Human Metabolome Database Version 3.5

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Showing metabocard for FAD (HMDB01248)

enzymes (164)

Blood
Urine

Record Information

Version

3.5

Creation Date

2005-11-16 08:48:42 -0700

Update Date

2013-02-08 17:10:10 -0700

HMDB ID

HMDB01248

Secondary Accession Numbers

None

Metabolite Identification

Common Name

FAD

Description

FAD is a condensation product of riboflavin and adenosine diphosphate. The coenzyme of various aerobic dehydrogenases, e.g., D-amino acid oxidase and L-amino acid oxidase. (Lehninger, Principles of Biochemistry, 1982, p972).

Structure

Download: MOL | SDF | SMILES | InChI
Display: 2D Structure | 3D Structure

Synonyms

1H-Purin-6-amine flavin dinucleotide
1H-Purin-6-amine flavine dinucleotide
Adenine-flavin dinucleotide
Adenine-flavine dinucleotide
Adenine-riboflavin dinuceotide
Adenine-riboflavin dinucleotide
Adenine-riboflavine dinucleotide
FAD
Flamitajin B
Flanin F
Flavin adenine dinucleotide
Flavin adenine dinucleotide oxidized
Flavin-adenine dinucleotide
Flavine adenosine diphosphate
Flavine-adenine dinucleotide
Flavitan
Flaziren
Isoalloxazine-adenine dinucleotide
Riboflavin 5'-adenosine diphosphate
Riboflavin-adenine dinucleotide
Riboflavine-adenine dinucleotide

Chemical Formula

C₂₇H₃₃N₉O₁₅P₂

Average Molecular Weight

785.5497

Monoisotopic Molecular Weight

785.157134455

IUPAC Name

{[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}[({[(2R,3S,4S)-5-{7,8-dimethyl-2,4-dioxo-2H,3H,4H,10H-benzo[g]pteridin-10-yl}-2,3,4-trihydroxypentyl]oxy}(hydroxy)phosphoryl)oxy]phosphinic acid

Traditional IUPAC Name

[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy({[(2R,3S,4S)-5-{7,8-dimethyl-2,4-dioxo-3H-benzo[g]pteridin-10-yl}-2,3,4-trihydroxypentyl]oxy(hydroxy)phosphoryl}oxy)phosphinic acid

CAS Registry Number

146-14-5

SMILES

CC1=CC2=C(C=C1C)N(C[C@H](O)[C@H](O)[C@H](O)COP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)N1C=NC3=C1N=CN=C3N)C1=NC(=O)NC(=O)C1=N2

InChI Identifier

InChI=1S/C27H33N9O15P2/c1-10-3-12-13(4-11(10)2)35(24-18(32-12)25(42)34-27(43)33-24)5-14(37)19(39)15(38)6-48-52(44,45)51-53(46,47)49-7-16-20(40)21(41)26(50-16)36-9-31-17-22(28)29-8-30-23(17)36/h3-4,8-9,14-16,19-21,26,37-41H,5-7H2,1-2H3,(H,44,45)(H,46,47)(H2,28,29,30)(H,34,42,43)/t14-,15+,16+,19-,20+,21+,26+/m0/s1

InChI Key

VWWQXMAJTJZDQX-UYBVJOGSSA-N

Chemical Taxonomy

Kingdom

Organic Compounds

Super Class

Nucleosides, Nucleotides, and Analogues

Class

Flavin Nucleotides

Sub Class

N/A

Other Descriptors

Aromatic Heteropolycyclic Compounds
flavin adenine dinucleotide(ChEBI)

Substituents

1,2 Diol
1 Phosphoribosyl Imidazole
Aminopyrimidine
Disaccharide Phosphate
Flavin
Glycosyl Compound
Imidazole
Imidazopyrimidine
Isoalloxazine
N Glycosyl Compound
Organic Hypophosphite
Organic Phosphite
Organic Pyrophosphate
Oxolane
Pentose Disaccharide
Phosphoric Acid Ester
Pteridine
Purine
Purine Ribonucleoside Diphosphate
Pyrazine
Pyrimidine
Pyrimidone
Quinoxaline
Saccharide
Secondary Alcohol
Toluene

Direct Parent

Flavin Nucleotides

Ontology

Status

Detected and Quantified

Origin

Endogenous

Biofunction

Enzyme cofactor

Application

Not Available

Cellular locations

Cytoplasm
Mitochondria
Endoplasmic reticulum
Peroxisome

Physical Properties

State

Solid

Experimental Properties

Property	Value	Reference
Melting Point	Not Available	Not Available
Boiling Point	Not Available	Not Available
Water Solubility	5 mg/mL	Not Available
LogP	Not Available	Not Available

Predicted Properties

Property	Value	Source
Water Solubility	4.25 g/L	ALOGPS
LogP	-0.78	ALOGPS
LogP	-5.3	ChemAxon
LogS	-2.27	ALOGPS
pKa (strongest acidic)	1.86	ChemAxon
pKa (strongest basic)	4.99	ChemAxon
Hydrogen Acceptor Count	19	ChemAxon
Hydrogen Donor Count	9	ChemAxon
Polar Surface Area	356.42 A²	ChemAxon
Rotatable Bond Count	13	ChemAxon
Refractivity	177.43	ChemAxon
Polarizability	70.11	ChemAxon
Formal Charge	0	ChemAxon
Physiological Charge	-3	ChemAxon

Spectra

1H NMR Spectrum

MS/MS Spectrum Quattro_QQQ 10

MS/MS Spectrum Quattro_QQQ 25

MS/MS Spectrum Quattro_QQQ 40

MS/MS Spectrum LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic)

[1H,1H] 2D NMR Spectrum

[1H,13C] 2D NMR Spectrum

Biological Properties

Cellular Locations

Cytoplasm
Mitochondria
Endoplasmic reticulum
Peroxisome

Biofluid Locations

Blood

Tissue Location

Muscle
Erythrocyte
Liver

Pathways

Name	SMPDB Link	KEGG Link
Citric Acid Cycle	SMP00057	map00020
Glycerol Phosphate Shuttle	SMP00124	Not Available
Riboflavin Metabolism	SMP00070	map00740

Normal Concentrations

Biofluid	Status	Value	Age	Sex	Condition	Comments
Blood	Detected and Quantified	0.061 (0.044-0.078) uM	Adult (>18 years old)	Female	Normal	Not Available
Blood	Detected and Quantified	0.078 +/- 0.054 uM	Adolescent (13-18 years old)	Female	Normal	Not Available
Blood	Detected and Quantified	0.075 (0.056-0.097) uM	Adult (>18 years old)	Both	Normal	Not Available

Abnormal Concentrations

Biofluid	Status		Value	Age	Sex	Condition	Comments
Blood	Detected and Quantified		0.031 +/- 0.01 uM	Children (1-13 year old)	Both	Severely malnourished children	Not Available
Blood	Detected and Quantified		0.048 +/- 0.023 uM	Adolescent (13-18 years old)	Female	Anorexia nervosa	Not Available

Associated Disorders and Diseases

Disease References

Anorexia nervosa

Capo-chichi CD, Gueant JL, Lefebvre E, Bennani N, Lorentz E, Vidailhet C, Vidailhet M: Riboflavin and riboflavin-derived cofactors in adolescent girls with anorexia nervosa. Am J Clin Nutr. 1999 Apr;69(4):672-8. Pubmed: 10197568

Associated OMIM IDs

606788 (Anorexia nervosa)

External Links

DrugBank ID

Not Available

Phenol Explorer Compound ID

Not Available

Phenol Explorer Metabolite ID

Not Available

FoodDB ID

FDB022511

KNApSAcK ID

Not Available

Chemspider ID

KEGG Compound ID

BioCyc ID

BiGG ID

Wikipedia Link

NuGOwiki Link

Metagene Link

METLIN ID

PubChem Compound

PDB ID

ChEBI ID

References

Synthesis Reference

Not Available

Material Safety Data Sheet (MSDS)

Download (PDF)

General References

Flatz G, Simmersbach F: Flavin adenine dinucleotide concentration in erythrocytes with normal and deficient glucose-6-phosphate dehydrogenase. Klin Wochenschr. 1970 Sep 1;48(17):1071-2. Pubmed: 5523465
Zempleni J: Determination of riboflavin and flavocoenzymes in human blood plasma by high-performance liquid chromatography. Ann Nutr Metab. 1995;39(4):224-6. Pubmed: 8546438
Becker K, Wilkinson AR: Flavin adenine dinucleotide levels in erythrocytes of very low birthweight infants under vitamin supplementation. Biol Neonate. 1993;63(2):80-5. Pubmed: 8448258
Lisowsky T, Lee JE, Polimeno L, Francavilla A, Hofhaus G: Mammalian augmenter of liver regeneration protein is a sulfhydryl oxidase. Dig Liver Dis. 2001 Mar;33(2):173-80. Pubmed: 11346147
Cimino JA, Jhangiani S, Schwartz E, Cooperman JM: Riboflavin metabolism in the hypothyroid human adult. Proc Soc Exp Biol Med. 1987 Feb;184(2):151-3. Pubmed: 3809170
Kodentsova VM, Vrzhesinskaia OA, Alekseeva IA, Spirichev VB: [Comparison of biochemical criteria for supplying the human body with riboflavin] Vopr Med Khim. 1991 Sep-Oct;37(5):76-9. Pubmed: 1759408
Lopez-Anaya A, Mayersohn M: Quantification of riboflavin, riboflavin 5'-phosphate and flavin adenine dinucleotide in plasma and urine by high-performance liquid chromatography. J Chromatogr. 1987 Dec 25;423:105-13. Pubmed: 3443641
Van Binsbergen CJ, Odink J, Van den Berg H, Koppeschaar H, Coelingh Bennink HJ: Nutritional status in anorexia nervosa: clinical chemistry, vitamins, iron and zinc. Eur J Clin Nutr. 1988 Nov;42(11):929-37. Pubmed: 3074921
Mohrenweiser HW, Novotny JE: ACP1GUA-1--a low-activity variant of human erythrocyte acid phosphatase: association with increased glutathione reductase activity. Am J Hum Genet. 1982 May;34(3):425-33. Pubmed: 7081221
Gianazza E, Vergani L, Wait R, Brizio C, Brambilla D, Begum S, Giancaspero TA, Conserva F, Eberini I, Bufano D, Angelini C, Pegoraro E, Tramontano A, Barile M: Coordinated and reversible reduction of enzymes involved in terminal oxidative metabolism in skeletal muscle mitochondria from a riboflavin-responsive, multiple acyl-CoA dehydrogenase deficiency patient. Electrophoresis. 2006 Mar;27(5-6):1182-98. Pubmed: 16470778
Cimino JA, Noto RA, Fusco CL, Cooperman JM: Riboflavin metabolism in the hypothyroid newborn. Am J Clin Nutr. 1988 Mar;47(3):481-3. Pubmed: 3348160

Enzymes

Name:	Dihydrolipoyl dehydrogenase, mitochondrial
Reactions:	protein N6-(dihydrolipoyl)lysine + NAD+ = protein N6-(lipoyl)lysine + NADH + H+ [RN:R08550]
Gene Name:	DLD
Uniprot ID:	P09622
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Long-chain specific acyl-CoA dehydrogenase, mitochondrial
Reactions:	acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor [RN:R00392]
Gene Name:	ACADL
Uniprot ID:	P28330
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Short-chain specific acyl-CoA dehydrogenase, mitochondrial
Reactions:	butanoyl-CoA + acceptor = 2-butenoyl-CoA + reduced acceptor [RN:R01178]
Gene Name:	ACADS
Uniprot ID:	P16219
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Medium-chain specific acyl-CoA dehydrogenase, mitochondrial
Reactions:	acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor [RN:R00392]
Gene Name:	ACADM
Uniprot ID:	P11310
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	NADH-ubiquinone oxidoreductase chain 1
Reactions:	NADH + H+ + ubiquinone = NAD+ + ubiquinol [RN:R02163]
Gene Name:	MT-ND1
Uniprot ID:	P03886
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1
Reactions:	--- []
Gene Name:	NDUFB1
Uniprot ID:	O75438
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Ectonucleotide pyrophosphatase/phosphodiesterase family member 1
Reactions:	a dinucleotide + H2O = 2 mononucleotides [RN:R00056]
Gene Name:	ENPP1
Uniprot ID:	P22413
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial
Reactions:	NADH + H+ + acceptor = NAD+ + reduced acceptor [RN:R00281]
Gene Name:	NDUFS2
Uniprot ID:	O75306
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Succinate dehydrogenase cytochrome b560 subunit, mitochondrial
Reactions:	--- []
Gene Name:	SDHC
Uniprot ID:	Q99643
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Peroxisomal sarcosine oxidase
Reactions:	L-pipecolate + O2 = 2,3,4,5-tetrahydropyridine-2-carboxylate + H2O2 [RN:R02204]
Gene Name:	PIPOX
Uniprot ID:	Q9P0Z9
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Peroxisomal N(1)-acetyl-spermine/spermidine oxidase
Reactions:	(1) N1-acetylspermidine + O2 + H2O = putrescine + 3-acetamidopropanal + H2O2 [RN:R09074] (2) N1-acetylspermine + O2 + H2O = spermidine + 3-acetamidopropanal + H2O2 [RN:R03899]
Gene Name:	PAOX
Uniprot ID:	Q6QHF9
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12
Reactions:	--- []
Gene Name:	NDUFA12
Uniprot ID:	Q9UI09
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	NADH-cytochrome b5 reductase 3
Reactions:	NADH + 2 ferricytochrome b5 = NAD+ + H+ + 2 ferrocytochrome b5 [RN:R00100]
Gene Name:	CYB5R3
Uniprot ID:	P00387
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Aldehyde oxidase
Reactions:	an aldehyde + H2O + O2 = a carboxylic acid + H2O2 [RN:R00635]
Gene Name:	AOX1
Uniprot ID:	Q06278
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1
Reactions:	--- []
Gene Name:	NDUFA1
Uniprot ID:	O15239
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2
Reactions:
Gene Name:	NDUFA4L2
Uniprot ID:	Q9NRX3
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3
Reactions:	--- []
Gene Name:	NDUFA3
Uniprot ID:	O95167
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8
Reactions:	--- []
Gene Name:	NDUFA8
Uniprot ID:	P51970
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4
Reactions:	--- []
Gene Name:	NDUFA4
Uniprot ID:	O00483
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	NADH-ubiquinone oxidoreductase chain 4L
Reactions:	NADH + H+ + ubiquinone = NAD+ + ubiquinol [RN:R02163]
Gene Name:	MT-ND4L
Uniprot ID:	P03901
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11
Reactions:	--- []
Gene Name:	NDUFA11
Uniprot ID:	Q86Y39
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Thioredoxin reductase 1, cytoplasmic
Reactions:	thioredoxin + NADP+ = thioredoxin disulfide + NADPH + H+ [RN:R02016]
Gene Name:	TXNRD1
Uniprot ID:	Q16881
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Lathosterol oxidase
Reactions:	5alpha-cholest-7-en-3beta-ol + NAD(P)H + H+ + O2 = cholesta-5,7-dien-3beta-ol + NAD(P)+ + 2 H2O [RN:R03310 R07215]
Gene Name:	SC5DL
Uniprot ID:	O75845
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial
Reactions:	--- []
Gene Name:	NDUFS4
Uniprot ID:	O43181
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Ribosyldihydronicotinamide dehydrogenase [quinone]
Reactions:	1-(beta-D-ribofuranosyl)-1,4-dihydronicotinamide + a quinone = 1-(beta-D-ribofuranosyl)nicotinamide + a hydroquinone [RN:R07361]
Gene Name:	NQO2
Uniprot ID:	P16083
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial
Reactions:	NADH + H+ + acceptor = NAD+ + reduced acceptor [RN:R00281]
Gene Name:	NDUFS3
Uniprot ID:	O75489
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	NADH dehydrogenase [ubiquinone] iron-sulfur protein 5
Reactions:	--- []
Gene Name:	NDUFS5
Uniprot ID:	O43920
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial
Reactions:	NADH + H+ + acceptor = NAD+ + reduced acceptor [RN:R00281]
Gene Name:	NDUFV2
Uniprot ID:	P19404
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Dimethylaniline monooxygenase [N-oxide-forming] 5
Reactions:	N,N-dimethylaniline + NADPH + H+ + O2 = N,N-dimethylaniline N-oxide + NADP+ + H2O [RN:R03344]
Gene Name:	FMO5
Uniprot ID:	P49326
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial
Reactions:	--- []
Gene Name:	NDUFA10
Uniprot ID:	O95299
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6
Reactions:	--- []
Gene Name:	NDUFA6
Uniprot ID:	P56556
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Peroxisomal acyl-coenzyme A oxidase 1
Reactions:	acyl-CoA + O2 = trans-2,3-dehydroacyl-CoA + H2O2 [RN:R00388]
Gene Name:	ACOX1
Uniprot ID:	Q15067
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	D-aspartate oxidase
Reactions:	D-aspartate + H2O + O2 = oxaloacetate + NH3 + H2O2 [RN:R00359]
Gene Name:	DDO
Uniprot ID:	Q99489
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4
Reactions:	--- []
Gene Name:	NDUFB4
Uniprot ID:	O95168
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial
Reactions:	succinate + ubiquinone = fumarate + ubiquinol [RN:R02164]
Gene Name:	SDHA
Uniprot ID:	P31040
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Heme oxygenase 2
Reactions:	heme + 3 AH2 + 3 O2 = biliverdin + Fe2+ + CO + 3 A + 3 H2O [RN:R00311]
Gene Name:	HMOX2
Uniprot ID:	P30519
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial
Reactions:	NADH + H+ + acceptor = NAD+ + reduced acceptor [RN:R00281]
Gene Name:	NDUFS8
Uniprot ID:	O00217
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Squalene monooxygenase
Reactions:	squalene + AH2 + O2 = (S)-squalene-2,3-epoxide + A + H2O [RN:R02873]
Gene Name:	SQLE
Uniprot ID:	Q14534
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	NADH-ubiquinone oxidoreductase chain 2
Reactions:	NADH + H+ + ubiquinone = NAD+ + ubiquinol [RN:R02163]
Gene Name:	MT-ND2
Uniprot ID:	P03891
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Dimethylaniline monooxygenase [N-oxide-forming] 2
Reactions:	N,N-dimethylaniline + NADPH + H+ + O2 = N,N-dimethylaniline N-oxide + NADP+ + H2O [RN:R03344]
Gene Name:	FMO2
Uniprot ID:	Q99518
Protein Sequence:	FASTA

Name:	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7
Reactions:	--- []
Gene Name:	NDUFA7
Uniprot ID:	O95182
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Thioredoxin reductase 2, mitochondrial
Reactions:	thioredoxin + NADP+ = thioredoxin disulfide + NADPH + H+ [RN:R02016]
Gene Name:	TXNRD2
Uniprot ID:	Q9NNW7
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2
Reactions:	--- []
Gene Name:	NDUFA2
Uniprot ID:	O43678
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Methionine synthase
Reactions:	5-methyltetrahydrofolate + L-homocysteine = tetrahydrofolate + L-methionine [RN:R00946]
Gene Name:	MTR
Uniprot ID:	Q99707
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Amine oxidase [flavin-containing] B
Reactions:	RCH2NHR' + H2O + O2 = RCHO + R'NH2 + H2O2 [RN:R01853]
Gene Name:	MAOB
Uniprot ID:	P27338
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial
Reactions:	NADH + H+ + acceptor = NAD+ + reduced acceptor [RN:R00281]
Gene Name:	NDUFS1
Uniprot ID:	P28331
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial
Reactions:	--- []
Gene Name:	NDUFB5
Uniprot ID:	O43674
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Peroxisomal acyl-coenzyme A oxidase 2
Reactions:	(25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA + H2O + acceptor = (24R,25R)-3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestan-26- oyl-CoA + reduced acceptor [RN:R07374]
Gene Name:	ACOX2
Uniprot ID:	Q99424
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Dimethylaniline monooxygenase [N-oxide-forming] 4
Reactions:	N,N-dimethylaniline + NADPH + H+ + O2 = N,N-dimethylaniline N-oxide + NADP+ + H2O [RN:R03344]
Gene Name:	FMO4
Uniprot ID:	P31512
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Isovaleryl-CoA dehydrogenase, mitochondrial
Reactions:	3-methylbutanoyl-CoA + acceptor = 3-methylbut-2-enoyl-CoA + reduced acceptor [RN:R04096]
Gene Name:	IVD
Uniprot ID:	P26440
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Amine oxidase [flavin-containing] A
Reactions:	RCH2NHR' + H2O + O2 = RCHO + R'NH2 + H2O2 [RN:R01853]
Gene Name:	MAOA
Uniprot ID:	P21397
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	NADH dehydrogenase [ubiquinone] 1 subunit C2
Reactions:	--- []
Gene Name:	NDUFC2
Uniprot ID:	O95298
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Dimethylaniline monooxygenase [N-oxide-forming] 3
Reactions:	N,N-dimethylaniline + NADPH + H+ + O2 = N,N-dimethylaniline N-oxide + NADP+ + H2O [RN:R03344]
Gene Name:	FMO3
Uniprot ID:	P31513
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3
Reactions:	--- []
Gene Name:	NDUFB3
Uniprot ID:	O43676
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7
Reactions:	--- []
Gene Name:	NDUFB7
Uniprot ID:	P17568
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Acyl carrier protein, mitochondrial
Reactions:	--- []
Gene Name:	NDUFAB1
Uniprot ID:	O14561
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5
Reactions:	--- []
Gene Name:	NDUFA5
Uniprot ID:	Q16718
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial
Reactions:	reduced electron-transferring flavoprotein + ubiquinone = electron-transferring flavoprotein + ubiquinol [RN:R04433]
Gene Name:	ETFDH
Uniprot ID:	Q16134
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial
Reactions:	--- []
Gene Name:	NDUFA9
Uniprot ID:	Q16795
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	NADH-ubiquinone oxidoreductase chain 4
Reactions:	NADH + H+ + ubiquinone = NAD+ + ubiquinol [RN:R02163]
Gene Name:	MT-ND4
Uniprot ID:	P03905
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial
Reactions:
Gene Name:	SDHD
Uniprot ID:	O14521
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial
Reactions:	NADH + H+ + acceptor = NAD+ + reduced acceptor [RN:R00281]
Gene Name:	NDUFS7
Uniprot ID:	O75251
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Xanthine dehydrogenase/oxidase
Reactions:	xanthine + H2O + O2 = urate + H2O2 [RN:R02107]
Gene Name:	XDH
Uniprot ID:	P47989
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	NADPH--cytochrome P450 reductase
Reactions:	NADPH + H+ + n oxidized hemoprotein = NADP+ + n reduced hemoprotein
Gene Name:	POR
Uniprot ID:	P16435
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Dihydroorotate dehydrogenase, mitochondrial
Reactions:	(S)-dihydroorotate + a quinone = orotate + a quinol [RN:R01868]
Gene Name:	DHODH
Uniprot ID:	Q02127
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Dimethylaniline monooxygenase [N-oxide-forming] 1
Reactions:	N,N-dimethylaniline + NADPH + H+ + O2 = N,N-dimethylaniline N-oxide + NADP+ + H2O [RN:R03344]
Gene Name:	FMO1
Uniprot ID:	Q01740
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial
Reactions:	NADH + H+ + acceptor = NAD+ + reduced acceptor [RN:R00281]
Gene Name:	NDUFV1
Uniprot ID:	P49821
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9
Reactions:	--- []
Gene Name:	NDUFB9
Uniprot ID:	Q9Y6M9
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Methylenetetrahydrofolate reductase
Reactions:	5-methyltetrahydrofolate + NAD(P)+ = 5,10-methylenetetrahydrofolate + NAD(P)H + H+ [RN:R01224 R07168]
Gene Name:	MTHFR
Uniprot ID:	P42898
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	NADH-ubiquinone oxidoreductase chain 6
Reactions:	NADH + H+ + ubiquinone = NAD+ + ubiquinol [RN:R02163]
Gene Name:	MT-ND6
Uniprot ID:	P03923
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13
Reactions:	--- []
Gene Name:	NDUFA13
Uniprot ID:	Q9P0J0
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial
Reactions:	--- []
Gene Name:	NDUFS6
Uniprot ID:	O75380
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Peroxisomal acyl-coenzyme A oxidase 3
Reactions:	acyl-CoA + O2 = trans-2,3-dehydroacyl-CoA + H2O2 [RN:R00388]
Gene Name:	ACOX3
Uniprot ID:	O15254
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
Reactions:	succinate + ubiquinone = fumarate + ubiquinol [RN:R02164]
Gene Name:	SDHB
Uniprot ID:	P21912
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Ectonucleotide pyrophosphatase/phosphodiesterase family member 3
Reactions:	a dinucleotide + H2O = 2 mononucleotides [RN:R00056]
Gene Name:	ENPP3
Uniprot ID:	O14638
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Glutathione reductase, mitochondrial
Reactions:	2 glutathione + NADP+ = glutathione disulfide + NADPH + H+ [RN:R00115]
Gene Name:	GSR
Uniprot ID:	P00390
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Glycerol-3-phosphate dehydrogenase, mitochondrial
Reactions:	sn-glycerol 3-phosphate + a quinone = glycerone phosphate + a quinol [RN:R00849]
Gene Name:	GPD2
Uniprot ID:	P43304
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Heme oxygenase 1
Reactions:	heme + 3 AH2 + 3 O2 = biliverdin + Fe2+ + CO + 3 A + 3 H2O [RN:R00311]
Gene Name:	HMOX1
Uniprot ID:	P09601
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Retinal dehydrogenase 1
Reactions:	retinal + NAD+ + H2O = retinoate + NADH + 2 H+ [RN:R02123]
Gene Name:	ALDH1A1
Uniprot ID:	P00352
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Choline dehydrogenase, mitochondrial
Reactions:	choline + acceptor = betaine aldehyde + reduced acceptor [RN:R01025]
Gene Name:	CHDH
Uniprot ID:	Q8NE62
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Glutaryl-CoA dehydrogenase, mitochondrial
Reactions:	glutaryl-CoA + acceptor = crotonoyl-CoA + CO2 + reduced acceptor [RN:R02488]
Gene Name:	GCDH
Uniprot ID:	Q92947
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Dimethylglycine dehydrogenase, mitochondrial
Reactions:	N,N-dimethylglycine + acceptor + H2O = sarcosine + formaldehyde + reduced acceptor [RN:R01565]
Gene Name:	DMGDH
Uniprot ID:	Q9UI17
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	NADPH:adrenodoxin oxidoreductase, mitochondrial
Reactions:	2 reduced ferredoxin + NADP+ + H+ = 2 oxidized ferredoxin + NADPH [RN:R01195]
Gene Name:	FDXR
Uniprot ID:	P22570
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Retinal dehydrogenase 2
Reactions:	retinal + NAD+ + H2O = retinoate + NADH + 2 H+ [RN:R02123]
Gene Name:	ALDH1A2
Uniprot ID:	O94788
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	D-amino-acid oxidase
Reactions:	a D-amino acid + H2O + O2 = a 2-oxo acid + NH3 + H2O2 [RN:R01340]
Gene Name:	DAO
Uniprot ID:	P14920
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Methionine synthase reductase
Reactions:	2 [methionine synthase]-methylcob(I)alamin + 2 S-adenosylhomocysteine + NADP+ = 2 [methionine synthase]-cob(II)alamin + NADPH + H+ + 2 S-adenosyl-L-methionine [RN:R05182]
Gene Name:	MTRR
Uniprot ID:	Q9UBK8
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	tRNA-dihydrouridine synthase 2-like
Reactions:
Gene Name:	DUS2L
Uniprot ID:	Q9NX74
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Dihydropyrimidine dehydrogenase [NADP+]
Reactions:	5,6-dihydrouracil + NADP+ = uracil + NADPH + H+ [RN:R00978]
Gene Name:	DPYD
Uniprot ID:	Q12882
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Sarcosine dehydrogenase, mitochondrial
Reactions:	sarcosine + acceptor + H2O = glycine + formaldehyde + reduced acceptor [RN:R00611]
Gene Name:	SARDH
Uniprot ID:	Q9UL12
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Nitric oxide synthase, inducible
Reactions:	L-arginine + n NADPH + n H+ + m O2 = citrulline + nitric oxide + n NADP+ [RN:R00557]
Gene Name:	NOS2
Uniprot ID:	P35228
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Nitric oxide synthase, brain
Reactions:	L-arginine + n NADPH + n H+ + m O2 = citrulline + nitric oxide + n NADP+ [RN:R00557]
Gene Name:	NOS1
Uniprot ID:	P29475
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Nitric oxide synthase, endothelial
Reactions:	L-arginine + n NADPH + n H+ + m O2 = citrulline + nitric oxide + n NADP+ [RN:R00557]
Gene Name:	NOS3
Uniprot ID:	P29474
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Protoporphyrinogen oxidase
Reactions:	protoporphyrinogen IX + 3 O2 = protoporphyrin IX + 3 H2O2 [RN:R03222]
Gene Name:	PPOX
Uniprot ID:	P50336
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial
Reactions:
Gene Name:	NDUFB11
Uniprot ID:	Q9NX14
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Alkyldihydroxyacetonephosphate synthase, peroxisomal
Reactions:	1-acyl-glycerone 3-phosphate + a long-chain alcohol = an alkyl-glycerone 3-phosphate + a long-chain acid anion [RN:R04311]
Gene Name:	AGPS
Uniprot ID:	O00116
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial
Reactions:	--- []
Gene Name:	ACADSB
Uniprot ID:	P45954
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	NAD(P)H dehydrogenase [quinone] 1
Reactions:	NAD(P)H + H+ + a quinone = NAD(P)+ + a hydroquinone [RN:R07358 R07359]
Gene Name:	NQO1
Uniprot ID:	P15559
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Cytochrome b-245 heavy chain
Reactions:
Gene Name:	CYBB
Uniprot ID:	P04839
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Electron transfer flavoprotein subunit alpha, mitochondrial
Reactions:
Gene Name:	ETFA
Uniprot ID:	P13804
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Putative dimethylaniline monooxygenase [N-oxide-forming] 6
Reactions:	N,N-dimethylaniline + NADPH + H+ + O2 = N,N-dimethylaniline N-oxide + NADP+ + H2O [RN:R03344]
Gene Name:	FMO6P
Uniprot ID:	O60774
Protein Sequence:	FASTA

Name:	24-dehydrocholesterol reductase
Reactions:
Gene Name:	DHCR24
Uniprot ID:	Q15392
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Amyloid beta A4 protein
Reactions:
Gene Name:	APP
Uniprot ID:	P05067
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Electron transfer flavoprotein subunit beta
Reactions:
Gene Name:	ETFB
Uniprot ID:	P38117
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Proline dehydrogenase, mitochondrial
Reactions:	L-proline + acceptor = (S)-1-pyrroline-5-carboxylate + reduced acceptor [RN:R01253]
Gene Name:	PRODH
Uniprot ID:	O43272
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	D-2-hydroxyglutarate dehydrogenase, mitochondrial
Reactions:
Gene Name:	D2HGDH
Uniprot ID:	Q8N465
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	L-2-hydroxyglutarate dehydrogenase, mitochondrial
Reactions:	(S)-2-hydroxyglutarate + acceptor = 2-oxoglutarate + reduced acceptor [RN:R00298]
Gene Name:	L2HGDH
Uniprot ID:	Q9H9P8
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Kynurenine 3-monooxygenase
Reactions:	L-kynurenine + NADPH + H+ + O2 = 3-hydroxy-L-kynurenine + NADP+ + H2O [RN:R01960]
Gene Name:	KMO
Uniprot ID:	O15229
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Spermine oxidase
Reactions:	spermine + O2 + H2O = spermidine + 3-aminopropanal + H2O2 [RN:R09076]
Gene Name:	SMOX
Uniprot ID:	Q9NWM0
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Apoptosis-inducing factor 1, mitochondrial
Reactions:
Gene Name:	AIFM1
Uniprot ID:	O95831
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Cryptochrome-1
Reactions:
Gene Name:	CRY1
Uniprot ID:	Q16526
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Dual oxidase 2
Reactions:	NAD(P)H + H+ + O2 = NAD(P)+ + H2O2 [RN:R07171 R07172]
Gene Name:	DUOX2
Uniprot ID:	Q9NRD8
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Probable D-lactate dehydrogenase, mitochondrial
Reactions:	(R)-lactate + 2 ferricytochrome c = pyruvate + 2 ferrocytochrome c [RN:R00197]
Gene Name:	LDHD
Uniprot ID:	Q86WU2
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Isobutyryl-CoA dehydrogenase, mitochondrial
Reactions:
Gene Name:	ACAD8
Uniprot ID:	Q9UKU7
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Acyl-CoA dehydrogenase family member 9, mitochondrial
Reactions:
Gene Name:	ACAD9
Uniprot ID:	Q9H845
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Probable proline dehydrogenase 2
Reactions:	L-proline + acceptor = (S)-1-pyrroline-5-carboxylate + reduced acceptor [RN:R01253]
Gene Name:	PRODH2
Uniprot ID:	Q9UF12
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Dual oxidase 1
Reactions:	NAD(P)H + H+ + O2 = NAD(P)+ + H2O2 [RN:R07171 R07172]
Gene Name:	DUOX1
Uniprot ID:	Q9NRD9
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Thioredoxin reductase 3
Reactions:	thioredoxin + NADP+ = thioredoxin disulfide + NADPH + H+ [RN:R02016]
Gene Name:	TXNRD3
Uniprot ID:	Q86VQ6
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	NADH-cytochrome b5 reductase 1
Reactions:	NADH + 2 ferricytochrome b5 = NAD+ + H+ + 2 ferrocytochrome b5 [RN:R00100]
Gene Name:	CYB5R1
Uniprot ID:	Q9UHQ9
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	NADH-cytochrome b5 reductase 2
Reactions:	NADH + 2 ferricytochrome b5 = NAD+ + H+ + 2 ferrocytochrome b5 [RN:R00100]
Gene Name:	CYB5R2
Uniprot ID:	Q6BCY4
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Cytochrome b5 reductase 4
Reactions:	NADH + 2 ferricytochrome b5 = NAD+ + H+ + 2 ferrocytochrome b5 [RN:R00100]
Gene Name:	CYB5R4
Uniprot ID:	Q7L1T6
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	NADH-cytochrome b5 reductase-like
Reactions:	NADH + 2 ferricytochrome b5 = NAD+ + H+ + 2 ferrocytochrome b5 [RN:R00100]
Gene Name:	CYB5RL
Uniprot ID:	Q6IPT4
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Putative uncharacterized protein DKFZp686B0215
Reactions:
Gene Name:	DKFZp686B0215
Uniprot ID:	Q5HYI4
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	FAD synthase
Reactions:	ATP + FMN = diphosphate + FAD [RN:R00161]
Gene Name:	FLAD1
Uniprot ID:	Q8NFF5
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Ubiquinone biosynthesis monooxygenase COQ6
Reactions:
Gene Name:	COQ6
Uniprot ID:	Q9Y2Z9
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	NADPH oxidase 5
Reactions:
Gene Name:	NOX5
Uniprot ID:	Q96PH1
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	NADPH oxidase 3
Reactions:
Gene Name:	NOX3
Uniprot ID:	Q9HBY0
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Metalloreductase STEAP3
Reactions:
Gene Name:	STEAP3
Uniprot ID:	Q658P3
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Very long-chain specific acyl-CoA dehydrogenase, mitochondrial
Reactions:
Gene Name:	ACADVL
Uniprot ID:	P49748
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Acyl-coenzyme A oxidase-like protein
Reactions:
Gene Name:	ACOXL
Uniprot ID:	Q9NUZ1
Protein Sequence:	FASTA

Name:	Apoptosis-inducing factor 2
Reactions:
Gene Name:	AIFM2
Uniprot ID:	Q9BRQ8
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Apoptosis-inducing factor 3
Reactions:
Gene Name:	AIFM3
Uniprot ID:	Q96NN9
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	FAD-linked sulfhydryl oxidase ALR
Reactions:	4 R'C(R)SH + O2 = 2 R'C(R)S-S(R)CR' + 2 H2O [RN:R00057]
Gene Name:	GFER
Uniprot ID:	P55789
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Lysine-specific histone demethylase 1B
Reactions:
Gene Name:	KDM1B
Uniprot ID:	Q8NB78
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Cryptochrome-2
Reactions:
Gene Name:	CRY2
Uniprot ID:	Q49AN0
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	tRNA-dihydrouridine synthase 1-like
Reactions:
Gene Name:	DUS1L
Uniprot ID:	Q6P1R4
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	tRNA-dihydrouridine synthase 3-like
Reactions:
Gene Name:	DUS3L
Uniprot ID:	Q96G46
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	tRNA-dihydrouridine synthase 4-like
Reactions:
Gene Name:	DUS4L
Uniprot ID:	O95620
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	ERO1-like protein alpha
Reactions:
Gene Name:	ERO1L
Uniprot ID:	Q96HE7
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	ERO1-like protein beta
Reactions:
Gene Name:	ERO1LB
Uniprot ID:	Q86YB8
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	FAD-dependent oxidoreductase domain-containing protein 1
Reactions:
Gene Name:	FOXRED1
Uniprot ID:	Q96CU9
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	FAD-dependent oxidoreductase domain-containing protein 2
Reactions:
Gene Name:	FOXRED2
Uniprot ID:	Q8IWF2
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Lysine-specific histone demethylase 1A
Reactions:
Gene Name:	KDM1A
Uniprot ID:	O60341
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	NEDD9-interacting protein with calponin homology and LIM domains
Reactions:
Gene Name:	MICAL1
Uniprot ID:	Q8TDZ2
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Protein MICAL-2
Reactions:
Gene Name:	MICAL2
Uniprot ID:	O94851
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Protein MICAL-3
Reactions:
Gene Name:	MICAL3
Uniprot ID:	Q7RTP6
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Protein MTO1 homolog, mitochondrial
Reactions:
Gene Name:	MTO1
Uniprot ID:	Q9Y2Z2
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	NADPH-dependent diflavin oxidoreductase 1
Reactions:
Gene Name:	NDOR1
Uniprot ID:	Q9UHB4
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	NADPH oxidase 1
Reactions:
Gene Name:	NOX1
Uniprot ID:	Q9Y5S8
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	NADPH oxidase 4
Reactions:
Gene Name:	NOX4
Uniprot ID:	Q9NPH5
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	L-amino-acid oxidase
Reactions:	an L-amino acid + H2O + O2 = a 2-oxo acid + NH3 + H2O2 [RN:R01259]
Gene Name:	IL4I1
Uniprot ID:	Q96RQ9
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Oxidoreductase NAD-binding domain-containing protein 1
Reactions:
Gene Name:	OXNAD1
Uniprot ID:	Q96HP4
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Prenylcysteine oxidase 1
Reactions:	an S-prenyl-L-cysteine + O2 + H2O = a prenal + L-cysteine + H2O2 [RN:R07360]
Gene Name:	PCYOX1
Uniprot ID:	Q9UHG3
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Prenylcysteine oxidase-like
Reactions:
Gene Name:	PCYOX1L
Uniprot ID:	Q8NBM8
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	[Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 2, mitochondrial
Reactions:	[pyruvate dehydrogenase (acetyl-transferring)] phosphate + H2O = [pyruvate dehydrogenase (acetyl-transferring)] + phosphate [RN:R03450]
Gene Name:	PDP2
Uniprot ID:	Q9P2J9
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Pyridine nucleotide-disulfide oxidoreductase domain-containing protein 1
Reactions:
Gene Name:	PYROXD1
Uniprot ID:	Q8WU10
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Sulfhydryl oxidase 1
Reactions:	4 R'C(R)SH + O2 = 2 R'C(R)S-S(R)CR' + 2 H2O [RN:R00057]
Gene Name:	QSOX1
Uniprot ID:	O00391
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Sulfhydryl oxidase 2
Reactions:	4 R'C(R)SH + O2 = 2 R'C(R)S-S(R)CR' + 2 H2O [RN:R00057]
Gene Name:	QSOX2
Uniprot ID:	Q6ZRP7
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Renalase
Reactions:
Gene Name:	RNLS
Uniprot ID:	Q5VYX0
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	All-trans-retinol 13,14-reductase
Reactions:	all-trans-13,14-dihydroretinol + acceptor = all-trans-retinol + reduced acceptor [RN:R07163]
Gene Name:	RETSAT
Uniprot ID:	Q6NUM9
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Sulfide:quinone oxidoreductase, mitochondrial
Reactions:
Gene Name:	SQRDL
Uniprot ID:	Q9Y6N5
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Metalloreductase STEAP1
Reactions:
Gene Name:	STEAP1
Uniprot ID:	Q9UHE8
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Metalloreductase STEAP2
Reactions:
Gene Name:	STEAP2
Uniprot ID:	Q8NFT2
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Metalloreductase STEAP4
Reactions:
Gene Name:	STEAP4
Uniprot ID:	Q687X5
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	NADH dehydrogenase (Ubiquinone) 1 beta subcomplex, 2, 8kDa
Reactions:
Gene Name:	NDUFB2
Uniprot ID:	A4D1T5
Protein Sequence:	FASTA
Gene Sequence:	FASTA