Hmdb loader
Identification
HMDB Protein ID HMDBP14524
Secondary Accession Numbers None
Name Bone morphogenetic protein 5
Synonyms
  1. BMP-5
Gene Name BMP5
Protein Type Unknown
Biological Properties
General Function Not Available
Specific Function Growth factor of the TGF-beta superfamily that plays essential roles in many developmental processes, including cartilage and bone formation or neurogenesis (PubMed:11580864, PubMed:29321139). Initiates the canonical BMP signaling cascade by associating with type I receptor BMPR1A and type II receptor BMPR2 (PubMed:11580864). In turn, BMPR1A propagates signal by phosphorylating SMAD1/5/8 that travel to the nucleus and act as activators and repressors of transcription of target genes (PubMed:29321139, PubMed:11580864). Can also signal through non-canonical pathway such as MAPK p38 signaling cascade to promote chondrogenic differentiation (PubMed:20402566).
Pathways
  • Cytokine-cytokine receptor interaction
  • Hippo signaling pathway
  • TGF-beta signaling pathway
Reactions Not Available
GO Classification
Biological Process
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
positive regulation of cell proliferation
SMAD protein signal transduction
BMP signaling pathway
positive regulation of pathway-restricted SMAD protein phosphorylation
positive regulation of dendrite development
endocardial cushion formation
skeletal system development
positive regulation of transcription from RNA polymerase II promoter
cardiac muscle tissue development
pharyngeal system development
ossification
type B pancreatic cell development
cartilage development
allantois development
cardiac septum morphogenesis
chorio-allantoic fusion
heart trabecula morphogenesis
positive regulation of epithelial cell proliferation
negative regulation of aldosterone biosynthetic process
negative regulation of cortisol biosynthetic process
negative regulation of mononuclear cell migration
negative regulation of steroid biosynthetic process
neural fold elevation formation
pericardium morphogenesis
hindbrain development
negative regulation of cell proliferation
negative regulation of insulin-like growth factor receptor signaling pathway
negative regulation of epithelial to mesenchymal transition
Cellular Component
vesicle
extracellular space
Molecular Function
BMP receptor binding
growth factor activity
cytokine activity
Cellular Location Not Available
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues 454
Molecular Weight 51736.285
Theoretical pI 8.886
Pfam Domain Function
Signals
  • 1-30;
Transmembrane Regions Not Available
Protein Sequence Not Available
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID P22003
UniProtKB/Swiss-Prot Entry Name BMP5_HUMAN
PDB IDs Not Available
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID Not Available
References
General References
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  5. Beck HN, Drahushuk K, Jacoby DB, Higgins D, Lein PJ: Bone morphogenetic protein-5 (BMP-5) promotes dendritic growth in cultured sympathetic neurons. BMC Neurosci. 2001;2:12. doi: 10.1186/1471-2202-2-12. Epub 2001 Sep 11. [PubMed:11580864 ]
  6. Snelling SJ, Hulley PA, Loughlin J: BMP5 activates multiple signaling pathways and promotes chondrogenic differentiation in the ATDC5 growth plate model. Growth Factors. 2010 Aug;28(4):268-79. doi: 10.3109/08977191003752296. [PubMed:20402566 ]
  7. Jovanovic VM, Salti A, Tilleman H, Zega K, Jukic MM, Zou H, Friedel RH, Prakash N, Blaess S, Edenhofer F, Brodski C: BMP/SMAD Pathway Promotes Neurogenesis of Midbrain Dopaminergic Neurons In Vivo and in Human Induced Pluripotent and Neural Stem Cells. J Neurosci. 2018 Feb 14;38(7):1662-1676. doi: 10.1523/JNEUROSCI.1540-17.2018. Epub 2018 Jan 10. [PubMed:29321139 ]