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Record Information
Version5.0
StatusDetected and Quantified
Creation Date2006-08-13 10:11:15 UTC
Update Date2023-02-21 17:16:53 UTC
HMDB IDHMDB0004063
Secondary Accession Numbers
  • HMDB04063
Metabolite Identification
Common NameMetanephrine
DescriptionMetanephrine is a metabolite of epinephrine created by action of catechol O-methyltransferase on epinephrine. Technically it is a product of epinephrine O-methylation. It is a commonly occurring, pharmacologically and physiologically inactive metabolite of epinephrine. The measurement of plasma free metanephrines is considered to be the best tool in the diagnosis of pheochromocytoma, a rare kind of adrenal medullary neoplasm. In adrenal chromaffin cells, leakage of norepinephrine and epinephrine from storage granules leads to substantial intracellular production of the O-methylated metabolite metanephrine. In fact, the adrenals constitute the single largest source out of any organ system including the liver for circulating metanephrine. In humans, about 93 percent of circulating metanephrine is derived from catecholamines metabolized within adrenal chromaffin cells. (PMID 15317907 ).
Structure
Data?1676999813
Synonyms
ValueSource
(+/-)-metanephrineHMDB
3-Methoxy-adrenalineHMDB
3-MethoxyadrenalineHMDB
3-O-Methyl-adrenalineHMDB
3-O-MethylepinephrineHMDB
4-Hydroxy-3-methoxy-N-methylphenethanolamineHMDB
DL-3-O-MethyladrenalineHMDB
DL-MetanephrineHMDB
m-O-MethyladrenalineHMDB
MetadrenalineHMDB
Chemical FormulaC10H15NO3
Average Molecular Weight197.231
Monoisotopic Molecular Weight197.105193351
IUPAC Name4-[1-hydroxy-2-(methylamino)ethyl]-2-methoxyphenol
Traditional Name(+/-)-metanephrine
CAS Registry Number5001-33-2
SMILES
CNCC(O)C1=CC(OC)=C(O)C=C1
InChI Identifier
InChI=1S/C10H15NO3/c1-11-6-9(13)7-3-4-8(12)10(5-7)14-2/h3-5,9,11-13H,6H2,1-2H3
InChI KeyJWJCTZKFYGDABJ-UHFFFAOYSA-N
Chemical Taxonomy
Description Belongs to the class of organic compounds known as methoxyphenols. Methoxyphenols are compounds containing a methoxy group attached to the benzene ring of a phenol moiety.
KingdomOrganic compounds
Super ClassBenzenoids
ClassPhenols
Sub ClassMethoxyphenols
Direct ParentMethoxyphenols
Alternative Parents
Substituents
  • Methoxyphenol
  • Phenoxy compound
  • Anisole
  • Phenol ether
  • Methoxybenzene
  • Alkyl aryl ether
  • 1-hydroxy-2-unsubstituted benzenoid
  • Aralkylamine
  • Monocyclic benzene moiety
  • Secondary alcohol
  • 1,2-aminoalcohol
  • Secondary amine
  • Ether
  • Secondary aliphatic amine
  • Hydrocarbon derivative
  • Organooxygen compound
  • Organonitrogen compound
  • Organopnictogen compound
  • Organic oxygen compound
  • Amine
  • Organic nitrogen compound
  • Alcohol
  • Aromatic alcohol
  • Aromatic homomonocyclic compound
Molecular FrameworkAromatic homomonocyclic compounds
External Descriptors
Ontology
Physiological effect
Disposition
Process
RoleNot Available
Physical Properties
StateSolid
Experimental Molecular Properties
PropertyValueReference
Melting PointNot AvailableNot Available
Boiling PointNot AvailableNot Available
Water SolubilityNot AvailableNot Available
LogPNot AvailableNot Available
Experimental Chromatographic PropertiesNot Available
Predicted Molecular Properties
PropertyValueSource
Water Solubility13 g/LALOGPS
logP-0.27ALOGPS
logP-0.00068ChemAxon
logS-1.2ALOGPS
pKa (Strongest Acidic)10.05ChemAxon
pKa (Strongest Basic)9.25ChemAxon
Physiological Charge1ChemAxon
Hydrogen Acceptor Count4ChemAxon
Hydrogen Donor Count3ChemAxon
Polar Surface Area61.72 ŲChemAxon
Rotatable Bond Count4ChemAxon
Refractivity53.71 m³·mol⁻¹ChemAxon
Polarizability21.13 ųChemAxon
Number of Rings1ChemAxon
BioavailabilityYesChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Predicted Chromatographic Properties

Predicted Collision Cross Sections

PredictorAdduct TypeCCS Value (Å2)Reference
DarkChem[M+H]+145.20831661259
DarkChem[M-H]-144.03631661259
DeepCCS[M+H]+144.09830932474
DeepCCS[M-H]-140.930932474
DeepCCS[M-2H]-177.65430932474
DeepCCS[M+Na]+153.19230932474
AllCCS[M+H]+145.232859911
AllCCS[M+H-H2O]+141.132859911
AllCCS[M+NH4]+149.032859911
AllCCS[M+Na]+150.132859911
AllCCS[M-H]-145.232859911
AllCCS[M+Na-2H]-146.132859911
AllCCS[M+HCOO]-147.232859911

Predicted Kovats Retention Indices

Underivatized

MetaboliteSMILESKovats RI ValueColumn TypeReference
MetanephrineCNCC(O)C1=CC(OC)=C(O)C=C12827.4Standard polar33892256
MetanephrineCNCC(O)C1=CC(OC)=C(O)C=C11736.0Standard non polar33892256
MetanephrineCNCC(O)C1=CC(OC)=C(O)C=C11719.3Semi standard non polar33892256

Derivatized

Derivative Name / StructureSMILESKovats RI ValueColumn TypeReference
Metanephrine,1TMS,isomer #1CNCC(O[Si](C)(C)C)C1=CC=C(O)C(OC)=C11702.2Semi standard non polar33892256
Metanephrine,1TMS,isomer #2CNCC(O)C1=CC=C(O[Si](C)(C)C)C(OC)=C11787.3Semi standard non polar33892256
Metanephrine,1TMS,isomer #3COC1=CC(C(O)CN(C)[Si](C)(C)C)=CC=C1O1893.2Semi standard non polar33892256
Metanephrine,2TMS,isomer #1CNCC(O[Si](C)(C)C)C1=CC=C(O[Si](C)(C)C)C(OC)=C11718.6Semi standard non polar33892256
Metanephrine,2TMS,isomer #2COC1=CC(C(CN(C)[Si](C)(C)C)O[Si](C)(C)C)=CC=C1O1856.4Semi standard non polar33892256
Metanephrine,2TMS,isomer #3COC1=CC(C(O)CN(C)[Si](C)(C)C)=CC=C1O[Si](C)(C)C1930.0Semi standard non polar33892256
Metanephrine,3TMS,isomer #1COC1=CC(C(CN(C)[Si](C)(C)C)O[Si](C)(C)C)=CC=C1O[Si](C)(C)C1912.7Semi standard non polar33892256
Metanephrine,3TMS,isomer #1COC1=CC(C(CN(C)[Si](C)(C)C)O[Si](C)(C)C)=CC=C1O[Si](C)(C)C1951.0Standard non polar33892256
Metanephrine,3TMS,isomer #1COC1=CC(C(CN(C)[Si](C)(C)C)O[Si](C)(C)C)=CC=C1O[Si](C)(C)C2065.6Standard polar33892256
Metanephrine,1TBDMS,isomer #1CNCC(O[Si](C)(C)C(C)(C)C)C1=CC=C(O)C(OC)=C11959.6Semi standard non polar33892256
Metanephrine,1TBDMS,isomer #2CNCC(O)C1=CC=C(O[Si](C)(C)C(C)(C)C)C(OC)=C12038.8Semi standard non polar33892256
Metanephrine,1TBDMS,isomer #3COC1=CC(C(O)CN(C)[Si](C)(C)C(C)(C)C)=CC=C1O2152.9Semi standard non polar33892256
Metanephrine,2TBDMS,isomer #1CNCC(O[Si](C)(C)C(C)(C)C)C1=CC=C(O[Si](C)(C)C(C)(C)C)C(OC)=C12205.9Semi standard non polar33892256
Metanephrine,2TBDMS,isomer #2COC1=CC(C(CN(C)[Si](C)(C)C(C)(C)C)O[Si](C)(C)C(C)(C)C)=CC=C1O2370.2Semi standard non polar33892256
Metanephrine,2TBDMS,isomer #3COC1=CC(C(O)CN(C)[Si](C)(C)C(C)(C)C)=CC=C1O[Si](C)(C)C(C)(C)C2429.3Semi standard non polar33892256
Metanephrine,3TBDMS,isomer #1COC1=CC(C(CN(C)[Si](C)(C)C(C)(C)C)O[Si](C)(C)C(C)(C)C)=CC=C1O[Si](C)(C)C(C)(C)C2609.2Semi standard non polar33892256
Metanephrine,3TBDMS,isomer #1COC1=CC(C(CN(C)[Si](C)(C)C(C)(C)C)O[Si](C)(C)C(C)(C)C)=CC=C1O[Si](C)(C)C(C)(C)C2592.1Standard non polar33892256
Metanephrine,3TBDMS,isomer #1COC1=CC(C(CN(C)[Si](C)(C)C(C)(C)C)O[Si](C)(C)C(C)(C)C)=CC=C1O[Si](C)(C)C(C)(C)C2448.4Standard polar33892256
Spectra

GC-MS Spectra

Spectrum TypeDescriptionSplash KeyDeposition DateSourceView
Experimental GC-MSGC-MS Spectrum - Metanephrine GC-MS (3 TMS)splash10-014i-0910000000-a886bef599ae583766b92014-06-16HMDB team, MONA, MassBankView Spectrum
Experimental GC-MSGC-MS Spectrum - Metanephrine GC-MS (Non-derivatized)splash10-014i-0910000000-a886bef599ae583766b92017-09-12HMDB team, MONA, MassBankView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - Metanephrine GC-MS (Non-derivatized) - 70eV, Positivesplash10-0006-9300000000-99e319cf43defe7cc6112017-09-01Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - Metanephrine GC-MS (2 TMS) - 70eV, Positivesplash10-0g6r-9553000000-f11ff40fb7a8af16bb252017-10-06Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - Metanephrine GC-MS (Non-derivatized) - 70eV, PositiveNot Available2021-10-12Wishart LabView Spectrum

MS/MS Spectra

Spectrum TypeDescriptionSplash KeyDeposition DateSourceView
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Metanephrine 10V, Positive-QTOFsplash10-001j-0900000000-4c31604c1b2a54419f922016-08-01Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Metanephrine 20V, Positive-QTOFsplash10-001j-0900000000-12556e41dd73a45751622016-08-01Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Metanephrine 40V, Positive-QTOFsplash10-0f6w-4900000000-403de00b0b43ed22918f2016-08-01Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Metanephrine 10V, Negative-QTOFsplash10-0002-0900000000-3d29615883725ba8e07c2016-08-03Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Metanephrine 20V, Negative-QTOFsplash10-0032-1900000000-1ccaa0d8ce9764cdfe352016-08-03Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Metanephrine 40V, Negative-QTOFsplash10-0pic-4900000000-051892c7895245a3de0c2016-08-03Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Metanephrine 10V, Positive-QTOFsplash10-001j-0900000000-545ae65ccf6b1aaf8f432021-09-22Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Metanephrine 20V, Positive-QTOFsplash10-001a-1900000000-ad33b1d4593df03f60e12021-09-22Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Metanephrine 40V, Positive-QTOFsplash10-000i-5900000000-61cd5865cf7abd2bba672021-09-22Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Metanephrine 10V, Negative-QTOFsplash10-0002-0900000000-33b506e73b8f2abe6bdb2021-09-23Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Metanephrine 20V, Negative-QTOFsplash10-000b-0900000000-361e5b74103dd493ac472021-09-23Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Metanephrine 40V, Negative-QTOFsplash10-0a4m-6900000000-49bdcf483f24e0b4ffd42021-09-23Wishart LabView Spectrum

NMR Spectra

Spectrum TypeDescriptionDeposition DateSourceView
Predicted 1D NMR13C NMR Spectrum (1D, 100 MHz, D2O, predicted)2021-09-24Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 100 MHz, D2O, predicted)2021-09-24Wishart LabView Spectrum
Predicted 1D NMR13C NMR Spectrum (1D, 1000 MHz, D2O, predicted)2021-09-24Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 1000 MHz, D2O, predicted)2021-09-24Wishart LabView Spectrum
Predicted 1D NMR13C NMR Spectrum (1D, 200 MHz, D2O, predicted)2021-09-24Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 200 MHz, D2O, predicted)2021-09-24Wishart LabView Spectrum
Predicted 1D NMR13C NMR Spectrum (1D, 300 MHz, D2O, predicted)2021-09-24Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 300 MHz, D2O, predicted)2021-09-24Wishart LabView Spectrum
Predicted 1D NMR13C NMR Spectrum (1D, 400 MHz, D2O, predicted)2021-09-24Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 400 MHz, D2O, predicted)2021-09-24Wishart LabView Spectrum
Predicted 1D NMR13C NMR Spectrum (1D, 500 MHz, D2O, predicted)2021-09-24Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 500 MHz, D2O, predicted)2021-09-24Wishart LabView Spectrum
Predicted 1D NMR13C NMR Spectrum (1D, 600 MHz, D2O, predicted)2021-09-24Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 600 MHz, D2O, predicted)2021-09-24Wishart LabView Spectrum
Predicted 1D NMR13C NMR Spectrum (1D, 700 MHz, D2O, predicted)2021-09-24Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 700 MHz, D2O, predicted)2021-09-24Wishart LabView Spectrum
Predicted 1D NMR13C NMR Spectrum (1D, 800 MHz, D2O, predicted)2021-09-24Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 800 MHz, D2O, predicted)2021-09-24Wishart LabView Spectrum
Predicted 1D NMR13C NMR Spectrum (1D, 900 MHz, D2O, predicted)2021-09-24Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 900 MHz, D2O, predicted)2021-09-24Wishart LabView Spectrum

IR Spectra

Spectrum TypeDescriptionDeposition DateSourceView
Predicted IR SpectrumIR Ion Spectrum (Predicted IRIS Spectrum, Adduct: [M-H]-)2023-02-03FELIX labView Spectrum
Predicted IR SpectrumIR Ion Spectrum (Predicted IRIS Spectrum, Adduct: [M+H]+)2023-02-03FELIX labView Spectrum
Predicted IR SpectrumIR Ion Spectrum (Predicted IRIS Spectrum, Adduct: [M+Na]+)2023-02-03FELIX labView Spectrum
Biological Properties
Cellular Locations
  • Cytoplasm
  • Extracellular
Biospecimen Locations
  • Blood
  • Cerebrospinal Fluid (CSF)
  • Urine
Tissue Locations
  • Adrenal Gland
  • Adrenal Medulla
Pathways
Normal Concentrations
BiospecimenStatusValueAgeSexConditionReferenceDetails
BloodDetected and Quantified0.0016 (0.00018-0.0025) uMAdult (>18 years old)BothNormal
    • Geigy Scientific ...
details
BloodDetected but not QuantifiedNot QuantifiedAdult (>18 years old)BothNormal details
Cerebrospinal Fluid (CSF)Detected and Quantified0.0004 uMNot SpecifiedNot SpecifiedNormal details
UrineDetected but not QuantifiedNot QuantifiedAdult (>18 years old)BothNormal details
UrineDetected and Quantified1.08 +/- 2.95 umol/mmol creatinineInfant (0-1 year old)BothNormal details
UrineDetected and Quantified0.0026 umol/mmol creatinineAdult (>18 years old)BothNormal details
UrineDetected and Quantified<0.145 umol/mmol creatinineAdult (>18 years old)BothNormal details
UrineDetected and Quantified< 0.467 umol/mmol creatinineAdult (>18 years old)BothNormal details
UrineDetected and Quantified0.0011 +/- 0.00034 umol/mmol creatinineAdult (>18 years old)BothNormal
    • Geigy Scientific ...
    • West Cadwell, N.J...
    • Basel, Switzerlan...
details
Abnormal Concentrations
BiospecimenStatusValueAgeSexConditionReferenceDetails
BloodDetected and Quantified0.00054 +/- 0.002 uMAdult (>18 years old)Not SpecifiedPheochromocytoma details
Associated Disorders and Diseases
Disease References
Pheochromocytoma
  1. Eisenhofer G, Keiser H, Friberg P, Mezey E, Huynh TT, Hiremagalur B, Ellingson T, Duddempudi S, Eijsbouts A, Lenders JW: Plasma metanephrines are markers of pheochromocytoma produced by catechol-O-methyltransferase within tumors. J Clin Endocrinol Metab. 1998 Jun;83(6):2175-85. [PubMed:9626157 ]
Associated OMIM IDs
DrugBank IDNot Available
Phenol Explorer Compound IDNot Available
FooDB IDFDB023296
KNApSAcK IDNot Available
Chemspider ID19844
KEGG Compound IDC05588
BioCyc IDNot Available
BiGG ID46078
Wikipedia LinkMetanephrine
METLIN ID65
PubChem Compound21100
PDB IDNot Available
ChEBI ID144365
Food Biomarker OntologyNot Available
VMH IDMEPI
MarkerDB IDNot Available
Good Scents IDNot Available
References
Synthesis ReferenceNot Available
Material Safety Data Sheet (MSDS)Not Available
General References
  1. Beck O, Faull KF: Extractive acylation and mass spectrometric assay of 3-methoxytyramine, normetanephrine, and metanephrine in cerebrospinal fluid. Anal Biochem. 1985 Sep;149(2):492-500. [PubMed:4073504 ]
  2. Goldstein DS, Eisenhofer G, Kopin IJ: Sources and significance of plasma levels of catechols and their metabolites in humans. J Pharmacol Exp Ther. 2003 Jun;305(3):800-11. Epub 2003 Mar 20. [PubMed:12649306 ]
  3. Uchikura K, Horikawa R, Tanimura T, Kabasawa Y: Determination of catecholamines by radioenzymatic assay using ion-pair liquid chromatography. J Chromatogr. 1981 Apr 10;223(1):41-50. [PubMed:7251775 ]
  4. Eisenhofer G, Keiser H, Friberg P, Mezey E, Huynh TT, Hiremagalur B, Ellingson T, Duddempudi S, Eijsbouts A, Lenders JW: Plasma metanephrines are markers of pheochromocytoma produced by catechol-O-methyltransferase within tumors. J Clin Endocrinol Metab. 1998 Jun;83(6):2175-85. [PubMed:9626157 ]
  5. Eisenhofer G, Kopin IJ, Goldstein DS: Catecholamine metabolism: a contemporary view with implications for physiology and medicine. Pharmacol Rev. 2004 Sep;56(3):331-49. [PubMed:15317907 ]
  6. Schmidt J, Mohr VD, Metzger P, Zirngibl H: Posttraumatic hypertension secondary to adrenal hemorrhage mimicking pheochromocytoma: case report. J Trauma. 1999 May;46(5):973-5. [PubMed:10338428 ]
  7. Higa S, Suzuki T, Sakoda S, Kishimoto S, Takaba Y, Nakajima A, Markey SP: Disturbed function of the pineal gland in familial amyloid polyneuropathy. J Neural Transm. 1987;69(1-2):97-103. [PubMed:3035087 ]
  8. van Dam PS, van Gils A, Canninga-van Dijk MR, de Koning EJ, Hofland LJ, de Herder WW: Sequential ACTH and catecholamine secretion in a phaeochromocytoma. Eur J Endocrinol. 2002 Aug;147(2):201-6. [PubMed:12153741 ]
  9. Artal R, Platt LD, Kammula RK, Strassner HT, Gratacos J, Golde SH: Sympathoadrenal activity in infants of diabetic mothers. Am J Obstet Gynecol. 1982 Feb 15;142(4):436-9. [PubMed:7058845 ]
  10. Artal R, Hobel CJ, Lam R, Oddie TH, Fisher DA: Free metanephrine in human amniotic fluid as an index of fetal sympathetic nervous system maturation. Am J Obstet Gynecol. 1979 Feb 15;133(4):452-4. [PubMed:434011 ]
  11. Kitamura T, Alroy J, Gatmaitan Z, Inoue M, Mikami T, Jansen P, Arias IM: Defective biliary excretion of epinephrine metabolites in mutant (TR-) rats: relation to the pathogenesis of black liver in the Dubin-Johnson syndrome and Corriedale sheep with an analogous excretory defect. Hepatology. 1992 Jun;15(6):1154-9. [PubMed:1592353 ]
  12. Pagliari R, Cottet-Emard JM, Peyrin L: Determination of free and conjugated normetanephrine and metanephrine in human plasma by high-performance liquid chromatography with electrochemical detection. J Chromatogr. 1991 Jan 18;563(1):23-36. [PubMed:2061394 ]
  13. Kaplan NM, Kramer NJ, Holland OB, Sheps SG, Gomez-Sanchez C: Single-voided urine metanephrine assays in screening for pheochromocytoma. Arch Intern Med. 1977 Feb;137(2):190-3. [PubMed:836117 ]
  14. Taylor RL, Singh RJ: Validation of liquid chromatography-tandem mass spectrometry method for analysis of urinary conjugated metanephrine and normetanephrine for screening of pheochromocytoma. Clin Chem. 2002 Mar;48(3):533-9. [PubMed:11861444 ]

Enzymes

General function:
Involved in oxidoreductase activity
Specific function:
Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOB preferentially degrades benzylamine and phenylethylamine.
Gene Name:
MAOB
Uniprot ID:
P27338
Molecular weight:
58762.475
Reactions
Metanephrine + Water + Oxygen → 3-Methoxy-4-hydroxyphenylglycolaldehyde + Hydrogen peroxide + Methylaminedetails
General function:
Involved in oxidoreductase activity
Specific function:
Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOA preferentially oxidizes biogenic amines such as 5-hydroxytryptamine (5-HT), norepinephrine and epinephrine.
Gene Name:
MAOA
Uniprot ID:
P21397
Molecular weight:
59681.27
Reactions
Metanephrine + Water + Oxygen → 3-Methoxy-4-hydroxyphenylglycolaldehyde + Hydrogen peroxide + Methylaminedetails
General function:
Involved in magnesium ion binding
Specific function:
Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol.
Gene Name:
COMT
Uniprot ID:
P21964
Molecular weight:
30036.77
Reactions
S-Adenosylmethionine + Epinephrine → S-Adenosylhomocysteine + Metanephrinedetails