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Showing Protein Chordin (HMDBP14523)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 1 metabolite
Identification
HMDB Protein ID HMDBP14523
Secondary Accession Numbers None
Name Chordin
Synonyms Not Available
Gene Name CHRD
Protein Type Unknown
Biological Properties
General Function Not Available
Specific Function Dorsalizing factor. Key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta family bone morphogenetic proteins (BMPs) and sequestering them in latent complexes.
Pathways
  • TGF-beta signaling pathway
Reactions Not Available
GO Classification
Biological Process
positive regulation of mesenchymal cell proliferation
positive regulation of cell adhesion
pattern specification process
osteoblast differentiation
gastrulation with mouth forming second
negative regulation of BMP signaling pathway
skeletal system development
mesoderm formation
negative regulation of cell migration
BMP signaling pathway involved in spinal cord dorsal/ventral patterning
negative regulation of osteoblast differentiation
dorsal/ventral pattern formation
forebrain development
central nervous system development
Cellular Component
extracellular space
Molecular Function
heparin binding
syndecan binding
Cellular Location Not Available
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues 948
Molecular Weight 101512.395
Theoretical pI 7.5
Pfam Domain Function
Signals
  • 1-26;
Transmembrane Regions Not Available
Protein Sequence Not Available
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID Q9Z0E2
UniProtKB/Swiss-Prot Entry Name CHRD_MOUSE
PDB IDs Not Available
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID Not Available
References
General References
  1. Pappano WN, Scott IC, Clark TG, Eddy RL, Shows TB, Greenspan DS: Coding sequence and expression patterns of mouse chordin and mapping of the cognate mouse chrd and human CHRD genes. Genomics. 1998 Sep 1;52(2):236-9. doi: 10.1006/geno.1998.5474. [PubMed:9782094 ]
  2. Scott IC, Blitz IL, Pappano WN, Maas SA, Cho KW, Greenspan DS: Homologues of Twisted gastrulation are extracellular cofactors in antagonism of BMP signalling. Nature. 2001 Mar 22;410(6827):475-8. doi: 10.1038/35068572. [PubMed:11260715 ]