Human Metabolome Database Version 3.5

Showing metabocard for Pyrophosphate (HMDB00250)

Record Information
Version 3.5
Creation Date 2005-11-16 08:48:42 -0700
Update Date 2013-02-08 17:08:10 -0700
HMDB ID HMDB00250
Secondary Accession Numbers None
Metabolite Identification
Common Name Pyrophosphate
Description In chemistry, the anion, the salts, and the esters of pyrophosphoric acid are called pyrophosphates. The anion is abbreviated PPi and is formed by the hydrolysis of ATP into AMP in cells. This hydrolysis is called pyrophosphorolysis. The pyrophosphate anion has the structure P2O74-, and is an acid anhydride of phosphate. It is unstable in aqueous solution and rapidly hydrolyzes into inorganic phosphate.
Structure Thumb
Download: MOL | SDF | PDB | SMILES | InChI
Display: 2D Structure | 3D Structure
Synonyms
  1. (4-)Diphosphoric acid ion
  2. (P2O74-)Diphosphate
  3. Diphosphate
  4. Diphosphoric acid
  5. PPi
  6. Pyrometaphosphate
  7. Pyrophosphate
  8. Pyrophosphate tetraanion
  9. Pyrophosphate(4-) ion
Chemical Formula O7P2
Average Molecular Weight 173.9433
Monoisotopic Molecular Weight 173.911925378
IUPAC Name (phosphonatooxy)phosphonate
Traditional IUPAC Name phosphonatooxyphosphonate
CAS Registry Number 14000-31-8
SMILES [O-]P([O-])(=O)OP([O-])([O-])=O
InChI Identifier InChI=1S/H4O7P2/c1-8(2,3)7-9(4,5)6/h(H2,1,2,3)(H2,4,5,6)/p-4
InChI Key XPPKVPWEQAFLFU-UHFFFAOYSA-J
Chemical Taxonomy
Kingdom Inorganic Compounds
Super Class Homogeneous Non-metal Compounds
Class Non-metal Oxoanionic Compounds
Sub Class Non-metal Pyrophosphates
Other Descriptors
  • phosphorus oxoanion(ChEBI)
Substituents
  • N/A
Direct Parent Non-metal Pyrophosphates
Ontology
Status Detected and Quantified
Origin
  • Endogenous
Biofunction
  • Component of Alanine and aspartate metabolism
  • Component of Aminoacyl-tRNA biosynthesis
  • Component of Aminophosphonate metabolism
  • Component of Aminosugars metabolism
  • Component of Arginine and proline metabolism
  • Component of Biotin metabolism
  • Component of Fatty acid metabolism
  • Component of Folate biosynthesis
  • Component of Fructose and mannose metabolism
  • Component of Galactose metabolism
  • Component of Glutamate metabolism
  • Component of Glycerophospholipid metabolism
  • Component of Glycine, serine and threonine metabolism
  • Component of Histidine metabolism
  • Component of Lysine biosynthesis
  • Component of Methionine metabolism
  • Component of Nicotinate and nicotinamide metabolism
  • Component of Nitrogen metabolism
  • Component of Nucleotide sugars metabolism
  • Component of Phenylalanine, tyrosine and tryptophan biosynthesis
  • Component of Porphyrin and chlorophyll metabolism
  • Component of Propanoate metabolism
  • Component of Purine metabolism
  • Component of Pyrimidine metabolism
  • Component of Pyruvate metabolism
  • Component of Selenoamino acid metabolism
  • Component of Starch and sucrose metabolism
  • Component of Sulfur metabolism
  • Component of Terpenoid biosynthesis
  • Component of Tryptophan metabolism
  • Component of Valine, leucine and isoleucine biosynthesis
Application Not Available
Cellular locations
  • Cytoplasm
  • Mitochondria
  • Nucleus
  • Endoplasmic reticulum
  • Peroxisome
Physical Properties
State Solid
Experimental Properties
Property Value Reference
Melting Point 61 °C Not Available
Boiling Point Not Available Not Available
Water Solubility Not Available Not Available
LogP Not Available Not Available
Predicted Properties
Property Value Source
Water Solubility ALOGPS
LogP -1.4 ChemAxon
pKa (strongest acidic) 1.7 ChemAxon
Hydrogen Acceptor Count 6 ChemAxon
Hydrogen Donor Count 0 ChemAxon
Polar Surface Area 135.61 A2 ChemAxon
Rotatable Bond Count 2 ChemAxon
Refractivity 21.04 ChemAxon
Polarizability 9.03 ChemAxon
Formal Charge -4 ChemAxon
Physiological Charge -3 ChemAxon
Spectra
MS/MS Spectrum Quattro_QQQ 10
MS/MS Spectrum Quattro_QQQ 25
MS/MS Spectrum Quattro_QQQ 40
MS/MS Spectrum GC-MS
Biological Properties
Cellular Locations
  • Cytoplasm
  • Mitochondria
  • Nucleus
  • Endoplasmic reticulum
  • Peroxisome
Biofluid Locations
  • Blood
  • Urine
Tissue Location
  • Skeletal Muscle
  • Fibroblasts
  • Intestine
  • Neuron
  • Testes
  • Epidermis
  • Prostate
  • Platelet
Pathways
Name SMPDB Link KEGG Link
Transcription/Translation SMP00019 Not Available
Normal Concentrations
Biofluid Status Value Age Sex Condition Reference
Blood Detected and Quantified
1.8 (0.64-2.96) uM Adult (>18 years old) Both Normal
  • Geigy Scient...
Urine Detected and Quantified
2.56 +/- 1.22 umol/mmol creatinine Children (1-13 year old) Both Normal
  • Geigy Scient...
Abnormal Concentrations
Not Available
Associated Disorders and Diseases
Disease References None
Associated OMIM IDs None
DrugBank ID Not Available
DrugBank Metabolite ID Not Available
Phenol Explorer Compound ID Not Available
Phenol Explorer Metabolite ID Not Available
FoodDB ID FDB021918
KNApSAcK ID Not Available
Chemspider ID 559142 Link_out
KEGG Compound ID C00013 Link_out
BioCyc ID PPI Link_out
BiGG ID 33511 Link_out
Wikipedia Link Pyrophosphate Link_out
NuGOwiki Link HMDB00250 Link_out
Metagene Link HMDB00250 Link_out
METLIN ID 3306 Link_out
PubChem Compound 644102 Link_out
PDB ID DPO Link_out
ChEBI ID 18361 Link_out
References
Synthesis Reference Dittmer, Donald C.; Silverstein, V. Opshelor. Production of pyrophosphate from S-n-butyl phosphorothioate. Journal of Organic Chemistry (1961), 26 4706-7.
Material Safety Data Sheet (MSDS) Download (PDF)
General References
  1. Broll H: [Effect of chloroquine diphosphate on the superhelix structure of DNA and protein synthesis in synovial cells in chronic polyarthritis] Wien Klin Wochenschr. 1983 Dec 23;95(24):877-80. Pubmed: 6670282 Link_out
  2. Golanski J, Pluta J, Baraniak J, Watala C: Limited usefulness of the PFA-100 for the monitoring of ADP receptor antagonists--in vitro experience. Clin Chem Lab Med. 2004 Jan;42(1):25-9. Pubmed: 15061376 Link_out
  3. Mateos-Trigos G, Evans RJ, Heath MF: Effects of P2Y(1) and P2Y(12) receptor antagonists on ADP-induced shape change of equine platelets: comparison with human platelets. Platelets. 2002 Aug-Sep;13(5-6):285-92. Pubmed: 12189014 Link_out
  4. Sirkis SI: [Serum and cerebrospinal fluid enzyme spectra in meningitis and their differential diagnostic value] Zh Nevropatol Psikhiatr Im S S Korsakova. 1982;82(2):193-7. Pubmed: 7072418 Link_out
  5. Barbier O, Torra IP, Sirvent A, Claudel T, Blanquart C, Duran-Sandoval D, Kuipers F, Kosykh V, Fruchart JC, Staels B: FXR induces the UGT2B4 enzyme in hepatocytes: a potential mechanism of negative feedback control of FXR activity. Gastroenterology. 2003 Jun;124(7):1926-40. Pubmed: 12806625 Link_out
  6. March JG, Simonet BM, Grases F: Determination of pyrophosphate in renal calculi and urine by means of an enzymatic method. Clin Chim Acta. 2001 Dec;314(1-2):187-94. Pubmed: 11718694 Link_out
  7. Namiki M, Kitamura M, Nonomura N, Sugao H, Nakamura M, Okuyama A, Utsunomiya M, Itatani H, Matsumoto K, Sonoda T: Direct inhibitory effect of estrogen on the human testis in vitro. Arch Androl. 1988;20(2):131-5. Pubmed: 3395157 Link_out
  8. Kosoglou T, Statkevich P, Johnson-Levonas AO, Paolini JF, Bergman AJ, Alton KB: Ezetimibe: a review of its metabolism, pharmacokinetics and drug interactions. Clin Pharmacokinet. 2005;44(5):467-94. Pubmed: 15871634 Link_out
  9. Pickett DA, Welch DF: Recognition of Staphylococcus saprophyticus in urine cultures by screening colonies for production of phosphatase. J Clin Microbiol. 1985 Mar;21(3):310-3. Pubmed: 2984240 Link_out
  10. Hua HT, Albadawi H, Entabi F, Conrad M, Stoner MC, Meriam BT, Sroufe R, Houser S, Lamuraglia GM, Watkins MT: Polyadenosine diphosphate-ribose polymerase inhibition modulates skeletal muscle injury following ischemia reperfusion. Arch Surg. 2005 Apr;140(4):344-51; discussion 351-2. Pubmed: 15837884 Link_out
  11. Dahlmann N, Ueckermann C: Separation of deoxythymidine-5'-triphosphatase from unspecific hydrolases. A recommended micromethod in the diagnostic evaluation of human carcinoma. Anticancer Res. 1984 Jul-Oct;4(4-5):299-303. Pubmed: 6091528 Link_out
  12. Ebadi M, Sharma SK, Ghafourifar P, Brown-Borg H, El Refaey H: Peroxynitrite in the pathogenesis of Parkinson's disease and the neuroprotective role of metallothioneins. Methods Enzymol. 2005;396:276-98. Pubmed: 16291239 Link_out
  13. Tallaksen CM, Sande A, Bohmer T, Bell H, Karlsen J: Kinetics of thiamin and thiamin phosphate esters in human blood, plasma and urine after 50 mg intravenously or orally. Eur J Clin Pharmacol. 1993;44(1):73-8. Pubmed: 8436160 Link_out
  14. Zhong D, Meins J, Scheidel B, Blume H: [Development of an HPLC method for determination of chloroquine in plasma] Pharmazie. 1993 May;48(5):349-52. Pubmed: 8327563 Link_out
  15. Recio JA, Paez JG, Maskeri B, Loveland M, Velasco JA, Notario V: Both normal and transforming PCPH proteins have guanosine diphosphatase activity but only the oncoprotein cooperates with Ras in activating extracellular signal-regulated kinase ERK1. Cancer Res. 2000 Mar 15;60(6):1720-8. Pubmed: 10749145 Link_out
  16. Puri RN, Colman RF, Colman RW: Modulation of platelet responses by 2-[3-(bromo-2-oxopropylthio)]adenosine-5'-diphosphate involves its binding to as well as covalent modification of an ADP-receptor, aggregin. Arch Biochem Biophys. 1997 Jul 1;343(1):140-5. Pubmed: 9210656 Link_out
  17. Hamagishi Y, Oki T, Tone H, Inui T: A radioimmunoassay for guanosine-5'-diphosphate-3'-diphosphate and adenosine-5'-triphosphate-3'-diphosphate. J Biochem (Tokyo). 1980 Dec;88(6):1785-92. Pubmed: 6780546 Link_out
  18. Lee AY, Youm YH, Kim NH, Yang H, Choi WI: Keratinocytes in the depigmented epidermis of vitiligo are more vulnerable to trauma (suction) than keratinocytes in the normally pigmented epidermis, resulting in their apoptosis. Br J Dermatol. 2004 Nov;151(5):995-1003. Pubmed: 15541077 Link_out
  19. Ito H, Yamamoto H, Kimura Y, Kambe H, Okochi T, Kishimoto S: Affinity chromatography of human plasma gelsolin with polyphosphate compounds on immobilized Cibacron Blue F3GA. J Chromatogr. 1990 Apr 6;526(2):397-406. Pubmed: 2163407 Link_out
  20. Sreekumar A, Poisson LM, Rajendiran TM, Khan AP, Cao Q, Yu J, Laxman B, Mehra R, Lonigro RJ, Li Y, Nyati MK, Ahsan A, Kalyana-Sundaram S, Han B, Cao X, Byun J, Omenn GS, Ghosh D, Pennathur S, Alexander DC, Berger A, Shuster JR, Wei JT, Varambally S, Beecher C, Chinnaiyan AM: Metabolomic profiles delineate potential role for sarcosine in prostate cancer progression. Nature. 2009 Feb 12;457(7231):910-4. Pubmed: 19212411 Link_out

Enzymes

Show all enzymes and transporters Important Only showing the first 50 enzymes. There are 351 enzymes in total.

Name: Acetyl-coenzyme A synthetase, cytoplasmic
Reactions:
Adenosine triphosphate + Acetic acid + Coenzyme A unknown Adenosine monophosphate + Pyrophosphate + Acetyl-CoA details
Adenosine triphosphate + Acetic acid unknown Pyrophosphate + Acetyl adenylate details
Adenosine triphosphate + Propionic acid unknown Pyrophosphate + Propinol adenylate details
Gene Name: ACSS2
Uniprot ID: Q9NR19 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Acetyl-coenzyme A synthetase 2-like, mitochondrial
Reactions:
Adenosine triphosphate + Acetic acid + Coenzyme A unknown Adenosine monophosphate + Pyrophosphate + Acetyl-CoA details
Adenosine triphosphate + Acetic acid unknown Pyrophosphate + Acetyl adenylate details
Adenosine triphosphate + Propionic acid unknown Pyrophosphate + Propinol adenylate details
Gene Name: ACSS1
Uniprot ID: Q9NUB1 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Serum paraoxonase/lactonase 3
Reactions: Not Available
Gene Name: PON3
Uniprot ID: Q15166 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Fucose-1-phosphate guanylyltransferase
Reactions:
Guanosine triphosphate + Fucose 1-phosphate unknown Pyrophosphate + GDP-L-fucose details
Gene Name: FPGT
Uniprot ID: O14772 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Squalene synthase
Reactions:
Farnesyl pyrophosphate + NAD(P)H unknown Squalene + Pyrophosphate + NAD(P)(+) details
Farnesyl pyrophosphate unknown Pyrophosphate + Presqualene diphosphate details
Presqualene diphosphate + NADPH + Hydrogen Ion unknown Pyrophosphate + Squalene + NADP details
Farnesyl pyrophosphate + NADPH + Hydrogen Ion unknown Squalene + Pyrophosphate + NADP details
Gene Name: FDFT1
Uniprot ID: P37268 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Phenylalanine--tRNA ligase alpha subunit
Reactions:
Adenosine triphosphate + L-Phenylalanine + tRNA(Phe) unknown Adenosine monophosphate + Pyrophosphate + L-phenylalanyl-tRNA(Phe) details
Adenosine triphosphate + L-Phenylalanine + tRNA(Phe) unknown Adenosine monophosphate + Pyrophosphate + L-Phenylalanyl-tRNA(Phe) details
Gene Name: FARSA
Uniprot ID: Q9Y285 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Phenylalanine--tRNA ligase, mitochondrial
Reactions:
Adenosine triphosphate + L-Phenylalanine + tRNA(Phe) unknown Adenosine monophosphate + Pyrophosphate + L-phenylalanyl-tRNA(Phe) details
Adenosine triphosphate + L-Phenylalanine + tRNA(Phe) unknown Adenosine monophosphate + Pyrophosphate + L-Phenylalanyl-tRNA(Phe) details
Gene Name: FARS2
Uniprot ID: O95363 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Alpha-aminoadipic semialdehyde dehydrogenase
Reactions:
Aminoadipic acid + Adenosine triphosphate unknown L-2-Aminoadipate adenylate + Pyrophosphate details
Gene Name: ALDH7A1
Uniprot ID: P49419 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Amidophosphoribosyltransferase
Reactions:
5-Phosphoribosylamine + Pyrophosphate + L-Glutamic acid unknown L-Glutamine + Phosphoribosyl pyrophosphate + Water details
Gene Name: PPAT
Uniprot ID: Q06203 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Nicotinamide mononucleotide adenylyltransferase 1
Reactions:
Adenosine triphosphate + beta-nicotinamide D-ribonucleotide unknown Pyrophosphate + NAD details
Adenosine triphosphate + beta-nicotinate-D-ribonucleotide unknown Pyrophosphate + Nicotinic acid adenine dinucleotide details
Adenosine triphosphate + nicotinate beta-D-ribonucleotide unknown Pyrophosphate + Nicotinic acid adenine dinucleotide details
Gene Name: NMNAT1
Uniprot ID: Q9HAN9 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Nicotinamide mononucleotide adenylyltransferase 3
Reactions:
Adenosine triphosphate + beta-nicotinamide D-ribonucleotide unknown Pyrophosphate + NAD details
Adenosine triphosphate + beta-nicotinate-D-ribonucleotide unknown Pyrophosphate + Nicotinic acid adenine dinucleotide details
Adenosine triphosphate + nicotinate beta-D-ribonucleotide unknown Pyrophosphate + Nicotinic acid adenine dinucleotide details
Gene Name: NMNAT3
Uniprot ID: Q96T66 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Nicotinate-nucleotide pyrophosphorylase [carboxylating]
Reactions:
nicotinate beta-D-ribonucleotide + Pyrophosphate + CO(2) unknown Quinolinic acid + Phosphoribosyl pyrophosphate details
nicotinate beta-D-ribonucleotide + Pyrophosphate + Carbon dioxide unknown Quinolinic acid + Phosphoribosyl pyrophosphate details
Gene Name: QPRT
Uniprot ID: Q15274 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Nicotinamide mononucleotide adenylyltransferase 2
Reactions:
Adenosine triphosphate + beta-nicotinamide D-ribonucleotide unknown Pyrophosphate + NAD details
Adenosine triphosphate + beta-nicotinate-D-ribonucleotide unknown Pyrophosphate + Nicotinic acid adenine dinucleotide details
Adenosine triphosphate + nicotinate beta-D-ribonucleotide unknown Pyrophosphate + Nicotinic acid adenine dinucleotide details
Gene Name: NMNAT2
Uniprot ID: Q9BZQ4 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1
Reactions:
Adenosine triphosphate + Oat gum unknown Pyrophosphate + Adenosine phosphosulfate details
Adenosine triphosphate + Selenocystathionine unknown Pyrophosphate + Adenylylselenate details
Gene Name: PAPSS1
Uniprot ID: O43252 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2
Reactions:
Adenosine triphosphate + Oat gum unknown Pyrophosphate + Adenosine phosphosulfate details
Adenosine triphosphate + Selenocystathionine unknown Pyrophosphate + Adenylylselenate details
Gene Name: PAPSS2
Uniprot ID: O95340 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: N-acylneuraminate cytidylyltransferase
Reactions:
Cytidine triphosphate + N-acylneuraminate unknown Pyrophosphate + Cytidine monophosphate N-acetylneuraminic acid details
Cytidine triphosphate + N-Acetylneuraminic acid unknown Pyrophosphate + Cytidine monophosphate N-acetylneuraminic acid details
Cytidine triphosphate + N-Glycolylneuraminic acid unknown Pyrophosphate + CMP-N-glycoloylneuraminate details
Gene Name: CMAS
Uniprot ID: Q8NFW8 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: S-adenosylmethionine synthase isoform type-2
Reactions:
Adenosine triphosphate + L-Methionine + Water unknown Phosphoric acid + Pyrophosphate + S-Adenosylmethionine details
Phosphoric acid + Pyrophosphate + S-Adenosylmethionine unknown Adenosine triphosphate + L-Methionine + Water details
Adenosine triphosphate + Selenomethionine + Water unknown Phosphoric acid + Pyrophosphate + Se-Adenosylselenomethionine details
Gene Name: MAT2A
Uniprot ID: P31153 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: S-adenosylmethionine synthase isoform type-1
Reactions:
Adenosine triphosphate + L-Methionine + Water unknown Phosphoric acid + Pyrophosphate + S-Adenosylmethionine details
Phosphoric acid + Pyrophosphate + S-Adenosylmethionine unknown Adenosine triphosphate + L-Methionine + Water details
Adenosine triphosphate + Selenomethionine + Water unknown Phosphoric acid + Pyrophosphate + Se-Adenosylselenomethionine details
Gene Name: MAT1A
Uniprot ID: Q00266 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Inosine triphosphate pyrophosphatase
Reactions:
A nucleoside triphosphate + Water unknown a nucleotide + Pyrophosphate details
Guanosine triphosphate + Water unknown Guanosine monophosphate + Pyrophosphate details
Uridine triphosphate + Water unknown Uridine 5'-monophosphate + Pyrophosphate details
Inosine triphosphate + Water unknown Inosinic acid + Pyrophosphate details
dGTP + Water unknown 2'-Deoxyguanosine 5'-monophosphate + Pyrophosphate details
Deoxyuridine triphosphate + Water unknown dUMP + Pyrophosphate details
Xanthosine 5-triphosphate + Water unknown Xanthylic acid + Pyrophosphate details
2'-Deoxyinosine triphosphate + Water unknown dIMP + Pyrophosphate details
6-Mercaptopurine ribonucleoside triphosphate + Water unknown 6-Thioinosine-5'-monophosphate + Pyrophosphate details
Gene Name: ITPA
Uniprot ID: Q9BY32 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial
Reactions:
Deoxyuridine triphosphate + Water unknown dUMP + Pyrophosphate details
Gene Name: DUT
Uniprot ID: P33316 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Adenine phosphoribosyltransferase
Reactions:
Adenosine monophosphate + Pyrophosphate unknown Adenine + Phosphoribosyl pyrophosphate details
Guanosine monophosphate + Pyrophosphate unknown Guanine + Phosphoribosyl pyrophosphate details
AICAR + Pyrophosphate unknown 5-Aminoimidazole-4-carboxamide + Phosphoribosyl pyrophosphate details
Gene Name: APRT
Uniprot ID: P07741 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Hypoxanthine-guanine phosphoribosyltransferase
Reactions:
Inosinic acid + Pyrophosphate unknown Hypoxanthine + Phosphoribosyl pyrophosphate details
Guanosine monophosphate + Pyrophosphate unknown Guanine + Phosphoribosyl pyrophosphate details
Adenosine monophosphate + Pyrophosphate unknown Adenine + Phosphoribosyl pyrophosphate details
Xanthylic acid + Pyrophosphate unknown Xanthine + Phosphoribosyl pyrophosphate details
Mercaptopurine + Phosphoribosyl pyrophosphate unknown 6-Thioinosine-5'-monophosphate + Pyrophosphate details
6-Methylmercaptopurine + Phosphoribosyl pyrophosphate unknown 6-Methylthiopurine 5'-monophosphate ribonucleotide + Pyrophosphate details
Thioguanine + Phosphoribosyl pyrophosphate unknown 6-Thioguanosine monophosphate + Pyrophosphate details
Gene Name: HPRT1
Uniprot ID: P00492 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Biotin--protein ligase
Reactions:
Adenosine triphosphate + Biotin + apo-[methylmalonyl-CoA:pyruvate carboxytransferase] unknown Adenosine monophosphate + Pyrophosphate + [methylmalonyl-CoA:pyruvate carboxytransferase] details
Adenosine triphosphate + Biotin + apo-[propionyl-CoA:carbon-dioxide ligase (ADP-forming)] unknown Adenosine monophosphate + Pyrophosphate + [propionyl-CoA:carbon-dioxide ligase (ADP-forming)] details
Adenosine triphosphate + Biotin + apo-[3-methylcrotonoyl-CoA:carbon-dioxide ligase (ADP-forming)] unknown Adenosine monophosphate + Pyrophosphate + [3-methylcrotonoyl-CoA:carbon-dioxide ligase (ADP-forming)] details
Adenosine triphosphate + Biotin + apo-[acetyl-CoA:carbon-dioxide ligase (ADP-forming)] unknown Adenosine monophosphate + Pyrophosphate + [acetyl-CoA:carbon-dioxide ligase (ADP-forming)] details
Adenosine triphosphate + Biotin unknown Pyrophosphate + Biotinyl-5'-AMP details
Gene Name: HLCS
Uniprot ID: P50747 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Phenylalanine--tRNA ligase beta subunit
Reactions:
Adenosine triphosphate + L-Phenylalanine + tRNA(Phe) unknown Adenosine monophosphate + Pyrophosphate + L-phenylalanyl-tRNA(Phe) details
Adenosine triphosphate + L-Phenylalanine + tRNA(Phe) unknown Adenosine monophosphate + Pyrophosphate + L-Phenylalanyl-tRNA(Phe) details
Gene Name: FARSB
Uniprot ID: Q9NSD9 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Ubiquitin-conjugating enzyme E2 A
Reactions:
Adenosine triphosphate + ubiquitin + protein lysine unknown Adenosine monophosphate + Pyrophosphate + protein N-ubiquityllysine details
Gene Name: UBE2A
Uniprot ID: P49459 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: NEDD8-conjugating enzyme Ubc12
Reactions:
Adenosine triphosphate + NEDD8 + protein lysine unknown Adenosine monophosphate + Pyrophosphate + protein N-NEDD8yllysine details
Gene Name: UBE2M
Uniprot ID: P61081 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Ubiquitin/ISG15-conjugating enzyme E2 L6
Reactions:
Adenosine triphosphate + ubiquitin + protein lysine unknown Adenosine monophosphate + Pyrophosphate + protein N-ubiquityllysine details
Gene Name: UBE2L6
Uniprot ID: O14933 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Glycine--tRNA ligase
Reactions:
Adenosine triphosphate + Glycine + tRNA(Gly) unknown Adenosine monophosphate + Pyrophosphate + glycyl-tRNA(Gly) details
Adenosine triphosphate + Glycine + tRNA(Gly) unknown Adenosine monophosphate + Pyrophosphate + Glycyl-tRNA(Gly) details
Gene Name: GARS
Uniprot ID: P41250 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Bifunctional glutamate/proline--tRNA ligase
Reactions:
Adenosine triphosphate + L-Glutamic acid + tRNA(Glu) unknown Adenosine monophosphate + Pyrophosphate + L-glutamyl-tRNA(Glu) details
Adenosine triphosphate + L-Proline + tRNA(Pro) unknown Adenosine monophosphate + Pyrophosphate + L-prolyl-tRNA(Pro) details
Adenosine triphosphate + L-Proline + tRNA(Pro) unknown Adenosine monophosphate + Pyrophosphate + L-Prolyl-tRNA(Pro) details
tRNA(Glu) + L-Glutamic acid + Adenosine triphosphate unknown L-Glutamyl-tRNA(Glu) + Pyrophosphate + Adenosine monophosphate details
Gene Name: EPRS
Uniprot ID: P07814 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Long-chain-fatty-acid--CoA ligase 4
Reactions:
Adenosine triphosphate + a long-chain fatty acid + Coenzyme A unknown Adenosine monophosphate + Pyrophosphate + an acyl-CoA details
Adenosine triphosphate + Palmitic acid + Coenzyme A unknown Adenosine monophosphate + hexadecanoyl-CoA + Pyrophosphate details
Gene Name: ACSL4
Uniprot ID: O60488 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Ubiquitin-conjugating enzyme E2 D1
Reactions:
Adenosine triphosphate + ubiquitin + protein lysine unknown Adenosine monophosphate + Pyrophosphate + protein N-ubiquityllysine details
Gene Name: UBE2D1
Uniprot ID: P51668 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Tryptophan--tRNA ligase, cytoplasmic
Reactions:
Adenosine triphosphate + L-Tryptophan + tRNA(Trp) unknown Adenosine monophosphate + Pyrophosphate + L-tryptophyl-tRNA(Trp) details
Adenosine triphosphate + L-Tryptophan + tRNA(Trp) unknown Adenosine monophosphate + Pyrophosphate + L-Tryptophanyl-tRNA(Trp) details
Gene Name: WARS
Uniprot ID: P23381 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Long-chain-fatty-acid--CoA ligase 1
Reactions:
Adenosine triphosphate + a long-chain fatty acid + Coenzyme A unknown Adenosine monophosphate + Pyrophosphate + an acyl-CoA details
Adenosine triphosphate + Palmitic acid + Coenzyme A unknown Adenosine monophosphate + hexadecanoyl-CoA + Pyrophosphate details
Gene Name: ACSL1
Uniprot ID: P33121 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Ubiquitin-conjugating enzyme E2 G1
Reactions:
Adenosine triphosphate + ubiquitin + protein lysine unknown Adenosine monophosphate + Pyrophosphate + protein N-ubiquityllysine details
Gene Name: UBE2G1
Uniprot ID: P62253 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Glutamine--tRNA ligase
Reactions:
Adenosine triphosphate + L-Glutamine + tRNA(Gln) unknown Adenosine monophosphate + Pyrophosphate + L-glutaminyl-tRNA(Gln) details
Adenosine triphosphate + L-Glutamine + tRNA(Gln) unknown Adenosine monophosphate + Pyrophosphate + Glutaminyl-tRNA details
Gene Name: QARS
Uniprot ID: P47897 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Threonine--tRNA ligase, cytoplasmic
Reactions:
Adenosine triphosphate + L-Threonine + tRNA(Thr) unknown Adenosine monophosphate + Pyrophosphate + L-threonyl-tRNA(Thr) details
Adenosine triphosphate + L-Threonine + tRNA(Thr) unknown Adenosine monophosphate + Pyrophosphate + L-Threonyl-tRNA(Thr) details
Gene Name: TARS
Uniprot ID: P26639 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Asparagine synthetase [glutamine-hydrolyzing]
Reactions:
Adenosine triphosphate + L-Aspartic acid + L-Glutamine + Water unknown Adenosine monophosphate + Pyrophosphate + L-Asparagine + L-Glutamic acid details
Gene Name: ASNS
Uniprot ID: P08243 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Ubiquitin-conjugating enzyme E2 E2
Reactions:
Adenosine triphosphate + ubiquitin + protein lysine unknown Adenosine monophosphate + Pyrophosphate + protein N-ubiquityllysine details
Gene Name: UBE2E2
Uniprot ID: Q96LR5 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Ubiquitin-conjugating enzyme E2 D2
Reactions:
Adenosine triphosphate + ubiquitin + protein lysine unknown Adenosine monophosphate + Pyrophosphate + protein N-ubiquityllysine details
Gene Name: UBE2D2
Uniprot ID: P62837 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: DNA ligase 4
Reactions:
Adenosine triphosphate + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) unknown Adenosine monophosphate + Pyrophosphate + (deoxyribonucleotide)(n+m) details
Gene Name: LIG4
Uniprot ID: P49917 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Arginine--tRNA ligase, cytoplasmic
Reactions:
Adenosine triphosphate + L-Arginine + tRNA(Arg) unknown Adenosine monophosphate + Pyrophosphate + L-arginyl-tRNA(Arg) details
Adenosine triphosphate + L-Arginine + tRNA(Arg) unknown Adenosine monophosphate + Pyrophosphate + L-Arginyl-tRNA(Arg) details
Gene Name: RARS
Uniprot ID: P54136 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: GMP synthase [glutamine-hydrolyzing]
Reactions:
Adenosine triphosphate + Xanthylic acid + L-Glutamine + Water unknown Adenosine monophosphate + Pyrophosphate + Guanosine monophosphate + L-Glutamic acid details
Adenosine triphosphate + Xanthylic acid + Ammonia unknown Adenosine monophosphate + Pyrophosphate + Guanosine monophosphate details
6-Thioxanthine 5'-monophosphate + Adenosine triphosphate + L-Glutamine + Water unknown 6-Thioguanosine monophosphate + Adenosine monophosphate + Pyrophosphate + L-Glutamic acid details
Gene Name: GMPS
Uniprot ID: P49915 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Ubiquitin-conjugating enzyme E2 E3
Reactions:
Adenosine triphosphate + ubiquitin + protein lysine unknown Adenosine monophosphate + Pyrophosphate + protein N-ubiquityllysine details
Gene Name: UBE2E3
Uniprot ID: Q969T4 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Ubiquitin-conjugating enzyme E2 B
Reactions:
Adenosine triphosphate + ubiquitin + protein lysine unknown Adenosine monophosphate + Pyrophosphate + protein N-ubiquityllysine details
Gene Name: UBE2B
Uniprot ID: P63146 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Probable leucine--tRNA ligase, mitochondrial
Reactions:
Adenosine triphosphate + L-Leucine + tRNA(Leu) unknown Adenosine monophosphate + Pyrophosphate + L-leucyl-tRNA(Leu) details
Adenosine triphosphate + L-Leucine + tRNA(Leu) unknown Adenosine monophosphate + Pyrophosphate + L-Leucyl-tRNA details
Gene Name: LARS2
Uniprot ID: Q15031 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Ubiquitin-conjugating enzyme E2 J2
Reactions:
Adenosine triphosphate + ubiquitin + protein lysine unknown Adenosine monophosphate + Pyrophosphate + protein N-ubiquityllysine details
Gene Name: UBE2J2
Uniprot ID: Q8N2K1 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Ubiquitin-conjugating enzyme E2 L3
Reactions:
Adenosine triphosphate + ubiquitin + protein lysine unknown Adenosine monophosphate + Pyrophosphate + protein N-ubiquityllysine details
Gene Name: UBE2L3
Uniprot ID: P68036 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: RNA 3'-terminal phosphate cyclase
Reactions:
Adenosine triphosphate + RNA 3'-terminal-phosphate unknown Adenosine monophosphate + Pyrophosphate + RNA terminal-2',3'-cyclic-phosphate details
Gene Name: RTCA
Uniprot ID: O00442 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Tyrosine--tRNA ligase, cytoplasmic
Reactions:
Adenosine triphosphate + L-Tyrosine + tRNA(Tyr) unknown Adenosine monophosphate + Pyrophosphate + L-tyrosyl-tRNA(Tyr) details
Adenosine triphosphate + L-Tyrosine + tRNA(Tyr) unknown Adenosine monophosphate + Pyrophosphate + L-Tyrosyl-tRNA(Tyr) details
Gene Name: YARS
Uniprot ID: P54577 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: DNA ligase 3
Reactions:
Adenosine triphosphate + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) unknown Adenosine monophosphate + Pyrophosphate + (deoxyribonucleotide)(n+m) details
Gene Name: LIG3
Uniprot ID: P49916 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA