Showing metabocard for Ethanolamine (HMDB0000149)

General function:

Involved in phosphatase activity

Specific function:

Phosphatase that has a high activity toward phosphoethanolamine (PEA) and phosphocholine (PCho). Involved in the generation of inorganic phosphate for bone mineralization.

Gene Name:

PHOSPHO1

Uniprot ID:

Q8TCT1

Molecular weight:

32350.505

Reactions

General function:

Cell wall/membrane/envelope biogenesis

Specific function:

Highly specific for ethanolamine phosphorylation. May be a rate-controlling step in phosphatidylethanolamine biosynthesis.

Gene Name:

ETNK1

Uniprot ID:

Q9HBU6

Molecular weight:

27994.955

Reactions

General function:

Involved in protein binding

Specific function:

Not Available

Gene Name:

Not Available

Uniprot ID:

Q59EA4

Molecular weight:

122007.8

General function:

Involved in protein binding

Specific function:

May have a role in signal-induced cytoskeletal regulation and/or endocytosis (By similarity).

Gene Name:

PLD2

Uniprot ID:

O14939

Molecular weight:

104656.485

Reactions

General function:

Involved in catalytic activity

Specific function:

Hydrolyzes lysophospholipids to produce lysophosphatidic acid (LPA) in extracellular fluids. Major substrate is lysophosphatidylcholine. Also can act on sphingosylphosphphorylcholine producing sphingosine-1-phosphate, a modulator of cell motility. Can hydrolyze, in vitro, bis-pNPP, to some extent pNP-TMP, and barely ATP. Involved in several motility-related processes such as angiogenesis and neurite outgrowth. Acts as an angiogenic factor by stimulating migration of smooth muscle cells and microtubule formation. Stimulates migration of melanoma cells, probably via a pertussis toxin-sensitive G protein. May have a role in induction of parturition. Possible involvement in cell proliferation and adipose tissue development. Tumor cell motility-stimulating factor.

Gene Name:

ENPP2

Uniprot ID:

Q13822

Molecular weight:

98992.78

Reactions

General function:

Involved in glycerophosphodiester phosphodiesterase activity

Specific function:

Has glycerophosphoinositol phosphodiesterase activity. Has little or no activity towards glycerophosphocholine. GDE1 activity can be modulated by G-protein signaling pathways (By similarity).

Gene Name:

GDE1

Uniprot ID:

Q9NZC3

Molecular weight:

37718.04

General function:

Cell wall/membrane/envelope biogenesis

Specific function:

Has a key role in phospholipid biosynthesis. Catalyzes the first step in phosphatidylethanolamine biosynthesis. Phosphorylates ethanolamine, and can also act on choline (in vitro). Has higher activity with ethanolamine. May not significantly contribute to in vivo phosphatidylcholine biosynthesis.

Gene Name:

CHKB

Uniprot ID:

Q9Y259

Molecular weight:

45270.99

Reactions

General function:

Cell wall/membrane/envelope biogenesis

Specific function:

Highly specific for ethanolamine phosphorylation. Does not have choline kinase activity (By similarity).

Gene Name:

ETNK2

Uniprot ID:

Q9NVF9

Molecular weight:

44781.125

Reactions

General function:

Involved in calcium ion binding

Specific function:

Inhibitor of phospholipase A2, also possesses anti- coagulant properties. Also cleaves the cyclic bond of inositol 1,2-cyclic phosphate to form inositol 1-phosphate

Gene Name:

ANXA3

Uniprot ID:

P12429

Molecular weight:

36374.8

General function:

Cell wall/membrane/envelope biogenesis

Specific function:

Has a key role in phospholipid biosynthesis and may contribute to tumor cell growth. Catalyzes the first step in phosphatidylcholine biosynthesis. Contributes to phosphatidylethanolamine biosynthesis. Phosphorylates choline and ethanolamine. Has higher activity with choline.

Gene Name:

CHKA

Uniprot ID:

P35790

Molecular weight:

52248.53

Reactions