Record Information
Version3.6
Creation Date2009-04-06 16:21:33 UTC
Update Date2013-02-09 00:28:34 UTC
HMDB IDHMDB12238
Secondary Accession NumbersNone
Metabolite Identification
Common NameIodide
DescriptionIodide can function as an antioxidant as it is a reducing species that can detoxify reactive oxygen species such as hydrogen peroxide. Over three billion years ago, blue-green algae were the most primitive oxygenic photosynthetic organisms and are the ancestors of multicellular eukaryotic algae (1). Algae that contain the highest amount of iodine (1-3 % of dry weight) and peroxidase enzymes, were the first living cells to produce poisonous oxygen in the atmosphere. Therefore algal cells required a protective antioxidant action of their molecular components, in which iodides, through peroxidase enzymes, seem to have had this specific role. In fact, iodides are greatly present and available in the sea, where algal phytoplankton, the basis of marine food-chain, acts as a biological accumulator of iodides, selenium, (and n-3 fatty acids) :; Antioxidant biochemical mechanism of iodides, probably one of the most ancient mechanisms of defense from poisonous reactive oxygen species:; An iodide ion is an iodine atom with a -1 charge. Compounds with iodine in formal oxidation state -1 are called iodides. This can include ionic compounds such as caesium iodide or covalent compounds such as phosphorus triiodide. This is the same naming scheme as is seen with chlorides and bromides. The chemical test for an iodide compound is to acidify the aqueous compound by adding some drops of acid, to dispel any carbonate ions present, then adding lead(II) nitrate, yielding a bright yellow precipitate of lead iodide. Most ionic iodides are soluble, with the exception of yellow silver iodide and yellow lead iodide. Aqueous solutions of iodide dissolve iodine better than pure water due to the formation of complex ions:.
Structure
Thumb
Synonyms
  1. Iodide
  2. Iodide anion
  3. Iodide ion
  4. Iodide Salt
  5. Iodide(1-)
  6. Iodinane
  7. Iodine anion
  8. Iodine ion
  9. Lambda(3)-iodane
  10. Trihydridoiodine
Chemical FormulaI
Average Molecular Weight126.90447
Monoisotopic Molecular Weight126.90446842
IUPAC Nameiodide
Traditional IUPAC Nameiodide
CAS Registry Number20461-54-5
SMILES
[I-]
InChI Identifier
InChI=1S/HI/h1H/p-1
InChI KeyXMBWDFGMSWQBCA-UHFFFAOYSA-M
Chemical Taxonomy
KingdomInorganic Compounds
Super ClassHomogeneous Non-metal Compounds
ClassHomogeneous Halogens
Sub ClassN/A
Other Descriptors
  • an anion(Cyc)
  • an iodide(Cyc)
  • halide anion(ChEBI)
  • monoatomic iodine(ChEBI)
Substituents
  • N/A
Direct ParentHomogeneous Halogens
Ontology
StatusDetected and Quantified
Origin
  • Endogenous
BiofunctionNot Available
ApplicationNot Available
Cellular locationsNot Available
Physical Properties
StateSolid
Experimental Properties
PropertyValueReference
Melting PointNot AvailableNot Available
Boiling PointNot AvailableNot Available
Water SolubilityNot AvailableNot Available
LogPNot AvailableNot Available
Predicted Properties
PropertyValueSource
logP1.02ChemAxon
pKa (strongest acidic)-9ChemAxon
physiological charge-1ChemAxon
hydrogen acceptor count0ChemAxon
hydrogen donor count0ChemAxon
polar surface area0ChemAxon
rotatable bond count0ChemAxon
refractivity13.95ChemAxon
polarizability5.07ChemAxon
Spectra
SpectraNot Available
Biological Properties
Cellular LocationsNot Available
Biofluid Locations
  • Blood
  • Urine
Tissue LocationNot Available
PathwaysNot Available
Normal Concentrations
BiofluidStatusValueAgeSexConditionReference
BloodExpected but not QuantifiedNot ApplicableNot AvailableNot AvailableCommentNormal
  • Not Applicable
UrineDetected and Quantified0.53 (0.20-1.65) umol/mmol creatinineChildren (1-13 year old)BothNormal
  • Geigy Scient...
UrineDetected and Quantified0.42 +/- 0.189 umol/mmol creatinineAdolescent (13-18 years old)MaleNormal
  • Geigy Scient...
UrineDetected and Quantified0.36 +/- 0.199 umol/mmol creatinineAdolescent (13-18 years old)FemaleNormal
  • Geigy Scient...
Abnormal Concentrations
Not Available
Associated Disorders and Diseases
Disease ReferencesNone
Associated OMIM IDsNone
DrugBank IDNot Available
DrugBank Metabolite IDNot Available
Phenol Explorer Compound IDNot Available
Phenol Explorer Metabolite IDNot Available
FoodDB IDFDB028881
KNApSAcK IDNot Available
Chemspider ID28015
KEGG Compound IDC00708
BioCyc IDCPD-387
BiGG ID35753
Wikipedia LinkNot Available
NuGOwiki LinkHMDB12238
Metagene LinkHMDB12238
METLIN IDNot Available
PubChem Compound30165
PDB IDIOD
ChEBI ID16382
References
Synthesis ReferenceNot Available
Material Safety Data Sheet (MSDS)Not Available
General ReferencesNot Available

Enzymes

Gene Name:
TPO
Uniprot ID:
P07202
Gene Name:
DIO1
Uniprot ID:
P49895
Gene Name:
DIO2
Uniprot ID:
Q92813
Gene Name:
IYD
Uniprot ID:
Q6PHW0
Gene Name:
DIO3
Uniprot ID:
P55073