Hmdb loader
Identification
HMDB Protein ID HMDBP14525
Secondary Accession Numbers None
Name Dapper homolog 2
Synonyms
  1. Dapper antagonist of catenin 2
Gene Name DACT2
Protein Type Unknown
Biological Properties
General Function Not Available
Specific Function Involved in regulation of intracellular signaling pathways during development. Negatively regulates the Nodal signaling pathway, possibly by promoting the lysosomal degradation of Nodal receptors, such as TGFBR1. May be involved in control of the morphogenetic behavior of kidney ureteric bud cells by keeping cells epithelial and restraining their mesenchymal character. May play an inhibitory role in the re-epithelialization of skin wounds by attenuating TGF-beta signaling (By similarity).
Pathways Not Available
Reactions Not Available
GO Classification
Biological Process
negative regulation of nodal signaling pathway
epithelial cell morphogenesis
inner medullary collecting duct development
negative regulation of cell adhesion
skin development
Cellular Component
cytoplasm
Molecular Function
transcription factor binding
protein kinase C binding
beta-catenin binding
delta-catenin binding
protein kinase A binding
Cellular Location Not Available
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues 774
Molecular Weight 82699.125
Theoretical pI 8.872
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence Not Available
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID Q5SW24
UniProtKB/Swiss-Prot Entry Name DACT2_HUMAN
PDB IDs Not Available
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID Not Available
References
General References
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