Not Available
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID Not Available
References
General References
  1. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [PubMed:15489334 ]
  2. Yahata T, de Caestecker MP, Lechleider RJ, Andriole S, Roberts AB, Isselbacher KJ, Shioda T: The MSG1 non-DNA-binding transactivator binds to the p300/CBP coactivators, enhancing their functional link to the Smad transcription factors. J Biol Chem. 2000 Mar 24;275(12):8825-34. doi: 10.1074/jbc.275.12.8825. [PubMed:10722728 ]
  3. Shioda T, Fenner MH, Isselbacher KJ: msg1, a novel melanocyte-specific gene, encodes a nuclear protein and is associated with pigmentation. Proc Natl Acad Sci U S A. 1996 Oct 29;93(22):12298-303. doi: 10.1073/pnas.93.22.12298. [PubMed:8901575 ]
  4. Yahata T, Shao W, Endoh H, Hur J, Coser KR, Sun H, Ueda Y, Kato S, Isselbacher KJ, Brown M, Shioda T: Selective coactivation of estrogen-dependent transcription by CITED1 CBP/p300-binding protein. Genes Dev. 2001 Oct 1;15(19):2598-612. doi: 10.1101/gad.906301. [PubMed:11581164 ]
  5. Rodriguez TA, Sparrow DB, Scott AN, Withington SL, Preis JI, Michalicek J, Clements M, Tsang TE, Shioda T, Beddington RS, Dunwoodie SL: Cited1 is required in trophoblasts for placental development and for embryo growth and survival. Mol Cell Biol. 2004 Jan;24(1):228-44. doi: 10.1128/MCB.24.1.228-244.2004. [PubMed:14673158 ]
  6. Dillon RL, Brown ST, Ling C, Shioda T, Muller WJ: An EGR2/CITED1 transcription factor complex and the 14-3-3sigma tumor suppressor are involved in regulating ErbB2 expression in a transgenic-mouse model of human breast cancer. Mol Cell Biol. 2007 Dec;27(24):8648-57. doi: 10.1128/MCB.00866-07. Epub 2007 Oct 15. [PubMed:17938205 ]
  7. Yang D, Guo J, Divieti P, Shioda T, Bringhurst FR: CBP/p300-interacting protein CITED1 modulates parathyroid hormone regulation of osteoblastic differentiation. Endocrinology. 2008 Apr;149(4):1728-35. doi: 10.1210/en.2007-0826. Epub 2008 Jan 10. [PubMed:18187554 ]