Human Metabolome Database Version 3.5

Showing metabocard for Iodide (HMDB12238)

Record Information
Version 3.5
Creation Date 2009-04-06 10:21:33 -0600
Update Date 2013-02-08 17:28:34 -0700
HMDB ID HMDB12238
Secondary Accession Numbers None
Metabolite Identification
Common Name Iodide
Description Iodide can function as an antioxidant as it is a reducing species that can detoxify reactive oxygen species such as hydrogen peroxide. Over three billion years ago, blue-green algae were the most primitive oxygenic photosynthetic organisms and are the ancestors of multicellular eukaryotic algae (1). Algae that contain the highest amount of iodine (1-3 % of dry weight) and peroxidase enzymes, were the first living cells to produce poisonous oxygen in the atmosphere. Therefore algal cells required a protective antioxidant action of their molecular components, in which iodides, through peroxidase enzymes, seem to have had this specific role. In fact, iodides are greatly present and available in the sea, where algal phytoplankton, the basis of marine food-chain, acts as a biological accumulator of iodides, selenium, (and n-3 fatty acids) :; Antioxidant biochemical mechanism of iodides, probably one of the most ancient mechanisms of defense from poisonous reactive oxygen species:; An iodide ion is an iodine atom with a -1 charge. Compounds with iodine in formal oxidation state -1 are called iodides. This can include ionic compounds such as caesium iodide or covalent compounds such as phosphorus triiodide. This is the same naming scheme as is seen with chlorides and bromides. The chemical test for an iodide compound is to acidify the aqueous compound by adding some drops of acid, to dispel any carbonate ions present, then adding lead(II) nitrate, yielding a bright yellow precipitate of lead iodide. Most ionic iodides are soluble, with the exception of yellow silver iodide and yellow lead iodide. Aqueous solutions of iodide dissolve iodine better than pure water due to the formation of complex ions:.
Structure Thumb
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Display: 2D Structure | 3D Structure
Synonyms
  1. Iodide
  2. Iodide anion
  3. Iodide ion
  4. Iodide Salt
  5. Iodide(1-)
  6. Iodinane
  7. Iodine anion
  8. Iodine ion
  9. Lambda(3)-iodane
  10. Trihydridoiodine
Chemical Formula I
Average Molecular Weight 126.90447
Monoisotopic Molecular Weight 126.90446842
IUPAC Name iodide
Traditional IUPAC Name iodide
CAS Registry Number 20461-54-5
SMILES [I-]
InChI Identifier InChI=1S/HI/h1H/p-1
InChI Key XMBWDFGMSWQBCA-UHFFFAOYSA-M
Chemical Taxonomy
Kingdom Inorganic Compounds
Super Class Homogeneous Non-metal Compounds
Class Homogeneous Halogens
Sub Class N/A
Other Descriptors
  • an anion(Cyc)
  • an iodide(Cyc)
  • halide anion(ChEBI)
  • monoatomic iodine(ChEBI)
Substituents
  • N/A
Direct Parent Homogeneous Halogens
Ontology
Status Detected and Quantified
Origin
  • Endogenous
Biofunction Not Available
Application Not Available
Cellular locations Not Available
Physical Properties
State Solid
Experimental Properties
Property Value Reference
Melting Point Not Available Not Available
Boiling Point Not Available Not Available
Water Solubility Not Available Not Available
LogP Not Available Not Available
Predicted Properties
Property Value Source
Water Solubility ALOGPS
LogP 1.02 ChemAxon
pKa (strongest acidic) -9 ChemAxon
Hydrogen Acceptor Count 0 ChemAxon
Hydrogen Donor Count 0 ChemAxon
Polar Surface Area 0 A2 ChemAxon
Rotatable Bond Count 0 ChemAxon
Refractivity 13.95 ChemAxon
Polarizability 5.07 ChemAxon
Formal Charge -1 ChemAxon
Physiological Charge -1 ChemAxon
Spectra
Not Available
Biological Properties
Cellular Locations Not Available
Biofluid Locations
  • Blood
  • Urine
Tissue Location Not Available
Pathways Not Available
Normal Concentrations
Biofluid Status Value Age Sex Condition Reference
Blood Expected but not Quantified
Not Applicable Not Available Not Available Comment Normal
  • Not Applicable
Urine Detected and Quantified
0.53 (0.20-1.65) umol/mmol creatinine Children (1-13 year old) Both Normal
  • Geigy Scient...
Urine Detected and Quantified
0.42 +/- 0.189 umol/mmol creatinine Adolescent (13-18 years old) Male Normal
  • Geigy Scient...
Urine Detected and Quantified
0.36 +/- 0.199 umol/mmol creatinine Adolescent (13-18 years old) Female Normal
  • Geigy Scient...
Abnormal Concentrations
Not Available
Associated Disorders and Diseases
Disease References None
Associated OMIM IDs None
DrugBank ID Not Available
DrugBank Metabolite ID Not Available
Phenol Explorer Compound ID Not Available
Phenol Explorer Metabolite ID Not Available
FoodDB ID FDB028881
KNApSAcK ID Not Available
Chemspider ID 28015 Link_out
KEGG Compound ID C00708 Link_out
BioCyc ID CPD-387 Link_out
BiGG ID 35753 Link_out
Wikipedia Link Not Available
NuGOwiki Link HMDB12238 Link_out
Metagene Link HMDB12238 Link_out
METLIN ID Not Available
PubChem Compound 30165 Link_out
PDB ID IOD Link_out
ChEBI ID 16382 Link_out
References
Synthesis Reference Not Available
Material Safety Data Sheet (MSDS) Download (PDF)
General References Not Available

Enzymes
Name: Thyroid peroxidase
Reactions: Not Available
Gene Name: TPO
Uniprot ID: P07202 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Type I iodothyronine deiodinase
Reactions: Not Available
Gene Name: DIO1
Uniprot ID: P49895 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Type II iodothyronine deiodinase
Reactions: Not Available
Gene Name: DIO2
Uniprot ID: Q92813 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Iodotyrosine dehalogenase 1
Reactions: Not Available
Gene Name: IYD
Uniprot ID: Q6PHW0 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Type III iodothyronine deiodinase
Reactions: Not Available
Gene Name: DIO3
Uniprot ID: P55073 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA