Showing Protein Cbp/p300-interacting transactivator 2 (HMDBP14530)
| Identification | |||||||||||||||||
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| HMDB Protein ID | HMDBP14530 | ||||||||||||||||
| Secondary Accession Numbers | None | ||||||||||||||||
| Name | Cbp/p300-interacting transactivator 2 | ||||||||||||||||
| Synonyms | Not Available | ||||||||||||||||
| Gene Name | CITED2 | ||||||||||||||||
| Protein Type | Unknown | ||||||||||||||||
| Biological Properties | |||||||||||||||||
| General Function | Not Available | ||||||||||||||||
| Specific Function | Transcriptional coactivator of the p300/CBP-mediated transcription complex. Acts as a bridge, linking TFAP2 transcription factors and the p300/CBP transcriptional coactivator complex in order to stimulate TFAP2-mediated transcriptional activation. Positively regulates TGF-beta signaling through its association with the SMAD/p300/CBP-mediated transcriptional coactivator complex. Stimulates the peroxisome proliferator-activated receptors PPARA transcriptional activity. Enhances estrogen-dependent transactivation mediated by estrogen receptors. Acts also as a transcriptional corepressor; interferes with the binding of the transcription factors HIF1A or STAT2 and the p300/CBP transcriptional coactivator complex. Participates in sex determination and early gonad development by stimulating transcription activation of SRY. Plays a role in controlling left-right patterning during embryogenesis; potentiates transcriptional activation of NODAL-mediated gene transcription in the left lateral plate mesoderm (LPM). Plays an essential role in differentiation of the adrenal cortex from the adrenogonadal primordium (AGP); stimulates WT1-mediated transcription activation thereby up-regulating the nuclear hormone receptor NR5A1 promoter activity. Associates with chromatin to the PITX2 P1 promoter region. | ||||||||||||||||
| Pathways | Not Available | ||||||||||||||||
| Reactions | Not Available | ||||||||||||||||
| GO Classification |
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| Cellular Location | Not Available | ||||||||||||||||
| Gene Properties | |||||||||||||||||
| Chromosome Location | Not Available | ||||||||||||||||
| Locus | Not Available | ||||||||||||||||
| SNPs | Not Available | ||||||||||||||||
| Gene Sequence | Not Available | ||||||||||||||||
| Protein Properties | |||||||||||||||||
| Number of Residues | Not Available | ||||||||||||||||
| Molecular Weight | Not Available | ||||||||||||||||
| Theoretical pI | Not Available | ||||||||||||||||
| Pfam Domain Function |
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| Signals | Not Available | ||||||||||||||||
| Transmembrane Regions | Not Available | ||||||||||||||||
| Protein Sequence | Not Available | ||||||||||||||||
| External Links | |||||||||||||||||
| GenBank ID Protein | Not Available | ||||||||||||||||
| UniProtKB/Swiss-Prot ID | A1YFU7 | ||||||||||||||||
| UniProtKB/Swiss-Prot Entry Name | CITE2_SAGLB | ||||||||||||||||
| PDB IDs | Not Available | ||||||||||||||||
| GenBank Gene ID | Not Available | ||||||||||||||||
| GeneCard ID | Not Available | ||||||||||||||||
| GenAtlas ID | Not Available | ||||||||||||||||
| HGNC ID | Not Available | ||||||||||||||||
| References | |||||||||||||||||
| General References | Not Available | ||||||||||||||||