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Showing Protein Bone morphogenetic protein 6 (HMDBP14518)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 1 metabolite
Identification
HMDB Protein ID HMDBP14518
Secondary Accession Numbers None
Name Bone morphogenetic protein 6
Synonyms
  1. BMP-6
  2. VG-1-related protein
  3. VGR-1
Gene Name BMP6
Protein Type Unknown
Biological Properties
General Function Not Available
Specific Function Growth factor of the TGF-beta superfamily that plays essential roles in many developmental processes including cartilage and bone formation (By similarity). Plays also an important role in the regulation of iron metabolism by acting as a ligand for hemojuvelin/HJV (By similarity). Initiates the canonical BMP signaling cascade by associating with type I receptor ACVR1 and type II receptor ACVR2B. In turn, ACVR1 propagates signal by phosphorylating SMAD1/5/8 that travel to the nucleus and act as activators and repressors of transcription of target. Can also signal through non-canonical pathway such as TAZ-Hippo signaling cascade to modulate VEGF signaling by regulating VEGFR2 expression (By similarity).
Pathways
  • Cytokine-cytokine receptor interaction
  • Hippo signaling pathway
  • Ovarian steroidogenesis
  • TGF-beta signaling pathway
Reactions Not Available
GO Classification
Biological Process
positive regulation of bone mineralization
response to iron ion
response to retinoic acid
SMAD protein signal transduction
inflammatory response
positive regulation of neuron differentiation
response to magnesium ion
BMP signaling pathway
positive regulation of pathway-restricted SMAD protein phosphorylation
positive regulation of endothelial cell differentiation
cellular iron ion homeostasis
positive regulation of chondrocyte differentiation
regulation of cell differentiation
osteoblast differentiation
positive regulation of peptidyl-tyrosine phosphorylation
response to glucocorticoid stimulus
positive regulation of lipopolysaccharide-mediated signaling pathway
negative regulation of transcription from RNA polymerase II promoter
immune response
positive regulation of transcription from RNA polymerase II promoter
cell differentiation
eye development
cellular response to iron ion
multicellular organismal iron ion homeostasis
negative regulation of adherens junction organization
positive regulation of osteoblast differentiation
negative regulation of cell-cell adhesion mediated by cadherin
positive regulation of aldosterone biosynthetic process
ossification
positive regulation of aldosterone secretion
male genitalia development
type B pancreatic cell development
response to activity
cartilage development
positive regulation of epithelial cell proliferation
positive regulation of SMAD protein signal transduction
kidney development
cellular response to mechanical stimulus
positive regulation of vascular permeability
positive regulation of gene expression
positive regulation of endothelial cell proliferation
cellular response to BMP stimulus
endochondral ossification
Cellular Component
cytoplasm
vesicle
extracellular space
Molecular Function
BMP receptor binding
growth factor activity
cytokine activity
protein heterodimerization activity
Cellular Location Not Available
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues 506
Molecular Weight 56222.125
Theoretical pI 8.006
Pfam Domain Function
Signals
  • 1-20;
Transmembrane Regions Not Available
Protein Sequence Not Available
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID Q04906
UniProtKB/Swiss-Prot Entry Name BMP6_RAT
PDB IDs Not Available
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID Not Available
References
General References
  1. Sauermann U, Meyermann R, Schluesener HJ: Cloning of a novel TGF-beta related cytokine, the vgr, from rat brain: cloning of and comparison to homologous human cytokines. J Neurosci Res. 1992 Sep;33(1):142-7. doi: 10.1002/jnr.490330118. [PubMed:1453478 ]