Record Information
Version3.6
Creation Date2006-08-16 14:07:20 UTC
Update Date2013-05-29 19:31:21 UTC
HMDB IDHMDB01377
Secondary Accession NumbersNone
Metabolite Identification
Common NameOxygen
DescriptionOxygen is the third most abundant element in the universe after hydrogen and helium and the most abundant element by mass in the Earth's crust. Diatomic oxygen gas constitutes 20.9% of the volume of air. All major classes of structural molecules in living organisms, such as proteins, carbohydrates, and fats, contain oxygen, as do the major inorganic compounds that comprise animal shells, teeth, and bone. Oxygen in the form of O2 is produced from water by cyanobacteria, algae and plants during photosynthesis and is used in cellular respiration for all living organisms. Green algae and cyanobacteria in marine environments provide about 70% of the free oxygen produced on earth and the rest is produced by terrestrial plants. Oxygen is used in mitochondria to help generate adenosine triphosphate (ATP) during oxidative phosphorylation. For animals, a constant supply of oxygen is indispensable for cardiac viability and function. To meet this demand, an adult human, at rest, inhales 1.8 to 2.4 grams of oxygen per minute. This amounts to more than 6 billion tonnes of oxygen inhaled by humanity per year. At a resting pulse rate, the heart consumes approximately 8-15 ml O2/min/100 g tissue. This is significantly more than that consumed by the brain (approximately 3 ml O2/min/100 g tissue) and can increase to more than 70 ml O2/min/100 g myocardial tissue during vigorous exercise. As a general rule, mammalian heart muscle cannot produce enough energy under anaerobic conditions to maintain essential cellular processes; thus, a constant supply of oxygen is indispensable to sustain cardiac function and viability. However, the role of oxygen and oxygen-associated processes in living systems is complex, and they and can be either beneficial or contribute to cardiac dysfunction and death (through reactive oxygen species). Reactive oxygen species (ROS) are a family of oxygen-derived free radicals that are produced in mammalian cells under normal and pathologic conditions. Many ROS, such as the superoxide anion (O2-)and hydrogen peroxide (H2O2), act within blood vessels, altering mechanisms mediating mechanical signal transduction and autoregulation of cerebral blood flow. Reactive oxygen species are believed to be involved in cellular signaling in blood vessels in both normal and pathologic states. The major pathway for the production of ROS is by way of the one-electron reduction of molecular oxygen to form an oxygen radical, the superoxide anion (O2-). Within the vasculature there are several enzymatic sources of O2-, including xanthine oxidase, the mitochondrial electron transport chain, and nitric oxide (NO) synthases. Studies in recent years, however, suggest that the major contributor to O2- levels in vascular cells is the membrane-bound enzyme NADPH-oxidase. Produced O2- can react with other radicals, such as NO, or spontaneously dismutate to produce hydrogen peroxide (H2O2). In cells, the latter reaction is an important pathway for normal O2- breakdown and is usually catalyzed by the enzyme superoxide dismutase (SOD). Once formed, H2O2 can undergo various reactions, both enzymatic and nonenzymatic. The antioxidant enzymes catalase and glutathione peroxidase act to limit ROS accumulation within cells by breaking down H2O2 to H2O. Metabolism of H2O2 can also produce other, more damaging ROS. For example, the endogenous enzyme myeloperoxidase uses H2O2 as a substrate to form the highly reactive compound hypochlorous acid. Alternatively, H2O2 can undergo Fenton or Haber-Weiss chemistry, reacting with Fe2+/Fe3+ ions to form toxic hydroxyl radicals (-.OH). (PMID: 17027622 , 15765131 ).
Structure
Thumb
Synonyms
  1. Dioxygen
  2. Molecular oxygen
  3. O2
  4. Oxygen
  5. Oxygen molecule
Chemical FormulaO2
Average Molecular Weight31.9988
Monoisotopic Molecular Weight31.989829244
IUPAC Nameoxidanone
Traditional IUPAC Nameoxygen
CAS Registry Number7782-44-7
SMILES
O=O
InChI Identifier
InChI=1S/O2/c1-2
InChI KeyMYMOFIZGZYHOMD-UHFFFAOYSA-N
Chemical Taxonomy
KingdomInorganic Compounds
Super ClassHomogeneous Non-metal Compounds
ClassOther Non-metal Organides
Sub ClassOther Non-metal Oxides
Other Descriptors
  • a non-metabolic compound(Cyc)
  • dioxygen(ChEBI)
Substituents
  • N/A
Direct ParentOther Non-metal Oxides
Ontology
StatusDetected and Quantified
Origin
  • Endogenous
Biofunction
  • Respiration, oxidation, signaling
ApplicationNot Available
Cellular locations
  • Extracellular
  • Mitochondria
  • Nucleus
  • Endoplasmic reticulum
  • Peroxisome
Physical Properties
StateLiquid
Experimental Properties
PropertyValueReference
Melting Point-218.4 °CNot Available
Boiling PointNot AvailableNot Available
Water Solubility37.5 mg/mL at 21 °CNot Available
LogP0.65HANSCH,C ET AL. (1995)
Predicted Properties
PropertyValueSource
logP-0.28ChemAxon
physiological charge0ChemAxon
hydrogen acceptor count2ChemAxon
hydrogen donor count0ChemAxon
polar surface area34.14ChemAxon
rotatable bond count0ChemAxon
refractivity2.89ChemAxon
polarizability1.53ChemAxon
Spectra
SpectraNot Available
Biological Properties
Cellular Locations
  • Extracellular
  • Mitochondria
  • Nucleus
  • Endoplasmic reticulum
  • Peroxisome
Biofluid Locations
  • Blood
Tissue Location
  • All Tissues
Pathways
NameSMPDB LinkKEGG Link
Arachidonic Acid MetabolismSMP00075map00590
Carnitine SynthesisSMP00465Not Available
Catecholamine BiosynthesisSMP00012map00350
D-Arginine and D-Ornithine MetabolismSMP00036map00472
Degradation of SuperoxidesSMP00468Not Available
Ethanol DegradationSMP00449Not Available
Glycine and Serine MetabolismSMP00004map00260
Mitochondrial Electron Transport ChainSMP00355map00190
Phenylalanine and Tyrosine MetabolismSMP00008map00360
Plasmalogen SynthesisSMP00479Not Available
Riboflavin MetabolismSMP00070map00740
Vitamin K MetabolismSMP00464Not Available
Normal Concentrations
BiofluidStatusValueAgeSexConditionReference
BloodDetected and Quantified6960.0 +/- 410.0 uMAdult (>18 years old)BothNormal
  • Geigy Scient...
BloodDetected and Quantified5760.0 +/- 580.0 uMAdult (>18 years old)MaleNormal
  • Geigy Scient...
BloodDetected and Quantified5490.0 (2780.0-7410.0) uMNewborn (0-30 days old)BothNormal
  • Geigy Scient...
Abnormal Concentrations
Not Available
Associated Disorders and Diseases
Disease ReferencesNone
Associated OMIM IDsNone
DrugBank IDNot Available
DrugBank Metabolite IDNot Available
Phenol Explorer Compound IDNot Available
Phenol Explorer Metabolite IDNot Available
FoodDB IDFDB022589
KNApSAcK IDNot Available
Chemspider ID952
KEGG Compound IDC00007
BioCyc IDCPD-6641
BiGG ID33493
Wikipedia LinkOxygen
NuGOwiki LinkHMDB01377
Metagene LinkHMDB01377
METLIN ID3195
PubChem Compound977
PDB IDOXY
ChEBI ID15379
References
Synthesis ReferenceWynn, Richard L. Production of hydrogen and oxygen by thermal disassociation of water. U.S. Pat. Appl. Publ. (2007), 26pp.
Material Safety Data Sheet (MSDS)Download (PDF)
General References
  1. Carrier M, Denault A, Lavoie J, Perrault LP: Randomized controlled trial of pericardial blood processing with a cell-saving device on neurologic markers in elderly patients undergoing coronary artery bypass graft surgery. Ann Thorac Surg. 2006 Jul;82(1):51-5. Pubmed: 16798186
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  5. Zhang YT, Geng ZJ, Zhang Q, Li W, Zhang J: Auditory cortical responses evoked by pure tones in healthy and sensorineural hearing loss subjects: functional MRI and magnetoencephalography. Chin Med J (Engl). 2006 Sep 20;119(18):1548-54. Pubmed: 16996009
  6. Ketcham EM, Cairns CB: Hemoglobin-based oxygen carriers: development and clinical potential. Ann Emerg Med. 1999 Mar;33(3):326-37. Pubmed: 10036348
  7. Capelli-Schellpfeffer M, Gerber GS: The use of hyperbaric oxygen in urology. J Urol. 1999 Sep;162(3 Pt 1):647-54. Pubmed: 10458334
  8. Weaver LK, Howe S, Hopkins R, Chan KJ: Carboxyhemoglobin half-life in carbon monoxide-poisoned patients treated with 100% oxygen at atmospheric pressure. Chest. 2000 Mar;117(3):801-8. Pubmed: 10713010
  9. Rooth G: Transcutaneous oxygen tension measurements in newborn infants. Pediatrics. 1975 Feb;55(2):232-5. Pubmed: 1090895
  10. Nath KA, Norby SM: Reactive oxygen species and acute renal failure. Am J Med. 2000 Dec 1;109(8):665-78. Pubmed: 11099687
  11. Kotecha S, Allen J: Oxygen therapy for infants with chronic lung disease. Arch Dis Child Fetal Neonatal Ed. 2002 Jul;87(1):F11-4. Pubmed: 12091281
  12. Van Heerebeek L, Meischl C, Stooker W, Meijer CJ, Niessen HW, Roos D: NADPH oxidase(s): new source(s) of reactive oxygen species in the vascular system? J Clin Pathol. 2002 Aug;55(8):561-8. Pubmed: 12147646
  13. Forman HJ, Torres M: Reactive oxygen species and cell signaling: respiratory burst in macrophage signaling. Am J Respir Crit Care Med. 2002 Dec 15;166(12 Pt 2):S4-8. Pubmed: 12471082
  14. Kemp PJ, Lewis A, Hartness ME, Searle GJ, Miller P, O'Kelly I, Peers C: Airway chemotransduction: from oxygen sensor to cellular effector. Am J Respir Crit Care Med. 2002 Dec 15;166(12 Pt 2):S17-24. Pubmed: 12471084
  15. Frey B, Shann F: Oxygen administration in infants. Arch Dis Child Fetal Neonatal Ed. 2003 Mar;88(2):F84-8. Pubmed: 12598492
  16. Wang C, Schwaitzberg S, Berliner E, Zarin DA, Lau J: Hyperbaric oxygen for treating wounds: a systematic review of the literature. Arch Surg. 2003 Mar;138(3):272-9; discussion 280. Pubmed: 12611573
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  18. Rodrigo GJ, Rodrigo C, Pollack CV, Rowe B: Use of helium-oxygen mixtures in the treatment of acute asthma: a systematic review. Chest. 2003 Mar;123(3):891-6. Pubmed: 12628893
  19. Wangsa-Wirawan ND, Linsenmeier RA: Retinal oxygen: fundamental and clinical aspects. Arch Ophthalmol. 2003 Apr;121(4):547-57. Pubmed: 12695252
  20. Cohn SM: Oxygen therapeutics in trauma and surgery. J Trauma. 2003 May;54(5 Suppl):S193-8. Pubmed: 12768124
  21. Gordillo GM, Sen CK: Revisiting the essential role of oxygen in wound healing. Am J Surg. 2003 Sep;186(3):259-63. Pubmed: 12946829
  22. Deedwania PC, Carbajal EV: Role of myocardial oxygen demand in the pathogenesis of silent ischemia during daily life. Am J Cardiol. 1992 Nov 16;70(16):19F-24F. Pubmed: 1442597
  23. Listello D, Glauser F: COPD: primary care management with drug and oxygen therapies. Geriatrics. 1992 Dec;47(12):28-30, 35-8. Pubmed: 1446842
  24. McDonagh M, Helfand M, Carson S, Russman BS: Hyperbaric oxygen therapy for traumatic brain injury: a systematic review of the evidence. Arch Phys Med Rehabil. 2004 Jul;85(7):1198-204. Pubmed: 15241774
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  27. Goldstein BJ, Mahadev K, Wu X: Redox paradox: insulin action is facilitated by insulin-stimulated reactive oxygen species with multiple potential signaling targets. Diabetes. 2005 Feb;54(2):311-21. Pubmed: 15677487
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  31. Burkhoff D, Lefer DJ: Cardioprotection before revascularization in ischemic myocardial injury and the potential role of hemoglobin-based oxygen carriers. Am Heart J. 2005 Apr;149(4):573-9. Pubmed: 15990736
  32. Glazier JJ: Attenuation of reperfusion microvascular ischemia by aqueous oxygen: experimental and clinical observations. Am Heart J. 2005 Apr;149(4):580-4. Pubmed: 15990737
  33. Kevin LG, Novalija E, Stowe DF: Reactive oxygen species as mediators of cardiac injury and protection: the relevance to anesthesia practice. Anesth Analg. 2005 Nov;101(5):1275-87. Pubmed: 16243980
  34. Bennett M, Kertesz T, Yeung P: Hyperbaric oxygen therapy for idiopathic sudden sensorineural hearing loss and tinnitus: a systematic review of randomized controlled trials. J Laryngol Otol. 2005 Oct;119(10):791-8. Pubmed: 16259656
  35. Levy MM: Pathophysiology of oxygen delivery in respiratory failure. Chest. 2005 Nov;128(5 Suppl 2):547S-553S. Pubmed: 16306052
  36. Huang YC: Monitoring oxygen delivery in the critically ill. Chest. 2005 Nov;128(5 Suppl 2):554S-560S. Pubmed: 16306053
  37. Liu Z, Xiong T, Meads C: Clinical effectiveness of treatment with hyperbaric oxygen for neonatal hypoxic-ischaemic encephalopathy: systematic review of Chinese literature. BMJ. 2006 Aug 19;333(7564):374. Epub 2006 May 11. Pubmed: 16690641
  38. Friedman HI, Fitzmaurice M, Lefaivre JF, Vecchiolla T, Clarke D: An evidence-based appraisal of the use of hyperbaric oxygen on flaps and grafts. Plast Reconstr Surg. 2006 Jun;117(7 Suppl):175S-190S; discussion 191S-192S. Pubmed: 16799386
  39. Terashvili M, Pratt PF, Gebremedhin D, Narayanan J, Harder DR: Reactive oxygen species cerebral autoregulation in health and disease. Pediatr Clin North Am. 2006 Oct;53(5):1029-37, xi. Pubmed: 17027622
  40. Colebourn CL, Barber V, Young JD: Use of helium-oxygen mixture in adult patients presenting with exacerbations of asthma and chronic obstructive pulmonary disease: a systematic review. Anaesthesia. 2007 Jan;62(1):34-42. Pubmed: 17156225
  41. Bradley JM, Lasserson T, Elborn S, Macmahon J, O'neill B: A systematic review of randomized controlled trials examining the short-term benefit of ambulatory oxygen in COPD. Chest. 2007 Jan;131(1):278-85. Pubmed: 17218587
  42. Tin W, Gupta S: Optimum oxygen therapy in preterm babies. Arch Dis Child Fetal Neonatal Ed. 2007 Mar;92(2):F143-7. Pubmed: 17337663
  43. Higgins RD, Bancalari E, Willinger M, Raju TN: Executive summary of the workshop on oxygen in neonatal therapies: controversies and opportunities for research. Pediatrics. 2007 Apr;119(4):790-6. Pubmed: 17403851
  44. Ness PM, Cushing MM: Oxygen therapeutics: pursuit of an alternative to the donor red blood cell. Arch Pathol Lab Med. 2007 May;131(5):734-41. Pubmed: 17488158
  45. Shelley KH: Photoplethysmography: beyond the calculation of arterial oxygen saturation and heart rate. Anesth Analg. 2007 Dec;105(6 Suppl):S31-6, tables of contents. Pubmed: 18048895
  46. Claure N: Automated regulation of inspired oxygen in preterm infants: oxygenation stability and clinician workload. Anesth Analg. 2007 Dec;105(6 Suppl):S37-41. Pubmed: 18048896
  47. Toffaletti J, Zijlstra WG: Misconceptions in reporting oxygen saturation. Anesth Analg. 2007 Dec;105(6 Suppl):S5-9. Pubmed: 18048899
  48. Ferrari R, Ceconi C, Curello S, Cargnoni A, Pasini E, De Giuli F, Albertini A: Role of oxygen free radicals in ischemic and reperfused myocardium. Am J Clin Nutr. 1991 Jan;53(1 Suppl):215S-222S. Pubmed: 1845919
  49. Kindwall EP, Gottlieb LJ, Larson DL: Hyperbaric oxygen therapy in plastic surgery: a review article. Plast Reconstr Surg. 1991 Nov;88(5):898-908. Pubmed: 1924583
  50. Cain SM, Curtis SE: Experimental models of pathologic oxygen supply dependency. Crit Care Med. 1991 May;19(5):603-12. Pubmed: 2026022
  51. Weg JG: Oxygen transport in adult respiratory distress syndrome and other acute circulatory problems: relationship of oxygen delivery and oxygen consumption. Crit Care Med. 1991 May;19(5):650-7. Pubmed: 2026027
  52. Edwards JD: Oxygen transport in cardiogenic and septic shock. Crit Care Med. 1991 May;19(5):658-63. Pubmed: 2026028
  53. Tuchschmidt J, Oblitas D, Fried JC: Oxygen consumption in sepsis and septic shock. Crit Care Med. 1991 May;19(5):664-71. Pubmed: 2026029
  54. Reilly PM, Schiller HJ, Bulkley GB: Pharmacologic approach to tissue injury mediated by free radicals and other reactive oxygen metabolites. Am J Surg. 1991 Apr;161(4):488-503. Pubmed: 2035771
  55. Burton GG, Wagshul FA, Henderson D, Kime SW: Fatal airway obstruction caused by a mucous ball from a transtracheal oxygen catheter. Chest. 1991 Jun;99(6):1520-3. Pubmed: 2036843
  56. McCord JM, Fridovich I: The biology and pathology of oxygen radicals. Ann Intern Med. 1978 Jul;89(1):122-7. Pubmed: 208444
  57. Ardehali A, Ports TA: Myocardial oxygen supply and demand. Chest. 1990 Sep;98(3):699-705. Pubmed: 2203620
  58. Edwards JD: Practical application of oxygen transport principles. Crit Care Med. 1990 Jan;18(1 Pt 2):S45-8. Pubmed: 2403513
  59. Kloner RA, Przyklenk K, Whittaker P: Deleterious effects of oxygen radicals in ischemia/reperfusion. Resolved and unresolved issues. Circulation. 1989 Nov;80(5):1115-27. Pubmed: 2553296
  60. Dart RC, Sanders AB: Oxygen free radicals and myocardial reperfusion injury. Ann Emerg Med. 1988 Jan;17(1):53-8. Pubmed: 3276245
  61. Cross CE, Halliwell B, Borish ET, Pryor WA, Ames BN, Saul RL, McCord JM, Harman D: Oxygen radicals and human disease. Ann Intern Med. 1987 Oct;107(4):526-45. Pubmed: 3307585
  62. Gabb G, Robin ED: Hyperbaric oxygen. A therapy in search of diseases. Chest. 1987 Dec;92(6):1074-82. Pubmed: 3315479
  63. Jackson RM: Pulmonary oxygen toxicity. Chest. 1985 Dec;88(6):900-5. Pubmed: 3905287
  64. Vik-Mo H, Mjos OD: Influence of free fatty acids on myocardial oxygen consumption and ischemic injury. Am J Cardiol. 1981 Aug;48(2):361-5. Pubmed: 6115579
  65. Klebanoff SJ: Oxygen metabolism and the toxic properties of phagocytes. Ann Intern Med. 1980 Sep;93(3):480-9. Pubmed: 6254418
  66. Tinits P: Oxygen therapy and oxygen toxicity. Ann Emerg Med. 1983 May;12(5):321-8. Pubmed: 6414343
  67. Lucey JF, Dangman B: A reexamination of the role of oxygen in retrolental fibroplasia. Pediatrics. 1984 Jan;73(1):82-96. Pubmed: 6419199
  68. Riley DJ, Berg RA, Edelman NH, Prockop DJ: Prevention of collagen deposition following pulmonary oxygen toxicity in the rat by cis-4-hydroxy-L-proline. J Clin Invest. 1980 Mar;65(3):643-51. Pubmed: 6986411
  69. DeVenuto F: Hemoglobin solutions as oxygen-delivering resuscitation fluids. Crit Care Med. 1982 Apr;10(4):238-45. Pubmed: 7039970
  70. Vlessis AA, Goldman RK, Trunkey DD: New concepts in the pathophysiology of oxygen metabolism during sepsis. Br J Surg. 1995 Jul;82(7):870-6. Pubmed: 7648095
  71. Seger D, Welch L: Carbon monoxide controversies: neuropsychologic testing, mechanism of toxicity, and hyperbaric oxygen. Ann Emerg Med. 1994 Aug;24(2):242-8. Pubmed: 8037390
  72. Frei B: Reactive oxygen species and antioxidant vitamins: mechanisms of action. Am J Med. 1994 Sep 26;97(3A):5S-13S; discussion 22S-28S. Pubmed: 8085584
  73. Jeroudi MO, Hartley CJ, Bolli R: Myocardial reperfusion injury: role of oxygen radicals and potential therapy with antioxidants. Am J Cardiol. 1994 Mar 10;73(6):2B-7B. Pubmed: 8141076
  74. Spahn DR, Leone BJ, Reves JG, Pasch T: Cardiovascular and coronary physiology of acute isovolemic hemodilution: a review of nonoxygen-carrying and oxygen-carrying solutions. Anesth Analg. 1994 May;78(5):1000-21. Pubmed: 8160966
  75. Helfman T, Falanga V: Gene expression in low oxygen tension. Am J Med Sci. 1993 Jul;306(1):37-41. Pubmed: 8328508
  76. Rudge FW: Carbon monoxide poisoning in infants: treatment with hyperbaric oxygen. South Med J. 1993 Mar;86(3):334-7. Pubmed: 8451675
  77. Ackerman WE 3rd, Molnar JM, Juneja MM: Beneficial effect of epidural anesthesia on oxygen consumption in a parturient with adult respiratory distress syndrome. South Med J. 1993 Mar;86(3):361-4. Pubmed: 8451680
  78. Haapaniemi T, Nylander G, Sirsjo A, Larsson J: Hyperbaric oxygen reduces ischemia-induced skeletal muscle injury. Plast Reconstr Surg. 1996 Mar;97(3):602-7; discussion 608-9. Pubmed: 8596792
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  80. Kerr ME, Bender CM, Monti EJ: An introduction to oxygen free radicals. Heart Lung. 1996 May-Jun;25(3):200-9; quiz 210-1. Pubmed: 8635921
  81. O'Donohue WJ Jr: Home oxygen therapy. Med Clin North Am. 1996 May;80(3):611-22. Pubmed: 8637306
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  83. Powell JF, Menon DK, Jones JG: The effects of hypoxaemia and recommendations for postoperative oxygen therapy. Anaesthesia. 1996 Aug;51(8):769-72. Pubmed: 8795322
  84. Dean E: Oxygen transport deficits in systemic disease and implications for physical therapy. Phys Ther. 1997 Feb;77(2):187-202. Pubmed: 9037219
  85. Feuerstein G, Yue TL, Ma X, Ruffolo RR: Novel mechanisms in the treatment of heart failure: inhibition of oxygen radicals and apoptosis by carvedilol. Prog Cardiovasc Dis. 1998 Jul-Aug;41(1 Suppl 1):17-24. Pubmed: 9715819
  86. Naito Y, Yoshikawa T, Yoshida N, Kondo M: Role of oxygen radical and lipid peroxidation in indomethacin-induced gastric mucosal injury. Dig Dis Sci. 1998 Sep;43(9 Suppl):30S-34S. Pubmed: 9753223
  87. Goodnough LT, Scott MG, Monk TG: Oxygen carriers as blood substitutes. Past, present, and future. Clin Orthop Relat Res. 1998 Dec;(357):89-100. Pubmed: 9917705

Only showing the first 50 proteins. There are 203 proteins in total.

Enzymes

Gene Name:
TYR
Uniprot ID:
P14679
Reactions
L-Dopa + Oxygen unknown Dopaquinone + Waterdetails
L-Tyrosine + Oxygen unknown Dopaquinone + Waterdetails
L-Tyrosine + Oxygen unknown L-Dopa + Waterdetails
L-Dopa + L-Tyrosine + Oxygen unknown Dopaquinone + L-Dopa + Waterdetails
Hydroquinone + Oxygen unknown Quinone + Waterdetails
Tyramine + Oxygen + NADH + Hydrogen Ion unknown Dopamine + NAD + Waterdetails
(S)-N-Methylcoclaurine + Oxygen + Reduced acceptor unknown (S)-3-Hydroxy-N-methylcoclaurine + Water + Acceptordetails
5,6-Dihydroxyindole + Oxygen unknown Indole-5,6-quinone + Waterdetails
Gene Name:
PIPOX
Uniprot ID:
Q9P0Z9
Reactions
Sarcosine + Water + Oxygen unknown Glycine + Formaldehyde + Hydrogen peroxidedetails
L-Pipecolic acid + Oxygen unknown (S)-2,3,4,5-tetrahydropyridine-2-carboxylate + Hydrogen peroxidedetails
Gene Name:
PAOX
Uniprot ID:
Q6QHF9
Reactions
N1-Acetylspermine + Oxygen + Water unknown Spermidine + Acetamidopropanal + Hydrogen peroxidedetails
N1-Acetylspermidine + Oxygen + Water unknown Putrescine + Acetamidopropanal + Hydrogen peroxidedetails
N1,N12-Diacetylspermine + Oxygen + Water unknown N1-Acetylspermidine + 3-Acetamidobutanal + Hydrogen peroxidedetails
Gene Name:
AOX1
Uniprot ID:
Q06278
Reactions
An aldehyde + Water + Oxygen unknown a carboxylate + Hydrogen peroxidedetails
Pyridoxal + Oxygen + Water unknown 4-Pyridoxic acid + Hydrogen peroxidedetails
Gentisic acid + Hydrogen peroxide unknown Gentisate aldehyde + Oxygen + Waterdetails
Methylmalonic acid + Hydrogen peroxide unknown (S)-Methylmalonic acid semialdehyde + Oxygen + Waterdetails
1-Methylnicotinamide + Oxygen + Water unknown N1-Methyl-4-pyridone-3-carboxamide + Hydrogen peroxide + Hydrogen Iondetails
5-Hydroxyindoleacetaldehyde + Oxygen + Water unknown 5-Hydroxyindoleacetic acid + Hydrogen peroxidedetails
Citalopram aldehyde + Water + Oxygen unknown Citalopram propionic acid + Hydrogen peroxidedetails
1-Methylnicotinamide + Oxygen + Water unknown N1-Methyl-2-pyridone-5-carboxamide + Hydrogen peroxide + Hydrogen Iondetails
Gene Name:
SC5DL
Uniprot ID:
O75845
Reactions
Lathosterol + NAD(P)H + Oxygen unknown 7-Dehydrocholesterol + NAD(P)(+) + Waterdetails
Lathosterol + NADH + Hydrogen Ion + Oxygen unknown 7-Dehydrocholesterol + NAD + Waterdetails
Lathosterol + NADPH + Hydrogen Ion + Oxygen unknown 7-Dehydrocholesterol + NADP + Waterdetails
Gene Name:
FMO5
Uniprot ID:
P49326
Reactions
N,N-Dimethylaniline + NADPH + Oxygen unknown Dimethylaniline-N-oxide + NADP + Waterdetails
Trimethylamine + NADPH + Hydrogen Ion + Oxygen unknown Trimethylamine N-oxide + NADP + Waterdetails
Tamoxifen + Oxygen + NADPH + Hydrogen Ion unknown Tamoxifen N-oxide + NADP + Waterdetails
Gene Name:
ACOX1
Uniprot ID:
Q15067
Reactions
Acyl-CoA + Oxygen unknown trans-2,3-dehydroacyl-CoA + Hydrogen peroxidedetails
Gene Name:
DDO
Uniprot ID:
Q99489
Reactions
D-Aspartic acid + Water + Oxygen unknown Oxalacetic acid + Ammonia + Hydrogen peroxidedetails
Gene Name:
HMOX2
Uniprot ID:
P30519
Reactions
Heme + AH(2) + Oxygen unknown Biliverdin + Fe2+ + CO + A + Waterdetails
Hemoglobin + FADH + Oxygen unknown Globin + Biliverdin + Carbon monoxide + Fe3+ + FAD + Waterdetails
Gene Name:
SQLE
Uniprot ID:
Q14534
Reactions
Squalene + NADPH + Oxygen unknown (3S)-2,3-epoxy-2,3-dihydrosqualene + NADP + Waterdetails
Squalene + Reduced acceptor + Oxygen unknown (3S)-2,3-epoxy-2,3-dihydrosqualene + Acceptor + Waterdetails
Squalene + Oxygen + NADPH + Hydrogen Ion unknown (3S)-2,3-epoxy-2,3-dihydrosqualene + NADP + Waterdetails
Gene Name:
FMO2
Uniprot ID:
Q99518
Reactions
N,N-Dimethylaniline + NADPH + Oxygen unknown Dimethylaniline-N-oxide + NADP + Waterdetails
Trimethylamine + NADPH + Hydrogen Ion + Oxygen unknown Trimethylamine N-oxide + NADP + Waterdetails
Tamoxifen + Oxygen + NADPH + Hydrogen Ion unknown Tamoxifen N-oxide + NADP + Waterdetails
Gene Name:
MAOB
Uniprot ID:
P27338
Reactions
RCH(2)NHR' + Water + Oxygen unknown RCHO + R'NH(2) + Hydrogen peroxidedetails
Tryptamine + Water + Oxygen unknown Indoleacetaldehyde + Ammonia + Hydrogen peroxidedetails
Tyramine + Water + Oxygen unknown 4-Hydroxyphenylacetaldehyde + Ammonia + Hydrogen peroxidedetails
Aminoacetone + Water + Oxygen unknown Pyruvaldehyde + Ammonia + Hydrogen peroxidedetails
Norepinephrine + Water + Oxygen unknown 3,4-Dihydroxymandelaldehyde + Ammonia + Hydrogen peroxidedetails
Phenylethylamine + Oxygen + Water unknown Phenylacetaldehyde + Ammonia + Hydrogen peroxidedetails
Serotonin + Water + Oxygen unknown 5-Hydroxyindoleacetaldehyde + Ammonia + Hydrogen peroxidedetails
Epinephrine + Water + Oxygen unknown 3,4-Dihydroxymandelaldehyde + Methylamine + Hydrogen peroxidedetails
N-Acetylputrescine + Water + Oxygen unknown N4-Acetylaminobutanal + Ammonia + Hydrogen peroxidedetails
Dopamine + Water + Oxygen unknown 3,4-Dihydroxyphenylacetaldehyde + Ammonia + Hydrogen peroxidedetails
1-Methylhistamine + Water + Oxygen unknown Methylimidazole acetaldehyde + Ammonia + Hydrogen peroxidedetails
3-Methoxytyramine + Water + Oxygen unknown Homovanillin + Hydrogen peroxide + Ammoniadetails
Normetanephrine + Water + Oxygen unknown 3-Methoxy-4-hydroxyphenylglycolaldehyde + Ammonia + Hydrogen peroxidedetails
Metanephrine + Water + Oxygen unknown 3-Methoxy-4-hydroxyphenylglycolaldehyde + Hydrogen peroxide + Methylaminedetails
3-Hydroxykynurenamine + Oxygen unknown Quinoline-4,8-diol + Ammonia + Hydrogen peroxidedetails
5-Hydroxykynurenamine + Water + Oxygen unknown 4,6-Dihydroxyquinoline + Ammonia + Hydrogen peroxide + Waterdetails
Citalopram + Oxygen + Water unknown Citalopram aldehyde + Dimethylamine + Hydrogen peroxidedetails
N-Desmethylcitalopram + Oxygen + Water unknown Citalopram aldehyde + Methylamine + Hydrogen peroxidedetails
Didemethylcitalopram + Water + Oxygen unknown Citalopram aldehyde + Ammonia + Hydrogen peroxidedetails
Gene Name:
FMO4
Uniprot ID:
P31512
Reactions
N,N-Dimethylaniline + NADPH + Oxygen unknown Dimethylaniline-N-oxide + NADP + Waterdetails
Trimethylamine + NADPH + Hydrogen Ion + Oxygen unknown Trimethylamine N-oxide + NADP + Waterdetails
Tamoxifen + Oxygen + NADPH + Hydrogen Ion unknown Tamoxifen N-oxide + NADP + Waterdetails
Gene Name:
MAOA
Uniprot ID:
P21397
Reactions
RCH(2)NHR' + Water + Oxygen unknown RCHO + R'NH(2) + Hydrogen peroxidedetails
Tryptamine + Water + Oxygen unknown Indoleacetaldehyde + Ammonia + Hydrogen peroxidedetails
Tyramine + Water + Oxygen unknown 4-Hydroxyphenylacetaldehyde + Ammonia + Hydrogen peroxidedetails
Aminoacetone + Water + Oxygen unknown Pyruvaldehyde + Ammonia + Hydrogen peroxidedetails
Norepinephrine + Water + Oxygen unknown 3,4-Dihydroxymandelaldehyde + Ammonia + Hydrogen peroxidedetails
Phenylethylamine + Oxygen + Water unknown Phenylacetaldehyde + Ammonia + Hydrogen peroxidedetails
Serotonin + Water + Oxygen unknown 5-Hydroxyindoleacetaldehyde + Ammonia + Hydrogen peroxidedetails
Epinephrine + Water + Oxygen unknown 3,4-Dihydroxymandelaldehyde + Methylamine + Hydrogen peroxidedetails
N-Acetylputrescine + Water + Oxygen unknown N4-Acetylaminobutanal + Ammonia + Hydrogen peroxidedetails
Dopamine + Water + Oxygen unknown 3,4-Dihydroxyphenylacetaldehyde + Ammonia + Hydrogen peroxidedetails
1-Methylhistamine + Water + Oxygen unknown Methylimidazole acetaldehyde + Ammonia + Hydrogen peroxidedetails
3-Methoxytyramine + Water + Oxygen unknown Homovanillin + Hydrogen peroxide + Ammoniadetails
Normetanephrine + Water + Oxygen unknown 3-Methoxy-4-hydroxyphenylglycolaldehyde + Ammonia + Hydrogen peroxidedetails
Metanephrine + Water + Oxygen unknown 3-Methoxy-4-hydroxyphenylglycolaldehyde + Hydrogen peroxide + Methylaminedetails
3-Hydroxykynurenamine + Oxygen unknown Quinoline-4,8-diol + Ammonia + Hydrogen peroxidedetails
5-Hydroxykynurenamine + Water + Oxygen unknown 4,6-Dihydroxyquinoline + Ammonia + Hydrogen peroxide + Waterdetails
Citalopram + Oxygen + Water unknown Citalopram aldehyde + Dimethylamine + Hydrogen peroxidedetails
N-Desmethylcitalopram + Oxygen + Water unknown Citalopram aldehyde + Methylamine + Hydrogen peroxidedetails
Didemethylcitalopram + Water + Oxygen unknown Citalopram aldehyde + Ammonia + Hydrogen peroxidedetails
Gene Name:
FMO3
Uniprot ID:
P31513
Reactions
N,N-Dimethylaniline + NADPH + Oxygen unknown Dimethylaniline-N-oxide + NADP + Waterdetails
Trimethylamine + NADPH + Oxygen unknown Trimethylamine N-oxide + NADP + Waterdetails
Trimethylamine + NADPH + Hydrogen Ion + Oxygen unknown Trimethylamine N-oxide + NADP + Waterdetails
Tamoxifen + Oxygen + NADPH + Hydrogen Ion unknown Tamoxifen N-oxide + NADP + Waterdetails
Gene Name:
XDH
Uniprot ID:
P47989
Reactions
Xanthine + Water + Oxygen unknown Uric acid + Hydrogen peroxidedetails
Hypoxanthine + Oxygen + Water unknown Xanthine + Hydrogen peroxidedetails
1-Methylxanthine + Water + Oxygen unknown 1-Methyluric acid + Hydrogen peroxidedetails
Paraxanthine + Oxygen + Water unknown 1,7-Dimethyluric acid + Hydrogen peroxidedetails
Theobromine + Water + Oxygen unknown 3,7-Dimethyluric acid + Hydrogen peroxidedetails
7-Methylxanthine + Oxygen + Water unknown 7-Methyluric acid + Hydrogen peroxidedetails
Mercaptopurine + Water + Oxygen unknown 6-Thiourate + Hydrogen peroxidedetails
Gene Name:
FMO1
Uniprot ID:
Q01740
Reactions
N,N-Dimethylaniline + NADPH + Oxygen unknown Dimethylaniline-N-oxide + NADP + Waterdetails
Trimethylamine + NADPH + Hydrogen Ion + Oxygen unknown Trimethylamine N-oxide + NADP + Waterdetails
Tamoxifen + Oxygen + NADPH + Hydrogen Ion unknown Tamoxifen N-oxide + NADP + Waterdetails
Gene Name:
ACOX3
Uniprot ID:
O15254
Reactions
Acyl-CoA + Oxygen unknown trans-2,3-dehydroacyl-CoA + Hydrogen peroxidedetails
Gene Name:
HMOX1
Uniprot ID:
P09601
Reactions
Heme + AH(2) + Oxygen unknown Biliverdin + Fe2+ + CO + A + Waterdetails
Hemoglobin + FADH + Oxygen unknown Globin + Biliverdin + Carbon monoxide + Fe3+ + FAD + Waterdetails
Gene Name:
DAO
Uniprot ID:
P14920
Reactions
A D-amino acid + Water + Oxygen unknown a 2-oxo acid + Ammonia + Hydrogen peroxidedetails
Glycine + Water + Oxygen unknown Glyoxylic acid + Ammonia + Hydrogen peroxidedetails
D-Ornithine + Water + Oxygen unknown 5-Amino-2-oxopentanoic acid + Ammonia + Hydrogen peroxidedetails
D-Proline + Oxygen unknown 1-Pyrroline-2-carboxylic acid + Hydrogen peroxidedetails
cis-4-Hydroxy-D-proline + Oxygen unknown 1-Pyrroline-4-hydroxy-2-carboxylate + Hydrogen peroxidedetails
Cephalosporin C + Water + Oxygen unknown (7R)-7-(5-Carboxy-5-oxopentanoyl)aminocephalosporinate + Ammonia + Hydrogen peroxidedetails
Gene Name:
CPOX
Uniprot ID:
P36551
Reactions
Coproporphyrinogen III + Oxygen + Hydrogen Ion unknown Protoporphyrinogen IX + CO(2) + Waterdetails
Coproporphyrinogen III + Oxygen unknown Protoporphyrinogen IX + Carbon dioxide + Waterdetails
Gene Name:
PAM
Uniprot ID:
P19021
Reactions
Peptidylglycine + Ascorbic acid + Oxygen unknown peptidyl(2-hydroxyglycine) + Dehydroascorbic acid + Waterdetails
Gene Name:
DBH
Uniprot ID:
P09172
Reactions
Dopamine + Ascorbic acid + Oxygen unknown xi-Norepinephrine + Dehydroascorbic acid + Waterdetails
Dopamine + Ascorbic acid + Oxygen unknown Norepinephrine + Dehydroascorbic acid + Waterdetails
Gene Name:
MSMO1
Uniprot ID:
Q15800
Reactions
4,4-Dimethyl-5-alpha-cholest-7-en-3-beta-ol + NAD(P)H + Oxygen unknown 4-beta-Hydroxymethyl-4-alpha-methyl-5-alpha-cholest-7-en-3-beta-ol + NAD(P)(+) + Waterdetails
4-beta-Hydroxymethyl-4-alpha-methyl-5-alpha-cholest-7-en-3-beta-ol + NAD(P)H + Oxygen unknown 3-beta-Hydroxy-4-beta-methyl-5-alpha-cholest-7-ene-4-alpha-carbaldehyde + NAD(P)(+) + Waterdetails
3-beta-Hydroxy-4-beta-methyl-5-alpha-cholest-7-ene-4-alpha-carbaldehyde + NAD(P)H + Oxygen unknown 3-beta-Hydroxy-4-beta-methyl-5-alpha-cholest-7-ene-4-alpha-carboxylate + NAD(P)(+) + Waterdetails
4,4-Dimethyl-5a-cholesta-8,24-dien-3-b-ol + NADPH + Hydrogen Ion + Oxygen unknown 4a-Carboxy-4b-methyl-5a-cholesta-8,24-dien-3b-ol + NADP + Waterdetails
4,4-Dimethyl-5a-cholesta-8,24-dien-3-b-ol + NADH + Hydrogen Ion + Oxygen unknown 3-beta-Hydroxy-4-beta-methyl-5-alpha-cholest-7-ene-4-alpha-carboxylate + NAD + Waterdetails
4,4-Dimethyl-5a-cholesta-8,24-dien-3-b-ol + NADPH + Hydrogen Ion + Oxygen unknown 3-beta-Hydroxy-4-beta-methyl-5-alpha-cholest-7-ene-4-alpha-carboxylate + NADP + Waterdetails
Gene Name:
CYP51A1
Uniprot ID:
Q16850
Reactions
Obtusifoliol + Oxygen + NADPH unknown Delta 8,14 -Sterol + Formic acid + NADP + Waterdetails
Lanosterin + Oxygen + NADPH + Hydrogen Ion unknown 4,4-Dimethylcholesta-8,14,24-trienol + Formic acid + NADP + Waterdetails
Obtusifoliol + Oxygen + NADPH + Hydrogen Ion unknown Delta 8,14 -Sterol + Formic acid + NADP + Waterdetails
Gene Name:
PHYH
Uniprot ID:
O14832
Reactions
Phytanoyl-CoA + Oxoglutaric acid + Oxygen unknown 2-Hydroxyphytanoyl-CoA + Succinic acid + CO(2)details
Gene Name:
TH
Uniprot ID:
P07101
Reactions
L-Tyrosine + L-erythro-tetrahydrobiopterin + Oxygen unknown L-Dopa + 4a-Hydroxytetrahydrobiopterindetails
L-erythro-tetrahydrobiopterin + L-Tyrosine + Oxygen unknown L-Dopa + 4a-Carbinolamine tetrahydrobiopterin + Waterdetails
Gene Name:
PAH
Uniprot ID:
P00439
Reactions
L-Phenylalanine + L-erythro-tetrahydrobiopterin + Oxygen unknown L-Tyrosine + 4a-Hydroxytetrahydrobiopterindetails
L-erythro-tetrahydrobiopterin + L-Phenylalanine + Oxygen unknown 4a-Carbinolamine tetrahydrobiopterin + L-Tyrosine + Waterdetails
Gene Name:
PRDX6
Uniprot ID:
P30041
Reactions
L-Phenylalanine + Oxygen unknown 2-Phenylacetamide + Carbon dioxidedetails
Gene Name:
P4HA2
Uniprot ID:
O15460
Reactions
L-proline-[procollagen] + Oxoglutaric acid + Oxygen unknown trans-4-hydroxy-L-proline-[procollagen] + Succinic acid + CO(2)details
L-Proline + Oxoglutaric acid + Oxygen unknown 4-Hydroxyproline + Succinic acid + Carbon dioxidedetails
Gene Name:
P4HA1
Uniprot ID:
P13674
Reactions
L-proline-[procollagen] + Oxoglutaric acid + Oxygen unknown trans-4-hydroxy-L-proline-[procollagen] + Succinic acid + CO(2)details
L-Proline + Oxoglutaric acid + Oxygen unknown 4-Hydroxyproline + Succinic acid + Carbon dioxidedetails
Gene Name:
SCD
Uniprot ID:
O00767
Reactions
Stearoyl-CoA + ferrocytochrome b5 + Oxygen + Hydrogen Ion unknown Oleoyl-CoA + ferricytochrome b5 + Waterdetails
Gene Name:
BBOX1
Uniprot ID:
O75936
Reactions
4-Trimethylammoniobutanoic acid + Oxoglutaric acid + Oxygen unknown L-Carnitine + Succinic acid + CO(2)details
4-Trimethylammoniobutanoic acid + Oxoglutaric acid + Oxygen unknown L-Carnitine + Succinic acid + Carbon dioxidedetails
Gene Name:
ABP1
Uniprot ID:
P19801
Reactions
Histamine + Water + Oxygen unknown Imidazole-4-acetaldehyde + Ammonia + Hydrogen peroxidedetails
Putrescine + Oxygen + Water unknown 4-Aminobutyraldehyde + Ammonia + Hydrogen peroxidedetails
Tryptamine + Water + Oxygen unknown Indoleacetaldehyde + Ammonia + Hydrogen peroxidedetails
Gene Name:
AOC3
Uniprot ID:
Q16853
Reactions
RCH(2)NH(2) + Water + Oxygen unknown RCHO + Ammonia + Hydrogen peroxidedetails
Tyramine + Water + Oxygen unknown 4-Hydroxyphenylacetaldehyde + Ammonia + Hydrogen peroxidedetails
Aminoacetone + Water + Oxygen unknown Pyruvaldehyde + Ammonia + Hydrogen peroxidedetails
Phenylethylamine + Oxygen + Water unknown Phenylacetaldehyde + Ammonia + Hydrogen peroxidedetails
1,3-Diaminopropane + Oxygen + Water unknown 3-Aminopropionaldehyde + Ammonia + Hydrogen peroxidedetails
N-Methylputrescine + Oxygen + Hydrogen Ion unknown 1-Methylpyrrolinium + Hydrogen peroxide + Ammoniadetails
Dopamine + Water + Oxygen unknown 3,4-Dihydroxyphenylacetaldehyde + Ammonia + Hydrogen peroxidedetails
Methylamine + Oxygen + Water unknown Formaldehyde + Ammonia + Hydrogen peroxidedetails
Cadaverine + Water + Oxygen unknown 5-Aminopentanal + Ammonia + Hydrogen peroxidedetails
Gene Name:
AOC2
Uniprot ID:
O75106
Reactions
RCH(2)NH(2) + Water + Oxygen unknown RCHO + Ammonia + Hydrogen peroxidedetails
Tyramine + Water + Oxygen unknown 4-Hydroxyphenylacetaldehyde + Ammonia + Hydrogen peroxidedetails
Aminoacetone + Water + Oxygen unknown Pyruvaldehyde + Ammonia + Hydrogen peroxidedetails
Phenylethylamine + Oxygen + Water unknown Phenylacetaldehyde + Ammonia + Hydrogen peroxidedetails
1,3-Diaminopropane + Oxygen + Water unknown 3-Aminopropionaldehyde + Ammonia + Hydrogen peroxidedetails
N-Methylputrescine + Oxygen + Hydrogen Ion unknown 1-Methylpyrrolinium + Hydrogen peroxide + Ammoniadetails
Dopamine + Water + Oxygen unknown 3,4-Dihydroxyphenylacetaldehyde + Ammonia + Hydrogen peroxidedetails
Methylamine + Oxygen + Water unknown Formaldehyde + Ammonia + Hydrogen peroxidedetails
Cadaverine + Water + Oxygen unknown 5-Aminopentanal + Ammonia + Hydrogen peroxidedetails
Gene Name:
CYP4A11
Uniprot ID:
Q02928
Reactions
Octane + reduced rubredoxin + Oxygen unknown Octanol + oxidized rubredoxin + Waterdetails
Fatty acid + Oxygen + Reduced flavoprotein unknown Glycolic acid + Oxidized flavoprotein + Waterdetails
Arachidonic acid + Oxygen + NADPH + Hydrogen Ion unknown 20-Hydroxyeicosatetraenoic acid + NADP + Waterdetails
Arachidonic acid + Oxygen + NADPH + Hydrogen Ion unknown 11,12-EpETrE + NADP + Waterdetails
All-trans-retinoic acid + NADPH + Hydrogen Ion + Oxygen unknown all-trans-18-Hydroxyretinoic acid + NADP + Waterdetails
Gene Name:
IDO1
Uniprot ID:
P14902
Reactions
D-Tryptophan + Oxygen unknown N'-Formylkynureninedetails
L-Tryptophan + Oxygen unknown L-Formylkynureninedetails
Oxitriptan + Oxygen unknown 5-Hydroxy-N-formylkynureninedetails
Serotonin + Oxygen unknown Formyl-5-hydroxykynurenaminedetails
Melatonin + Oxygen unknown Acetyl-N-formyl-5-methoxykynurenaminedetails
Gene Name:
CYP11B1
Uniprot ID:
P15538
Reactions
A steroid + reduced adrenal ferredoxin + Oxygen unknown an 11-beta-hydroxysteroid + oxidized adrenal ferredoxin + Waterdetails
Progesterone + Reduced ferredoxin + Oxygen unknown 11b-Hydroxyprogesterone + Oxidized ferredoxin + Waterdetails
Reduced adrenal ferredoxin + Androstenedione + Oxygen unknown 11b-Hydroxyandrost-4-ene-3,17-dione + Oxidized adrenal ferredoxin + Waterdetails
Cortexolone + Reduced ferredoxin + Oxygen unknown Hydrocortisone + Oxidized ferredoxin + Waterdetails
17-Hydroxyprogesterone + Reduced ferredoxin + Oxygen unknown 21-Deoxycortisol + Oxidized ferredoxin + Waterdetails
Deoxycorticosterone + Reduced ferredoxin + Oxygen unknown Corticosterone + Oxidized ferredoxin + Waterdetails
17a,21-Dihydroxypreg-nenolone + Reduced ferredoxin + Oxygen unknown 11b,17a,21-Trihydroxypreg-nenolone + Oxidized ferredoxin + Waterdetails
Deoxycorticosterone + Reduced adrenal ferredoxin + Oxygen unknown Aldosterone + Oxidized adrenal ferredoxin + Waterdetails
Gene Name:
PLOD1
Uniprot ID:
Q02809
Reactions
L-lysine-[procollagen] + Oxoglutaric acid + Oxygen unknown (2S,5R)-5-hydroxy-L-lysine-[procollagen] + Succinic acid + CO(2)details
Protein lysine + Oxoglutaric acid + Oxygen unknown Procollagen 5-hydroxy-L-lysine + Succinic acid + Carbon dioxide + Waterdetails
Gene Name:
PLOD2
Uniprot ID:
O00469
Reactions
L-lysine-[procollagen] + Oxoglutaric acid + Oxygen unknown (2S,5R)-5-hydroxy-L-lysine-[procollagen] + Succinic acid + CO(2)details
Protein lysine + Oxoglutaric acid + Oxygen unknown Procollagen 5-hydroxy-L-lysine + Succinic acid + Carbon dioxide + Waterdetails
Gene Name:
PLOD3
Uniprot ID:
O60568
Reactions
L-lysine-[procollagen] + Oxoglutaric acid + Oxygen unknown (2S,5R)-5-hydroxy-L-lysine-[procollagen] + Succinic acid + CO(2)details
Protein lysine + Oxoglutaric acid + Oxygen unknown Procollagen 5-hydroxy-L-lysine + Succinic acid + Carbon dioxide + Waterdetails
Gene Name:
TPH1
Uniprot ID:
P17752
Reactions
L-Tryptophan + L-erythro-tetrahydrobiopterin + Oxygen unknown Oxitriptan + 4a-Hydroxytetrahydrobiopterindetails
L-erythro-tetrahydrobiopterin + L-Tryptophan + Oxygen unknown Oxitriptan + 4a-Carbinolamine tetrahydrobiopterin + Waterdetails
Gene Name:
FTMT
Uniprot ID:
Q8N4E7
Reactions
Fe2+ + Hydrogen Ion + Oxygen unknown Fe3+ + Waterdetails
Gene Name:
TPH2
Uniprot ID:
Q8IWU9
Reactions
L-Tryptophan + L-erythro-tetrahydrobiopterin + Oxygen unknown Oxitriptan + 4a-Hydroxytetrahydrobiopterindetails
L-erythro-tetrahydrobiopterin + L-Tryptophan + Oxygen unknown Oxitriptan + 4a-Carbinolamine tetrahydrobiopterin + Waterdetails
Gene Name:
CP
Uniprot ID:
P00450
Reactions
Fe2+ + Hydrogen Ion + Oxygen unknown Fe3+ + Waterdetails
Gene Name:
CYP7A1
Uniprot ID:
P22680
Reactions
Cholesterol + NADPH + Oxygen unknown 7a-Hydroxycholesterol + NADP + Waterdetails
Cholesterol + Oxygen + NADPH + Hydrogen Ion unknown 7a-Hydroxycholesterol + NADP + Waterdetails
27-Hydroxycholesterol + NADPH + Hydrogen Ion + Oxygen unknown 7-a,27-Dihydroxycholesterol + NADP + Waterdetails
Dehydroepiandrosterone + Oxygen + NADPH + Hydrogen Ion unknown 7a-Hydroxydehydroepiandrosterone + NADP + Waterdetails
Gene Name:
PNPO
Uniprot ID:
Q9NVS9
Reactions
Pyridoxamine 5'-phosphate + Water + Oxygen unknown Pyridoxal 5'-phosphate + Ammonia + Hydrogen peroxidedetails
Pyridoxine 5'-phosphate + Oxygen unknown Pyridoxal 5'-phosphate + Hydrogen peroxidedetails
Pyridoxamine + Water + Oxygen unknown Pyridoxal + Ammonia + Hydrogen peroxidedetails
Pyridoxine + Oxygen unknown Pyridoxal + Hydrogen peroxidedetails

Only showing the first 50 proteins. There are 203 proteins in total.