Record Information
Version3.6
Creation Date2005-11-16 15:48:42 UTC
Update Date2013-05-29 19:24:38 UTC
HMDB IDHMDB00051
Secondary Accession NumbersNone
Metabolite Identification
Common NameAmmonia
DescriptionAmmonia is a colorless alkaline gas with a characteristic sharp smell. Ammonia is one of the most abundant nitrogen-containing compounds in the atmosphere. It is an irritant with a characteristic pungent odor, which is widely used in industry. Inasmuch as ammonia is highly soluble in water and, upon inhalation, is deposited in the upper airways, occupational exposures to ammonia have commonly been associated with sinusitis, upper airway irritation, and eye irritation. Acute exposures to high levels of ammonia have also been associated with diseases of the lower airways and interstitial lung. Ammonia has been shown to be a neurotoxin that predominantly affects astrocytes. Disturbed mitochondrial function and oxidative stress, factors implicated in the induction of the mitochondrial permeability transition, appear to be involved in the mechanism of ammonia neurotoxicity. Ammonia is formed in nearly all tissues and organs of the vertebrate organism; it is the most common endogenous neurotoxic compounds. Ammonia can affect the glutamatergic and GABAergic neuronal systems, the two prevailing neuronal systems of the cortical structures. Ammonia is well recognized to be central in the pathogenesis of hepatic encephalopathy and has been of importance to generations dating back to the early Egyptians. The gut produces ammonia which is metabolized in the liver and almost all organ systems are involved in ammonia metabolism. Colonic bacteria produce ammonia by splitting urea and other amino acids, however this does not explain hyperammonemia and hepatic encephalopathy. The alternative explanation is that hyperammonemia is the result of intestinal breakdown of amino acids, especially glutamine. The intestines have significant glutaminase activity, predominantly located in the enterocytes. On the other hand, this organ has only a little glutamine synthetase activity, making it a major glutamine-consuming organ. In addition to the intestine, the kidney is an important source of blood ammonia in patients with liver disease. Ammonia is also taken up by the muscle and brain in hepatic coma, and there is confirmation that ammonia is metabolized in muscle. The excessive formation of ammonia in the brains of Alzheimer's disease patients has been demonstrated, and it has been shown that some Alzheimer's disease patients exhibit elevated blood ammonia concentrations. Ammonia is the most important natural modulator of lysosomal protein processing: there is evidence for the involvement of aberrant lysosomal processing of beta-amyloid precursor protein (beta-APP) in the formation of amyloid deposits. Inflammatory processes and activation of microglia are widely believed to be implicated in the pathology of Alzheimer's disease. Ammonia is able to affect the characteristic functions of microglia, such as endocytosis, and cytokine production. Based on these facts, an ammonia-based hypothesis for Alzheimer's disease has been suggested. (PMID: 17006913 , 16167195 , 15377862 , 15369278 , 12020619 ).
Structure
Thumb
Synonyms
  1. Ammonia anhydrous
  2. Ammonia inhalant
  3. Ammonia solution strong [usan]
  4. Ammonia water
  5. Ammoniak
  6. Liquid ammonia
  7. Am-fol
  8. Ammonia
  9. Ammonia (conc 20% or greater)
  10. Ammonia gas
  11. Ammonia solution
  12. Ammonia solution strong (NF)
  13. Ammonia water (JP15)
  14. Ammoniac [french]
  15. Ammoniaca [italian]
  16. Ammoniacum gummi
  17. Ammoniak kconzentrierter
  18. Ammoniak [german]
  19. Ammoniakgas
  20. Ammonium ion
  21. Amoniak [polish]
  22. Anhydrous ammonia
  23. Aromatic ammonia vaporole
  24. Azane
  25. NH(3)
  26. NH3
  27. Nitro-sil
  28. Primaeres amin
  29. Sekundaeres amin
  30. Spirit of hartshorn
  31. Tertiaeres amin
Chemical FormulaH3N
Average Molecular Weight17.0305
Monoisotopic Molecular Weight17.026549101
IUPAC Nameammonia
Traditional IUPAC Nameammonia
CAS Registry Number7664-41-7
SMILES
N
InChI Identifier
InChI=1S/H3N/h1H3
InChI KeyQGZKDVFQNNGYKY-UHFFFAOYSA-N
Chemical Taxonomy
KingdomInorganic Compounds
Super ClassHomogeneous Non-metal Compounds
ClassOther Non-metal Organides
Sub ClassOther Non-metal Hydrides
Other Descriptors
  • a small molecule(Cyc)
  • azane(ChEBI)
  • mononuclear parent hydride(ChEBI)
Substituents
  • N/A
Direct ParentOther Non-metal Hydrides
Ontology
StatusDetected and Quantified
Origin
  • Endogenous
Biofunction
  • Component of Alanine and aspartate metabolism
  • Component of Aminosugars metabolism
  • Component of Arginine and proline metabolism
  • Component of Cysteine metabolism
  • Component of D-Arginine and D-ornithine metabolism
  • Component of D-Glutamine and D-glutamate metabolism
  • Component of Glutamate metabolism
  • Component of Glycine, serine and threonine metabolism
  • Component of Histidine metabolism
  • Component of Methionine metabolism
  • Component of Nitrogen metabolism
  • Component of Peptidoglycan biosynthesis
  • Component of Phenylalanine metabolism
  • Component of Purine metabolism
  • Component of Pyrimidine metabolism
  • Component of Selenoamino acid metabolism
  • Component of Tryptophan metabolism
  • Component of Tyrosine metabolism
  • Component of Vitamin B6 metabolism
  • Component of beta-Alanine metabolism
ApplicationNot Available
Cellular locations
  • Cytoplasm
Physical Properties
StateLiquid
Experimental Properties
PropertyValueReference
Melting Point-77.7 °CNot Available
Boiling PointNot AvailableNot Available
Water Solubility482 mg/mL at 24 °CNot Available
LogPNot AvailableNot Available
Predicted Properties
PropertyValueSource
logP-0.98ChemAxon
pKa (strongest basic)8.86ChemAxon
physiological charge1ChemAxon
hydrogen acceptor count1ChemAxon
hydrogen donor count1ChemAxon
polar surface area13.59ChemAxon
rotatable bond count0ChemAxon
refractivity15.51ChemAxon
polarizability1.99ChemAxon
Spectra
SpectraNot Available
Biological Properties
Cellular Locations
  • Cytoplasm
Biofluid Locations
  • Blood
  • Cellular Cytoplasm
  • Cerebrospinal Fluid (CSF)
  • Urine
Tissue Location
  • All Tissues
Pathways
NameSMPDB LinkKEGG Link
Amino Sugar MetabolismSMP00045map00520
Ammonia RecyclingSMP00009map00910
Arginine and Proline MetabolismSMP00020map00330
D-Arginine and D-Ornithine MetabolismSMP00036map00472
Folate MetabolismSMP00053map00670
Glucose-Alanine CycleSMP00127Not Available
Glutamate MetabolismSMP00072map00250
Glycine and Serine MetabolismSMP00004map00260
Homocysteine DegradationSMP00455Not Available
Phenylalanine and Tyrosine MetabolismSMP00008map00360
Threonine and 2-Oxobutanoate DegradationSMP00452Not Available
Urea CycleSMP00059map00330
Normal Concentrations
BiofluidStatusValueAgeSexConditionReference
BloodDetected and Quantified27.5 +/- 3.6 uMNewborn (0-30 days old)BothNormal
  • Geigy Scient...
BloodDetected and Quantified29.0 (10.0-47.0) uMAdult (>18 years old)BothNormal
  • The Merck Ma...
BloodDetected and Quantified40.0 (0 - 80.0) uMAdult (>18 years old)BothNormal
BloodDetected and Quantified29.0 (13.0 - 46.0) uMAdult (>18 years old)BothNormal
  • Geigy Scient...
BloodDetected and Quantified35.0 (20.0 - 58.0) uMAdult (>18 years old)MaleNormal
  • Geigy Scient...
BloodDetected and Quantified29.0 (17.0 - 51.0) uMAdult (>18 years old)FemaleNormal
  • Geigy Scient...
BloodDetected and Quantified52.5 (25.0-80.0) uMAdult (>18 years old)BothNormal
Cellular CytoplasmDetected and Quantified800 (700-900) uMAdult (>18 years old)BothNormal
Cerebrospinal Fluid (CSF)Detected and Quantified11.9 uMAdult (>18 years old)BothNormal
  • Geigy Scient...
UrineDetected and Quantified2810.0 +/- 947.0 umol/mmol creatinineAdult (>18 years old)MaleNormal
  • Geigy Scient...
  • West Cadwell...
  • Basel, Switz...
UrineDetected and Quantified1900.0 +/- 350.0 umol/mmol creatinineAdult (>18 years old)BothNormal
UrineDetected and Quantified2330.0 (724.0-3950.0) umol/mmol creatinineAdult (>18 years old)BothNormal
    Abnormal Concentrations
    BiofluidStatusValueAgeSexConditionReference
    BloodDetected and Quantified1100.0 (200.0-2000.0) uMChildren (1-13 year old)BothArgininosuccinic aciduria (ASL)
    BloodDetected and Quantified1100.0 (200.0-2000.0) uMChildren (1-13 year old)BothCitrullinemia Type I
    BloodDetected and Quantified175.0 (150.0-200.0) uMChildren (1-13 year old)BothFumaric Aciduria
    BloodDetected and Quantified50.4 +/- 17.0 uMAdult (>18 years old)BothShort bowel syndrome
    BloodDetected and Quantified1030.0 (60.0-2000.0) uMChildren (1-13 year old)Both3-Hydroxy-3-Methylglutaryl-CoA Lyase Deficiency
    BloodDetected and Quantified200.0 (100.0-300.0) uMChildren (1-13 year old)Both3-Methyl-Crotonyl-Glycinuria
    Associated Disorders and Diseases
    Disease References
    3-Hydroxy-3-methylglutaryl-CoA lyase deficiency
    Argininosuccinic aciduria
    3-methyl-crotonyl-glycinuria
    Citrullinemia type I
    Fumarase deficiency
    Short bowel syndrome
    • Pita AM, Wakabayashi Y, Fernandez-Bustos MA, Virgili N, Riudor E, Soler J, Farriol M: Plasma urea-cycle-related amino acids, ammonium levels, and urinary orotic acid excretion in short-bowel patients managed with an oral diet. Clin Nutr. 2003 Feb;22(1):93-8. Pubmed: 12553956
    Associated OMIM IDs
      246450 (3-Hydroxy-3-methylglutaryl-CoA lyase deficiency)210200 (3-methyl-crotonyl-glycinuria)207900 (Argininosuccinic aciduria)215700 (Citrullinemia type I)606812 (Fumarase deficiency)
    DrugBank IDNot Available
    DrugBank Metabolite IDNot Available
    Phenol Explorer Compound IDNot Available
    Phenol Explorer Metabolite IDNot Available
    FoodDB IDFDB003908
    KNApSAcK IDC00007267
    Chemspider ID217
    KEGG Compound IDC00014
    BioCyc IDAMMONIA
    BiGG IDNot Available
    Wikipedia LinkAmmonia
    NuGOwiki LinkHMDB00051
    Metagene LinkHMDB00051
    METLIN ID3189
    PubChem Compound222
    PDB IDNH3
    ChEBI ID16134
    References
    Synthesis ReferenceMohr, Rudolf. Ammonia separation from offgas obtained from melamine synthesis. U.S. (1971), 5 pp. CODEN: USXXAM US 3555784 19710119 CAN 77:50902 AN 1972:450902
    Material Safety Data Sheet (MSDS)Not Available
    General References
    1. Yoshida Y, Higashi T, Nouso K, Nakatsukasa H, Nakamura SI, Watanabe A, Tsuji T: Effects of zinc deficiency/zinc supplementation on ammonia metabolism in patients with decompensated liver cirrhosis. Acta Med Okayama. 2001 Dec;55(6):349-55. Pubmed: 11779097
    2. Huizenga JR, Teelken AW, Tangerman A, de Jager AE, Gips CH, Jansen PL: Determination of ammonia in cerebrospinal fluid using the indophenol direct method. Mol Chem Neuropathol. 1998 Jun-Aug;34(2-3):169-77. Pubmed: 10327416
    3. Cohen BI: The significance of ammonia/gamma-aminobutyric acid (GABA) ratio for normality and liver disorders. Med Hypotheses. 2002 Dec;59(6):757-8. Pubmed: 12445521
    4. Kochar DK, Agarwal P, Kochar SK, Jain R, Rawat N, Pokharna RK, Kachhawa S, Srivastava T: Hepatocyte dysfunction and hepatic encephalopathy in Plasmodium falciparum malaria. QJM. 2003 Jul;96(7):505-12. Pubmed: 12881593
    5. Zupke C, Sinskey AJ, Stephanopoulos G: Intracellular flux analysis applied to the effect of dissolved oxygen on hybridomas. Appl Microbiol Biotechnol. 1995 Dec;44(1-2):27-36. Pubmed: 8579834
    6. Cooper AJ: Role of glutamine in cerebral nitrogen metabolism and ammonia neurotoxicity. Ment Retard Dev Disabil Res Rev. 2001;7(4):280-6. Pubmed: 11754523
    7. Remer T: Influence of nutrition on acid-base balance--metabolic aspects. Eur J Nutr. 2001 Oct;40(5):214-20. Pubmed: 11842946
    8. Kaiho T, Tanaka T, Tsuchiya S, Yanagisawa S, Takeuchi O, Miura M, Saigusa N, Miyazaki M: Effect of the herbal medicine Dai-kenchu-to for serum ammonia in hepatectomized patients. Hepatogastroenterology. 2005 Jan-Feb;52(61):161-5. Pubmed: 15783019
    9. Nybo L, Dalsgaard MK, Steensberg A, Moller K, Secher NH: Cerebral ammonia uptake and accumulation during prolonged exercise in humans. J Physiol. 2005 Feb 15;563(Pt 1):285-90. Epub 2004 Dec 20. Pubmed: 15611036
    10. Huizenga JR, Vissink A, Kuipers EJ, Gips CH: Helicobacter pylori and ammonia concentrations of whole, parotid and submandibular/sublingual saliva. Clin Oral Investig. 1999 Jun;3(2):84-7. Pubmed: 10803116
    11. Satoh M, Yokoya S, Hachiya Y, Hachiya M, Fujisawa T, Hoshino K, Saji T: Two hyperandrogenic adolescent girls with congenital portosystemic shunt. Eur J Pediatr. 2001 May;160(5):307-11. Pubmed: 11388600
    12. Suarez I, Bodega G, Fernandez B: Glutamine synthetase in brain: effect of ammonia. Neurochem Int. 2002 Aug-Sep;41(2-3):123-42. Pubmed: 12020613
    13. Helewski K, Kowalczyk-Ziomek G, Konecki J: [Ammonia and GABA-ergic neurotransmission in pathogenesis of hepatic encephalopathy] Wiad Lek. 2003;56(11-12):560-3. Pubmed: 15058165
    14. Grasten SM, Juntunen KS, Poutanen KS, Gylling HK, Miettinen TA, Mykkanen HM: Rye bread improves bowel function and decreases the concentrations of some compounds that are putative colon cancer risk markers in middle-aged women and men. J Nutr. 2000 Sep;130(9):2215-21. Pubmed: 10958815
    15. Pita AM, Wakabayashi Y, Fernandez-Bustos MA, Virgili N, Riudor E, Soler J, Farriol M: Plasma urea-cycle-related amino acids, ammonium levels, and urinary orotic acid excretion in short-bowel patients managed with an oral diet. Clin Nutr. 2003 Feb;22(1):93-8. Pubmed: 12553956
    16. Geier M, Bosch OJ, Boeckh J: Ammonia as an attractive component of host odour for the yellow fever mosquito, Aedes aegypti. Chem Senses. 1999 Dec;24(6):647-53. Pubmed: 10587497
    17. Iwata H, Ueda Y: Pharmacokinetic considerations in development of a bioartificial liver. Clin Pharmacokinet. 2004;43(4):211-25. Pubmed: 15005636
    18. Ohmoto K, Miyake I, Tsuduki M, Ohno S, Yamamoto S: Control of solitary gastric fundal varices and portosystemic encephalopathy accompanying liver cirrhosis by balloon-occluded retrograde transvenous obliteration (B-RTO): a case report. Hepatogastroenterology. 1999 Mar-Apr;46(26):1249-52. Pubmed: 10370701
    19. Verrotti A, Greco R, Morgese G, Chiarelli F: Carnitine deficiency and hyperammonemia in children receiving valproic acid with and without other anticonvulsant drugs. Int J Clin Lab Res. 1999;29(1):36-40. Pubmed: 10356662
    20. Hussein HS, Flickinger EA, Fahey GC Jr: Petfood applications of inulin and oligofructose. J Nutr. 1999 Jul;129(7 Suppl):1454S-6S. Pubmed: 10395620
    21. Shawcross DL, Damink SW, Butterworth RF, Jalan R: Ammonia and hepatic encephalopathy: the more things change, the more they remain the same. Metab Brain Dis. 2005 Sep;20(3):169-79. Pubmed: 16167195
    22. Albrecht J, Norenberg MD: Glutamine: a Trojan horse in ammonia neurotoxicity. Hepatology. 2006 Oct;44(4):788-94. Pubmed: 17006913
    23. Norenberg MD, Rama Rao KV, Jayakumar AR: Ammonia neurotoxicity and the mitochondrial permeability transition. J Bioenerg Biomembr. 2004 Aug;36(4):303-7. Pubmed: 15377862
    24. Brautbar N, Wu MP, Richter ED: Chronic ammonia inhalation and interstitial pulmonary fibrosis: a case report and review of the literature. Arch Environ Health. 2003 Sep;58(9):592-6. Pubmed: 15369278
    25. Seiler N: Ammonia and Alzheimer's disease. Neurochem Int. 2002 Aug-Sep;41(2-3):189-207. Pubmed: 12020619

    Only showing the first 50 proteins. There are 85 proteins in total.

    Enzymes

    Gene Name:
    DCTD
    Uniprot ID:
    P32321
    Reactions
    dCMP + Water unknown dUMP + Ammoniadetails
    Gene Name:
    DDO
    Uniprot ID:
    Q99489
    Reactions
    D-Aspartic acid + Water + Oxygen unknown Oxalacetic acid + Ammonia + Hydrogen peroxidedetails
    Gene Name:
    MAOB
    Uniprot ID:
    P27338
    Reactions
    Tryptamine + Water + Oxygen unknown Indoleacetaldehyde + Ammonia + Hydrogen peroxidedetails
    Tyramine + Water + Oxygen unknown 4-Hydroxyphenylacetaldehyde + Ammonia + Hydrogen peroxidedetails
    Aminoacetone + Water + Oxygen unknown Pyruvaldehyde + Ammonia + Hydrogen peroxidedetails
    Norepinephrine + Water + Oxygen unknown 3,4-Dihydroxymandelaldehyde + Ammonia + Hydrogen peroxidedetails
    Phenylethylamine + Oxygen + Water unknown Phenylacetaldehyde + Ammonia + Hydrogen peroxidedetails
    Serotonin + Water + Oxygen unknown 5-Hydroxyindoleacetaldehyde + Ammonia + Hydrogen peroxidedetails
    N-Acetylputrescine + Water + Oxygen unknown N4-Acetylaminobutanal + Ammonia + Hydrogen peroxidedetails
    Dopamine + Water + Oxygen unknown 3,4-Dihydroxyphenylacetaldehyde + Ammonia + Hydrogen peroxidedetails
    1-Methylhistamine + Water + Oxygen unknown Methylimidazole acetaldehyde + Ammonia + Hydrogen peroxidedetails
    3-Methoxytyramine + Water + Oxygen unknown Homovanillin + Hydrogen peroxide + Ammoniadetails
    Normetanephrine + Water + Oxygen unknown 3-Methoxy-4-hydroxyphenylglycolaldehyde + Ammonia + Hydrogen peroxidedetails
    3-Hydroxykynurenamine + Oxygen unknown Quinoline-4,8-diol + Ammonia + Hydrogen peroxidedetails
    5-Hydroxykynurenamine + Water + Oxygen unknown 4,6-Dihydroxyquinoline + Ammonia + Hydrogen peroxide + Waterdetails
    Didemethylcitalopram + Water + Oxygen unknown Citalopram aldehyde + Ammonia + Hydrogen peroxidedetails
    Gene Name:
    MAOA
    Uniprot ID:
    P21397
    Reactions
    Tryptamine + Water + Oxygen unknown Indoleacetaldehyde + Ammonia + Hydrogen peroxidedetails
    Tyramine + Water + Oxygen unknown 4-Hydroxyphenylacetaldehyde + Ammonia + Hydrogen peroxidedetails
    Aminoacetone + Water + Oxygen unknown Pyruvaldehyde + Ammonia + Hydrogen peroxidedetails
    Norepinephrine + Water + Oxygen unknown 3,4-Dihydroxymandelaldehyde + Ammonia + Hydrogen peroxidedetails
    Phenylethylamine + Oxygen + Water unknown Phenylacetaldehyde + Ammonia + Hydrogen peroxidedetails
    Serotonin + Water + Oxygen unknown 5-Hydroxyindoleacetaldehyde + Ammonia + Hydrogen peroxidedetails
    N-Acetylputrescine + Water + Oxygen unknown N4-Acetylaminobutanal + Ammonia + Hydrogen peroxidedetails
    Dopamine + Water + Oxygen unknown 3,4-Dihydroxyphenylacetaldehyde + Ammonia + Hydrogen peroxidedetails
    1-Methylhistamine + Water + Oxygen unknown Methylimidazole acetaldehyde + Ammonia + Hydrogen peroxidedetails
    3-Methoxytyramine + Water + Oxygen unknown Homovanillin + Hydrogen peroxide + Ammoniadetails
    Normetanephrine + Water + Oxygen unknown 3-Methoxy-4-hydroxyphenylglycolaldehyde + Ammonia + Hydrogen peroxidedetails
    3-Hydroxykynurenamine + Oxygen unknown Quinoline-4,8-diol + Ammonia + Hydrogen peroxidedetails
    5-Hydroxykynurenamine + Water + Oxygen unknown 4,6-Dihydroxyquinoline + Ammonia + Hydrogen peroxide + Waterdetails
    Didemethylcitalopram + Water + Oxygen unknown Citalopram aldehyde + Ammonia + Hydrogen peroxidedetails
    Gene Name:
    DAO
    Uniprot ID:
    P14920
    Reactions
    A D-amino acid + Water + Oxygen unknown a 2-oxo acid + Ammonia + Hydrogen peroxidedetails
    Glycine + Water + Oxygen unknown Glyoxylic acid + Ammonia + Hydrogen peroxidedetails
    D-Ornithine + Water + Oxygen unknown 5-Amino-2-oxopentanoic acid + Ammonia + Hydrogen peroxidedetails
    Cephalosporin C + Water + Oxygen unknown (7R)-7-(5-Carboxy-5-oxopentanoyl)aminocephalosporinate + Ammonia + Hydrogen peroxidedetails
    Gene Name:
    GNPDA1
    Uniprot ID:
    P46926
    Reactions
    Glucosamine 6-phosphate + Water unknown Fructose 6-phosphate + Ammoniadetails
    Gene Name:
    HMBS
    Uniprot ID:
    P08397
    Reactions
    Porphobilinogen + Water unknown Hydroxymethylbilane + Ammoniadetails
    Gene Name:
    CPS1
    Uniprot ID:
    P31327
    Reactions
    Adenosine triphosphate + Ammonia + CO(2) + Water unknown ADP + Phosphoric acid + Carbamoyl phosphatedetails
    Adenosine triphosphate + Ammonia + Carbon dioxide + Water unknown ADP + Phosphoric acid + Carbamoyl phosphatedetails
    Gene Name:
    ABP1
    Uniprot ID:
    P19801
    Reactions
    Histamine + Water + Oxygen unknown Imidazole-4-acetaldehyde + Ammonia + Hydrogen peroxidedetails
    Putrescine + Oxygen + Water unknown 4-Aminobutyraldehyde + Ammonia + Hydrogen peroxidedetails
    Tryptamine + Water + Oxygen unknown Indoleacetaldehyde + Ammonia + Hydrogen peroxidedetails
    Gene Name:
    AOC3
    Uniprot ID:
    Q16853
    Reactions
    RCH(2)NH(2) + Water + Oxygen unknown RCHO + Ammonia + Hydrogen peroxidedetails
    Tyramine + Water + Oxygen unknown 4-Hydroxyphenylacetaldehyde + Ammonia + Hydrogen peroxidedetails
    Aminoacetone + Water + Oxygen unknown Pyruvaldehyde + Ammonia + Hydrogen peroxidedetails
    Phenylethylamine + Oxygen + Water unknown Phenylacetaldehyde + Ammonia + Hydrogen peroxidedetails
    1,3-Diaminopropane + Oxygen + Water unknown 3-Aminopropionaldehyde + Ammonia + Hydrogen peroxidedetails
    N-Methylputrescine + Oxygen + Hydrogen Ion unknown 1-Methylpyrrolinium + Hydrogen peroxide + Ammoniadetails
    Dopamine + Water + Oxygen unknown 3,4-Dihydroxyphenylacetaldehyde + Ammonia + Hydrogen peroxidedetails
    Methylamine + Oxygen + Water unknown Formaldehyde + Ammonia + Hydrogen peroxidedetails
    Cadaverine + Water + Oxygen unknown 5-Aminopentanal + Ammonia + Hydrogen peroxidedetails
    Gene Name:
    AOC2
    Uniprot ID:
    O75106
    Reactions
    RCH(2)NH(2) + Water + Oxygen unknown RCHO + Ammonia + Hydrogen peroxidedetails
    Tyramine + Water + Oxygen unknown 4-Hydroxyphenylacetaldehyde + Ammonia + Hydrogen peroxidedetails
    Aminoacetone + Water + Oxygen unknown Pyruvaldehyde + Ammonia + Hydrogen peroxidedetails
    Phenylethylamine + Oxygen + Water unknown Phenylacetaldehyde + Ammonia + Hydrogen peroxidedetails
    1,3-Diaminopropane + Oxygen + Water unknown 3-Aminopropionaldehyde + Ammonia + Hydrogen peroxidedetails
    N-Methylputrescine + Oxygen + Hydrogen Ion unknown 1-Methylpyrrolinium + Hydrogen peroxide + Ammoniadetails
    Dopamine + Water + Oxygen unknown 3,4-Dihydroxyphenylacetaldehyde + Ammonia + Hydrogen peroxidedetails
    Methylamine + Oxygen + Water unknown Formaldehyde + Ammonia + Hydrogen peroxidedetails
    Cadaverine + Water + Oxygen unknown 5-Aminopentanal + Ammonia + Hydrogen peroxidedetails
    Gene Name:
    CCBL1
    Uniprot ID:
    Q16773
    Reactions
    RS-CH(2)-CH(NH(3)(+))COO(-) + Water unknown RSH + Ammonia + Pyruvic aciddetails
    Gene Name:
    CTH
    Uniprot ID:
    P32929
    Reactions
    L-Cystathionine + Water unknown L-Cysteine + Ammonia + 2-Ketobutyric aciddetails
    L-Cysteine + Water unknown Hydrogen sulfide + Pyruvic acid + Ammoniadetails
    L-Cystine + Water unknown Pyruvic acid + Ammonia + Thiocysteinedetails
    Selenomethionine + Water unknown Methaneselenol + Ammonia + 2-Ketobutyric aciddetails
    Selenocystathionine + Water unknown Selenocysteine + Ammonia + 2-Ketobutyric aciddetails
    Gene Name:
    UPB1
    Uniprot ID:
    Q9UBR1
    Reactions
    Ureidopropionic acid + Water unknown Beta-Alanine + CO(2) + Ammoniadetails
    Ureidopropionic acid + Water unknown Beta-Alanine + Carbon dioxide + Ammoniadetails
    Ureidoisobutyric acid + Water unknown 3-Aminoisobutanoic acid + Carbon dioxide + Ammoniadetails
    alpha-Fluoro-beta-ureidopropionic acid + Water unknown alpha-Fluoro-beta-alanine + Carbon dioxide + Ammoniadetails
    Gene Name:
    BTD
    Uniprot ID:
    P43251
    Reactions
    Biotin amide + Water unknown Biotin + Ammoniadetails
    Gene Name:
    GMPS
    Uniprot ID:
    P49915
    Reactions
    Adenosine triphosphate + Xanthylic acid + Ammonia unknown Adenosine monophosphate + Pyrophosphate + Guanosine monophosphatedetails
    Gene Name:
    AMPD3
    Uniprot ID:
    Q01432
    Reactions
    Adenosine monophosphate + Water unknown Inosinic acid + Ammoniadetails
    Gene Name:
    AMPD2
    Uniprot ID:
    Q01433
    Reactions
    Adenosine monophosphate + Water unknown Inosinic acid + Ammoniadetails
    Gene Name:
    AMPD1
    Uniprot ID:
    P23109
    Reactions
    Adenosine monophosphate + Water unknown Inosinic acid + Ammoniadetails
    Gene Name:
    ADA
    Uniprot ID:
    P00813
    Reactions
    Adenosine + Water unknown Inosine + Ammoniadetails
    Deoxyadenosine + Water unknown Deoxyinosine + Ammoniadetails
    Gene Name:
    TGM3
    Uniprot ID:
    Q08188
    Reactions
    Protein glutamine + alkylamine unknown protein N(5)-alkylglutamine + Ammoniadetails
    Gene Name:
    GLUD2
    Uniprot ID:
    P49448
    Reactions
    L-Glutamic acid + Water + NAD(P)(+) unknown Oxoglutaric acid + Ammonia + NAD(P)Hdetails
    L-Glutamic acid + NAD + Water unknown Oxoglutaric acid + Ammonia + NADH + Hydrogen Iondetails
    L-Glutamic acid + NADP + Water unknown Oxoglutaric acid + Ammonia + NADPH + Hydrogen Iondetails
    Gene Name:
    TGM2
    Uniprot ID:
    P21980
    Reactions
    Protein glutamine + alkylamine unknown protein N(5)-alkylglutamine + Ammoniadetails
    Gene Name:
    PADI6
    Uniprot ID:
    Q6TGC4
    Reactions
    Protein L-arginine + Water unknown protein L-citrulline + Ammoniadetails
    Gene Name:
    GLUL
    Uniprot ID:
    P15104
    Reactions
    Adenosine triphosphate + L-Glutamic acid + Ammonia unknown ADP + Phosphoric acid + L-Glutaminedetails
    Gene Name:
    SDS
    Uniprot ID:
    P20132
    Reactions
    L-Serine unknown Pyruvic acid + Ammoniadetails
    L-Threonine unknown 2-Ketobutyric acid + Ammoniadetails
    Gene Name:
    F13A1
    Uniprot ID:
    P00488
    Reactions
    Protein glutamine + alkylamine unknown protein N(5)-alkylglutamine + Ammoniadetails
    Gene Name:
    PADI4
    Uniprot ID:
    Q9UM07
    Reactions
    Protein L-arginine + Water unknown protein L-citrulline + Ammoniadetails
    Gene Name:
    PNPO
    Uniprot ID:
    Q9NVS9
    Reactions
    Pyridoxamine 5'-phosphate + Water + Oxygen unknown Pyridoxal 5'-phosphate + Ammonia + Hydrogen peroxidedetails
    Pyridoxamine + Water + Oxygen unknown Pyridoxal + Ammonia + Hydrogen peroxidedetails
    Gene Name:
    GLS2
    Uniprot ID:
    Q9UI32
    Reactions
    L-Glutamine + Water unknown L-Glutamic acid + Ammoniadetails
    D-Glutamine + Water unknown D-Glutamic acid + Ammoniadetails
    Gene Name:
    CTPS1
    Uniprot ID:
    P17812
    Reactions
    Adenosine triphosphate + Uridine triphosphate + Ammonia unknown ADP + Phosphoric acid + Cytidine triphosphatedetails
    Gene Name:
    PADI3
    Uniprot ID:
    Q9ULW8
    Reactions
    Protein L-arginine + Water unknown protein L-citrulline + Ammoniadetails
    Gene Name:
    GMPR2
    Uniprot ID:
    Q9P2T1
    Reactions
    Inosinic acid + Ammonia + NADP unknown Guanosine monophosphate + NADPHdetails
    Inosinic acid + Ammonia + NADP unknown Guanosine monophosphate + NADPH + Hydrogen Iondetails
    Gene Name:
    TGM5
    Uniprot ID:
    O43548
    Reactions
    Protein glutamine + alkylamine unknown protein N(5)-alkylglutamine + Ammoniadetails
    Gene Name:
    GLS
    Uniprot ID:
    O94925
    Reactions
    L-Glutamine + Water unknown L-Glutamic acid + Ammoniadetails
    D-Glutamine + Water unknown D-Glutamic acid + Ammoniadetails
    Gene Name:
    TGM4
    Uniprot ID:
    P49221
    Reactions
    Protein glutamine + alkylamine unknown protein N(5)-alkylglutamine + Ammoniadetails
    Gene Name:
    TGM1
    Uniprot ID:
    P22735
    Reactions
    Protein glutamine + alkylamine unknown protein N(5)-alkylglutamine + Ammoniadetails
    Gene Name:
    HAL
    Uniprot ID:
    P42357
    Reactions
    L-Histidine unknown Urocanic acid + Ammoniadetails
    Gene Name:
    PADI2
    Uniprot ID:
    Q9Y2J8
    Reactions
    Protein L-arginine + Water unknown protein L-citrulline + Ammoniadetails
    Gene Name:
    GMPR
    Uniprot ID:
    P36959
    Reactions
    Inosinic acid + Ammonia + NADP unknown Guanosine monophosphate + NADPHdetails
    Inosinic acid + Ammonia + NADP unknown Guanosine monophosphate + NADPH + Hydrogen Iondetails
    Gene Name:
    FTCD
    Uniprot ID:
    O95954
    Reactions
    5-Formiminotetrahydrofolic acid unknown 5,10-Methenyltetrahydrofolic acid + Ammoniadetails
    5-Formiminotetrahydrofolic acid + Hydrogen Ion unknown 5,10-Methenyltetrahydrofolic acid + Ammoniadetails
    Gene Name:
    PADI1
    Uniprot ID:
    Q9ULC6
    Reactions
    Protein L-arginine + Water unknown protein L-citrulline + Ammoniadetails
    Gene Name:
    AMT
    Uniprot ID:
    P48728
    Reactions
    [Protein]-S(8)-aminomethyldihydrolipoyllysine + Tetrahydrofolic acid unknown [protein]-dihydrolipoyllysine + 5,10-Methylene-THF + Ammoniadetails
    Glycine + Tetrahydrofolic acid + NAD unknown 5,10-Methylene-THF + Ammonia + Carbon dioxide + NADH + Hydrogen Iondetails
    S-Aminomethyldihydrolipoylprotein + Tetrahydrofolic acid unknown Dihydrolipoylprotein + 5,10-Methylene-THF + Ammoniadetails
    Gene Name:
    GDA
    Uniprot ID:
    Q9Y2T3
    Reactions
    Guanine + Water unknown Xanthine + Ammoniadetails
    Gene Name:
    TGM6
    Uniprot ID:
    O95932
    Reactions
    Protein glutamine + alkylamine unknown protein N(5)-alkylglutamine + Ammoniadetails
    Gene Name:
    QPCT
    Uniprot ID:
    Q16769
    Reactions
    L-glutaminyl-peptide unknown 5-oxoprolyl-peptide + Ammoniadetails
    Gene Name:
    TGM7
    Uniprot ID:
    Q96PF1
    Reactions
    Protein glutamine + alkylamine unknown protein N(5)-alkylglutamine + Ammoniadetails
    Gene Name:
    GLUD1
    Uniprot ID:
    P00367
    Reactions
    L-Glutamic acid + Water + NAD(P)(+) unknown Oxoglutaric acid + Ammonia + NAD(P)Hdetails
    L-Glutamic acid + NAD + Water unknown Oxoglutaric acid + Ammonia + NADH + Hydrogen Iondetails
    L-Glutamic acid + NADP + Water unknown Oxoglutaric acid + Ammonia + NADPH + Hydrogen Iondetails
    Gene Name:
    LOX
    Uniprot ID:
    P28300
    Reactions
    Peptidyl-L-lysyl-peptide + Oxygen + Water unknown peptidyl-allysyl-peptide + Ammonia + Hydrogen peroxidedetails
    Gene Name:
    RHAG
    Uniprot ID:
    Q02094

    Only showing the first 50 proteins. There are 85 proteins in total.