Human Metabolome Database Version 3.5

Showing metabocard for Estrone (HMDB00145)

Record Information
Version 3.5
Creation Date 2005-11-16 08:48:42 -0700
Update Date 2013-05-29 13:24:51 -0600
HMDB ID HMDB00145
Secondary Accession Numbers
  • HMDB04449
Metabolite Identification
Common Name Estrone
Description Estrone is a major mammalian estrogen. The conversion of the natural C19 steroids, testosterone and androstenedione into estrone is dependent on a complex key reaction catalyzed by the cytochrome P450 aromatase (EC 1.14.14.1, unspecific monooxygenase), which is expressed in many tissues of the adult human (e.g. ovary, fat tissue), but not in the liver. The ovaries after menopause continue to produce androstenedione and testosterone in significant amounts and these androgens are converted in fat, muscle, and skin into estrone. When women between the ages of 45 and 64 years have prophylactic oophorectomy (when hysterectomy is performed for benign disease to prevent the development of ovarian cancer), evidence suggests that oophorectomy increases the subsequent risk of coronary heart disease (CHD) and osteoporosis. Whereas 14,000 women die of ovarian cancer every year nearly 490,000 women die of heart disease and 48,000 women die within 1 year after hip fracture. Therefore, the decision to perform prophylactic oophorectomy should be approached with great caution for the majority of women who are at low risk of developing ovarian cancer. Steroid sulfatase (EC 3.1.6.2, STS) hydrolyzes steroid sulfates, such as estrone sulfate to estrone which can be converted to steroids with potent estrogenic properties, that is, estradiol; STS activity is much higher in breast tumors and high levels of STS mRNA expression in tumors are associated with a poor prognosis. The biological roles of estrogens in tumorigenesis are certainly different between the endometrium and breast, although both are considered "estrogen-dependent tissues". 17beta-hydroxysteroid dehydrogenases (EC 1.1.1.62, 17-HSDs) are enzymes involved in the formation of active sex steroids. estrone is interconverted by two enzymes 17-HSD types. Type 1 converts estrone to estradiol and Type 2 catalyzes the reverse reaction. (PMID: 17653961 Link_out, 17513923 Link_out, 17470679 Link_out, 17464097 Link_out).
Structure Thumb
Download: MOL | SDF | PDB | SMILES | InChI
Display: 2D Structure | 3D Structure
Synonyms
  1. (+)-Estrone
  2. 1,3,5(10)-Estratrien-3-ol-17-one
  3. 3-Hydroxy-17-keto-estra-1,3,5-triene
  4. 3-Hydroxyestra-1,3,5(10)-trien-17-one
  5. 3-Hydroxyestra-1,3,5(10)-triene-17-one
  6. 3-Hydroxyoestra-1,3,5(10)-trien-17-one
  7. D1,3,5(10)-Estratrien-3-ol-17-one
Chemical Formula C18H22O2
Average Molecular Weight 270.3661
Monoisotopic Molecular Weight 270.161979948
IUPAC Name (1S,10R,11S,15S)-5-hydroxy-15-methyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadeca-2,4,6-trien-14-one
Traditional IUPAC Name estrone
CAS Registry Number 53-16-7
SMILES [H][C@@]12CCC(=O)[C@@]1(C)CC[C@]1([H])C3=C(CC[C@@]21[H])C=C(O)C=C3
InChI Identifier InChI=1S/C18H22O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h3,5,10,14-16,19H,2,4,6-9H2,1H3/t14-,15-,16+,18+/m1/s1
InChI Key DNXHEGUUPJUMQT-CBZIJGRNSA-N
Chemical Taxonomy
Kingdom Organic Compounds
Super Class Lipids
Class Steroids and Steroid Derivatives
Sub Class Estrogens and Derivatives
Other Descriptors
  • 17-oxo steroid(ChEBI)
  • Aromatic Homomonocyclic Compounds
  • Aromatic Homopolycyclic Compounds
  • C18 steroids (estrogens) and derivatives(KEGG)
  • C18 steroids (estrogens) and derivatives(Lipidmaps)
  • Estrane and derivatives(KEGG)
  • Estrane(KEGG)
  • Estrogens(KEGG)
  • Hydroxysteroids
  • Ketosteroids
  • estrogen(ChEBI)
Substituents
  • Cyclohexane
  • Cyclohexene
  • Ketone
  • Phenanthrene
  • Phenol
  • Phenol Derivative
  • Sesquiterpene Backbone
  • Tetralin
Direct Parent Estrogens and Derivatives
Ontology
Status Detected and Quantified
Origin
  • Drug metabolite
  • Endogenous
  • Food
Biofunction
  • Cell signaling
  • Component of Androgen and estrogen metabolism
  • Component of Sulfur metabolism
  • Fuel and energy storage
  • Fuel or energy source
  • Membrane integrity/stability
  • Waste products
Application
  • Nutrients
  • Stabilizers
  • Surfactants and Emulsifiers
Cellular locations
  • Cytoplasm
  • Extracellular
  • Membrane (predicted from logP)
  • Endoplasmic reticulum
Physical Properties
State Solid
Experimental Properties
Property Value Reference
Melting Point 258 - 260 °C Not Available
Boiling Point Not Available Not Available
Water Solubility 0.03 mg/mL Not Available
LogP 3.13 HANSCH,C ET AL. (1995)
Predicted Properties
Property Value Source
Water Solubility 0.0039 g/L ALOGPS
LogP 4.03 ALOGPS
LogP 4.31 ChemAxon
LogS -4.84 ALOGPS
pKa (strongest acidic) 10.33 ChemAxon
pKa (strongest basic) -5.4 ChemAxon
Hydrogen Acceptor Count 2 ChemAxon
Hydrogen Donor Count 1 ChemAxon
Polar Surface Area 37.3 A2 ChemAxon
Rotatable Bond Count 0 ChemAxon
Refractivity 79.08 ChemAxon
Polarizability 31.3 ChemAxon
Formal Charge 0 ChemAxon
Physiological Charge 0 ChemAxon
Spectra
Gas-MS Spectrum
MS/MS Spectrum Quattro_QQQ 10
MS/MS Spectrum Quattro_QQQ 25
MS/MS Spectrum Quattro_QQQ 40
MS/MS Spectrum EI-B (HITACHI M-80)
MS/MS Spectrum GC-MS
MS/MS Spectrum GC-MS
MS/MS Spectrum GC-MS
[1H,13C] 2D NMR Spectrum
Biological Properties
Cellular Locations
  • Cytoplasm
  • Extracellular
  • Membrane (predicted from logP)
  • Endoplasmic reticulum
Biofluid Locations
  • Blood
  • Urine
Tissue Location
  • Kidney
  • Liver
Pathways
Name SMPDB Link KEGG Link
Sulfate/Sulfite Metabolism SMP00041 map00920 Link_out
Androgen and Estrogen Metabolism SMP00068 map00150 Link_out
Normal Concentrations
Biofluid Status Value Age Sex Condition Reference
Blood Detected and Quantified
0.00017 +/- 0.000071 uM Adult (>18 years old) Female Normal
Blood Detected and Quantified
0.00020 (0.00011-0.00030) uM Adult (>18 years old) Male Normal
  • The Merck Ma...
Blood Detected and Quantified
0.00012 (0.0-0.00024) uM Adult (>18 years old) Female Normal
  • The Merck Ma...
Urine Detected and Quantified
0.0013 +/- 0.00085 umol/mmol creatinine Adult (>18 years old) Female Normal
Abnormal Concentrations
Biofluid Status Value Age Sex Condition Reference
Blood Detected and Quantified 0.00022 (0.00013-0.00038) uM Adult (>18 years old) Male Positive coronary arteriograms
Blood Detected and Quantified 0.00021 (0.00011-0.00037) uM Adult (>18 years old) Both Minor electrocardiongraphic abnormalities and/or arrhythmia with negative coronary arteriograms
Blood Detected and Quantified 0.00035 (0.00014-0.00056) uM Adult (>18 years old) Female Menstrual cycle (follicular phase)
  • The Merck Ma...
Blood Detected and Quantified 0.00050 (0.00028-0.00074) uM Adult (>18 years old) Female Menstrual cycle (midcycle)
  • The Merck Ma...
Blood Detected and Quantified 0.00030 (0.00018-0.00042) uM Adult (>18 years old) Female Menstrual cycle (luteal phase)
  • The Merck Ma...
Associated Disorders and Diseases
Disease References
Menstrual cycle
    • The Merck Manual, 17th ed. Mark H. Beers, MD, Robert Berkow, MD, eds. Whitehouse Station, NJ: Merck Research Labs, 1999.
      Normal
        • The Merck Manual, 17th ed. Mark H. Beers, MD, Robert Berkow, MD, eds. Whitehouse Station, NJ: Merck Research Labs, 1999.
          Associated OMIM IDs None
          DrugBank ID Not Available
          DrugBank Metabolite ID DBMET00490 Link_out
          Phenol Explorer Compound ID Not Available
          Phenol Explorer Metabolite ID Not Available
          FoodDB ID FDB012798
          KNApSAcK ID C00003663 Link_out
          Chemspider ID 5660 Link_out
          KEGG Compound ID C00468 Link_out
          BioCyc ID ESTRONE Link_out
          BiGG ID 35059 Link_out
          Wikipedia Link Estrone Link_out
          NuGOwiki Link HMDB00145 Link_out
          Metagene Link HMDB00145 Link_out
          METLIN ID 264 Link_out
          PubChem Compound 5870 Link_out
          PDB ID J3Z Link_out
          ChEBI ID 17263 Link_out
          References
          Synthesis Reference Kocovsky, Paved; Baines, Richard S. Synthesis of estrone via a thallium(III)-mediated fragmentation of a 19-hydroxyandrost-5-ene precursor. Tetrahedron Letters (1993), 34(38), 6139-40.
          Material Safety Data Sheet (MSDS) Download (PDF)
          General References
          1. Czernik PJ, Little JM, Barone GW, Raufman JP, Radominska-Pandya A: Glucuronidation of estrogens and retinoic acid and expression of UDP-glucuronosyltransferase 2B7 in human intestinal mucosa. Drug Metab Dispos. 2000 Oct;28(10):1210-6. Pubmed: 10997942 Link_out
          2. Pfeiffer E, Graf E, Gerstner S, Metzler M: Stimulation of estradiol glucuronidation: a protective mechanism against estradiol-mediated carcinogenesis? Mol Nutr Food Res. 2006 Apr;50(4-5):385-9. Pubmed: 16598814 Link_out
          3. Kuhl H, Wiegratz I: Can 19-nortestosterone derivatives be aromatized in the liver of adult humans? Are there clinical implications? Climacteric. 2007 Aug;10(4):344-53. Pubmed: 17653961 Link_out
          4. Parker WH, Broder MS, Liu Z, Shoupe D, Farquhar C, Berek JS: Ovarian conservation at the time of hysterectomy for benign disease. Clin Obstet Gynecol. 2007 Jun;50(2):354-61. Pubmed: 17513923 Link_out
          5. Stanway SJ, Delavault P, Purohit A, Woo LW, Thurieau C, Potter BV, Reed MJ: Steroid sulfatase: a new target for the endocrine therapy of breast cancer. Oncologist. 2007 Apr;12(4):370-4. Pubmed: 17470679 Link_out
          6. Ito K: Hormone replacement therapy and cancers: the biological roles of estrogen and progestin in tumorigenesis are different between the endometrium and breast. Tohoku J Exp Med. 2007 May;212(1):1-12. Pubmed: 17464097 Link_out

          Enzymes

          Show all enzymes and transporters Important Only showing the first 50 enzymes. There are 60 enzymes in total.

          Name: Arylsulfatase D
          Reactions: Not Available
          Gene Name: ARSD
          Uniprot ID: P51689 Link_out
          Protein Sequence: FASTA
          Gene Sequence: FASTA
          Name: Arylsulfatase E
          Reactions: Not Available
          Gene Name: ARSE
          Uniprot ID: P51690 Link_out
          Protein Sequence: FASTA
          Gene Sequence: FASTA
          Name: Estrogen sulfotransferase
          Reactions:
          Phosphoadenosine phosphosulfate + Estrone unknown Adenosine 3',5'-diphosphate + Estrone sulfate details
          Gene Name: SULT1E1
          Uniprot ID: P49888 Link_out
          Protein Sequence: FASTA
          Gene Sequence: FASTA
          Name: Estradiol 17-beta-dehydrogenase 2
          Reactions:
          Estradiol + NAD(P)(+) unknown Estrone + NAD(P)H details
          Estradiol + NAD unknown Estrone + NADH + Hydrogen Ion details
          Estradiol + NADP unknown Estrone + NADPH + Hydrogen Ion details
          Gene Name: HSD17B2
          Uniprot ID: P37059 Link_out
          Protein Sequence: FASTA
          Gene Sequence: FASTA
          Name: UDP-glucuronosyltransferase 2B28
          Reactions:
          Estrone + Uridine diphosphate glucuronic acid unknown Estrone glucuronide + Uridine 5'-diphosphate details
          Gene Name: UGT2B28
          Uniprot ID: Q9BY64 Link_out
          Protein Sequence: FASTA
          Gene Sequence: FASTA
          Name: Estradiol 17-beta-dehydrogenase 8
          Reactions:
          Estradiol + NAD(P)(+) unknown Estrone + NAD(P)H details
          Estradiol + NAD unknown Estrone + NADH + Hydrogen Ion details
          Estradiol + NADP unknown Estrone + NADPH + Hydrogen Ion details
          Gene Name: HSD17B8
          Uniprot ID: Q92506 Link_out
          Protein Sequence: FASTA
          Gene Sequence: FASTA
          Name: UDP-glucuronosyltransferase 2B4
          Reactions:
          Estrone + Uridine diphosphate glucuronic acid unknown Estrone glucuronide + Uridine 5'-diphosphate details
          Gene Name: UGT2B4
          Uniprot ID: P06133 Link_out
          Protein Sequence: FASTA
          Gene Sequence: FASTA
          Name: UDP-glucuronosyltransferase 1-4
          Reactions:
          Estrone + Uridine diphosphate glucuronic acid unknown Estrone glucuronide + Uridine 5'-diphosphate details
          Gene Name: UGT1A4
          Uniprot ID: P22310 Link_out
          Protein Sequence: FASTA
          Gene Sequence: FASTA
          Name: UDP-glucuronosyltransferase 2B10
          Reactions:
          Estrone + Uridine diphosphate glucuronic acid unknown Estrone glucuronide + Uridine 5'-diphosphate details
          Gene Name: UGT2B10
          Uniprot ID: P36537 Link_out
          Protein Sequence: FASTA
          Gene Sequence: FASTA
          Name: UDP-glucuronosyltransferase 2B7
          Reactions:
          Estrone + Uridine diphosphate glucuronic acid unknown Estrone glucuronide + Uridine 5'-diphosphate details
          Gene Name: UGT2B7
          Uniprot ID: P16662 Link_out
          Protein Sequence: FASTA
          Gene Sequence: FASTA
          Name: UDP-glucuronosyltransferase 2B15
          Reactions:
          Estrone + Uridine diphosphate glucuronic acid unknown Estrone glucuronide + Uridine 5'-diphosphate details
          Gene Name: UGT2B15
          Uniprot ID: P54855 Link_out
          Protein Sequence: FASTA
          Gene Sequence: FASTA
          Name: UDP-glucuronosyltransferase 2A1
          Reactions:
          Estrone + Uridine diphosphate glucuronic acid unknown Estrone glucuronide + Uridine 5'-diphosphate details
          Gene Name: UGT2A1
          Uniprot ID: Q9Y4X1 Link_out
          Protein Sequence: FASTA
          Gene Sequence: FASTA
          Name: UDP-glucuronosyltransferase 1-1
          Reactions:
          Estrone + Uridine diphosphate glucuronic acid unknown Estrone glucuronide + Uridine 5'-diphosphate details
          Gene Name: UGT1A1
          Uniprot ID: P22309 Link_out
          Protein Sequence: FASTA
          Gene Sequence: FASTA
          Name: UDP-glucuronosyltransferase 1-9
          Reactions:
          Estrone + Uridine diphosphate glucuronic acid unknown Estrone glucuronide + Uridine 5'-diphosphate details
          Gene Name: UGT1A9
          Uniprot ID: O60656 Link_out
          Protein Sequence: FASTA
          Gene Sequence: FASTA
          Name: UDP-glucuronosyltransferase 1-8
          Reactions:
          Estrone + Uridine diphosphate glucuronic acid unknown Estrone glucuronide + Uridine 5'-diphosphate details
          Gene Name: UGT1A8
          Uniprot ID: Q9HAW9 Link_out
          Protein Sequence: FASTA
          Gene Sequence: FASTA
          Name: UDP-glucuronosyltransferase 1-3
          Reactions:
          Estrone + Uridine diphosphate glucuronic acid unknown Estrone glucuronide + Uridine 5'-diphosphate details
          Gene Name: UGT1A3
          Uniprot ID: P35503 Link_out
          Protein Sequence: FASTA
          Gene Sequence: FASTA
          Name: UDP-glucuronosyltransferase 1-10
          Reactions:
          Estrone + Uridine diphosphate glucuronic acid unknown Estrone glucuronide + Uridine 5'-diphosphate details
          Gene Name: UGT1A10
          Uniprot ID: Q9HAW8 Link_out
          Protein Sequence: FASTA
          Gene Sequence: FASTA
          Name: UDP-glucuronosyltransferase 2B17
          Reactions:
          Estrone + Uridine diphosphate glucuronic acid unknown Estrone glucuronide + Uridine 5'-diphosphate details
          Gene Name: UGT2B17
          Uniprot ID: O75795 Link_out
          Protein Sequence: FASTA
          Gene Sequence: FASTA
          Name: UDP-glucuronosyltransferase 1-6
          Reactions:
          Estrone + Uridine diphosphate glucuronic acid unknown Estrone glucuronide + Uridine 5'-diphosphate details
          Gene Name: UGT1A6
          Uniprot ID: P19224 Link_out
          Protein Sequence: FASTA
          Gene Sequence: FASTA
          Name: UDP-glucuronosyltransferase 1-5
          Reactions:
          Estrone + Uridine diphosphate glucuronic acid unknown Estrone glucuronide + Uridine 5'-diphosphate details
          Gene Name: UGT1A5
          Uniprot ID: P35504 Link_out
          Protein Sequence: FASTA
          Gene Sequence: FASTA
          Name: UDP-glucuronosyltransferase 2B11
          Reactions:
          Estrone + Uridine diphosphate glucuronic acid unknown Estrone glucuronide + Uridine 5'-diphosphate details
          Gene Name: UGT2B11
          Uniprot ID: O75310 Link_out
          Protein Sequence: FASTA
          Gene Sequence: FASTA
          Name: Steryl-sulfatase
          Reactions: Not Available
          Gene Name: STS
          Uniprot ID: P08842 Link_out
          Protein Sequence: FASTA
          Gene Sequence: FASTA
          Name: UDP-glucuronosyltransferase 1-7
          Reactions:
          Estrone + Uridine diphosphate glucuronic acid unknown Estrone glucuronide + Uridine 5'-diphosphate details
          Gene Name: UGT1A7
          Uniprot ID: Q9HAW7 Link_out
          Protein Sequence: FASTA
          Gene Sequence: FASTA
          Name: Estradiol 17-beta-dehydrogenase 11
          Reactions:
          Estradiol + NAD(P)(+) unknown Estrone + NAD(P)H details
          Gene Name: HSD17B11
          Uniprot ID: Q8NBQ5 Link_out
          Protein Sequence: FASTA
          Gene Sequence: FASTA
          Name: Estradiol 17-beta-dehydrogenase 1
          Reactions:
          Estradiol + NAD(P)(+) unknown Estrone + NAD(P)H details
          Estradiol + NAD unknown Estrone + NADH + Hydrogen Ion details
          Estradiol + NADP unknown Estrone + NADPH + Hydrogen Ion details
          Gene Name: HSD17B1
          Uniprot ID: P14061 Link_out
          Protein Sequence: FASTA
          Gene Sequence: FASTA
          Name: 3-keto-steroid reductase
          Reactions:
          Estradiol + NAD(P)(+) unknown Estrone + NAD(P)H details
          Estradiol + NAD unknown Estrone + NADH + Hydrogen Ion details
          Estradiol + NADP unknown Estrone + NADPH + Hydrogen Ion details
          Gene Name: HSD17B7
          Uniprot ID: P56937 Link_out
          Protein Sequence: FASTA
          Gene Sequence: FASTA
          Name: Cytochrome P450 3A4
          Reactions: Not Available
          Gene Name: CYP3A4
          Uniprot ID: P08684 Link_out
          Protein Sequence: FASTA
          Gene Sequence: FASTA
          Name: Cytochrome P450 2C9
          Reactions: Not Available
          Gene Name: CYP2C9
          Uniprot ID: P11712 Link_out
          Protein Sequence: FASTA
          Gene Sequence: FASTA
          Name: Cytochrome P450 2C19
          Reactions: Not Available
          Gene Name: CYP2C19
          Uniprot ID: P33261 Link_out
          Protein Sequence: FASTA
          Gene Sequence: FASTA
          Name: Cytochrome P450 2E1
          Reactions: Not Available
          Gene Name: CYP2E1
          Uniprot ID: P05181 Link_out
          Protein Sequence: FASTA
          Gene Sequence: FASTA
          Name: Cytochrome P450 3A43
          Reactions: Not Available
          Gene Name: CYP3A43
          Uniprot ID: Q9HB55 Link_out
          Protein Sequence: FASTA
          Gene Sequence: FASTA
          Name: Cytochrome P450 1B1
          Reactions: Not Available
          Gene Name: CYP1B1
          Uniprot ID: Q16678 Link_out
          Protein Sequence: FASTA
          Gene Sequence: FASTA
          Name: Cytochrome P450 2C18
          Reactions: Not Available
          Gene Name: CYP2C18
          Uniprot ID: P33260 Link_out
          Protein Sequence: FASTA
          Gene Sequence: FASTA
          Name: Cytochrome P450 2F1
          Reactions: Not Available
          Gene Name: CYP2F1
          Uniprot ID: P24903 Link_out
          Protein Sequence: FASTA
          Gene Sequence: FASTA
          Name: Cytochrome P450 4X1
          Reactions: Not Available
          Gene Name: CYP4X1
          Uniprot ID: Q8N118 Link_out
          Protein Sequence: FASTA
          Gene Sequence: FASTA
          Name: Cytochrome P450 2B6
          Reactions: Not Available
          Gene Name: CYP2B6
          Uniprot ID: P20813 Link_out
          Protein Sequence: FASTA
          Gene Sequence: FASTA
          Name: Cytochrome P450 3A5
          Reactions: Not Available
          Gene Name: CYP3A5
          Uniprot ID: P20815 Link_out
          Protein Sequence: FASTA
          Gene Sequence: FASTA
          Name: Cytochrome P450 1A1
          Reactions: Not Available
          Gene Name: CYP1A1
          Uniprot ID: P04798 Link_out
          Protein Sequence: FASTA
          Gene Sequence: FASTA
          Name: Cytochrome P450 2A13
          Reactions: Not Available
          Gene Name: CYP2A13
          Uniprot ID: Q16696 Link_out
          Protein Sequence: FASTA
          Gene Sequence: FASTA
          Name: Cytochrome P450 3A7
          Reactions: Not Available
          Gene Name: CYP3A7
          Uniprot ID: P24462 Link_out
          Protein Sequence: FASTA
          Gene Sequence: FASTA
          Name: Cytochrome P450 4B1
          Reactions: Not Available
          Gene Name: CYP4B1
          Uniprot ID: P13584 Link_out
          Protein Sequence: FASTA
          Gene Sequence: FASTA
          Name: Cytochrome P450 4Z1
          Reactions: Not Available
          Gene Name: CYP4Z1
          Uniprot ID: Q86W10 Link_out
          Protein Sequence: FASTA
          Gene Sequence: FASTA
          Name: Cytochrome P450 1A2
          Reactions: Not Available
          Gene Name: CYP1A2
          Uniprot ID: P05177 Link_out
          Protein Sequence: FASTA
          Gene Sequence: FASTA
          Name: Cytochrome P450 19A1
          Reactions: Not Available
          Gene Name: CYP19A1
          Uniprot ID: P11511 Link_out
          Protein Sequence: FASTA
          Gene Sequence: FASTA
          Name: Cytochrome P450 2C8
          Reactions: Not Available
          Gene Name: CYP2C8
          Uniprot ID: P10632 Link_out
          Protein Sequence: FASTA
          Gene Sequence: FASTA
          Name: Cytochrome P450 2S1
          Reactions: Not Available
          Gene Name: CYP2S1
          Uniprot ID: Q96SQ9 Link_out
          Protein Sequence: FASTA
          Gene Sequence: FASTA
          Name: Cytochrome P450 2J2
          Reactions: Not Available
          Gene Name: CYP2J2
          Uniprot ID: P51589 Link_out
          Protein Sequence: FASTA
          Gene Sequence: FASTA
          Name: Cytochrome P450 2A7
          Reactions: Not Available
          Gene Name: CYP2A7
          Uniprot ID: P20853 Link_out
          Protein Sequence: FASTA
          Gene Sequence: FASTA
          Name: Cytochrome P450 2A6
          Reactions: Not Available
          Gene Name: CYP2A6
          Uniprot ID: P11509 Link_out
          Protein Sequence: FASTA
          Gene Sequence: FASTA
          Name: Sex hormone-binding globulin
          Reactions: Not Available
          Gene Name: SHBG
          Uniprot ID: P04278 Link_out
          Protein Sequence: FASTA
          Gene Sequence: FASTA
          Transporters
          Name: Solute carrier organic anion transporter family member 1B1
          Reactions: Not Available
          Gene Name: SLCO1B1
          Uniprot ID: Q9Y6L6 Link_out
          Protein Sequence: FASTA
          Gene Sequence: FASTA
          Name: Solute carrier family 22 member 7
          Reactions: Not Available
          Gene Name: SLC22A7
          Uniprot ID: Q9Y694 Link_out
          Protein Sequence: FASTA
          Gene Sequence: FASTA