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Human Metabolome Database Version 3.5

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Showing metabocard for Oxygen (HMDB01377)

Record Information
Version 3.5
Creation Date 2006-08-16 08:07:20 -0600
Update Date 2013-02-08 11:20:58 -0700
HMDB ID HMDB01377
Secondary Accession Numbers None
Metabolite Identification
Common Name Oxygen
Description Oxygen is the third most abundant element in the universe after hydrogen and helium and the most abundant element by mass in the Earth's crust. Diatomic oxygen gas constitutes 20.9% of the volume of air. All major classes of structural molecules in living organisms, such as proteins, carbohydrates, and fats, contain oxygen, as do the major inorganic compounds that comprise animal shells, teeth, and bone. Oxygen in the form of O2 is produced from water by cyanobacteria, algae and plants during photosynthesis and is used in cellular respiration for all living organisms. Green algae and cyanobacteria in marine environments provide about 70% of the free oxygen produced on earth and the rest is produced by terrestrial plants. Oxygen is used in mitochondria to help generate adenosine triphosphate (ATP) during oxidative phosphorylation. For animals, a constant supply of oxygen is indispensable for cardiac viability and function. To meet this demand, an adult human, at rest, inhales 1.8 to 2.4 grams of oxygen per minute. This amounts to more than 6 billion tonnes of oxygen inhaled by humanity per year. At a resting pulse rate, the heart consumes approximately 8-15 ml O2/min/100 g tissue. This is significantly more than that consumed by the brain (approximately 3 ml O2/min/100 g tissue) and can increase to more than 70 ml O2/min/100 g myocardial tissue during vigorous exercise. As a general rule, mammalian heart muscle cannot produce enough energy under anaerobic conditions to maintain essential cellular processes; thus, a constant supply of oxygen is indispensable to sustain cardiac function and viability. However, the role of oxygen and oxygen-associated processes in living systems is complex, and they and can be either beneficial or contribute to cardiac dysfunction and death (through reactive oxygen species). Reactive oxygen species (ROS) are a family of oxygen-derived free radicals that are produced in mammalian cells under normal and pathologic conditions. Many ROS, such as the superoxide anion (O2-)and hydrogen peroxide (H2O2), act within blood vessels, altering mechanisms mediating mechanical signal transduction and autoregulation of cerebral blood flow. Reactive oxygen species are believed to be involved in cellular signaling in blood vessels in both normal and pathologic states. The major pathway for the production of ROS is by way of the one-electron reduction of molecular oxygen to form an oxygen radical, the superoxide anion (O2-). Within the vasculature there are several enzymatic sources of O2-, including xanthine oxidase, the mitochondrial electron transport chain, and nitric oxide (NO) synthases. Studies in recent years, however, suggest that the major contributor to O2- levels in vascular cells is the membrane-bound enzyme NADPH-oxidase. Produced O2- can react with other radicals, such as NO, or spontaneously dismutate to produce hydrogen peroxide (H2O2). In cells, the latter reaction is an important pathway for normal O2- breakdown and is usually catalyzed by the enzyme superoxide dismutase (SOD). Once formed, H2O2 can undergo various reactions, both enzymatic and nonenzymatic. The antioxidant enzymes catalase and glutathione peroxidase act to limit ROS accumulation within cells by breaking down H2O2 to H2O. Metabolism of H2O2 can also produce other, more damaging ROS. For example, the endogenous enzyme myeloperoxidase uses H2O2 as a substrate to form the highly reactive compound hypochlorous acid. Alternatively, H2O2 can undergo Fenton or Haber-Weiss chemistry, reacting with Fe2+/Fe3+ ions to form toxic hydroxyl radicals (-.OH). (PMID: 17027622 Link_out, 15765131 Link_out).
Structure Thumb
Download: MOL | SDF | SMILES | InChI
Display: 2D Structure | 3D Structure
Synonyms
  1. Dioxygen
  2. Molecular oxygen
  3. O2
  4. Oxygen
  5. Oxygen molecule
Chemical Formula O2
Average Molecular Weight 31.9988
Monoisotopic Molecular Weight 31.989829244
IUPAC Name oxidanone
Traditional IUPAC Name oxygen
CAS Registry Number 7782-44-7
SMILES O=O
InChI Identifier InChI=1S/O2/c1-2
InChI Key MYMOFIZGZYHOMD-UHFFFAOYSA-N
Chemical Taxonomy
Kingdom Inorganic Compounds
Super Class Homogeneous Non-metal Compounds
Class Other Non-metal Organides
Sub Class Other Non-metal Oxides
Other Descriptors
  • a non-metabolic compound(Cyc)
  • dioxygen(ChEBI)
Substituents
  • N/A
Direct Parent Other Non-metal Oxides
Ontology
Status Detected and Quantified
Origin
  • Endogenous
Biofunction
  • Respiration, oxidation, signaling
Application Not Available
Cellular locations
  • Extracellular
  • Mitochondria
  • Nucleus
  • Endoplasmic reticulum
  • Peroxisome
Physical Properties
State Liquid
Experimental Properties
Property Value Reference
Melting Point -218.4 °C Not Available
Boiling Point Not Available Not Available
Water Solubility 37.5 mg/mL at 21 °C Not Available
LogP 0.65 HANSCH,C ET AL. (1995)
Predicted Properties
Property Value Source
LogP -0.28 ChemAxon
Hydrogen Acceptor Count 2 ChemAxon
Hydrogen Donor Count 0 ChemAxon
Polar Surface Area 34.14 A2 ChemAxon
Rotatable Bond Count 0 ChemAxon
Refractivity 2.89 ChemAxon
Polarizability 1.53 ChemAxon
Formal Charge 0 ChemAxon
Physiological Charge 0 ChemAxon
Spectra
Not Available
Biological Properties
Cellular Locations
  • Extracellular
  • Mitochondria
  • Nucleus
  • Endoplasmic reticulum
  • Peroxisome
Biofluid Locations
  • Blood
Tissue Location
  • All Tissues
Pathways
Name SMPDB Link KEGG Link
D-Arginine and D-Ornithine Metabolism SMP00036 map00472 Link_out
Riboflavin Metabolism SMP00070 map00740 Link_out
Phenylalanine and Tyrosine Metabolism SMP00008 map00360 Link_out
Mitochondrial Electron Transport Chain SMP00355 map00190 Link_out
Ethanol Degradation SMP00449 Not Available
Vitamin K Metabolism SMP00464 Not Available
Carnitine Synthesis SMP00465 Not Available
Degradation of Superoxides SMP00468 Not Available
Catecholamine Biosynthesis SMP00012 map00350 Link_out
Plasmalogen Synthesis SMP00479 Not Available
Arachidonic Acid Metabolism SMP00075 map00590 Link_out
Glycine and Serine Metabolism SMP00004 map00260 Link_out
Normal Concentrations
Biofluid Status Value Age Sex Condition Comments
Blood Detected and Quantified
Article_icon
6960.0 +/- 410.0 uM Adult (>18 years old) Both Normal Not Available
Blood Detected and Quantified
Article_icon
5760.0 +/- 580.0 uM Adult (>18 years old) Male Normal Not Available
Blood Detected and Quantified
Article_icon
5490.0 (2780.0-7410.0) uM Newborn (0-30 days old) Both Normal Not Available
Abnormal Concentrations
Not Available
Associated Disorders and Diseases
Disease References None
Associated OMIM IDs None
DrugBank ID Not Available
Phenol Explorer Compound ID Not Available
Phenol Explorer Metabolite ID Not Available
FoodDB ID FDB022589
KNApSAcK ID Not Available
Chemspider ID 952 Link_out
KEGG Compound ID C00007 Link_out
BioCyc ID CPD-6641 Link_out
BiGG ID 33493 Link_out
Wikipedia Link Oxygen Link_out
NuGOwiki Link HMDB01377 Link_out
Metagene Link HMDB01377 Link_out
METLIN ID 3195 Link_out
PubChem Compound 977 Link_out
PDB ID OXY Link_out
ChEBI ID 15379 Link_out
References
Synthesis Reference Wynn, Richard L. Production of hydrogen and oxygen by thermal disassociation of water. U.S. Pat. Appl. Publ. (2007), 26pp.
Material Safety Data Sheet (MSDS) Download (PDF)
General References
  1. Carrier M, Denault A, Lavoie J, Perrault LP: Randomized controlled trial of pericardial blood processing with a cell-saving device on neurologic markers in elderly patients undergoing coronary artery bypass graft surgery. Ann Thorac Surg. 2006 Jul;82(1):51-5. Pubmed: 16798186 Link_out
  2. Valadka AB, Furuya Y, Hlatky R, Robertson CS: Global and regional techniques for monitoring cerebral oxidative metabolism after severe traumatic brain injury. Neurosurg Focus. 2000 Nov 15;9(5):e3. Pubmed: 16821755 Link_out
  3. Armonda RA, Vo AH, Bell R, Neal C, Campbell WW: Multimodal monitoring during emergency hemicraniectomy for vein of Labbe thrombosis. Neurocrit Care. 2006;4(3):241-4. Pubmed: 16757831 Link_out
  4. Sassaroli A, deB Frederick B, Tong Y, Renshaw PF, Fantini S: Spatially weighted BOLD signal for comparison of functional magnetic resonance imaging and near-infrared imaging of the brain. Neuroimage. 2006 Nov 1;33(2):505-14. Epub 2006 Aug 30. Pubmed: 16945553 Link_out
  5. Zhang YT, Geng ZJ, Zhang Q, Li W, Zhang J: Auditory cortical responses evoked by pure tones in healthy and sensorineural hearing loss subjects: functional MRI and magnetoencephalography. Chin Med J (Engl). 2006 Sep 20;119(18):1548-54. Pubmed: 16996009 Link_out
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  8. Weaver LK, Howe S, Hopkins R, Chan KJ: Carboxyhemoglobin half-life in carbon monoxide-poisoned patients treated with 100% oxygen at atmospheric pressure. Chest. 2000 Mar;117(3):801-8. Pubmed: 10713010 Link_out
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  11. Kotecha S, Allen J: Oxygen therapy for infants with chronic lung disease. Arch Dis Child Fetal Neonatal Ed. 2002 Jul;87(1):F11-4. Pubmed: 12091281 Link_out
  12. Van Heerebeek L, Meischl C, Stooker W, Meijer CJ, Niessen HW, Roos D: NADPH oxidase(s): new source(s) of reactive oxygen species in the vascular system? J Clin Pathol. 2002 Aug;55(8):561-8. Pubmed: 12147646 Link_out
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  32. Glazier JJ: Attenuation of reperfusion microvascular ischemia by aqueous oxygen: experimental and clinical observations. Am Heart J. 2005 Apr;149(4):580-4. Pubmed: 15990737 Link_out
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  34. Bennett M, Kertesz T, Yeung P: Hyperbaric oxygen therapy for idiopathic sudden sensorineural hearing loss and tinnitus: a systematic review of randomized controlled trials. J Laryngol Otol. 2005 Oct;119(10):791-8. Pubmed: 16259656 Link_out
  35. Levy MM: Pathophysiology of oxygen delivery in respiratory failure. Chest. 2005 Nov;128(5 Suppl 2):547S-553S. Pubmed: 16306052 Link_out
  36. Huang YC: Monitoring oxygen delivery in the critically ill. Chest. 2005 Nov;128(5 Suppl 2):554S-560S. Pubmed: 16306053 Link_out
  37. Liu Z, Xiong T, Meads C: Clinical effectiveness of treatment with hyperbaric oxygen for neonatal hypoxic-ischaemic encephalopathy: systematic review of Chinese literature. BMJ. 2006 Aug 19;333(7564):374. Epub 2006 May 11. Pubmed: 16690641 Link_out
  38. Friedman HI, Fitzmaurice M, Lefaivre JF, Vecchiolla T, Clarke D: An evidence-based appraisal of the use of hyperbaric oxygen on flaps and grafts. Plast Reconstr Surg. 2006 Jun;117(7 Suppl):175S-190S; discussion 191S-192S. Pubmed: 16799386 Link_out
  39. Terashvili M, Pratt PF, Gebremedhin D, Narayanan J, Harder DR: Reactive oxygen species cerebral autoregulation in health and disease. Pediatr Clin North Am. 2006 Oct;53(5):1029-37, xi. Pubmed: 17027622 Link_out
  40. Colebourn CL, Barber V, Young JD: Use of helium-oxygen mixture in adult patients presenting with exacerbations of asthma and chronic obstructive pulmonary disease: a systematic review. Anaesthesia. 2007 Jan;62(1):34-42. Pubmed: 17156225 Link_out
  41. Bradley JM, Lasserson T, Elborn S, Macmahon J, O'neill B: A systematic review of randomized controlled trials examining the short-term benefit of ambulatory oxygen in COPD. Chest. 2007 Jan;131(1):278-85. Pubmed: 17218587 Link_out
  42. Tin W, Gupta S: Optimum oxygen therapy in preterm babies. Arch Dis Child Fetal Neonatal Ed. 2007 Mar;92(2):F143-7. Pubmed: 17337663 Link_out
  43. Higgins RD, Bancalari E, Willinger M, Raju TN: Executive summary of the workshop on oxygen in neonatal therapies: controversies and opportunities for research. Pediatrics. 2007 Apr;119(4):790-6. Pubmed: 17403851 Link_out
  44. Ness PM, Cushing MM: Oxygen therapeutics: pursuit of an alternative to the donor red blood cell. Arch Pathol Lab Med. 2007 May;131(5):734-41. Pubmed: 17488158 Link_out
  45. Shelley KH: Photoplethysmography: beyond the calculation of arterial oxygen saturation and heart rate. Anesth Analg. 2007 Dec;105(6 Suppl):S31-6, tables of contents. Pubmed: 18048895 Link_out
  46. Claure N: Automated regulation of inspired oxygen in preterm infants: oxygenation stability and clinician workload. Anesth Analg. 2007 Dec;105(6 Suppl):S37-41. Pubmed: 18048896 Link_out
  47. Toffaletti J, Zijlstra WG: Misconceptions in reporting oxygen saturation. Anesth Analg. 2007 Dec;105(6 Suppl):S5-9. Pubmed: 18048899 Link_out
  48. Ferrari R, Ceconi C, Curello S, Cargnoni A, Pasini E, De Giuli F, Albertini A: Role of oxygen free radicals in ischemic and reperfused myocardium. Am J Clin Nutr. 1991 Jan;53(1 Suppl):215S-222S. Pubmed: 1845919 Link_out
  49. Kindwall EP, Gottlieb LJ, Larson DL: Hyperbaric oxygen therapy in plastic surgery: a review article. Plast Reconstr Surg. 1991 Nov;88(5):898-908. Pubmed: 1924583 Link_out
  50. Cain SM, Curtis SE: Experimental models of pathologic oxygen supply dependency. Crit Care Med. 1991 May;19(5):603-12. Pubmed: 2026022 Link_out
  51. Weg JG: Oxygen transport in adult respiratory distress syndrome and other acute circulatory problems: relationship of oxygen delivery and oxygen consumption. Crit Care Med. 1991 May;19(5):650-7. Pubmed: 2026027 Link_out
  52. Edwards JD: Oxygen transport in cardiogenic and septic shock. Crit Care Med. 1991 May;19(5):658-63. Pubmed: 2026028 Link_out
  53. Tuchschmidt J, Oblitas D, Fried JC: Oxygen consumption in sepsis and septic shock. Crit Care Med. 1991 May;19(5):664-71. Pubmed: 2026029 Link_out
  54. Reilly PM, Schiller HJ, Bulkley GB: Pharmacologic approach to tissue injury mediated by free radicals and other reactive oxygen metabolites. Am J Surg. 1991 Apr;161(4):488-503. Pubmed: 2035771 Link_out
  55. Burton GG, Wagshul FA, Henderson D, Kime SW: Fatal airway obstruction caused by a mucous ball from a transtracheal oxygen catheter. Chest. 1991 Jun;99(6):1520-3. Pubmed: 2036843 Link_out
  56. McCord JM, Fridovich I: The biology and pathology of oxygen radicals. Ann Intern Med. 1978 Jul;89(1):122-7. Pubmed: 208444 Link_out
  57. Ardehali A, Ports TA: Myocardial oxygen supply and demand. Chest. 1990 Sep;98(3):699-705. Pubmed: 2203620 Link_out
  58. Edwards JD: Practical application of oxygen transport principles. Crit Care Med. 1990 Jan;18(1 Pt 2):S45-8. Pubmed: 2403513 Link_out
  59. Kloner RA, Przyklenk K, Whittaker P: Deleterious effects of oxygen radicals in ischemia/reperfusion. Resolved and unresolved issues. Circulation. 1989 Nov;80(5):1115-27. Pubmed: 2553296 Link_out
  60. Dart RC, Sanders AB: Oxygen free radicals and myocardial reperfusion injury. Ann Emerg Med. 1988 Jan;17(1):53-8. Pubmed: 3276245 Link_out
  61. Cross CE, Halliwell B, Borish ET, Pryor WA, Ames BN, Saul RL, McCord JM, Harman D: Oxygen radicals and human disease. Ann Intern Med. 1987 Oct;107(4):526-45. Pubmed: 3307585 Link_out
  62. Gabb G, Robin ED: Hyperbaric oxygen. A therapy in search of diseases. Chest. 1987 Dec;92(6):1074-82. Pubmed: 3315479 Link_out
  63. Jackson RM: Pulmonary oxygen toxicity. Chest. 1985 Dec;88(6):900-5. Pubmed: 3905287 Link_out
  64. Vik-Mo H, Mjos OD: Influence of free fatty acids on myocardial oxygen consumption and ischemic injury. Am J Cardiol. 1981 Aug;48(2):361-5. Pubmed: 6115579 Link_out
  65. Klebanoff SJ: Oxygen metabolism and the toxic properties of phagocytes. Ann Intern Med. 1980 Sep;93(3):480-9. Pubmed: 6254418 Link_out
  66. Tinits P: Oxygen therapy and oxygen toxicity. Ann Emerg Med. 1983 May;12(5):321-8. Pubmed: 6414343 Link_out
  67. Lucey JF, Dangman B: A reexamination of the role of oxygen in retrolental fibroplasia. Pediatrics. 1984 Jan;73(1):82-96. Pubmed: 6419199 Link_out
  68. Riley DJ, Berg RA, Edelman NH, Prockop DJ: Prevention of collagen deposition following pulmonary oxygen toxicity in the rat by cis-4-hydroxy-L-proline. J Clin Invest. 1980 Mar;65(3):643-51. Pubmed: 6986411 Link_out
  69. DeVenuto F: Hemoglobin solutions as oxygen-delivering resuscitation fluids. Crit Care Med. 1982 Apr;10(4):238-45. Pubmed: 7039970 Link_out
  70. Vlessis AA, Goldman RK, Trunkey DD: New concepts in the pathophysiology of oxygen metabolism during sepsis. Br J Surg. 1995 Jul;82(7):870-6. Pubmed: 7648095 Link_out
  71. Seger D, Welch L: Carbon monoxide controversies: neuropsychologic testing, mechanism of toxicity, and hyperbaric oxygen. Ann Emerg Med. 1994 Aug;24(2):242-8. Pubmed: 8037390 Link_out
  72. Frei B: Reactive oxygen species and antioxidant vitamins: mechanisms of action. Am J Med. 1994 Sep 26;97(3A):5S-13S; discussion 22S-28S. Pubmed: 8085584 Link_out
  73. Jeroudi MO, Hartley CJ, Bolli R: Myocardial reperfusion injury: role of oxygen radicals and potential therapy with antioxidants. Am J Cardiol. 1994 Mar 10;73(6):2B-7B. Pubmed: 8141076 Link_out
  74. Spahn DR, Leone BJ, Reves JG, Pasch T: Cardiovascular and coronary physiology of acute isovolemic hemodilution: a review of nonoxygen-carrying and oxygen-carrying solutions. Anesth Analg. 1994 May;78(5):1000-21. Pubmed: 8160966 Link_out
  75. Helfman T, Falanga V: Gene expression in low oxygen tension. Am J Med Sci. 1993 Jul;306(1):37-41. Pubmed: 8328508 Link_out
  76. Rudge FW: Carbon monoxide poisoning in infants: treatment with hyperbaric oxygen. South Med J. 1993 Mar;86(3):334-7. Pubmed: 8451675 Link_out
  77. Ackerman WE 3rd, Molnar JM, Juneja MM: Beneficial effect of epidural anesthesia on oxygen consumption in a parturient with adult respiratory distress syndrome. South Med J. 1993 Mar;86(3):361-4. Pubmed: 8451680 Link_out
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  79. Heyland DK, Cook DJ, King D, Kernerman P, Brun-Buisson C: Maximizing oxygen delivery in critically ill patients: a methodologic appraisal of the evidence. Crit Care Med. 1996 Mar;24(3):517-24. Pubmed: 8625644 Link_out
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  81. O'Donohue WJ Jr: Home oxygen therapy. Med Clin North Am. 1996 May;80(3):611-22. Pubmed: 8637306 Link_out
  82. Cornwell EE 3rd, Kennedy F, Rodriguez J: The critical care of the severely injured patient--I. Assessing and improving oxygen delivery. Surg Clin North Am. 1996 Aug;76(4):959-69. Pubmed: 8782482 Link_out
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  84. Dean E: Oxygen transport deficits in systemic disease and implications for physical therapy. Phys Ther. 1997 Feb;77(2):187-202. Pubmed: 9037219 Link_out
  85. Feuerstein G, Yue TL, Ma X, Ruffolo RR: Novel mechanisms in the treatment of heart failure: inhibition of oxygen radicals and apoptosis by carvedilol. Prog Cardiovasc Dis. 1998 Jul-Aug;41(1 Suppl 1):17-24. Pubmed: 9715819 Link_out
  86. Naito Y, Yoshikawa T, Yoshida N, Kondo M: Role of oxygen radical and lipid peroxidation in indomethacin-induced gastric mucosal injury. Dig Dis Sci. 1998 Sep;43(9 Suppl):30S-34S. Pubmed: 9753223 Link_out
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Enzymes
Name: Tyrosinase
Reactions:
  • L-tyrosine + L-dopa + O2 = L-dopa + dopaquinone + H2O [RN:R02078]
Gene Name: TYR
Uniprot ID: P14679 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Peroxisomal sarcosine oxidase
Reactions:
  • L-pipecolate + O2 = 2,3,4,5-tetrahydropyridine-2-carboxylate + H2O2 [RN:R02204]
Gene Name: PIPOX
Uniprot ID: Q9P0Z9 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Peroxisomal N(1)-acetyl-spermine/spermidine oxidase
Reactions:
  • (1) N1-acetylspermidine + O2 + H2O = putrescine + 3-acetamidopropanal + H2O2 [RN:R09074]
  • (2) N1-acetylspermine + O2 + H2O = spermidine + 3-acetamidopropanal + H2O2 [RN:R03899]
Gene Name: PAOX
Uniprot ID: Q6QHF9 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Aldehyde oxidase
Reactions:
  • an aldehyde + H2O + O2 = a carboxylic acid + H2O2 [RN:R00635]
Gene Name: AOX1
Uniprot ID: Q06278 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Lathosterol oxidase
Reactions:
  • 5alpha-cholest-7-en-3beta-ol + NAD(P)H + H+ + O2 = cholesta-5,7-dien-3beta-ol + NAD(P)+ + 2 H2O [RN:R03310 R07215]
Gene Name: SC5DL
Uniprot ID: O75845 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Dimethylaniline monooxygenase [N-oxide-forming] 5
Reactions:
  • N,N-dimethylaniline + NADPH + H+ + O2 = N,N-dimethylaniline N-oxide + NADP+ + H2O [RN:R03344]
Gene Name: FMO5
Uniprot ID: P49326 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Peroxisomal acyl-coenzyme A oxidase 1
Reactions:
  • acyl-CoA + O2 = trans-2,3-dehydroacyl-CoA + H2O2 [RN:R00388]
Gene Name: ACOX1
Uniprot ID: Q15067 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: D-aspartate oxidase
Reactions:
  • D-aspartate + H2O + O2 = oxaloacetate + NH3 + H2O2 [RN:R00359]
Gene Name: DDO
Uniprot ID: Q99489 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Heme oxygenase 2
Reactions:
  • heme + 3 AH2 + 3 O2 = biliverdin + Fe2+ + CO + 3 A + 3 H2O [RN:R00311]
Gene Name: HMOX2
Uniprot ID: P30519 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Dimethylaniline monooxygenase [N-oxide-forming] 2
Reactions:
  • N,N-dimethylaniline + NADPH + H+ + O2 = N,N-dimethylaniline N-oxide + NADP+ + H2O [RN:R03344]
Gene Name: FMO2
Uniprot ID: Q99518 Link_out
Protein Sequence: FASTA
Name: Amine oxidase [flavin-containing] B
Reactions:
  • RCH2NHR' + H2O + O2 = RCHO + R'NH2 + H2O2 [RN:R01853]
Gene Name: MAOB
Uniprot ID: P27338 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Dimethylaniline monooxygenase [N-oxide-forming] 4
Reactions:
  • N,N-dimethylaniline + NADPH + H+ + O2 = N,N-dimethylaniline N-oxide + NADP+ + H2O [RN:R03344]
Gene Name: FMO4
Uniprot ID: P31512 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Amine oxidase [flavin-containing] A
Reactions:
  • RCH2NHR' + H2O + O2 = RCHO + R'NH2 + H2O2 [RN:R01853]
Gene Name: MAOA
Uniprot ID: P21397 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Dimethylaniline monooxygenase [N-oxide-forming] 3
Reactions:
  • N,N-dimethylaniline + NADPH + H+ + O2 = N,N-dimethylaniline N-oxide + NADP+ + H2O [RN:R03344]
Gene Name: FMO3
Uniprot ID: P31513 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Xanthine dehydrogenase/oxidase
Reactions:
  • xanthine + H2O + O2 = urate + H2O2 [RN:R02107]
Gene Name: XDH
Uniprot ID: P47989 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Dihydroorotate dehydrogenase, mitochondrial
Reactions:
  • (S)-dihydroorotate + a quinone = orotate + a quinol [RN:R01868]
Gene Name: DHODH
Uniprot ID: Q02127 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Peroxisomal acyl-coenzyme A oxidase 3
Reactions:
  • acyl-CoA + O2 = trans-2,3-dehydroacyl-CoA + H2O2 [RN:R00388]
Gene Name: ACOX3
Uniprot ID: O15254 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Heme oxygenase 1
Reactions:
  • heme + 3 AH2 + 3 O2 = biliverdin + Fe2+ + CO + 3 A + 3 H2O [RN:R00311]
Gene Name: HMOX1
Uniprot ID: P09601 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: D-amino-acid oxidase
Reactions:
  • a D-amino acid + H2O + O2 = a 2-oxo acid + NH3 + H2O2 [RN:R01340]
Gene Name: DAO
Uniprot ID: P14920 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Coproporphyrinogen-III oxidase, mitochondrial
Reactions:
  • coproporphyrinogen III + O2 + 2 H+ = protoporphyrinogen-IX + 2 CO2 + 2 H2O [RN:R03220]
Gene Name: CPOX
Uniprot ID: P36551 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Peptidyl-glycine alpha-amidating monooxygenase
Reactions:
  • peptidylamidoglycolate = peptidyl amide + glyoxylate [RN:R03874]
Gene Name: PAM
Uniprot ID: P19021 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Dopamine beta-hydroxylase
Reactions:
  • 3,4-dihydroxyphenethylamine + ascorbate + O2 = noradrenaline + dehydroascorbate + H2O [RN:R02535]
Gene Name: DBH
Uniprot ID: P09172 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: C-4 methylsterol oxidase
Reactions:
  • (1) (1a) 4,4-dimethyl-5alpha-cholest-7-en-3beta-ol + NAD(P)H + H+ + O2 = 4beta-hydroxymethyl-4alpha-methyl-5alpha-cholest-7-en-3beta-ol + NAD(P)+ + H2O [RN:R04501 R05736]
  • (2) (1b) 4beta-hydroxymethyl-4alpha-methyl-5alpha-cholest-7-en-3beta-ol + NAD(P)H + H+ + O2 = 3beta-hydroxy-4beta-methyl-5alpha-cholest-7-ene-4alpha-carbaldehyde + NAD(P)+ + 2 H2O [RN:R05733 R05737]
  • (3) (1c) 3beta-hydroxy-4beta-methyl-5alpha-cholest-7-ene-4alpha-carbaldehyde + NAD(P)H + H+ + O2 = 3beta-hydroxy-4beta-methyl-5alpha-cholest-7-ene-4alpha-carboxylate + NAD(P)+ + H2O [RN:R05734 R05738]
Gene Name: SC4MOL
Uniprot ID: Q15800 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating
Reactions:
  • 3beta-hydroxy-4beta-methyl-5alpha-cholest-7-ene-4alpha-carboxylate + NAD(P)+ = 4alpha-methyl-5alpha-cholest-7-en-3-one + CO2 + NAD(P)H [RN:R04483 R07149]
Gene Name: NSDHL
Uniprot ID: Q15738 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Lanosterol 14-alpha demethylase
Reactions:
  • obtusifoliol + 3 O2 + 3 NADPH + 3 H+ = 4alpha-methyl-5alpha-ergosta-8,14,24(28)-trien-3beta-ol + formate + 3 NADP+ + 4 H2O [RN:R05731]
Gene Name: CYP51A1
Uniprot ID: Q16850 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Phytanoyl-CoA dioxygenase, peroxisomal
Reactions:
  • phytanoyl-CoA + 2-oxoglutarate + O2 = 2-hydroxyphytanoyl-CoA + succinate + CO2 [RN:R05722]
Gene Name: PHYH
Uniprot ID: O14832 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Tyrosine 3-monooxygenase
Reactions:
  • L-tyrosine + tetrahydrobiopterin + O2 = 3,4-dihydroxy-L-phenylalanine + 4a-hydroxytetrahydrobiopterin [RN:R07212]
Gene Name: TH
Uniprot ID: P07101 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Phenylalanine-4-hydroxylase
Reactions:
  • L-phenylalanine + tetrahydrobiopterin + O2 = L-tyrosine + 4a-hydroxytetrahydrobiopterin [RN:R07211]
Gene Name: PAH
Uniprot ID: P00439 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Prolyl 4-hydroxylase subunit alpha-2
Reactions:
  • procollagen L-proline + 2-oxoglutarate + O2 = procollagen trans-4-hydroxy-L-proline + succinate + CO2 [RN:R03219]
Gene Name: P4HA2
Uniprot ID: O15460 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Prolyl 4-hydroxylase subunit alpha-1
Reactions:
  • procollagen L-proline + 2-oxoglutarate + O2 = procollagen trans-4-hydroxy-L-proline + succinate + CO2 [RN:R03219]
Gene Name: P4HA1
Uniprot ID: P13674 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Acyl-CoA desaturase
Reactions:
  • stearoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+ = oleoyl-CoA + 2 ferricytochrome b5 + 2 H2O [RN:R02222]
Gene Name: SCD
Uniprot ID: O00767 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Gamma-butyrobetaine dioxygenase
Reactions:
  • 4-trimethylammoniobutanoate + 2-oxoglutarate + O2 = 3-hydroxy-4-trimethylammoniobutanoate + succinate + CO2 [RN:R02397]
Gene Name: BBOX1
Uniprot ID: O75936 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Amiloride-sensitive amine oxidase [copper-containing]
Reactions:
  • histamine + H2O + O2 = (imidazol-4-yl)acetaldehyde + NH3 + H2O2 [RN:R02150]
Gene Name: ABP1
Uniprot ID: P19801 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Membrane primary amine oxidase
Reactions:
  • RCH2NH2 + H2O + O2 = RCHO + NH3 + H2O2 [RN:R01853]
Gene Name: AOC3
Uniprot ID: Q16853 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Retina-specific copper amine oxidase
Reactions:
  • RCH2NH2 + H2O + O2 = RCHO + NH3 + H2O2 [RN:R01853]
Gene Name: AOC2
Uniprot ID: O75106 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Cytochrome P450 4A11
Reactions:
  • octane + reduced rubredoxin + O2 = 1-octanol + oxidized rubredoxin + H2O [RN:R02879]
Gene Name: CYP4A11
Uniprot ID: Q02928 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Indoleamine 2,3-dioxygenase 1
Reactions:
  • (1) D-tryptophan + O2 = N-formyl-D-kynurenine [RN:R07362]
  • (2) L-tryptophan + O2 = N-formyl-L-kynurenine [RN:R00678]
Gene Name: IDO1
Uniprot ID: P14902 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Cytochrome P450 11B1, mitochondrial
Reactions:
  • a steroid + reduced adrenal ferredoxin + O2 = an 11beta-hydroxysteroid + oxidized adrenal ferredoxin + H2O [RN:R02726]
Gene Name: CYP11B1
Uniprot ID: P15538 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1
Reactions:
  • L-lysine-[procollagen] + 2-oxoglutarate + O2 = (2S,5R)- 5-hydroxy-L-lysine-[procollagen] + succinate + CO2
Gene Name: PLOD1
Uniprot ID: Q02809 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2
Reactions:
  • L-lysine-[procollagen] + 2-oxoglutarate + O2 = (2S,5R)- 5-hydroxy-L-lysine-[procollagen] + succinate + CO2
Gene Name: PLOD2
Uniprot ID: O00469 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3
Reactions:
  • L-lysine-[procollagen] + 2-oxoglutarate + O2 = (2S,5R)- 5-hydroxy-L-lysine-[procollagen] + succinate + CO2
Gene Name: PLOD3
Uniprot ID: O60568 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Tryptophan 5-hydroxylase 1
Reactions:
  • L-tryptophan + tetrahydrobiopterin + O2 = 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin [RN:R07213]
Gene Name: TPH1
Uniprot ID: P17752 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Ferritin, mitochondrial
Reactions:
  • 4 Fe(II) + 4 H+ + O2 = 4 Fe(III) + 2 H2O [RN:R00078]
Gene Name: FTMT
Uniprot ID: Q8N4E7 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Tryptophan 5-hydroxylase 2
Reactions:
  • L-tryptophan + tetrahydrobiopterin + O2 = 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin [RN:R07213]
Gene Name: TPH2
Uniprot ID: Q8IWU9 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Cholesterol 7-alpha-monooxygenase
Reactions:
  • cholesterol + NADPH + H+ + O2 = 7alpha-hydroxycholesterol + NADP+ + H2O [RN:R01463]
Gene Name: CYP7A1
Uniprot ID: P22680 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Pyridoxine-5'-phosphate oxidase
Reactions:
  • (1) pyridoxamine 5'-phosphate + H2O + O2 = pyridoxal 5'-phosphate + NH3 + H2O2 [RN:R00277]
  • (2) pyridoxine 5'-phosphate + O2 = pyridoxal 5'-phosphate + H2O2 [RN:R00278]
Gene Name: PNPO
Uniprot ID: Q9NVS9 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Protein-lysine 6-oxidase
Reactions:
  • peptidyl-L-lysyl-peptide + O2 + H2O = peptidyl-allysyl-peptide + NH3 + H2O2 [RN:R04239]
Gene Name: LOX
Uniprot ID: P28300 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Cholesterol side-chain cleavage enzyme, mitochondrial
Reactions:
  • cholesterol + reduced adrenal ferredoxin + O2 = pregnenolone + 4-methylpentanal + oxidized adrenal ferredoxin + H2O [RN:R02724]
Gene Name: CYP11A1
Uniprot ID: P05108 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Hydroxyacid oxidase 2
Reactions:
  • an (S)-2-hydroxy acid + O2 = a 2-oxo acid + H2O2 [RN:R01341]
Gene Name: HAO2
Uniprot ID: Q9NYQ3 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Inositol oxygenase
Reactions:
  • myo-inositol + O2 = D-glucuronate + H2O [RN:R01184]
Gene Name: MIOX
Uniprot ID: Q9UGB7 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: 4-hydroxyphenylpyruvate dioxygenase
Reactions:
  • 4-hydroxyphenylpyruvate + O2 = homogentisate + CO2 [RN:R02521]
Gene Name: HPD
Uniprot ID: P32754 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Homogentisate 1,2-dioxygenase
Reactions:
  • homogentisate + O2 = 4-maleylacetoacetate [RN:R02519]
Gene Name: HGD
Uniprot ID: Q93099 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: 3-keto-steroid reductase
Reactions:
  • 4alpha-methyl-5alpha-cholest-7-en-3beta-ol + NADP+ = 4alpha-methyl-5alpha-cholest-7-en-3-one + NADPH + H+ [RN:R05691]
Gene Name: HSD17B7
Uniprot ID: P56937 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Nitric oxide synthase, inducible
Reactions:
  • L-arginine + n NADPH + n H+ + m O2 = citrulline + nitric oxide + n NADP+ [RN:R00557]
Gene Name: NOS2
Uniprot ID: P35228 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Cysteine dioxygenase type 1
Reactions:
  • L-cysteine + O2 = 3-sulfinoalanine [RN:R00893]
Gene Name: CDO1
Uniprot ID: Q16878 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Arachidonate 5-lipoxygenase
Reactions:
  • (1) arachidonate + O2 = (5S,6S,7E,9E,11Z,14Z)-5,6-epoxyicosa-7,9,11,14-tetraenoate + H2O (overall reaction) [RN:R08527]
  • (2) (1a) arachidonate + O2 = (5S,6E,8Z,11Z,14Z)-5-hydroperoxyicosa-6,8,11,14-tetraenoate [RN:R01595]
  • (3) (1b) (5S,6E,8Z,11Z,14Z)-5-hydroperoxyicosa-6,8,11,14-tetraenoate = (5S,6S,7E,9E,11Z,14Z)-5,6-epoxyicosa-7,9,11,14-tetraenoate + H2O [RN:R03058]
Gene Name: ALOX5
Uniprot ID: P09917 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Arachidonate 15-lipoxygenase B
Reactions:
  • arachidonate + O2 = (5Z,8Z,11Z,13E)-(15S)-15-hydroperoxyicosa-5,8,11,13-tetraenoate [RN:R01593]
Gene Name: ALOX15B
Uniprot ID: O15296 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Arachidonate 12-lipoxygenase, 12S-type
Reactions:
  • arachidonate + O2 = (5Z,8Z,10E,14Z)-(12S)-12-hydroperoxyicosa-5,8,10,14-tetraenoate [RN:R01596]
Gene Name: ALOX12
Uniprot ID: P18054 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Prostaglandin G/H synthase 2
Reactions:
  • arachidonate + AH2 + 2 O2 = prostaglandin H2 + A + H2O [RN:R01599]
Gene Name: PTGS2
Uniprot ID: P35354 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Prostaglandin G/H synthase 1
Reactions:
  • arachidonate + AH2 + 2 O2 = prostaglandin H2 + A + H2O [RN:R01599]
Gene Name: PTGS1
Uniprot ID: P23219 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Arachidonate 15-lipoxygenase
Reactions:
  • arachidonate + O2 = (5Z,8Z,11Z,13E)-(15S)-15-hydroperoxyicosa-5,8,11,13-tetraenoate [RN:R01593]
Gene Name: ALOX15
Uniprot ID: P16050 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Leukotriene-B(4) omega-hydroxylase 1
Reactions:
  • (6Z,8E,10E,14Z)-(5S,12R)-5,12-dihydroxyicosa-6,8,10,14-tetraenoate + NADPH + H+ + O2 = (6Z,8E,10E,14Z)-(5S,12R)-5,12,20-trihydroxyicosa-6,8,10,14- tetraenoate + NADP+ + H2O [RN:R03866]
Gene Name: CYP4F2
Uniprot ID: P78329 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Leukotriene-B(4) omega-hydroxylase 2
Reactions:
  • (6Z,8E,10E,14Z)-(5S,12R)-5,12-dihydroxyicosa-6,8,10,14-tetraenoate + NADPH + H+ + O2 = (6Z,8E,10E,14Z)-(5S,12R)-5,12,20-trihydroxyicosa-6,8,10,14- tetraenoate + NADP+ + H2O [RN:R03866]
Gene Name: CYP4F3
Uniprot ID: Q08477 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Cytochrome P450 3A4
Reactions:
  • (1) taurochenodeoxycholate + NADPH + H+ + O2 = taurohyocholate + NADP+ + H2O [RN:R07205]
  • (2) lithocholate + NADPH + H+ + O2 = hyodeoxycholate + NADP+ + H2O [RN:R07206]
Gene Name: CYP3A4
Uniprot ID: P08684 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Protoporphyrinogen oxidase
Reactions:
  • protoporphyrinogen IX + 3 O2 = protoporphyrin IX + 3 H2O2 [RN:R03222]
Gene Name: PPOX
Uniprot ID: P50336 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Aspartyl/asparaginyl beta-hydroxylase
Reactions:
  • peptide-L-aspartate + 2-oxoglutarate + O2 = peptide-3-hydroxy-L-aspartate + succinate + CO2 [RN:R04073]
Gene Name: ASPH
Uniprot ID: Q12797 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Hypoxia-inducible factor 1-alpha inhibitor
Reactions:
  • peptide-L-aspartate + 2-oxoglutarate + O2 = peptide-3-hydroxy-L-aspartate + succinate + CO2 [RN:R04073]
Gene Name: HIF1AN
Uniprot ID: Q9NWT6 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Cytochrome P450 2C9
Reactions:
  • (R)-limonene + NADPH + H+ + O2 = (+)-trans-carveol + NADP+ + H2O [RN:R06119]
Gene Name: CYP2C9
Uniprot ID: P11712 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Sterol 26-hydroxylase, mitochondrial
Reactions:
  • 5beta-cholestane-3alpha,7alpha,12alpha-triol + NADPH + H+ + O2 = (25R)-5beta-cholestane-3alpha,7alpha,12alpha,26-tetraol + NADP+ + H2O [RN:R04807]
Gene Name: CYP27A1
Uniprot ID: Q02318 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Cytochrome P450 2C19
Reactions:
  • (R)-limonene + NADPH + H+ + O2 = (+)-trans-carveol + NADP+ + H2O [RN:R06119]
Gene Name: CYP2C19
Uniprot ID: P33261 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial
Reactions:
  • calcidiol + NADPH + H+ + O2 = calcitriol + NADP+ + H2O [RN:R03610]
Gene Name: CYP27B1
Uniprot ID: O15528 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Steroid 17-alpha-hydroxylase/17,20 lyase
Reactions:
  • a steroid + AH2 + O2 = a 17alpha-hydroxysteroid + A + H2O [RN:R02131]
Gene Name: CYP17A1
Uniprot ID: P05093 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Sulfite oxidase, mitochondrial
Reactions:
  • sulfite + O2 + H2O = sulfate + H2O2 [RN:R00533]
Gene Name: SUOX
Uniprot ID: P51687 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: 3-hydroxyanthranilate 3,4-dioxygenase
Reactions:
  • 3-hydroxyanthranilate + O2 = 2-amino-3-carboxymuconate semialdehyde [RN:R02665]
Gene Name: HAAO
Uniprot ID: P46952 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Cytochrome P450 2E1
Reactions:
  • --- []
Gene Name: CYP2E1
Uniprot ID: P05181 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Cytochrome P450 3A43
Reactions:
  • RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O [RN:R04122]
Gene Name: CYP3A43
Uniprot ID: Q9HB55 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Cytochrome P450 1B1
Reactions:
  • RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O [RN:R04122]
Gene Name: CYP1B1
Uniprot ID: Q16678 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Cytochrome P450 2C18
Reactions:
  • RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O [RN:R04122]
Gene Name: CYP2C18
Uniprot ID: P33260 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Cytochrome P450 2F1
Reactions:
  • RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O [RN:R04122]
Gene Name: CYP2F1
Uniprot ID: P24903 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Cytochrome P450 4X1
Reactions:
  • RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O [RN:R04122]
Gene Name: CYP4X1
Uniprot ID: Q8N118 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Cytochrome P450 2B6
Reactions:
  • RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O [RN:R04122]
Gene Name: CYP2B6
Uniprot ID: P20813 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Cytochrome P450 3A5
Reactions:
  • RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O [RN:R04122]
Gene Name: CYP3A5
Uniprot ID: P20815 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Cytochrome P450 2A13
Reactions:
  • RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O [RN:R04122]
Gene Name: CYP2A13
Uniprot ID: Q16696 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Cytochrome P450 3A7
Reactions:
  • RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O [RN:R04122]
Gene Name: CYP3A7
Uniprot ID: P24462 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Cytochrome P450 4B1
Reactions:
  • RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O [RN:R04122]
Gene Name: CYP4B1
Uniprot ID: P13584 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Cytochrome P450 4Z1
Reactions:
  • RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O [RN:R04122]
Gene Name: CYP4Z1
Uniprot ID: Q86W10 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Cytochrome P450 1A2
Reactions:
  • RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O [RN:R04122]
Gene Name: CYP1A2
Uniprot ID: P05177 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Cytochrome P450 19A1
Reactions:
  • RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O [RN:R04122]
Gene Name: CYP19A1
Uniprot ID: P11511 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Cytochrome P450 2C8
Reactions:
  • RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O [RN:R04122]
Gene Name: CYP2C8
Uniprot ID: P10632 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Cytochrome P450 2S1
Reactions:
  • RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O [RN:R04122]
Gene Name: CYP2S1
Uniprot ID: Q96SQ9 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Cytochrome P450 2J2
Reactions:
  • RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O [RN:R04122]
Gene Name: CYP2J2
Uniprot ID: P51589 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Cytochrome P450 2A7
Reactions:
  • RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O [RN:R04122]
Gene Name: CYP2A7
Uniprot ID: P20853 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Cytochrome P450 2A6
Reactions:
  • RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O [RN:R04122]
Gene Name: CYP2A6
Uniprot ID: P11509 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Beta,beta-carotene 15,15'-monooxygenase
Reactions:
  • beta-carotene + O2 = 2 retinal [RN:R00032]
Gene Name: BCMO1
Uniprot ID: Q9HAY6 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Catalase
Reactions:
  • 2 H2O2 = O2 + 2 H2O [RN:R00009]
Gene Name: CAT
Uniprot ID: P04040 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Hemoglobin subunit beta
Reactions:
    Gene Name: HBB
    Uniprot ID: P68871 Link_out
    Protein Sequence: FASTA
    Gene Sequence: FASTA
    Name: Hemoglobin subunit alpha
    Reactions:
      Gene Name: HBA1
      Uniprot ID: P69905 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: 25-hydroxycholesterol 7-alpha-hydroxylase
      Reactions:
      • (1) cholest-5-ene-3beta,25-diol + NADPH + H+ + O2 = cholest-5-ene-3beta,7alpha,25-triol + NADP+ + H2O [RN:R07209]
      • (2) cholest-5-ene-3beta,27-diol + NADPH + H+ + O2 = cholest-5-ene-3beta,7alpha,27-triol + NADP+ + H2O [RN:R07372]
      Gene Name: CYP7B1
      Uniprot ID: O75881 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: Cytochrome c oxidase subunit 1
      Reactions:
      • 4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O [RN:R00081]
      Gene Name: MT-CO1
      Uniprot ID: P00395 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: Superoxide dismutase [Mn], mitochondrial
      Reactions:
      • 2 O2.- + 2 H+ = O2 + H2O2 [RN:R00275]
      Gene Name: SOD2
      Uniprot ID: P04179 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: Superoxide dismutase [Cu-Zn]
      Reactions:
      • 2 O2.- + 2 H+ = O2 + H2O2 [RN:R00275]
      Gene Name: SOD1
      Uniprot ID: P00441 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: Cytochrome c oxidase subunit 7A1, mitochondrial
      Reactions:
      • --- []
      Gene Name: COX7A1
      Uniprot ID: P24310 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: Myoglobin
      Reactions:
        Gene Name: MB
        Uniprot ID: P02144 Link_out
        Protein Sequence: FASTA
        Gene Sequence: FASTA
        Name: Kynurenine 3-monooxygenase
        Reactions:
        • L-kynurenine + NADPH + H+ + O2 = 3-hydroxy-L-kynurenine + NADP+ + H2O [RN:R01960]
        Gene Name: KMO
        Uniprot ID: O15229 Link_out
        Protein Sequence: FASTA
        Gene Sequence: FASTA
        Name: Hemoglobin subunit gamma-2
        Reactions:
          Gene Name: HBG2
          Uniprot ID: P69892 Link_out
          Protein Sequence: FASTA
          Gene Sequence: FASTA
          Name: Cytochrome c oxidase subunit 7A2, mitochondrial
          Reactions:
            Gene Name: COX7A2
            Uniprot ID: P14406 Link_out
            Protein Sequence: FASTA
            Gene Sequence: FASTA
            Name: Cholesterol 25-hydroxylase
            Reactions:
            • cholesterol + AH2 + O2 = 25-hydroxycholesterol + A + H2O [RN:R07218]
            Gene Name: CH25H
            Uniprot ID: O95992 Link_out
            Protein Sequence: FASTA
            Gene Sequence: FASTA
            Name: Cytochrome c oxidase subunit 6A2, mitochondrial
            Reactions:
            • --- []
            Gene Name: COX6A2
            Uniprot ID: Q02221 Link_out
            Protein Sequence: FASTA
            Gene Sequence: FASTA
            Name: Extracellular superoxide dismutase [Cu-Zn]
            Reactions:
            • 2 O2.- + 2 H+ = O2 + H2O2 [RN:R00275]
            Gene Name: SOD3
            Uniprot ID: P08294 Link_out
            Protein Sequence: FASTA
            Gene Sequence: FASTA
            Name: Cytochrome c oxidase subunit 7B, mitochondrial
            Reactions:
            • --- []
            Gene Name: COX7B
            Uniprot ID: P24311 Link_out
            Protein Sequence: FASTA
            Gene Sequence: FASTA
            Name: Cytochrome c oxidase subunit 7C, mitochondrial
            Reactions:
            • --- []
            Gene Name: COX7C
            Uniprot ID: P15954 Link_out
            Protein Sequence: FASTA
            Gene Sequence: FASTA
            Name: Cytochrome c oxidase subunit 5B, mitochondrial
            Reactions:
            • --- []
            Gene Name: COX5B
            Uniprot ID: P10606 Link_out
            Protein Sequence: FASTA
            Gene Sequence: FASTA
            Name: Cytochrome c oxidase subunit 6B1
            Reactions:
            • --- []
            Gene Name: COX6B1
            Uniprot ID: P14854 Link_out
            Protein Sequence: FASTA
            Gene Sequence: FASTA
            Name: Cytochrome c oxidase subunit 7B2, mitochondrial
            Reactions:
              Gene Name: COX7B2
              Uniprot ID: Q8TF08 Link_out
              Protein Sequence: FASTA
              Gene Sequence: FASTA
              Name: Cytochrome c oxidase subunit 4 isoform 1, mitochondrial
              Reactions:
              • --- []
              Gene Name: COX4I1
              Uniprot ID: P13073 Link_out
              Protein Sequence: FASTA
              Gene Sequence: FASTA
              Name: Cytochrome c oxidase subunit 6B2
              Reactions:
                Gene Name: COX6B2
                Uniprot ID: Q6YFQ2 Link_out
                Protein Sequence: FASTA
                Gene Sequence: FASTA
                Name: Cytochrome c oxidase subunit 8A, mitochondrial
                Reactions:
                • --- []
                Gene Name: COX8A
                Uniprot ID: P10176 Link_out
                Protein Sequence: FASTA
                Gene Sequence: FASTA
                Name: Cytochrome c oxidase subunit 6C
                Reactions:
                • --- []
                Gene Name: COX6C
                Uniprot ID: P09669 Link_out
                Protein Sequence: FASTA
                Gene Sequence: FASTA
                Name: Cytochrome c oxidase subunit 7A-related protein, mitochondrial
                Reactions:
                  Gene Name: COX7A2L
                  Uniprot ID: O14548 Link_out
                  Protein Sequence: FASTA
                  Gene Sequence: FASTA
                  Name: Cytochrome c oxidase subunit 8C, mitochondrial
                  Reactions:
                    Gene Name: COX8C
                    Uniprot ID: Q7Z4L0 Link_out
                    Protein Sequence: FASTA
                    Gene Sequence: FASTA
                    Name: Trimethyllysine dioxygenase, mitochondrial
                    Reactions:
                    • N6,N6,N6-trimethyl-L-lysine + 2-oxoglutarate + O2 = 3-hydroxy-N6,N6,N6-trimethyl-L-lysine + succinate + CO2 [RN:R03451]
                    Gene Name: TMLHE
                    Uniprot ID: Q9NVH6 Link_out
                    Protein Sequence: FASTA
                    Gene Sequence: FASTA
                    Name: Cholesterol 24-hydroxylase
                    Reactions:
                    • cholesterol + NADPH + H+ + O2 = (24S)-24-hydroxycholesterol + NADP+ + H2O [RN:R07207]
                    Gene Name: CYP46A1
                    Uniprot ID: Q9Y6A2 Link_out
                    Protein Sequence: FASTA
                    Gene Sequence: FASTA
                    Name: Cytochrome c oxidase subunit 2
                    Reactions:
                      Gene Name: MT-CO2
                      Uniprot ID: P00403 Link_out
                      Protein Sequence: FASTA
                      Gene Sequence: FASTA
                      Name: Cytochrome c oxidase subunit 6A1, mitochondrial
                      Reactions:
                        Gene Name: COX6A1
                        Uniprot ID: P12074 Link_out
                        Protein Sequence: FASTA
                        Gene Sequence: FASTA
                        Name: Cytochrome c oxidase subunit 4 isoform 2, mitochondrial
                        Reactions:
                          Gene Name: COX4I2
                          Uniprot ID: Q96KJ9 Link_out
                          Protein Sequence: FASTA
                          Gene Sequence: FASTA
                          Name: Cytochrome P450 4A22
                          Reactions:
                          • octane + reduced rubredoxin + O2 = 1-octanol + oxidized rubredoxin + H2O [RN:R02879]
                          Gene Name: CYP4A22
                          Uniprot ID: Q5TCH4 Link_out
                          Protein Sequence: FASTA
                          Gene Sequence: FASTA
                          Name: Stearoyl-CoA desaturase 5
                          Reactions:
                          • stearoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+ = oleoyl-CoA + 2 ferricytochrome b5 + 2 H2O [RN:R02222]
                          Gene Name: SCD5
                          Uniprot ID: Q86SK9 Link_out
                          Protein Sequence: FASTA
                          Gene Sequence: FASTA
                          Name: Putative uncharacterized protein DKFZp686B0215
                          Reactions:
                            Gene Name: DKFZp686B0215
                            Uniprot ID: Q5HYI4 Link_out
                            Protein Sequence: FASTA
                            Gene Sequence: FASTA
                            Name: Indoleamine 2,3-dioxygenase 2
                            Reactions:
                              Gene Name: IDO2
                              Uniprot ID: Q6ZQW0 Link_out
                              Protein Sequence: FASTA
                              Gene Sequence: FASTA
                              Name: Cytochrome P450, family 1, subfamily A, polypeptide 1
                              Reactions:
                                Gene Name: CYP1A1
                                Uniprot ID: A0N0X8 Link_out
                                Protein Sequence: FASTA
                                Gene Sequence: FASTA
                                Name: Prenylcysteine oxidase 1
                                Reactions:
                                • an S-prenyl-L-cysteine + O2 + H2O = a prenal + L-cysteine + H2O2 [RN:R07360]
                                Gene Name: PCYOX1
                                Uniprot ID: Q9UHG3 Link_out
                                Protein Sequence: FASTA
                                Gene Sequence: FASTA
                                Name: Sulfhydryl oxidase 1
                                Reactions:
                                • 4 R'C(R)SH + O2 = 2 R'C(R)S-S(R)CR' + 2 H2O [RN:R00057]
                                Gene Name: QSOX1
                                Uniprot ID: O00391 Link_out
                                Protein Sequence: FASTA
                                Gene Sequence: FASTA
                                Name: Sulfhydryl oxidase 2
                                Reactions:
                                • 4 R'C(R)SH + O2 = 2 R'C(R)S-S(R)CR' + 2 H2O [RN:R00057]
                                Gene Name: QSOX2
                                Uniprot ID: Q6ZRP7 Link_out
                                Protein Sequence: FASTA
                                Gene Sequence: FASTA
                                Name: Cytoglobin
                                Reactions:
                                  Gene Name: CYGB
                                  Uniprot ID: Q8WWM9 Link_out
                                  Protein Sequence: FASTA
                                  Gene Sequence: FASTA
                                  Name: Hemoglobin subunit delta
                                  Reactions:
                                    Gene Name: HBD
                                    Uniprot ID: P02042 Link_out
                                    Protein Sequence: FASTA
                                    Gene Sequence: FASTA
                                    Name: Neuroglobin
                                    Reactions:
                                      Gene Name: NGB
                                      Uniprot ID: Q9NPG2 Link_out
                                      Protein Sequence: FASTA
                                      Gene Sequence: FASTA
                                      Name: 2-aminoethanethiol dioxygenase
                                      Reactions:
                                      • 2-aminoethanethiol + O2 = hypotaurine [RN:R02467]
                                      Gene Name: ADO
                                      Uniprot ID: Q96SZ5 Link_out
                                      Protein Sequence: FASTA
                                      Gene Sequence: FASTA
                                      Name: Ferritin heavy chain
                                      Reactions:
                                      • 4 Fe(II) + 4 H+ + O2 = 4 Fe(III) + 2 H2O [RN:R00078]
                                      Gene Name: FTH1
                                      Uniprot ID: P02794 Link_out
                                      Protein Sequence: FASTA
                                      Gene Sequence: FASTA
                                      Name: Prolyl 4-hydroxylase subunit alpha-3
                                      Reactions:
                                      • procollagen L-proline + 2-oxoglutarate + O2 = procollagen trans-4-hydroxy-L-proline + succinate + CO2 [RN:R03219]
                                      Gene Name: P4HA3
                                      Uniprot ID: Q7Z4N8 Link_out
                                      Protein Sequence: FASTA
                                      Gene Sequence: FASTA
                                      Name: Deoxyhypusine hydroxylase
                                      Reactions:
                                      • protein N6-(4-aminobutyl)-L-lysine + AH2 + O2 = protein N6-[(R)-4-amino-2-hydroxybutyl]-L-lysine + A + H2O [RN:R04437]
                                      Gene Name: DOHH
                                      Uniprot ID: Q9BU89 Link_out
                                      Protein Sequence: FASTA
                                      Gene Sequence: FASTA
                                      Name: Cytochrome P450, family 21, subfamily A, polypeptide 2
                                      Reactions:
                                        Gene Name: CYP21A2
                                        Uniprot ID: Q08AG9 Link_out
                                        Protein Sequence: FASTA
                                        Gene Sequence: FASTA
                                        Name: Cytochrome P450 2D6
                                        Reactions:
                                          Gene Name: CYP2D6
                                          Uniprot ID: Q6NWU0 Link_out
                                          Protein Sequence: FASTA
                                          Gene Sequence: FASTA
                                          Name: CP protein
                                          Reactions:
                                            Gene Name: CP
                                            Uniprot ID: A5PL27 Link_out
                                            Protein Sequence: FASTA
                                            Gene Sequence: FASTA
                                            Name: NOS1 mutant
                                            Reactions:
                                              Gene Name: NOS1
                                              Uniprot ID: B3VK56 Link_out
                                              Protein Sequence: FASTA
                                              Gene Sequence: FASTA