Showing metabocard for Ethanolamine (HMDB0000149)

General function:

Involved in protein binding

Specific function:

May have a role in signal-induced cytoskeletal regulation and/or endocytosis (By similarity).

Gene Name:

PLD2

Uniprot ID:

O14939

Molecular weight:

104656.485

Reactions

General function:

Involved in protein binding

Specific function:

Implicated as a critical step in numerous cellular pathways, including signal transduction, membrane trafficking, and the regulation of mitosis. May be involved in the regulation of perinuclear intravesicular membrane traffic (By similarity).

Gene Name:

PLD1

Uniprot ID:

Q13393

Molecular weight:

124183.135

Reactions

General function:

Involved in catalytic activity

Specific function:

Hydrolyzes lysophospholipids to produce lysophosphatidic acid (LPA) in extracellular fluids. Major substrate is lysophosphatidylcholine. Also can act on sphingosylphosphphorylcholine producing sphingosine-1-phosphate, a modulator of cell motility. Can hydrolyze, in vitro, bis-pNPP, to some extent pNP-TMP, and barely ATP. Involved in several motility-related processes such as angiogenesis and neurite outgrowth. Acts as an angiogenic factor by stimulating migration of smooth muscle cells and microtubule formation. Stimulates migration of melanoma cells, probably via a pertussis toxin-sensitive G protein. May have a role in induction of parturition. Possible involvement in cell proliferation and adipose tissue development. Tumor cell motility-stimulating factor.

Gene Name:

ENPP2

Uniprot ID:

Q13822

Molecular weight:

98992.78

Reactions

General function:

Involved in calcium ion binding

Specific function:

Inhibitor of phospholipase A2, also possesses anti- coagulant properties. Also cleaves the cyclic bond of inositol 1,2-cyclic phosphate to form inositol 1-phosphate

Gene Name:

ANXA3

Uniprot ID:

P12429

Molecular weight:

36374.8

General function:

Cell wall/membrane/envelope biogenesis

Specific function:

Has a key role in phospholipid biosynthesis. Catalyzes the first step in phosphatidylethanolamine biosynthesis. Phosphorylates ethanolamine, and can also act on choline (in vitro). Has higher activity with ethanolamine. May not significantly contribute to in vivo phosphatidylcholine biosynthesis.

Gene Name:

CHKB

Uniprot ID:

Q9Y259

Molecular weight:

45270.99

Reactions

General function:

Cell wall/membrane/envelope biogenesis

Specific function:

Has a key role in phospholipid biosynthesis and may contribute to tumor cell growth. Catalyzes the first step in phosphatidylcholine biosynthesis. Contributes to phosphatidylethanolamine biosynthesis. Phosphorylates choline and ethanolamine. Has higher activity with choline.

Gene Name:

CHKA

Uniprot ID:

P35790

Molecular weight:

52248.53

Reactions

General function:

Cell wall/membrane/envelope biogenesis

Specific function:

Highly specific for ethanolamine phosphorylation. May be a rate-controlling step in phosphatidylethanolamine biosynthesis.

Gene Name:

ETNK1

Uniprot ID:

Q9HBU6

Molecular weight:

27994.955

Reactions

General function:

Involved in phosphatidylserine biosynthetic process

Specific function:

Catalyzes a base-exchange reaction in which the polar head group of phosphatidylethanolamine (PE) or phosphatidylcholine (PC) is replaced by L-serine. In membranes, PTDSS1 catalyzes mainly the conversion of phosphatidylcholine. Also converts, in vitro and to a lesser extent, phosphatidylethanolamine.

Gene Name:

PTDSS1

Uniprot ID:

P48651

Molecular weight:

55527.18

Reactions

General function:

Involved in carbon-nitrogen ligase activity, with glutamine as amido-N-donor

Specific function:

Degrades bioactive fatty acid amides like oleamide, the endogenous cannabinoid, anandamide and myristic amide to their corresponding acids, thereby serving to terminate the signaling functions of these molecules. Hydrolyzes polyunsaturated substrate anandamide preferentially as compared to monounsaturated substrates.

Gene Name:

FAAH

Uniprot ID:

O00519

Molecular weight:

63065.28

Reactions

General function:

Involved in phosphatidylserine biosynthetic process

Specific function:

Catalyzes a base-exchange reaction in which the polar head group of phosphatidylethanolamine (PE) or phosphatidylcholine (PC) is replaced by L-serine. PTDSS2 is specific for phosphatatidylethanolamine and does not act on phosphatidylcholine.

Gene Name:

PTDSS2

Uniprot ID:

Q9BVG9

Molecular weight:

56252.55

Reactions