Showing Protein Endoglin (HMDBP14529)
| Identification | |||||||||||||||||||
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| HMDB Protein ID | HMDBP14529 | ||||||||||||||||||
| Secondary Accession Numbers | None | ||||||||||||||||||
| Name | Endoglin | ||||||||||||||||||
| Synonyms | Not Available | ||||||||||||||||||
| Gene Name | ENG | ||||||||||||||||||
| Protein Type | Unknown | ||||||||||||||||||
| Biological Properties | |||||||||||||||||||
| General Function | Not Available | ||||||||||||||||||
| Specific Function | Vascular endothelium glycoprotein that plays an important role in the regulation of angiogenesis. Required for normal structure and integrity of adult vasculature. Regulates the migration of vascular endothelial cells (By similarity). Required for normal extraembryonic angiogenesis and for embryonic heart development (By similarity). May regulate endothelial cell shape changes in response to blood flow, which drive vascular remodeling and establishment of normal vascular morphology during angiogenesis (By similarity). May play a role in the binding of endothelial cells to integrins (By similarity). Acts as TGF-beta coreceptor and is involved in the TGF-beta/BMP signaling cascade that ultimately leads to the activation of SMAD transcription factors (PubMed:8294451). Required for GDF2/BMP9 signaling through SMAD1 in endothelial cells and modulates TGFB1 signaling through SMAD3 (By similarity). | ||||||||||||||||||
| Pathways | Not Available | ||||||||||||||||||
| Reactions | Not Available | ||||||||||||||||||
| GO Classification |
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| Cellular Location | Not Available | ||||||||||||||||||
| Gene Properties | |||||||||||||||||||
| Chromosome Location | Not Available | ||||||||||||||||||
| Locus | Not Available | ||||||||||||||||||
| SNPs | Not Available | ||||||||||||||||||
| Gene Sequence | Not Available | ||||||||||||||||||
| Protein Properties | |||||||||||||||||||
| Number of Residues | 653 | ||||||||||||||||||
| Molecular Weight | 70278.99 | ||||||||||||||||||
| Theoretical pI | 5.852 | ||||||||||||||||||
| Pfam Domain Function |
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| Signals |
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| Transmembrane Regions |
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| Protein Sequence | Not Available | ||||||||||||||||||
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| GenBank ID Protein | Not Available | ||||||||||||||||||
| UniProtKB/Swiss-Prot ID | P37176 | ||||||||||||||||||
| UniProtKB/Swiss-Prot Entry Name | EGLN_PIG | ||||||||||||||||||
| PDB IDs | Not Available | ||||||||||||||||||
| GenBank Gene ID | Not Available | ||||||||||||||||||
| GeneCard ID | Not Available | ||||||||||||||||||
| GenAtlas ID | Not Available | ||||||||||||||||||
| HGNC ID | Not Available | ||||||||||||||||||
| References | |||||||||||||||||||
| General References |
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