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Record Information
Version4.0
StatusDetected and Quantified
Creation Date2005-11-16 15:48:42 UTC
Update Date2017-10-23 17:06:26 UTC
HMDB IDHMDB0000063
Secondary Accession Numbers
  • HMDB00063
Metabolite Identification
Common NameCortisol
DescriptionCortisol is a corticosteroid hormone produced by the adrenal cortex that is involved in the response to stress; The main glucocorticoid secreted by the adrenal cortex. Its synthetic counterpart is used, either as an injection or topically, in the treatment of inflammation, allergy, collagen diseases, asthma, adrenocortical deficiency, shock, and some neoplastic conditions. As an oral or injectable drug, cortisol is also known as hydrocortisone. It is used as an immunosuppressive drug, given by injection in the treatment of severe allergic reactions such as anaphylaxis and angioedema, in place of prednisolone in patients who need steroid treatment but cannot take oral medication, and peri-operatively in patients on long-term steroid treatment to prevent an Addisonian crisis. Cortisol or Hydrocortisone is a corticosteroid hormone produced by the adrenal cortex that is involved in the response to stress. It increases blood pressure, blood sugar levels, may cause infertility in women, and suppresses the immune system. Its synthetic counterpart (hydrocortisone) is used, either as an injection or topically, in the treatment of inflammation, allergy, collagen diseases, asthma, adrenocortical deficiency, shock, and some neoplastic conditions. Cortisol is synthesized from pregnenolone. The amount of cortisol present in the serum undergoes diurnal variation, with the highest levels present in the early morning, and lower levels in the evening, several hours after the onset of sleep. Cortisol is a corticosteroid hormone produced by the adrenal cortex that is involved in the response to stress; it increases blood pressure, blood sugar levels, may cause infertility in women, and suppresses the immune system. Synthetic cortisol, also known as hydrocortisone, is used as a drug mainly to fight allergies and inflammation; it increases blood pressure, blood sugar levels, may cause infertility in women, and suppresses the immune system. Synthetic cortisol, also known as hydrocortisone, is used as a drug mainly to fight allergies and inflammation.
Structure
Thumb
SynonymsNot Available
Chemical FormulaC21H30O5
Average Molecular Weight362.4599
Monoisotopic Molecular Weight362.20932407
IUPAC NameNot Available
Traditional NameNot Available
CAS Registry Number50-23-7
SMILESNot Available
InChI Identifier
InChI=1S/C21H30O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h9,14-16,18,22,24,26H,3-8,10-11H2,1-2H3/t14-,15-,16-,18+,19-,20-,21+/m0/s1
InChI KeyJYGXADMDTFJGBT-CZFMHFDVSA-N
Chemical Taxonomy
ClassificationNot classified
Ontology
Physiological effect

Health effect:

  Health condition:

Disposition

Biological Location:

  Subcellular:

  Biofluid and excreta:

  Tissue and substructures:

  Organ and components:

    Endocrine gland:

  Cell and elements:

    Cell:

    Element:

Source:

  Biological:

    Animal:

Route of exposure:

  Enteral:

Process

Naturally occurring process:

  Biological process:

    Biochemical pathway:

    Cellular process:

Role

Industrial application:

Biological role:

  Molecular messenger:

Physical Properties
StateSolid
Experimental Properties
PropertyValueReference
Melting Point220 °CNot Available
Boiling PointNot AvailableNot Available
Water Solubility0.32 mg/mLNot Available
LogP1.61HANSCH,C ET AL. (1995)
Predicted PropertiesNot Available
Spectra
Spectra
Spectrum TypeDescriptionSplash Key
Predicted GC-MSPredicted GC-MS Spectrum - GC-MS (Non-derivatized) - 70eV, Positivesplash10-053r-3967000000-125d928e479016368100View in MoNA
Predicted GC-MSPredicted GC-MS Spectrum - GC-MS (3 TMS) - 70eV, Positivesplash10-03di-3521090000-92c353a6bf125d408dd4View in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, Positivesplash10-01ot-0009000000-862028a83a35574ed4d7View in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, Positivesplash10-01tj-0249000000-f36b2ecd66c42004e163View in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, Positivesplash10-0a59-1492000000-120c7b567d593551959fView in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, Negativesplash10-03di-0009000000-cfde4c83b4f9237d6b99View in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, Negativesplash10-114u-2019000000-f70fb8347b279a4639b6View in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, Negativesplash10-0a4i-9075000000-3b98ca796996f423bcadView in MoNA
Biological Properties
Cellular Locations
  • Cytoplasm
  • Extracellular
  • Membrane
  • Mitochondria
  • Endoplasmic reticulum
Biofluid Locations
  • Blood
  • Cerebrospinal Fluid (CSF)
  • Saliva
  • Urine
Tissue Location
  • Adipose Tissue
  • Adrenal Cortex
  • Adrenal Gland
  • Adrenal Medulla
  • Bladder
  • Brain
  • Fetus
  • Fibroblasts
  • Gonads
  • Gut
  • Intestine
  • Kidney
  • Liver
  • Lymphocyte
  • Muscle
  • Nerve Cells
  • Neuron
  • Pancreas
  • Placenta
  • Platelet
  • Prostate
  • Skeletal Muscle
  • Skin
  • Spleen
  • Testes
Pathways
NameSMPDB/PathwhizKEGG
11-beta-hydroxylase deficiency (CYP11B1)Pw000551Pw000551 greyscalePw000551 simpleNot Available
17-alpha-hydroxylase deficiency (CYP17)Pw000542Pw000542 greyscalePw000542 simpleNot Available
21-hydroxylase deficiency (CYP21)Pw000552Pw000552 greyscalePw000552 simpleNot Available
3-Beta-Hydroxysteroid Dehydrogenase DeficiencyPw000695Pw000695 greyscalePw000695 simpleNot Available
Adrenal Hyperplasia Type 3 or Congenital Adrenal Hyperplasia due to 21-hydroxylase DeficiencyPw000177Pw000177 greyscalePw000177 simpleNot Available
Displaying entries 1 - 5 of 12 in total
Normal Concentrations
BiofluidStatusValueAgeSexConditionReferenceDetails
BloodDetected and Quantified0.287 +/- 0.099 uMAdult (>18 years old)BothNormal details
BloodDetected and Quantified0.0130-0.340 uMNewborn (2 - <15 days old)Both
Normal
    • CALIPER Paediatri...
details
BloodDetected and Quantified0.014-0.46 uMInfant (15 days - <1 year old)Both
Normal
    • CALIPER Paediatri...
details
BloodDetected and Quantified0.048-0.30 uMChildren (1 - <9 years old)Both
Normal
    • CALIPER Paediatri...
details
BloodDetected and Quantified0.060-0.35 uMChildren (9 - <14 years old)Both
Normal
    • CALIPER Paediatri...
details
BloodDetected and Quantified0.077-0.45 uMAdolescent (14 - <17 years old)Both
Normal
    • CALIPER Paediatri...
details
BloodDetected and Quantified0.097-0.51 uMAdolescent (17 - <19 years old)Both
Normal
    • CALIPER Paediatri...
details
BloodDetected and Quantified0.32 +/- 0.19 uMAdult (>18 years old)BothNormal details
BloodDetected but not Quantified Adult (>18 years old)Male
Normal
details
BloodDetected and Quantified0.199 (0.058-0.475) uMInfant (0-1 year old)Both
Normal
details
BloodDetected and Quantified0.359 (0.130-0.519) uMInfant (0-1 year old)BothNormal details
BloodDetected and Quantified0.427 (0.110-0.744) uMInfant (0-1 year old)BothNormal details
BloodDetected and Quantified0.386 (0.100-0.671) uMInfant (0-1 year old)BothNormal details
BloodDetected and Quantified0.348 (0.090-0.605) uMInfant (0-1 year old)BothNormal details
BloodDetected and Quantified0.313 (0.081-0.545) uMInfant (0-1 year old)BothNormal details
BloodDetected and Quantified0.282 (0.073-0.491) uMInfant (0-1 year old)BothNormal details
BloodDetected and Quantified0.255 (0.066-0.443) uMInfant (0-1 year old)BothNormal details
BloodDetected and Quantified0.46 +/- 0.30 uMAdult (>18 years old)BothNormal details
BloodDetected and Quantified0.14 (0.0-0.28) uMAdult (>18 years old)BothNormal details
Cerebrospinal Fluid (CSF)Detected and Quantified0.052 +/- 0.023 uMElderly (>65 years old)Not SpecifiedNormal details
Cerebrospinal Fluid (CSF)Detected and Quantified0.02 +/- 0.011 uMAdult (>18 years old)MaleNormal details
Cerebrospinal Fluid (CSF)Detected and Quantified0.03 +/- 0.005 uMAdult (>18 years old)Male
Normal
details
SalivaDetected and Quantified0.0069 +/- 0.0058 uMAdult (>18 years old)Both
Normal
details
SalivaDetected and Quantified0.0063 +/- 0.0052 uMAdult (>18 years old)Both
Normal
details
SalivaDetected and Quantified0.0063 +/- 0.005 uMAdult (>18 years old)Both
Normal
details
SalivaDetected and Quantified0.0077 +/- 0.0052 uMAdult (>18 years old)Both
Normal
details
SalivaDetected and Quantified2.35 uMAdult (>18 years old)BothNormal details
UrineDetected and Quantified0.0081 (0.0019-0.014) umol/mmol creatinineAdult (>18 years old)BothNormal details
UrineDetected and Quantified0.016(0.012-0.021) umol/mmol creatinineAdult (>18 years old)BothNormal details
UrineDetected and Quantified0.0061 +/- 0.00064 umol/mmol creatinineAdult (>18 years old)BothNormal details
Abnormal Concentrations
BiofluidStatusValueAgeSexConditionReferenceDetails
BloodDetected and Quantified0.34 (0.028-0.66) uMAdult (>18 years old)BothACTH deficiency, isolated details
BloodDetected and Quantified0.001 (0.00-0.002) uMChildren (1-13 years old)BothGlucocorticoid deficiency details
BloodDetected and Quantified0.001 (0.0-0.002) uMChildren (1-13 years old)BothAdrenal Hypolasia details
BloodDetected and Quantified0.326 +/- 0.090 uMAdult (>18 years old)BothSchizophrenia details
BloodDetected and Quantified10.55 +/- 1.93 uMAdult (>18 years old)BothSchizophrenia details
BloodDetected but not Quantified Adult (>18 years old)Male
Schizophrenia
details
BloodDetected and Quantified0.001 (0.00-0.002) uMChildren (1-13 years old)BothGlucocorticoid deficiency details
BloodDetected and Quantified0.27 +/- 0.06 uMAdult (>18 years old)BothMajor affective disorder details
BloodDetected and Quantified0.41 +/- 0.2 uMAdult (>18 years old)BothTic disorder details
Cerebrospinal Fluid (CSF)Detected and Quantified0.0096 (0.0027-0.016) uMAdult (>18 years old)FemaleGynecological diseases (benign) details
Cerebrospinal Fluid (CSF)Detected and Quantified0.0001+/- 0.00001 uMAdult (>18 years old)FemaleFunctional hypothalamic amenorrhea details
SalivaDetected and Quantified8.69 uMAdult (>18 years old)BothStress period details
UrineDetected and Quantified0.021 +/- 0.0097 umol/mmol creatinineAdult (>18 years old)Both
Systemic lupus erythematosus (SLE)
details
UrineDetected and Quantified0.0082 +/- 0.0014 umol/mmol creatinineAdult (>18 years old)Both
Systemic lupus erythematosus (SLE)
details
UrineDetected and Quantified0.026 +/- 0.011 umol/mmol creatinineAdult (>18 years old)Both
Rheumatoid arthritis
details
UrineDetected and Quantified0.0052 +/- 0.001 umol/mmol creatinineAdult (>18 years old)Both
Rheumatoid arthritis
details
UrineDetected and Quantified0.44 +/- 0.09 umol/mmol creatinineAdult (>18 years old)BothAnorexia nervosa details
Associated Disorders and Diseases
Disease References
Anorexia nervosa
  1. Vierhapper H, Kiss A, Nowotny P, Wiesnagrotzki S, Monder C, Waldhausl W: Metabolism of cortisol in anorexia nervosa. Acta Endocrinol (Copenh). 1990 Jun;122(6):753-8. [PubMed:2165347 ]
Benign gynecological diseases
  1. Murakami K, Nakagawa T, Shozu M, Uchide K, Koike K, Inoue M: Changes with aging of steroidal levels in the cerebrospinal fluid of women. Maturitas. 1999 Sep 24;33(1):71-80. [PubMed:10585175 ]
Bipolar disorder
  1. Walker EF, Bonsall R, Walder DJ: Plasma hormones and catecholamine metabolites in monozygotic twins discordant for psychosis. Neuropsychiatry Neuropsychol Behav Neurol. 2002 Mar;15(1):10-7. [PubMed:11877547 ]
Schizophrenia
  1. Walker EF, Bonsall R, Walder DJ: Plasma hormones and catecholamine metabolites in monozygotic twins discordant for psychosis. Neuropsychiatry Neuropsychol Behav Neurol. 2002 Mar;15(1):10-7. [PubMed:11877547 ]
  2. Schwarz E, Guest PC, Rahmoune H, Harris LW, Wang L, Leweke FM, Rothermundt M, Bogerts B, Koethe D, Kranaster L, Ohrmann P, Suslow T, McAllister G, Spain M, Barnes A, van Beveren NJ, Baron-Cohen S, Steiner J, Torrey FE, Yolken RH, Bahn S: Identification of a biological signature for schizophrenia in serum. Mol Psychiatry. 2012 May;17(5):494-502. doi: 10.1038/mp.2011.42. Epub 2011 Apr 12. [PubMed:21483431 ]
  3. Bicikova M, Hill M, Ripova D, Mohr P, Hampl R: Determination of steroid metabolome as a possible tool for laboratory diagnosis of schizophrenia. J Steroid Biochem Mol Biol. 2013 Jan;133:77-83. doi: 10.1016/j.jsbmb.2012.08.009. Epub 2012 Aug 24. [PubMed:22944140 ]
Functional hypothalamic amenorrhea
  1. Brundu B, Loucks TL, Adler LJ, Cameron JL, Berga SL: Increased cortisol in the cerebrospinal fluid of women with functional hypothalamic amenorrhea. J Clin Endocrinol Metab. 2006 Apr;91(4):1561-5. Epub 2006 Feb 7. [PubMed:16464944 ]
Rheumatoid arthritis
  1. Straub RH, Weidler C, Demmel B, Herrmann M, Kees F, Schmidt M, Scholmerich J, Schedel J: Renal clearance and daily excretion of cortisol and adrenal androgens in patients with rheumatoid arthritis and systemic lupus erythematosus. Ann Rheum Dis. 2004 Aug;63(8):961-8. [PubMed:15249323 ]
Stress
  1. Krahwinkel T, Nastali S, Azrak B, Willershausen B: The effect of examination stress conditions on the cortisol content of saliva - a study of students from clinical semesters. Eur J Med Res. 2004 May 28;9(5):256-60. [PubMed:15257879 ]
Tic disorder
  1. Hoekstra PJ, Anderson GM, Troost PW, Kallenberg CG, Minderaa RB: Plasma kynurenine and related measures in tic disorder patients. Eur Child Adolesc Psychiatry. 2007 Jun;16 Suppl 1:71-7. doi: 10.1007/s00787-007-1009-1. [PubMed:17665285 ]
ACTH deficiency, isolated
    MetaGene
Adrenal hypoplasia
    MetaGene
Glucocorticoid deficiency, familial isolated
    MetaGene
Associated OMIM IDs
DrugBank IDNot Available
DrugBank Metabolite IDNot Available
Phenol Explorer Compound IDNot Available
Phenol Explorer Metabolite IDNot Available
FoodDB IDFDB021888
KNApSAcK IDNot Available
Chemspider ID571435
KEGG Compound IDC00735
BioCyc IDCORTISOL
BiGG ID35828
Wikipedia LinkCortisol
METLIN ID5124
PubChem Compound657311
PDB IDNot Available
ChEBI IDNot Available
References
Synthesis ReferenceHanson, Frederick R.; Mann, Kingsley M.; Nielson, Eldon D.; Anderson, Hugh V.; Brunner, Mari P.; Karnemaat, John N.; Colingsworth, Donald R.; Haines, Wm. J. Microbiological transformations of steroids. VIII. Preparation of 17a-hydroxycorticosterone. Journ
Material Safety Data Sheet (MSDS)Download (PDF)
General References
  1. Schwarz S, Pohl P: Steroid hormones and steroid hormone binding globulins in cerebrospinal fluid studied in individuals with intact and with disturbed blood-cerebrospinal fluid barrier. Neuroendocrinology. 1992 Feb;55(2):174-82. [PubMed:1620285 ]
  2. Al-Damluji S, Iveson T, Thomas JM, Pendlebury DJ, Rees LH, Besser GM: Food-induced cortisol secretion is mediated by central alpha-1 adrenoceptor modulation of pituitary ACTH secretion. Clin Endocrinol (Oxf). 1987 May;26(5):629-36. [PubMed:2822298 ]
  3. Krahwinkel T, Nastali S, Azrak B, Willershausen B: The effect of examination stress conditions on the cortisol content of saliva - a study of students from clinical semesters. Eur J Med Res. 2004 May 28;9(5):256-60. [PubMed:15257879 ]
  4. Rubin RT, Miller TH, Rhodes ME, Czambel RK: Adrenal cortical responses to low- and high-dose ACTH(1-24) administration in major depressives vs. matched controls. Psychiatry Res. 2006 Jun 30;143(1):43-50. Epub 2006 May 16. [PubMed:16707164 ]
  5. Morris JG, Nevill ME, Boobis LH, Macdonald IA, Williams C: Muscle metabolism, temperature, and function during prolonged, intermittent, high-intensity running in air temperatures of 33 degrees and 17 degrees C. Int J Sports Med. 2005 Dec;26(10):805-14. [PubMed:16320162 ]
  6. Deuschle M, Lecei O, Stalla GK, Landgraf R, Hamann B, Lederbogen F, Uhr M, Luppa P, Maras A, Colla M, Heuser I: Steroid synthesis inhibition with ketoconazole and its effect upon the regulation of the hypothalamus-pituitary-adrenal system in healthy humans. Neuropsychopharmacology. 2003 Feb;28(2):379-83. Epub 2002 Aug 12. [PubMed:12589391 ]
  7. Clauss SB, Holmes KW, Hopkins P, Stein E, Cho M, Tate A, Johnson-Levonas AO, Kwiterovich PO: Efficacy and safety of lovastatin therapy in adolescent girls with heterozygous familial hypercholesterolemia. Pediatrics. 2005 Sep;116(3):682-8. [PubMed:16140708 ]
  8. Stark JG, Werner S, Homrighausen S, Tang Y, Krieg M, Derendorf H, Moellmann H, Hochhaus G: Pharmacokinetic/pharmacodynamic modeling of total lymphocytes and selected subtypes after oral budesonide. J Pharmacokinet Pharmacodyn. 2006 Aug;33(4):441-59. Epub 2006 Apr 22. [PubMed:16633890 ]
  9. Makras P, Koukoulis GN, Bourikas G, Papatheodorou G, Bedevis K, Menounos P, Pappas D, Kartalis G: Effect of 4 weeks of basic military training on peripheral blood leucocytes and urinary excretion of catecholamines and cortisol. J Sports Sci. 2005 Aug;23(8):825-34. [PubMed:16195034 ]
  10. Costa A, Benedetto C, Fabris C, Giraudi GF, Testori O, Bertino E, Marozio L, Varvello G, Arisio R, Ariano M, Emanuel A: Cortisol in human tissues at different stages of life. J Endocrinol Invest. 1996 Jul-Aug;19(7):463-71. [PubMed:8884541 ]
  11. Targher G, Bertolini L, Zoppini G, Zenari L, Falezza G: Relationship of non-alcoholic hepatic steatosis to cortisol secretion in diet-controlled Type 2 diabetic patients. Diabet Med. 2005 Sep;22(9):1146-50. [PubMed:16108840 ]
  12. Pruessner JC, Baldwin MW, Dedovic K, Renwick R, Mahani NK, Lord C, Meaney M, Lupien S: Self-esteem, locus of control, hippocampal volume, and cortisol regulation in young and old adulthood. Neuroimage. 2005 Dec;28(4):815-26. Epub 2005 Jul 14. [PubMed:16023372 ]
  13. Whorwood CB, Donovan SJ, Flanagan D, Phillips DI, Byrne CD: Increased glucocorticoid receptor expression in human skeletal muscle cells may contribute to the pathogenesis of the metabolic syndrome. Diabetes. 2002 Apr;51(4):1066-75. [PubMed:11916927 ]
  14. Takahashi T, Ikeda K, Ishikawa M, Tsukasaki T, Nakama D, Tanida S, Kameda T: Social stress-induced cortisol elevation acutely impairs social memory in humans. Neurosci Lett. 2004 Jun 10;363(2):125-30. [PubMed:15172099 ]
  15. Chapman TE, Kraan GP, Nagel GT, Wolthers BG, Drayer NM: Measurement of the cortisol production rate in two sisters with 17 alpha-hydroxylase deficiency using [1,2,3,4-13C]cortisol and isotope dilution mass spectrometry. J Steroid Biochem Mol Biol. 1991 Apr;38(4):489-96. [PubMed:2031862 ]
  16. Heckmann M, Wudy SA, Haack D, Pohlandt F: Reference range for serum cortisol in well preterm infants. Arch Dis Child Fetal Neonatal Ed. 1999 Nov;81(3):F171-4. [PubMed:10525017 ]
  17. Turpeinen U, Markkanen H, Valimaki M, Stenman UH: Determination of urinary free cortisol by HPLC. Clin Chem. 1997 Aug;43(8 Pt 1):1386-91. [PubMed:9267318 ]
  18. Chrousos GP, Ghaly L, Shedden A, Iezzoni DG, Harris AG: Effects of mometasone furoate dry powder inhaler and beclomethasone dipropionate hydrofluoroalkane and chlorofluorocarbon on the hypothalamic-pituitary-adrenal axis in asthmatic subjects. Chest. 2005 Jul;128(1):70-7. [PubMed:16002918 ]
  19. Ritsner M, Gibel A, Maayan R, Ratner Y, Ram E, Biadsy H, Modai I, Weizman A: Cortisol/dehydroepiandrosterone ratio and responses to antipsychotic treatment in schizophrenia. Neuropsychopharmacology. 2005 Oct;30(10):1913-22. [PubMed:15870835 ]
  20. Seidegard J, Dahlstrom K, Kullberg A: Effect of grapefruit juice on urinary 6 beta-hydroxycortisol/cortisol excretion. Clin Exp Pharmacol Physiol. 1998 May;25(5):379-81. [PubMed:9612666 ]
  21. Simons K, Toomre D: Lipid rafts and signal transduction. Nat Rev Mol Cell Biol. 2000 Oct;1(1):31-9. [PubMed:11413487 ]
  22. Watson AD: Thematic review series: systems biology approaches to metabolic and cardiovascular disorders. Lipidomics: a global approach to lipid analysis in biological systems. J Lipid Res. 2006 Oct;47(10):2101-11. Epub 2006 Aug 10. [PubMed:16902246 ]
  23. Sethi JK, Vidal-Puig AJ: Thematic review series: adipocyte biology. Adipose tissue function and plasticity orchestrate nutritional adaptation. J Lipid Res. 2007 Jun;48(6):1253-62. Epub 2007 Mar 20. [PubMed:17374880 ]
  24. Lingwood D, Simons K: Lipid rafts as a membrane-organizing principle. Science. 2010 Jan 1;327(5961):46-50. doi: 10.1126/science.1174621. [PubMed:20044567 ]
  25. Gunstone, Frank D., John L. Harwood, and Albert J. Dijkstra (2007). The lipid handbook with CD-ROM. CRC Press.

Enzymes

General function:
Involved in monooxygenase activity
Specific function:
Has steroid 11-beta-hydroxylase activity. In addition to this activity, the 18 or 19-hydroxylation of steroids and the aromatization of androstendione to estrone have also been ascribed to cytochrome P450 XIB.
Gene Name:
CYP11B1
Uniprot ID:
P15538
Molecular weight:
57572.44
General function:
Involved in oxidoreductase activity
Specific function:
Catalyzes the conversion of cortisol to the inactive metabolite cortisone. Modulates intracellular glucocorticoid levels, thus protecting the nonselective mineralocorticoid receptor from occupation by glucocorticoids.
Gene Name:
HSD11B2
Uniprot ID:
P80365
Molecular weight:
44126.06
General function:
Involved in oxidoreductase activity
Specific function:
Catalyzes reversibly the conversion of cortisol to the inactive metabolite cortisone. Catalyzes reversibly the conversion of 7-ketocholesterol to 7-beta-hydroxycholesterol. In intact cells, the reaction runs only in one direction, from 7-ketocholesterol to 7-beta-hydroxycholesterol (By similarity).
Gene Name:
HSD11B1
Uniprot ID:
P28845
Molecular weight:
32400.665
General function:
Involved in sequence-specific DNA binding transcription factor activity
Specific function:
Receptor for both mineralocorticoids (MC) such as aldosterone and glucocorticoids (GC) such as corticosterone or cortisol. Binds to mineralocorticoid response elements (MRE) and transactivates target genes. The effect of MC is to increase ion and water transport and thus raise extracellular fluid volume and blood pressure and lower potassium levels
Gene Name:
NR3C2
Uniprot ID:
P08235
Molecular weight:
107066.6
General function:
Involved in 3-beta-hydroxy-delta5-steroid dehydrogenase activity
Specific function:
3-beta-HSD is a bifunctional enzyme, that catalyzes the oxidative conversion of Delta(5)-ene-3-beta-hydroxy steroid, and the oxidative conversion of ketosteroids. The 3-beta-HSD enzymatic system plays a crucial role in the biosynthesis of all classes of hormonal steroids.
Gene Name:
HSD3B2
Uniprot ID:
P26439
Molecular weight:
42051.845
General function:
Involved in monooxygenase activity
Specific function:
Not Available
Gene Name:
P450-CYP21B
Uniprot ID:
Q16874
Molecular weight:
56000.9
General function:
Involved in monooxygenase activity
Specific function:
Not Available
Gene Name:
CYP21A2
Uniprot ID:
Q08AG9
Molecular weight:
55972.9