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Record Information
Version3.6
Creation Date2005-11-16 15:48:42 UTC
Update Date2016-02-11 01:02:51 UTC
HMDB IDHMDB00538
Secondary Accession NumbersNone
Metabolite Identification
Common NameAdenosine triphosphate
DescriptionAdenosine triphosphate (ATP) is a nucleotide consisting of a purine base (adenine) attached to the first carbon atom of ribose (a pentose sugar). Three phosphate groups are esterified at the fifth carbon atom of the ribose. ATP is incorporated into nucleic acids by polymerases in the processes of DNA replication and transcription. ATP contributes to cellular energy charge and participates in overall energy balance, maintaining cellular homeostasis. ATP can act as an extracellular signaling molecule via interactions with specific purinergic receptors to mediate a wide variety of processes as diverse as neurotransmission, inflammation, apoptosis, and bone remodelling. Extracellular ATP and its metabolite adenosine have also been shown to exert a variety of effects on nearly every cell type in human skin, and ATP seems to play a direct role in triggering skin inflammatory, regenerative, and fibrotic responses to mechanical injury, an indirect role in melanocyte proliferation and apoptosis, and a complex role in Langerhans cell-directed adaptive immunity. During exercise, intracellular homeostasis depends on the matching of adenosine triphosphate (ATP) supply and ATP demand. Metabolites play a useful role in communicating the extent of ATP demand to the metabolic supply pathways. Effects as different as proliferation or differentiation, chemotaxis, release of cytokines or lysosomal constituents, and generation of reactive oxygen or nitrogen species are elicited upon stimulation of blood cells with extracellular ATP. The increased concentration of adenosine triphosphate (ATP) in erythrocytes from patients with chronic renal failure (CRF) has been observed in many studies but the mechanism leading to these abnormalities still is controversial. (PMID: 15490415 , 15129319 , 14707763 , 14696970 , 11157473 ).
Structure
Thumb
Synonyms
ValueSource
Adenosine 5'-triphosphateChEBI
Adenosine triphosphateChEBI
ADENOSINE-5'-triphosphATEChEBI
AdephosChEBI
AdetolChEBI
AdynolChEBI
AtipiChEBI
AtriphosChEBI
CardenosineChEBI
FosfobionChEBI
GlucobasinChEBI
H4ATPChEBI
MyotriphosChEBI
TriadenylChEBI
TriphosphadenChEBI
Adenosine 5'-triphosphoric acidGenerator
Adenosine triphosphoric acidGenerator
ADENOSINE-5'-triphosphoric acidGenerator
5'-(Tetrahydrogen triphosphate) adenosineHMDB
5'-ATPHMDB
Adenosine 5'-triphosphorateHMDB
AdenylpyrophosphorateHMDB
Adenylpyrophosphoric acidHMDB
ATPHMDB
PhosphobionHMDB
StriadyneHMDB
Triphosphoric acid adenosine esterHMDB
Chemical FormulaC10H16N5O13P3
Average Molecular Weight507.181
Monoisotopic Molecular Weight506.995745159
IUPAC Name({[({[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy](hydroxy)phosphoryl}oxy)phosphonic acid
Traditional Nameadenosine triphosphate
CAS Registry Number56-65-5
SMILES
NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O
InChI Identifier
InChI=1S/C10H16N5O13P3/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(26-10)1-25-30(21,22)28-31(23,24)27-29(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H,23,24)(H2,11,12,13)(H2,18,19,20)/t4-,6-,7-,10-/m1/s1
InChI KeyInChIKey=ZKHQWZAMYRWXGA-KQYNXXCUSA-N
Chemical Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as purine ribonucleoside triphosphates. These are purine ribobucleotides with a triphosphate group linked to the ribose moiety.
KingdomOrganic compounds
Super ClassNucleosides, nucleotides, and analogues
ClassPurine nucleotides
Sub ClassPurine ribonucleotides
Direct ParentPurine ribonucleoside triphosphates
Alternative Parents
Substituents
  • Purine ribonucleoside triphosphate
  • N-glycosyl compound
  • Glycosyl compound
  • Organic pyrophosphate
  • Monosaccharide phosphate
  • 6-aminopurine
  • Purine
  • Imidazopyrimidine
  • Monoalkyl phosphate
  • Aminopyrimidine
  • Imidolactam
  • Alkyl phosphate
  • Pyrimidine
  • Primary aromatic amine
  • Phosphoric acid ester
  • Organic phosphoric acid derivative
  • Organic phosphate
  • N-substituted imidazole
  • Monosaccharide
  • Saccharide
  • Heteroaromatic compound
  • Oxolane
  • Imidazole
  • Azole
  • Secondary alcohol
  • 1,2-diol
  • Oxacycle
  • Azacycle
  • Organoheterocyclic compound
  • Hydrocarbon derivative
  • Primary amine
  • Organooxygen compound
  • Organonitrogen compound
  • Amine
  • Alcohol
  • Aromatic heteropolycyclic compound
Molecular FrameworkAromatic heteropolycyclic compounds
External Descriptors
Ontology
StatusDetected and Quantified
Origin
  • Endogenous
Biofunction
  • Component of Aminosugars metabolism
  • Component of Fructose and mannose metabolism
  • Component of Galactose metabolism
  • Component of Starch and sucrose metabolism
  • Component of Streptomycin biosynthesis
ApplicationNot Available
Cellular locations
  • Cytoplasm
  • Extracellular
  • Mitochondria
  • Nucleus
  • Endoplasmic reticulum
  • Peroxisome
Physical Properties
StateSolid
Experimental Properties
PropertyValueReference
Melting PointNot AvailableNot Available
Boiling PointNot AvailableNot Available
Water Solubility1000.0 mg/mL; 862 mg/mL (magnesium salt)MERCK INDEX (1996); Human Metabolome Project (salt)
LogPNot AvailableNot Available
Predicted Properties
PropertyValueSource
Water Solubility4.49 mg/mLALOGPS
logP-0.84ALOGPS
logP-6ChemAxon
logS-2ALOGPS
pKa (Strongest Acidic)0.9ChemAxon
pKa (Strongest Basic)5ChemAxon
Physiological Charge-3ChemAxon
Hydrogen Acceptor Count14ChemAxon
Hydrogen Donor Count7ChemAxon
Polar Surface Area279.13 Å2ChemAxon
Rotatable Bond Count8ChemAxon
Refractivity95.81 m3·mol-1ChemAxon
Polarizability38.92 Å3ChemAxon
Number of Rings3ChemAxon
Bioavailability0ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Spectra
Spectrum TypeDescriptionSplash Key
LC-MS/MSLC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientific ) , Negativesplash10-0a4i-0131190000-316dbdca27f38ad8ee57View in MoNA
LC-MS/MSLC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientific ) , Negativesplash10-004i-0000900000-f5ffc4694dfd302fd52dView in MoNA
LC-MS/MSLC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientific ) , Negativesplash10-0a4i-0000900000-e9a09b9360491c310280View in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, NegativeNot Available
1D NMR13C NMR SpectrumNot Available
1D NMR1H NMR SpectrumNot Available
2D NMR[1H,13C] 2D NMR SpectrumNot Available
Biological Properties
Cellular Locations
  • Cytoplasm
  • Extracellular
  • Mitochondria
  • Nucleus
  • Endoplasmic reticulum
  • Peroxisome
Biofluid Locations
  • Blood
  • Cellular Cytoplasm
  • Cerebrospinal Fluid (CSF)
  • Saliva
Tissue Location
  • Adipose Tissue
  • Bladder
  • Fibroblasts
  • Intestine
  • Kidney
  • Muscle
  • Myelin
  • Nerve Cells
  • Neuron
  • Pancreas
  • Platelet
  • Skeletal Muscle
Pathways
NameSMPDB LinkKEGG Link
2-Hydroxyglutric Aciduria (D And L Form)SMP00136Not Available
2-ketoglutarate dehydrogenase complex deficiencySMP00549Not Available
2-Methyl-3-Hydroxybutryl CoA Dehydrogenase DeficiencySMP00137Not Available
27-Hydroxylase DeficiencySMP00720Not Available
3-Hydroxy-3-Methylglutaryl-CoA Lyase DeficiencySMP00138Not Available
3-hydroxyisobutyric acid dehydrogenase deficiencySMP00521Not Available
3-hydroxyisobutyric aciduriaSMP00522Not Available
3-Methylcrotonyl Coa Carboxylase Deficiency Type ISMP00237Not Available
3-Methylglutaconic Aciduria Type ISMP00139Not Available
3-Methylglutaconic Aciduria Type IIISMP00140Not Available
3-Methylglutaconic Aciduria Type IVSMP00141Not Available
3-Methylthiofentanyl Action PathwaySMP00679Not Available
3-Phosphoglycerate dehydrogenase deficiencySMP00721Not Available
4-Hydroxybutyric Aciduria/Succinic Semialdehyde Dehydrogenase DeficiencySMP00243Not Available
5-oxoprolinase deficiencySMP00500Not Available
5-OxoprolinuriaSMP00143Not Available
Abacavir Action PathwaySMP00737Not Available
Acebutolol PathwaySMP00296Not Available
Acetaminophen Metabolism PathwaySMP00640Not Available
Adefovir Dipivoxil Metabolism PathwaySMP00629Not Available
Adefovir Dipivoxil PathwaySMP00418Not Available
Adenine phosphoribosyltransferase deficiency (APRT)SMP00535Not Available
Adenosine Deaminase DeficiencySMP00144Not Available
Adenylosuccinate Lyase DeficiencySMP00167Not Available
Adrenoleukodystrophy, X-linkedSMP00516Not Available
AICA-RibosiduriaSMP00168Not Available
Alanine MetabolismSMP00055map00250
Alendronate pathwaySMP00095Not Available
Alfentanil PathwaySMP00413Not Available
Alprenolol PathwaySMP00297Not Available
Alvimopan Action PathwaySMP00685Not Available
Amikacin PathwaySMP00253Not Available
Amino Sugar MetabolismSMP00045map00520
Amiodarone Action PathwaySMP00665Not Available
Amlodipine PathwaySMP00376Not Available
Ammonia RecyclingSMP00009map00910
Anileridine Action PathwaySMP00674Not Available
Arbekacin Action PathwaySMP00713Not Available
Arbutamine Action PathwaySMP00664Not Available
Arginine and Proline MetabolismSMP00020map00330
Arginine: Glycine Amidinotransferase Deficiency (AGAT Deficiency)SMP00362Not Available
ArgininemiaSMP00357Not Available
Argininosuccinic AciduriaSMP00003Not Available
Aspartate MetabolismSMP00067map00250
Atenolol PathwaySMP00298Not Available
Atorvastatin PathwaySMP00131Not Available
Azathioprine PathwaySMP00427Not Available
Azithromycin PathwaySMP00247Not Available
Benzocaine PathwaySMP00392Not Available
Beta Oxidation of Very Long Chain Fatty AcidsSMP00052map01040
Beta Ureidopropionase DeficiencySMP00172Not Available
Beta-Ketothiolase DeficiencySMP00173Not Available
Beta-mercaptolactate-cysteine disulfiduriaSMP00499Not Available
Betaine MetabolismSMP00123map00260
Betaxolol PathwaySMP00299Not Available
Betazole Action PathwaySMP00736Not Available
Bevantolol Action PathwaySMP00668Not Available
Bile Acid BiosynthesisSMP00035map00120
Biotin MetabolismSMP00066map00780
Biotinidase DeficiencySMP00174Not Available
Bisoprolol PathwaySMP00300Not Available
Bopindolol Action PathwaySMP00657Not Available
Bupivacaine PathwaySMP00393Not Available
Bupranolol Action PathwaySMP00670Not Available
Buprenorphine Action PathwaySMP00684Not Available
Butyrate MetabolismSMP00073map00650
Canavan DiseaseSMP00175Not Available
Carbamoyl Phosphate Synthetase DeficiencySMP00002Not Available
Carfentanil PathwaySMP00414Not Available
Carnitine palmitoyl transferase deficiency (I)SMP00538Not Available
Carnitine palmitoyl transferase deficiency (II)SMP00541Not Available
Carnitine-acylcarnitine translocase deficiencySMP00517Not Available
Carteolol Action PathwaySMP00658Not Available
Carvedilol PathwaySMP00367Not Available
Cerebrotendinous Xanthomatosis (CTX)SMP00315Not Available
Cerivastatin PathwaySMP00111Not Available
CHILD SyndromeSMP00387Not Available
Chloramphenicol Action PathwaySMP00729Not Available
Chloroprocaine PathwaySMP00394Not Available
Cholesteryl ester storage diseaseSMP00508Not Available
Chondrodysplasia Punctata II, X Linked Dominant (CDPX2)SMP00388Not Available
Cimetidine PathwaySMP00232Not Available
Citalopram PathwaySMP00424Not Available
Citric Acid CycleSMP00057map00020
Citrullinemia Type ISMP00001Not Available
Clarithromycin PathwaySMP00248Not Available
Clindamycin PathwaySMP00249Not Available
Clomocycline PathwaySMP00262Not Available
Clopidogrel Metabolism PathwaySMP00610Not Available
Clopidogrel PathwaySMP00260Not Available
Cocaine PathwaySMP00395Not Available
Codeine PathwaySMP00405Not Available
Congenital Bile Acid Synthesis Defect Type IISMP00314Not Available
Congenital Bile Acid Synthesis Defect Type IIISMP00318Not Available
Congenital disorder of glycosylation CDG-IIdSMP00579Not Available
Congenital lactic acidosisSMP00546Not Available
Corticotropin Activation of Cortisol ProductionSMP00310Not Available
Creatine deficiency, guanidinoacetate methyltransferase deficiencySMP00504Not Available
Cystathionine Beta-Synthase DeficiencySMP00177Not Available
Cysteine MetabolismSMP00013map00270
Cystinosis, ocular nonnephropathicSMP00722Not Available
D-glyceric aciduraSMP00529Not Available
Delavirdine Action PathwaySMP00738Not Available
Demeclocycline PathwaySMP00290Not Available
Desipramine PathwaySMP00423Not Available
DesmosterolosisSMP00386Not Available
Dezocine Action PathwaySMP00676Not Available
Dibucaine PathwaySMP00396Not Available
Didanosine Action PathwaySMP00739Not Available
Dihydromorphine Action PathwaySMP00689Not Available
Dihydropyrimidinase DeficiencySMP00178Not Available
Dihydropyrimidine Dehydrogenase Deficiency (DHPD)SMP00179Not Available
Diltiazem PathwaySMP00359Not Available
Dimethylglycine Dehydrogenase DeficiencySMP00242Not Available
Dimethylglycine Dehydrogenase DeficiencySMP00484Not Available
Dimethylthiambutene Action PathwaySMP00680Not Available
Diphenoxylate Action PathwaySMP00675Not Available
Disopyramide PathwaySMP00325Not Available
Disulfiram PathwaySMP00429Not Available
DNA Replication ForkSMP00477Not Available
Dobutamine Action PathwaySMP00662Not Available
Docetaxel PathwaySMP00435Not Available
Dopamine Activation of Neurological Reward SystemSMP00308Not Available
Doxorubicin Metabolism PathwaySMP00650Not Available
Doxycycline PathwaySMP00291Not Available
Efavirenz Action PathwaySMP00740Not Available
Emtricitabine Action PathwaySMP00741Not Available
Epinephrine Action PathwaySMP00661Not Available
Erlotinib PathwaySMP00472Not Available
Erythromycin PathwaySMP00250Not Available
Escitalopram PathwaySMP00425Not Available
Esmolol PathwaySMP00301Not Available
Esomeprazole PathwaySMP00225Not Available
Ethanol DegradationSMP00449Not Available
Ethylmalonic EncephalopathySMP00181Not Available
Ethylmorphine Action PathwaySMP00681Not Available
Etoposide Metabolism PathwaySMP00601Not Available
Etoposide PathwaySMP00442Not Available
Excitatory Neural Signalling Through 5-HTR 4 and SerotoninSMP00309Not Available
Excitatory Neural Signalling Through 5-HTR 6 and Serotonin SMP00312Not Available
Excitatory Neural Signalling Through 5-HTR 7 and Serotonin SMP00311Not Available
Fabry diseaseSMP00525Not Available
Familial Hypercholanemia (FHCA)SMP00317Not Available
Familial lipoprotein lipase deficiencySMP00530Not Available
Famotidine PathwaySMP00231Not Available
Fanconi-bickel syndromeSMP00572Not Available
Fatty acid MetabolismSMP00051map00071
Felodipine PathwaySMP00377Not Available
Fentanyl PathwaySMP00415Not Available
Flecainide PathwaySMP00331Not Available
Fluoxetine PathwaySMP00426Not Available
Fluvastatin PathwaySMP00119Not Available
Folate malabsorption, hereditarySMP00724Not Available
Folate MetabolismSMP00053map00670
Fosphenytoin (Antiarrhythmic) PathwaySMP00326Not Available
Fructose and Mannose DegradationSMP00064map00051
Fructose intolerance, hereditarySMP00725Not Available
Fructose-1,6-diphosphatase deficiencySMP00562Not Available
FructosuriaSMP00561Not Available
Fumarase deficiencySMP00547Not Available
G(M2)-Gangliosidosis: Variant B, Tay-sachs diseaseSMP00534Not Available
Galactose MetabolismSMP00043map00052
GalactosemiaSMP00182Not Available
Galactosemia II (GALK)SMP00495Not Available
Galactosemia IIISMP00496Not Available
Gamma-glutamyl-transpeptidase deficiencySMP00501Not Available
Gamma-Glutamyltransferase DeficiencySMP00183Not Available
Gastric Acid ProductionSMP00589Not Available
Gaucher DiseaseSMP00349Not Available
Gemcitabine Metabolism PathwaySMP00603Not Available
Gemcitabine PathwaySMP00446Not Available
Gentamicin PathwaySMP00254Not Available
Glibenclamide PathwaySMP00460Not Available
Gliclazide PathwaySMP00461Not Available
Globoid Cell LeukodystrophySMP00348Not Available
GluconeogenesisSMP00128map00010
Glucose-6-phosphate dehydrogenase deficiencySMP00518Not Available
GLUT-1 deficiency syndromeSMP00580Not Available
Glutamate MetabolismSMP00072map00250
Glutaminolysis and CancerSMP02298Not Available
Glutaric Aciduria Type ISMP00185Not Available
Glutathione MetabolismSMP00015map00480
Glutathione Synthetase DeficiencySMP00337Not Available
Glycerol Kinase DeficiencySMP00187Not Available
Glycerolipid MetabolismSMP00039map00561
Glycine and Serine MetabolismSMP00004map00260
Glycine N-methyltransferase DeficiencySMP00222Not Available
Glycogen Storage Disease Type 1A (GSD1A) or Von Gierke DiseaseSMP00374Not Available
Glycogen synthetase deficiencySMP00552Not Available
Glycogenosis, Type IA. Von gierke diseaseSMP00581Not Available
Glycogenosis, Type IBSMP00573Not Available
Glycogenosis, Type ICSMP00574Not Available
Glycogenosis, Type III. Cori disease, Debrancher glycogenosisSMP00553Not Available
Glycogenosis, Type IV. Amylopectinosis, Anderson diseaseSMP00554Not Available
Glycogenosis, Type VI. Hers diseaseSMP00555Not Available
Glycogenosis, Type VII. Tarui diseaseSMP00531Not Available
GlycolysisSMP00040map00010
Gout or Kelley-Seegmiller SyndromeSMP00365Not Available
Guanidinoacetate Methyltransferase Deficiency (GAMT Deficiency)SMP00188Not Available
Heroin PathwaySMP00407Not Available
Histidine MetabolismSMP00044map00340
HistidinemiaSMP00191Not Available
HomocarnosinosisSMP00385Not Available
Homocystinuria-megaloblastic anemia due to defect in cobalamin metabolism, cblG complementation typeSMP00570Not Available
Hydrocodone PathwaySMP00411Not Available
Hydromorphone PathwaySMP00410Not Available
Hyper-IgD syndromeSMP00509Not Available
HypercholesterolemiaSMP00209Not Available
Hyperglycinemia, non-ketoticSMP00485Not Available
Hyperinsulinism-Hyperammonemia SyndromeSMP00339Not Available
HypermethioninemiaSMP00341Not Available
Hyperornithinemia with gyrate atrophy (HOGA)SMP00505Not Available
Hyperornithinemia-hyperammonemia-homocitrullinuria [HHH-syndrome]SMP00506Not Available
Hyperprolinemia Type ISMP00361Not Available
Hyperprolinemia Type IISMP00360Not Available
HypoacetylaspartiaSMP00192Not Available
Ibandronate PathwaySMP00079Not Available
Ibutilide PathwaySMP00332Not Available
Imipramine PathwaySMP00422Not Available
Inositol MetabolismSMP00011map00562
Inositol Phosphate MetabolismSMP00462map00562
Intracellular Signalling Through Adenosine Receptor A2a and AdenosineSMP00320Not Available
Intracellular Signalling Through Adenosine Receptor A2b and AdenosineSMP00321Not Available
Intracellular Signalling Through FSH Receptor and Follicle Stimulating HormoneSMP00333Not Available
Intracellular Signalling Through Histamine H2 Receptor and HistamineSMP00335Not Available
Intracellular Signalling Through LHCGR Receptor and Luteinizing Hormone/ChoriogonadotropinSMP00338Not Available
Intracellular Signalling Through PGD2 receptor and Prostaglandin D2SMP00343Not Available
Intracellular Signalling Through Prostacyclin Receptor and ProstacyclinSMP00354Not Available
Irinotecan Metabolism PathwaySMP00600Not Available
Irinotecan PathwaySMP00433Not Available
Isobutyryl-coa dehydrogenase deficiencySMP00523Not Available
Isoprenaline Action PathwaySMP00663Not Available
Isovaleric acidemiaSMP00524Not Available
Isovaleric AciduriaSMP00238Not Available
Isradipine PathwaySMP00378Not Available
Josamycin Action PathwaySMP00731Not Available
Joubert syndromeSMP00582Not Available
Kanamycin PathwaySMP00255Not Available
Ketobemidone Action PathwaySMP00690Not Available
Krabbe diseaseSMP00526Not Available
L-arginine:glycine amidinotransferase deficiencySMP00507Not Available
Labetalol PathwaySMP00368Not Available
Lactic AcidemiaSMP00313Not Available
Lactose DegradationSMP00457Not Available
Lactose IntoleranceSMP00458Not Available
Lactose SynthesisSMP00444Not Available
Lamivudine Action PathwaySMP00742Not Available
Lamivudine Metabolism PathwaySMP00649Not Available
Lansoprazole PathwaySMP00227Not Available
Leigh SyndromeSMP00196Not Available
Lesch-Nyhan Syndrome (LNS)SMP00364Not Available
Levallorphan Action PathwaySMP00683Not Available
Levobunolol Action PathwaySMP00666Not Available
Levobupivacaine PathwaySMP00397Not Available
Levomethadyl Acetate Action Action PathwaySMP00677Not Available
Levorphanol Action PathwaySMP00673Not Available
Lidocaine (Antiarrhythmic) PathwaySMP00328Not Available
Lidocaine (Local Anaesthetic) PathwaySMP00398Not Available
Lincomycin Action PathwaySMP00728Not Available
Long chain acyl-CoA dehydrogenase deficiency (LCAD)SMP00539Not Available
Lovastatin PathwaySMP00099Not Available
Lymecycline PathwaySMP00295Not Available
Lysosomal Acid Lipase Deficiency (Wolman Disease)SMP00319Not Available
Malonic AciduriaSMP00198Not Available
Malonyl-coa decarboxylase deficiencySMP00502Not Available
Maple Syrup Urine DiseaseSMP00199Not Available
Medium chain acyl-coa dehydrogenase deficiency (MCAD)SMP00542Not Available
Mepivacaine PathwaySMP00399Not Available
Mercaptopurine Metabolism PathwaySMP00609Not Available
Mercaptopurine PathwaySMP00428Not Available
Metachromatic Leukodystrophy (MLD)SMP00347Not Available
Methacycline Action PathwaySMP00727Not Available
Methadone PathwaySMP00408Not Available
Methadyl Acetate Action PathwaySMP00678Not Available
Methionine Adenosyltransferase DeficiencySMP00221Not Available
Methionine MetabolismSMP00033map00270
Methotrexate PathwaySMP00432Not Available
Methylenetetrahydrofolate Reductase Deficiency (MTHFRD)SMP00543Not Available
Methylenetetrahydrofolate Reductase Deficiency (MTHFRD)SMP00340Not Available
Methylmalonate Semialdehyde Dehydrogenase DeficiencySMP00384Not Available
Methylmalonic AciduriaSMP00200Not Available
Methylmalonic Aciduria Due to Cobalamin-Related DisordersSMP00201Not Available
Metiamide Action PathwaySMP00735Not Available
Metipranolol Action PathwaySMP00667Not Available
Metoprolol PathwaySMP00302Not Available
Mevalonic aciduriaSMP00510Not Available
Mexiletine PathwaySMP00329Not Available
Minocycline PathwaySMP00292Not Available
Mitochondrial Beta-Oxidation of Long Chain Saturated Fatty AcidsSMP00482Not Available
Mitochondrial Beta-Oxidation of Medium Chain Saturated Fatty AcidsSMP00481Not Available
Mitochondrial Beta-Oxidation of Short Chain Saturated Fatty AcidsSMP00480Not Available
Mitochondrial complex II deficiencySMP00548Not Available
Mitochondrial DNA depletion syndromeSMP00536Not Available
Mitochondrial Electron Transport ChainSMP00355map00190
MNGIE (Mitochondrial Neurogastrointestinal Encephalopathy)SMP00202Not Available
Molybdenum Cofactor DeficiencySMP00203Not Available
Morphine PathwaySMP00406Not Available
Mucopolysaccharidosis VI. Sly syndromeSMP00556Not Available
Multiple carboxylase deficiency, neonatal or early onset formSMP00564Not Available
Muscle/Heart ContractionSMP00588Not Available
Mycophenolic Acid Metabolism PathwaySMP00652Not Available
Myoadenylate deaminase deficiencySMP00537Not Available
Nadolol PathwaySMP00303Not Available
Nalbuphine Action PathwaySMP00691Not Available
Naloxone Action PathwaySMP00688Not Available
Naltrexone Action PathwaySMP00687Not Available
Nateglinide PathwaySMP00453Not Available
Nebivolol PathwaySMP00366Not Available
Neomycin PathwaySMP00256Not Available
Netilmicin PathwaySMP00257Not Available
Nevirapine Action PathwaySMP00743Not Available
Nevirapine Metabolism PathwaySMP00642Not Available
Nicotinate and Nicotinamide MetabolismSMP00048map00760
Nicotine PathwaySMP00431Not Available
Nifedipine PathwaySMP00379Not Available
Nimodipine PathwaySMP00380Not Available
Nisoldipine PathwaySMP00381Not Available
Nitrendipine PathwaySMP00382Not Available
Nizatidine PathwaySMP00233Not Available
Non Ketotic HyperglycinemiaSMP00223Not Available
Nucleotide Sugars MetabolismSMP00010map00520
Omeprazole PathwaySMP00226Not Available
Ornithine Aminotransferase Deficiency (OAT Deficiency)SMP00363Not Available
Ornithine Transcarbamylase Deficiency (OTC Deficiency)SMP00205Not Available
Oxidation of Branched Chain Fatty AcidsSMP00030Not Available
Oxprenolol PathwaySMP00304Not Available
Oxybuprocaine PathwaySMP00400Not Available
Oxycodone PathwaySMP00409Not Available
Oxymorphone PathwaySMP00412Not Available
Oxytetracycline PathwaySMP00293Not Available
Paclitaxel PathwaySMP00434Not Available
Pamidronate PathwaySMP00117Not Available
Pancreas FunctionSMP00643Not Available
Pantoprazole PathwaySMP00228Not Available
Pantothenate and CoA BiosynthesisSMP00027map00770
Paromomycin Action PathwaySMP00714Not Available
Penbutolol PathwaySMP00305Not Available
Pentazocine Action PathwaySMP00686Not Available
Pentose Phosphate PathwaySMP00031map00030
Phenylacetate MetabolismSMP00126map00360
Phenylalanine and Tyrosine MetabolismSMP00008map00360
PhenylketonuriaSMP00206Not Available
Phenytoin (Antiarrhythmic) PathwaySMP00327Not Available
Phosphatidylinositol Phosphate MetabolismSMP00463map00562
Phosphoenolpyruvate carboxykinase deficiency 1 (PEPCK1)SMP00560Not Available
Phytanic Acid Peroxisomal OxidationSMP00450Not Available
Pindolol PathwaySMP00306Not Available
Pirenzepine PathwaySMP00246Not Available
Practolol Action PathwaySMP00669Not Available
Pravastatin PathwaySMP00089Not Available
Prilocaine PathwaySMP00401Not Available
Primary hyperoxaluria II, PH2SMP00558Not Available
Primary Hyperoxaluria Type ISMP00352Not Available
Procainamide (Antiarrhythmic) PathwaySMP00324Not Available
Procaine PathwaySMP00402Not Available
Prolidase Deficiency (PD)SMP00207Not Available
Prolinemia Type IISMP00208Not Available
Propanoate MetabolismSMP00016map00640
Proparacaine PathwaySMP00403Not Available
Propionic AcidemiaSMP00236Not Available
Propoxyphene Action PathwaySMP00672Not Available
Propranolol PathwaySMP00307Not Available
Purine MetabolismSMP00050map00230
Purine Nucleoside Phosphorylase DeficiencySMP00210Not Available
Pyrimidine MetabolismSMP00046map00240
Pyruvate Carboxylase DeficiencySMP00350Not Available
Pyruvate Decarboxylase E1 Component Deficiency (PDHE1 Deficiency)SMP00334Not Available
Pyruvate Dehydrogenase Complex DeficiencySMP00212Not Available
Pyruvate dehydrogenase deficiency (E2)SMP00551Not Available
Pyruvate dehydrogenase deficiency (E3)SMP00550Not Available
Pyruvate kinase deficiencySMP00559Not Available
Pyruvate MetabolismSMP00060map00620
Quinidine PathwaySMP00323Not Available
Rabeprazole PathwaySMP00229Not Available
Ranitidine PathwaySMP00230Not Available
Refsum DiseaseSMP00451Not Available
Remifentanil PathwaySMP00416Not Available
Repaglinide PathwaySMP00454Not Available
Riboflavin MetabolismSMP00070map00740
Ribose-5-phosphate isomerase deficiencySMP00519Not Available
Rilpivirine Action PathwaySMP00744Not Available
Risedronate PathwaySMP00112Not Available
Rolitetracycline Action PathwaySMP00726Not Available
Ropivacaine PathwaySMP00404Not Available
Rosuvastatin PathwaySMP00092Not Available
Roxatidine acetate Action PathwaySMP00734Not Available
Roxithromycin PathwaySMP00251Not Available
S-Adenosylhomocysteine (SAH) Hydrolase DeficiencySMP00214Not Available
Salla Disease/Infantile Sialic Acid Storage DiseaseSMP00240Not Available
sarcosine oncometabolite pathway SMP02313Not Available
SarcosinemiaSMP00244Not Available
Selenoamino Acid MetabolismSMP00029map00450
Short Chain Acyl CoA Dehydrogenase Deficiency (SCAD Deficiency)SMP00235Not Available
Short-chain 3-hydroxyacyl-CoA dehydrogenase deficiency (SCHAD)SMP00568Not Available
Sialuria or French Type SialuriaSMP00216Not Available
Sialuria or French Type SialuriaSMP00217Not Available
Simvastatin Action PathwaySMP00082Not Available
Smith-Lemli-Opitz Syndrome (SLOS)SMP00389Not Available
Sotalol Action PathwaySMP00660Not Available
Spectinomycin PathwaySMP00258Not Available
Spermidine and Spermine BiosynthesisSMP00445Not Available
Sphingolipid MetabolismSMP00034map00500
Starch and Sucrose MetabolismSMP00058map00500
Stavudine Action PathwaySMP00745Not Available
Steroid BiosynthesisSMP00023map00100
Streptomycin PathwaySMP00259Not Available
Succinic semialdehyde dehydrogenase deficiencySMP00567Not Available
Sucrase-isomaltase deficiencySMP00557Not Available
Sufentanil PathwaySMP00417Not Available
Sulfate/Sulfite MetabolismSMP00041map00920
Sulfite oxidase deficiencySMP00532Not Available
Tay-Sachs DiseaseSMP00390Not Available
Telithromycin PathwaySMP00252Not Available
Tenofovir Metabolism PathwaySMP00630Not Available
Tenofovir PathwaySMP00419Not Available
Tetracycline PathwaySMP00294Not Available
The oncogenic action of 2-hydroxyglutarateSMP02291Not Available
The oncogenic action of D-2-hydroxyglutarate in Hydroxygluaricaciduria SMP02359Not Available
The oncogenic action of FumarateSMP02295Not Available
The oncogenic action of L-2-hydroxyglutarate in HydroxygluaricaciduriaSMP02358Not Available
The oncogenic action of SuccinateSMP02292Not Available
Thiamine MetabolismSMP00076map00730
Thioguanine PathwaySMP00430Not Available
Threonine and 2-Oxobutanoate DegradationSMP00452Not Available
Tigecycline Action PathwaySMP00712Not Available
Timolol Action PathwaySMP00659Not Available
Tobramycin Action PathwaySMP00711Not Available
Tocainide PathwaySMP00330Not Available
Tramadol Action Action PathwaySMP00671Not Available
Tramadol Metabolism PathwaySMP00637Not Available
Transaldolase deficiencySMP00520Not Available
Transcription/TranslationSMP00019Not Available
Transfer of Acetyl Groups into MitochondriaSMP00466Not Available
Trehalose DegradationSMP00467Not Available
Trifunctional protein deficiencySMP00545Not Available
Triosephosphate isomeraseSMP00563Not Available
Troleandomycin Action PathwaySMP00730Not Available
Tryptophan MetabolismSMP00063map00380
Tyrosinemia Type 2 (or Richner-Hanhart syndrome)SMP00369Not Available
Tyrosinemia Type 3 (TYRO3)SMP00370Not Available
UMP Synthase Deiciency (Orotic Aciduria)SMP00219Not Available
Urea CycleSMP00059map00330
Valine, Leucine and Isoleucine DegradationSMP00032map00280
Valproic Acid Metabolism PathwaySMP00635Not Available
Vasopressin Regulation of Water HomeostasisSMP00322Not Available
Verapamil PathwaySMP00375Not Available
Very-long-chain acyl coa dehydrogenase deficiency (VLCAD)SMP00540Not Available
Vinblastine PathwaySMP00436Not Available
Vincristine PathwaySMP00437Not Available
Vindesine PathwaySMP00438Not Available
Vinorelbine PathwaySMP00439Not Available
Warburg EffectSMP00654Not Available
Wolman diseaseSMP00511Not Available
Xanthine Dehydrogenase Deficiency (Xanthinuria)SMP00220Not Available
Xanthinuria type ISMP00512Not Available
Xanthinuria type IISMP00513Not Available
Zalcitabine Action PathwaySMP00746Not Available
Zellweger SyndromeSMP00316Not Available
Zidovudine Action PathwaySMP00747Not Available
Zoledronate PathwaySMP00107Not Available
Normal Concentrations
BiofluidStatusValueAgeSexConditionReferenceDetails
BloodDetected and Quantified1077.0 +/- 210.0 uMNewborn (0-30 days old)BothNormal
    • Geigy Scientific ...
details
BloodDetected and Quantified1552.0 +/- 161.0 uMAdult (>18 years old)MaleNormal
    • Geigy Scientific ...
details
BloodDetected and Quantified1390.0 +/- 170.0 uMAdult (>18 years old)BothNormal
    • Geigy Scientific ...
details
BloodDetected and Quantified3152.0 +/- 1698.0 uMAdult (>18 years old)BothNormal details
Cellular CytoplasmDetected and Quantified1540 (1290-1790) uMAdult (>18 years old)BothNormal details
Cerebrospinal Fluid (CSF)Detected and Quantified1.85 +/- 0.03 uMAdult (>18 years old)BothNormal details
SalivaDetected and Quantified0.47 +/- 0.36 uMAdult (>18 years old)BothNormal
    • Zerihun T. Dame, ...
details
SalivaDetected and Quantified0.52 +/- 0.15 uMAdult (>18 years old)Both
Normal
details
SalivaDetected and Quantified0.47 +/- 0.15 uMAdult (>18 years old)Both
Normal
details
SalivaDetected and Quantified0.46 +/- 0.15 uMAdult (>18 years old)Both
Normal
details
Abnormal Concentrations
BiofluidStatusValueAgeSexConditionReferenceDetails
Cerebrospinal Fluid (CSF)Detected and Quantified0.23 +/- 0.19 uMAdult (>18 years old)BothRachialgia details
Cerebrospinal Fluid (CSF)Detected and Quantified0.80 +/- 0.63 uMAdult (>18 years old)BothSubarachnoid hemorrhage details
Cerebrospinal Fluid (CSF)Detected and Quantified1.08 +/- 0.77 uMAdult (>18 years old)BothEpilepsy details
Cerebrospinal Fluid (CSF)Detected and Quantified0.26 +/- 0.11 uMAdult (>18 years old)Both
Stroke
details
Cerebrospinal Fluid (CSF)Detected and Quantified1.09 +/- 0.76 uMAdult (>18 years old)BothNeuroinfection details
Associated Disorders and Diseases
Disease References
Subarachnoid hemorrhage
  1. Czarnecka J, Cieslak M, Michal K: Application of solid phase extraction and high-performance liquid chromatography to qualitative and quantitative analysis of nucleotides and nucleosides in human cerebrospinal fluid. J Chromatogr B Analyt Technol Biomed Life Sci. 2005 Aug 5;822(1-2):85-90. [15993662 ]
Epilepsy
  1. Czarnecka J, Cieslak M, Michal K: Application of solid phase extraction and high-performance liquid chromatography to qualitative and quantitative analysis of nucleotides and nucleosides in human cerebrospinal fluid. J Chromatogr B Analyt Technol Biomed Life Sci. 2005 Aug 5;822(1-2):85-90. [15993662 ]
Neuroinfection
  1. Czarnecka J, Cieslak M, Michal K: Application of solid phase extraction and high-performance liquid chromatography to qualitative and quantitative analysis of nucleotides and nucleosides in human cerebrospinal fluid. J Chromatogr B Analyt Technol Biomed Life Sci. 2005 Aug 5;822(1-2):85-90. [15993662 ]
Rachialgia
  1. Czarnecka J, Cieslak M, Michal K: Application of solid phase extraction and high-performance liquid chromatography to qualitative and quantitative analysis of nucleotides and nucleosides in human cerebrospinal fluid. J Chromatogr B Analyt Technol Biomed Life Sci. 2005 Aug 5;822(1-2):85-90. [15993662 ]
Stroke
  1. Czarnecka J, Cieslak M, Michal K: Application of solid phase extraction and high-performance liquid chromatography to qualitative and quantitative analysis of nucleotides and nucleosides in human cerebrospinal fluid. J Chromatogr B Analyt Technol Biomed Life Sci. 2005 Aug 5;822(1-2):85-90. [15993662 ]
Associated OMIM IDs
DrugBank IDNot Available
DrugBank Metabolite IDNot Available
Phenol Explorer Compound IDNot Available
Phenol Explorer Metabolite IDNot Available
FoodDB IDFDB021813
KNApSAcK IDNot Available
Chemspider ID5742
KEGG Compound IDC00002
BioCyc IDATP
BiGG ID33477
Wikipedia LinkAdenosine triphosphate
NuGOwiki LinkHMDB00538
Metagene LinkHMDB00538
METLIN ID5523
PubChem Compound5957
PDB IDATP
ChEBI ID15422
References
Synthesis ReferenceClark, V. M.; Kirby, G. W.; Todd, Alexander. Phosphorylation. XV. Use of phosphoramidic esters in acylation-new preparation of adenosine 5'-pyrophosphate and adenosine 5'-triphosphate. Journal of the Chemical Society (1957), 1497-1501.
Material Safety Data Sheet (MSDS)Not Available
General References
  1. Nakayama Y, Kinoshita A, Tomita M: Dynamic simulation of red blood cell metabolism and its application to the analysis of a pathological condition. Theor Biol Med Model. 2005 May 9;2(1):18. [15882454 ]
  2. Gottlieb C, Svanborg K, Eneroth P, Bygdeman M: Effect of prostaglandins on human sperm function in vitro and seminal adenosine triphosphate content. Fertil Steril. 1988 Feb;49(2):322-7. [3338588 ]
  3. Mahmoud AM, Comhaire FH, Vermeulen L, Andreou E: Comparison of the resazurin test, adenosine triphosphate in semen, and various sperm parameters. Hum Reprod. 1994 Sep;9(9):1688-93. [7836519 ]
  4. Kadmon M, Klunemann C, Bohme M, Ishikawa T, Gorgas K, Otto G, Herfarth C, Keppler D: Inhibition by cyclosporin A of adenosine triphosphate-dependent transport from the hepatocyte into bile. Gastroenterology. 1993 May;104(5):1507-14. [7683296 ]
  5. Sun Y, MaLossi J, Jacobs SC, Chai TC: Effect of doxazosin on stretch-activated adenosine triphosphate release in bladder urothelial cells from patients with benign prostatic hyperplasia. Urology. 2002 Aug;60(2):351-6. [12137852 ]
  6. Ryan LM, Rachow JW, McCarty BA, McCarty DJ: Adenosine triphosphate levels in human plasma. J Rheumatol. 1996 Feb;23(2):214-9. [8882021 ]
  7. Yoshida M, Miyamae K, Iwashita H, Otani M, Inadome A: Management of detrusor dysfunction in the elderly: changes in acetylcholine and adenosine triphosphate release during aging. Urology. 2004 Mar;63(3 Suppl 1):17-23. [15013648 ]
  8. Bar-Meir M, Elpeleg ON, Saada A: Effect of various agents on adenosine triphosphate synthesis in mitochondrial complex I deficiency. J Pediatr. 2001 Dec;139(6):868-70. [11743516 ]
  9. Mannucci L, Pastore A, Rizzo C, Piemonte F, Rizzoni G, Emma F: Impaired activity of the gamma-glutamyl cycle in nephropathic cystinosis fibroblasts. Pediatr Res. 2006 Feb;59(2):332-5. [16439602 ]
  10. Livingston JH, Brown JK, Harkness RA, McCreanor GM: Cerebrospinal fluid nucleotide metabolites following non-convulsive status epilepticus. Dev Med Child Neurol. 1989 Apr;31(2):168-73. [2737369 ]
  11. Rutkowski B, Swierczynski J, Slominska E, Szolkiewicz M, Smolenski RT, Marlewski M, Butto B, Rutkowski P: Disturbances of purine nucleotide metabolism in uremia. Semin Nephrol. 2004 Sep;24(5):479-83. [15490415 ]
  12. Holzer AM, Granstein RD: Role of extracellular adenosine triphosphate in human skin. J Cutan Med Surg. 2004 Mar-Apr;8(2):90-6. Epub 2004 May 3. [15129319 ]
  13. Myburgh KH: Can any metabolites partially alleviate fatigue manifestations at the cross-bridge? Med Sci Sports Exerc. 2004 Jan;36(1):20-7. [14707763 ]
  14. Gartland A, Buckley KA, Hipskind RA, Bowler WB, Gallagher JA: P2 receptors in bone--modulation of osteoclast formation and activity via P2X7 activation. Crit Rev Eukaryot Gene Expr. 2003;13(2-4):237-42. [14696970 ]
  15. Di Virgilio F, Chiozzi P, Ferrari D, Falzoni S, Sanz JM, Morelli A, Torboli M, Bolognesi G, Baricordi OR: Nucleotide receptors: an emerging family of regulatory molecules in blood cells. Blood. 2001 Feb 1;97(3):587-600. [11157473 ]

Only showing the first 50 proteins. There are 1040 proteins in total.

Enzymes

General function:
Involved in calcium ion binding
Specific function:
Calcium-dependent nucleotidase with a preference for UDP. The order of activity with different substrates is UDP > GDP > UTP > GTP. Has very low activity towards ADP and even lower activity towards ATP. Does not hydrolyze AMP and GMP. Involved in proteoglycan synthesis.
Gene Name:
CANT1
Uniprot ID:
Q8WVQ1
Molecular weight:
44839.24
General function:
Involved in acyl carrier activity
Specific function:
Acyl-CoA synthases catalyze the initial reaction in fatty acid metabolism, by forming a thioester with CoA
Gene Name:
AASDH
Uniprot ID:
Q4L235
Molecular weight:
122596.1
General function:
Involved in oxidoreductase activity
Specific function:
Plays a pivotal role in cell survival by repairing damaged DNA in a p53/TP53-dependent manner. Supplies deoxyribonucleotides for DNA repair in cells arrested at G1 or G2. Contains an iron-tyrosyl free radical center required for catalysis. Forms an active ribonucleotide reductase (RNR) complex with RRM1 which is expressed both in resting and proliferating cells in response to DNA damage.
Gene Name:
RRM2B
Uniprot ID:
Q7LG56
Molecular weight:
48786.6
General function:
Involved in oxidation reduction
Specific function:
Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.
Gene Name:
RRM1
Uniprot ID:
P23921
Molecular weight:
90069.375
General function:
Involved in oxidoreductase activity
Specific function:
Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. Inhibits Wnt signaling.
Gene Name:
RRM2
Uniprot ID:
P31350
Molecular weight:
44877.25
General function:
Involved in hydrolase activity
Specific function:
This protein is a "fusion" protein encoding four enzymatic activities of the pyrimidine pathway (GATase, CPSase, ATCase and DHOase).
Gene Name:
CAD
Uniprot ID:
P27708
Molecular weight:
242981.73
Reactions
Adenosine triphosphate + L-Glutamine + Carbonic acid + Water → ADP + Phosphoric acid + L-Glutamic acid + Carbamoyl phosphatedetails
General function:
Involved in ATP citrate synthase activity
Specific function:
ATP citrate-lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. Has a central role in de novo lipid synthesis. In nervous tissue it may be involved in the biosynthesis of acetylcholine.
Gene Name:
ACLY
Uniprot ID:
P53396
Molecular weight:
120838.27
Reactions
ADP + Phosphoric acid + Acetyl-CoA + Oxalacetic acid → Adenosine triphosphate + Citric acid + Coenzyme Adetails
Adenosine triphosphate + Citric acid + Coenzyme A → ADP + Phosphoric acid + Acetyl-CoA + Oxalacetic aciddetails
General function:
Involved in magnesium ion binding
Specific function:
Catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis.
Gene Name:
PRPS1
Uniprot ID:
P60891
Molecular weight:
12324.195
Reactions
Adenosine triphosphate + D-Ribose 5-phosphate → Adenosine monophosphate + Phosphoribosyl pyrophosphatedetails
General function:
Involved in magnesium ion binding
Specific function:
Catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis.
Gene Name:
PRPS2
Uniprot ID:
P11908
Molecular weight:
35054.06
Reactions
Adenosine triphosphate + D-Ribose 5-phosphate → Adenosine monophosphate + Phosphoribosyl pyrophosphatedetails
General function:
Involved in methionine adenosyltransferase activity
Specific function:
Catalyzes the formation of S-adenosylmethionine from methionine and ATP.
Gene Name:
MAT1A
Uniprot ID:
Q00266
Molecular weight:
43647.6
Reactions
Adenosine triphosphate + L-Methionine + Water → Phosphoric acid + Pyrophosphate + S-Adenosylmethioninedetails
Phosphoric acid + Pyrophosphate + S-Adenosylmethionine → Adenosine triphosphate + L-Methionine + Waterdetails
Adenosine triphosphate + Selenomethionine + Water → Phosphoric acid + Pyrophosphate + Se-Adenosylselenomethioninedetails
General function:
Involved in ATP binding
Specific function:
Not Available
Gene Name:
MMAB
Uniprot ID:
Q96EY8
Molecular weight:
27387.975
Reactions
Adenosine triphosphate + Cob(I)yrinate a,c diamide → Triphosphate + adenosylcob(III)yrinic acid a,c-diamidedetails
Adenosine triphosphate + Cobinamide → Triphosphate + Adenosyl cobinamidedetails
Cob(I)yrinate a,c diamide + Adenosine triphosphate → Adenosyl cobyrinic acid a,c diamide + PPPidetails
Adenosine triphosphate + Cobinamide → PPPi + Adenosyl cobinamidedetails
General function:
Involved in ATP binding
Specific function:
Catalyzes the initial step in utilization of glucose by the beta-cell and liver at physiological glucose concentration. Glucokinase has a high Km for glucose, and so it is effective only when glucose is abundant. The role of GCK is to provide G6P for the synthesis of glycogen. Pancreatic glucokinase plays an important role in modulating insulin secretion. Hepatic glucokinase helps to facilitate the uptake and conversion of glucose by acting as an insulin-sensitive determinant of hepatic glucose usage.
Gene Name:
GCK
Uniprot ID:
P35557
Molecular weight:
52191.07
Reactions
Adenosine triphosphate + D-Glucose → ADP + Glucose 6-phosphatedetails
Adenosine triphosphate + Beta-D-Glucose → ADP + Beta-D-Glucose 6-phosphatedetails
Adenosine triphosphate + Alpha-D-Glucose → ADP + Glucose 6-phosphatedetails
General function:
Involved in ATP binding
Specific function:
Not Available
Gene Name:
HK2
Uniprot ID:
P52789
Molecular weight:
102379.06
Reactions
Adenosine triphosphate + D-Galactose → ADP + Glucose 6-phosphatedetails
Adenosine triphosphate + D-Glucose → ADP + Glucose 6-phosphatedetails
Adenosine triphosphate + D-Fructose → ADP + Beta-D-Fructose 6-phosphatedetails
Adenosine triphosphate + D-Mannose → ADP + Mannose 6-phosphatedetails
Adenosine triphosphate + Beta-D-Glucose → ADP + Beta-D-Glucose 6-phosphatedetails
Adenosine triphosphate + Alpha-D-Glucose → ADP + Glucose 6-phosphatedetails
Adenosine triphosphate + Glucosamine → ADP + Glucosamine 6-phosphatedetails
Adenosine triphosphate + D-Fructose → ADP + Beta-D-Fructose 6-phosphatedetails
General function:
Involved in ATP binding
Specific function:
Not Available
Gene Name:
HK3
Uniprot ID:
P52790
Molecular weight:
99024.56
Reactions
Adenosine triphosphate + D-Galactose → ADP + Glucose 6-phosphatedetails
Adenosine triphosphate + D-Glucose → ADP + Glucose 6-phosphatedetails
Adenosine triphosphate + D-Fructose → ADP + Beta-D-Fructose 6-phosphatedetails
Adenosine triphosphate + D-Mannose → ADP + Mannose 6-phosphatedetails
Adenosine triphosphate + Beta-D-Glucose → ADP + Beta-D-Glucose 6-phosphatedetails
Adenosine triphosphate + Alpha-D-Glucose → ADP + Glucose 6-phosphatedetails
Adenosine triphosphate + Glucosamine → ADP + Glucosamine 6-phosphatedetails
Adenosine triphosphate + D-Fructose → ADP + Beta-D-Fructose 6-phosphatedetails
General function:
Carbohydrate transport and metabolism
Specific function:
Not Available
Gene Name:
KHK
Uniprot ID:
P50053
Molecular weight:
32730.055
Reactions
Adenosine triphosphate + D-Fructose → ADP + D-fructose 1-phosphatedetails
Adenosine triphosphate + Sedoheptulose → ADP + Sedoheptulose 1-phosphatedetails
General function:
Involved in galactokinase activity
Specific function:
Major enzyme for galactose metabolism.
Gene Name:
GALK1
Uniprot ID:
P51570
Molecular weight:
42271.805
Reactions
Adenosine triphosphate + Beta-D-Galactose → ADP + Galactose 1-phosphatedetails
General function:
Involved in 6-phosphofructokinase activity
Specific function:
Catalyzes the third step of glycolysis, the phosphorylation of fructose-6-phosphate (F6P) by ATP to generate fructose-1,6-bisphosphate (FBP) and ADP.
Gene Name:
PFKL
Uniprot ID:
P17858
Molecular weight:
85017.825
Reactions
Adenosine triphosphate + Fructose 6-phosphate → ADP + Fructose 1,6-bisphosphatedetails
D-Tagatose 6-phosphate + Adenosine triphosphate → D-Tagatose 1,6-bisphosphate + ADPdetails
Adenosine triphosphate + Beta-D-Fructose 6-phosphate → ADP + beta-D-Fructose 1,6-bisphosphatedetails
General function:
Involved in 6-phosphofructokinase activity
Specific function:
Catalyzes the third step of glycolysis, the phosphorylation of fructose-6-phosphate (F6P) by ATP to generate fructose-1,6-bisphosphate (FBP) and ADP.
Gene Name:
PFKM
Uniprot ID:
P08237
Molecular weight:
85181.925
Reactions
Adenosine triphosphate + Fructose 6-phosphate → ADP + Fructose 1,6-bisphosphatedetails
D-Tagatose 6-phosphate + Adenosine triphosphate → D-Tagatose 1,6-bisphosphate + ADPdetails
Adenosine triphosphate + Beta-D-Fructose 6-phosphate → ADP + beta-D-Fructose 1,6-bisphosphatedetails
General function:
Involved in 6-phosphofructokinase activity
Specific function:
Catalyzes the third step of glycolysis, the phosphorylation of fructose-6-phosphate (F6P) by ATP to generate fructose-1,6-bisphosphate (FBP) and ADP.
Gene Name:
PFKP
Uniprot ID:
Q01813
Molecular weight:
85595.405
Reactions
Adenosine triphosphate + Fructose 6-phosphate → ADP + Fructose 1,6-bisphosphatedetails
D-Tagatose 6-phosphate + Adenosine triphosphate → D-Tagatose 1,6-bisphosphate + ADPdetails
Adenosine triphosphate + Beta-D-Fructose 6-phosphate → ADP + beta-D-Fructose 1,6-bisphosphatedetails
General function:
Involved in phosphotransferase activity, alcohol group as acceptor
Specific function:
Acts as a modulator of macrophage activation through control of glucose metabolism (By similarity).
Gene Name:
SHPK
Uniprot ID:
Q9UHJ6
Molecular weight:
51504.425
Reactions
Adenosine triphosphate + Sedoheptulose → ADP + D-Sedoheptulose 7-phosphatedetails
General function:
Involved in ribokinase activity
Specific function:
Not Available
Gene Name:
RBKS
Uniprot ID:
Q9H477
Molecular weight:
34142.685
Reactions
Adenosine triphosphate + D-Ribose → ADP + D-Ribose 5-phosphatedetails
Deoxyribose 5-monophosphate + ADP → Deoxyribose + Adenosine triphosphatedetails
General function:
Involved in phosphotransferase activity, alcohol group as acceptor
Specific function:
Not Available
Gene Name:
XYLB
Uniprot ID:
O75191
Molecular weight:
58381.695
Reactions
Adenosine triphosphate + D-Xylulose → ADP + Xylulose 5-phosphatedetails
General function:
Involved in adenosine kinase activity
Specific function:
ATP dependent phosphorylation of adenosine and other related nucleoside analogs to monophosphate derivatives. Serves as a potential regulator of concentrations of extracellular adenosine and intracellular adenine nucleotides.
Gene Name:
ADK
Uniprot ID:
P55263
Molecular weight:
38702.93
Reactions
Adenosine triphosphate + Adenosine → ADP + Adenosine monophosphatedetails
General function:
Involved in ATP binding
Specific function:
Not Available
Gene Name:
Not Available
Uniprot ID:
Q8IZR3
Molecular weight:
35439.6
General function:
Involved in catalytic activity
Specific function:
Bifunctional enzyme that catalyzes the fourth and fifth sequential steps of CoA biosynthetic pathway. The fourth reaction is catalyzed by the phosphopantetheine adenylyltransferase, coded by the coaD domain; the fifth reaction is catalyzed by the dephospho-CoA kinase, coded by the coaE domain. May act as a point of CoA biosynthesis regulation.
Gene Name:
COASY
Uniprot ID:
Q13057
Molecular weight:
62328.245
Reactions
Adenosine triphosphate + Pantetheine 4'-phosphate → Pyrophosphate + Dephospho-CoAdetails
Adenosine triphosphate + Dephospho-CoA → ADP + Coenzyme Adetails
General function:
Involved in ATP binding
Specific function:
Bifunctional enzyme with both ATP sulfurylase and APS kinase activity, which mediates two steps in the sulfate activation pathway. The first step is the transfer of a sulfate group to ATP to yield adenosine 5'-phosphosulfate (APS), and the second step is the transfer of a phosphate group from ATP to APS yielding 3'-phosphoadenylylsulfate (PAPS: activated sulfate donor used by sulfotransferase). In mammals, PAPS is the sole source of sulfate; APS appears to be only an intermediate in the sulfate-activation pathway. May have a important role in skeletogenesis during postnatal growth (By similarity).
Gene Name:
PAPSS2
Uniprot ID:
O95340
Molecular weight:
69969.8
Reactions
Adenosine triphosphate + Oat gum → Pyrophosphate + Adenosine phosphosulfatedetails
Adenosine triphosphate + Adenosine phosphosulfate → ADP + Phosphoadenosine phosphosulfatedetails
Adenosine triphosphate + Adenylylselenate → ADP + 3-Phosphoadenylylselenatedetails
Adenosine triphosphate + Selenocystathionine → Pyrophosphate + Adenylylselenatedetails
General function:
Involved in ATP binding
Specific function:
Bifunctional enzyme with both ATP sulfurylase and APS kinase activity, which mediates two steps in the sulfate activation pathway. The first step is the transfer of a sulfate group to ATP to yield adenosine 5'-phosphosulfate (APS), and the second step is the transfer of a phosphate group from ATP to APS yielding 3'-phosphoadenylylsulfate (PAPS: activated sulfate donor used by sulfotransferase). In mammals, PAPS is the sole source of sulfate; APS appears to be only an intermediate in the sulfate-activation pathway. Also involved in the biosynthesis of sulfated L-selectin ligands in endothelial cells.
Gene Name:
PAPSS1
Uniprot ID:
O43252
Molecular weight:
70832.725
Reactions
Adenosine triphosphate + Oat gum → Pyrophosphate + Adenosine phosphosulfatedetails
Adenosine triphosphate + Adenosine phosphosulfate → ADP + Phosphoadenosine phosphosulfatedetails
Adenosine triphosphate + Adenylylselenate → ADP + 3-Phosphoadenylylselenatedetails
Adenosine triphosphate + Selenocystathionine → Pyrophosphate + Adenylylselenatedetails
General function:
Involved in riboflavin kinase activity
Specific function:
Catalyzes the phosphorylation of riboflavin (vitamin B2) to form flavin-mononucleotide (FMN).
Gene Name:
RFK
Uniprot ID:
Q969G6
Molecular weight:
17623.08
Reactions
Adenosine triphosphate + Riboflavin → ADP + Flavin Mononucleotidedetails
General function:
Carbohydrate transport and metabolism
Specific function:
Catalyzes both the phosphorylation of dihydroxyacetone and of glyceraldehyde, and the splitting of ribonucleoside diphosphate-X compounds among which FAD is the best substrate.
Gene Name:
DAK
Uniprot ID:
Q3LXA3
Molecular weight:
58946.49
Reactions
Adenosine triphosphate + Dihydroxyacetone → ADP + Dihydroxyacetone phosphatedetails
Adenosine triphosphate + Glyceraldehyde → ADP + D-Glyceraldehyde 3-phosphatedetails
General function:
Involved in phosphotransferase activity, alcohol group as acceptor
Specific function:
Key enzyme in the regulation of glycerol uptake and metabolism (By similarity).
Gene Name:
GK2
Uniprot ID:
Q14410
Molecular weight:
60593.32
Reactions
Adenosine triphosphate + Glycerol → ADP + Glycerol 3-phosphatedetails
General function:
Carbohydrate transport and metabolism
Specific function:
Not Available
Gene Name:
GLYCTK
Uniprot ID:
Q8IVS8
Molecular weight:
25036.865
Reactions
Adenosine triphosphate + Glyceric acid → ADP + 3-Phosphoglyceric aciddetails
General function:
Cell wall/membrane/envelope biogenesis
Specific function:
Has a key role in phospholipid biosynthesis and may contribute to tumor cell growth. Catalyzes the first step in phosphatidylcholine biosynthesis. Contributes to phosphatidylethanolamine biosynthesis. Phosphorylates choline and ethanolamine. Has higher activity with choline.
Gene Name:
CHKA
Uniprot ID:
P35790
Molecular weight:
52248.53
Reactions
Adenosine triphosphate + Choline → ADP + Phosphorylcholinedetails
Adenosine triphosphate + Ethanolamine → ADP + O-Phosphoethanolaminedetails
General function:
Involved in pantothenate kinase activity
Specific function:
Plays a role in the physiological regulation of the intracellular CoA concentration (By similarity).
Gene Name:
PANK1
Uniprot ID:
Q8TE04
Molecular weight:
35578.965
Reactions
Adenosine triphosphate + Pantothenic acid → ADP + D-4'-Phosphopantothenatedetails
Adenosine triphosphate + Pantetheine → ADP + Pantetheine 4'-phosphatedetails
Adenosine triphosphate + D-Pantothenoyl-L-cysteine → ADP + 4-Phosphopantothenoylcysteinedetails
General function:
Involved in pantothenate kinase activity
Specific function:
Plays a role in the physiological regulation of the intracellular CoA concentration (By similarity).
Gene Name:
PANK4
Uniprot ID:
Q9NVE7
Molecular weight:
85990.12
Reactions
Adenosine triphosphate + Pantothenic acid → ADP + D-4'-Phosphopantothenatedetails
Adenosine triphosphate + Pantetheine → ADP + Pantetheine 4'-phosphatedetails
Adenosine triphosphate + D-Pantothenoyl-L-cysteine → ADP + 4-Phosphopantothenoylcysteinedetails
General function:
Involved in pantothenate kinase activity
Specific function:
Plays a role in the physiological regulation of the intracellular CoA concentration (By similarity).
Gene Name:
PANK3
Uniprot ID:
Q9H999
Molecular weight:
41093.695
Reactions
Adenosine triphosphate + Pantothenic acid → ADP + D-4'-Phosphopantothenatedetails
Adenosine triphosphate + Pantetheine → ADP + Pantetheine 4'-phosphatedetails
Adenosine triphosphate + D-Pantothenoyl-L-cysteine → ADP + 4-Phosphopantothenoylcysteinedetails
General function:
Involved in pyridoxal kinase activity
Specific function:
Required for synthesis of pyridoxal-5-phosphate from vitamin B6.
Gene Name:
PDXK
Uniprot ID:
O00764
Molecular weight:
35102.105
Reactions
Adenosine triphosphate + Pyridoxal → ADP + Pyridoxal 5'-phosphatedetails
Adenosine triphosphate + Pyridoxine → ADP + Pyridoxine 5'-phosphatedetails
Adenosine triphosphate + Pyridoxamine → ADP + Pyridoxamine 5'-phosphatedetails
General function:
Involved in magnesium ion binding
Specific function:
Plays a key role in glycolysis (By similarity).
Gene Name:
PKLR
Uniprot ID:
P30613
Molecular weight:
61829.575
Reactions
Adenosine triphosphate + Pyruvic acid → ADP + Phosphoenolpyruvic aciddetails
General function:
Involved in ATP binding
Specific function:
May contribute to UTP accumulation needed for blast transformation and proliferation.
Gene Name:
UCKL1
Uniprot ID:
Q9NWZ5
Molecular weight:
59465.77
Reactions
Adenosine triphosphate + Uridine → ADP + Uridine 5'-monophosphatedetails
Adenosine triphosphate + Cytidine → ADP + Cytidine monophosphatedetails
5-Fluorouridine + Adenosine triphosphate → 5-Fluorouridine monophosphate + ADPdetails
General function:
Involved in ATP binding
Specific function:
Phosphorylates uridine and cytidine to uridine monophosphate and cytidine monophosphate. Does not phosphorylate deoxyribonucleosides or purine ribonucleosides. Can use ATP or GTP as a phosphate donor. Can also phosphorylate cytidine and uridine nucleoside analogs such as 6-azauridine, 5-fluorouridine, 4-thiouridine, 5-bromouridine, N(4)-acetylcytidine, N(4)-benzoylcytidine, 5-fluorocytidine, 2-thiocytidine, 5-methylcytidine, and N(4)-anisoylcytidine.
Gene Name:
UCK2
Uniprot ID:
Q9BZX2
Molecular weight:
29298.92
Reactions
Adenosine triphosphate + Uridine → ADP + Uridine 5'-monophosphatedetails
Adenosine triphosphate + Cytidine → ADP + Cytidine monophosphatedetails
5-Fluorouridine + Adenosine triphosphate → 5-Fluorouridine monophosphate + ADPdetails
General function:
Involved in ATP binding
Specific function:
Takes part in the salvage pathway for reutilization of fucose from the degradation of oligosaccharides.
Gene Name:
FUK
Uniprot ID:
Q8N0W3
Molecular weight:
117621.795
Reactions
Adenosine triphosphate + L-Fucose → ADP + Fucose 1-phosphatedetails
General function:
Carbohydrate transport and metabolism
Specific function:
Converts endogenous N-acetylglucosamine (GlcNAc), a major component of complex carbohydrates, from lysosomal degradation or nutritional sources into GlcNAc 6-phosphate. Involved in the N-glycolylneuraminic acid (Neu5Gc) degradation pathway: although human is not able to catalyze formation of Neu5Gc due to the inactive CMAHP enzyme, Neu5Gc is present in food and must be degraded. Also has ManNAc kinase activity.
Gene Name:
NAGK
Uniprot ID:
Q9UJ70
Molecular weight:
42037.295
Reactions
Adenosine triphosphate + N-Acetyl-D-glucosamine → ADP + N-Acetyl-D-Glucosamine 6-Phosphatedetails
General function:
Involved in binding
Specific function:
Acts on phosphatidylinositol (PtdIns) in the first committed step in the production of the second messenger inositol- 1,4,5,-trisphosphate
Gene Name:
PI4KA
Uniprot ID:
P42356
Molecular weight:
231316.9
General function:
Not Available
Specific function:
Not Available
Gene Name:
PIK4CB
Uniprot ID:
Q9UBF8
Molecular weight:
92726.0
General function:
Involved in protein binding
Specific function:
The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol-3,5-bisphosphate (PtdIns(3,5)P2). Catalyzes the phosphorylation of phosphatidylinositol-3-phosphate on the fifth hydroxyl of the myo- inositol ring, to form phosphatidylinositol-3,5-bisphosphate. Required for endocytic-vacuolar pathway and nuclear migration. Plays a role in the biogenesis of endosome carrier vesicles (ECV)/ multivesicular bodies (MVB) transport intermediates from early endosomes
Gene Name:
PIKFYVE
Uniprot ID:
Q9Y2I7
Molecular weight:
237134.1
General function:
Involved in phosphatidylinositol phosphate kinase activity
Specific function:
Plays a role in membrane ruffling and assembly of clathrin-coated pits at the synapse. Mediates RAC1-dependent reorganization of actin filaments. Participates in the biosynthesis of phosphatidylinositol-4,5-bisphosphate
Gene Name:
PIP5K1C
Uniprot ID:
O60331
Molecular weight:
73259.3
General function:
Involved in phosphatidylinositol phosphate kinase activity
Specific function:
May play an important role in the production of Phosphatidylinositol bisphosphate (PIP2), in the endoplasmic reticulum
Gene Name:
PIP4K2C
Uniprot ID:
Q8TBX8
Molecular weight:
47285.5
General function:
Involved in phosphatidylinositol phosphate kinase activity
Specific function:
Participates in the biosynthesis of phosphatidylinositol-4,5-bisphosphate
Gene Name:
PIP4K2B
Uniprot ID:
P78356
Molecular weight:
47377.6
General function:
Involved in ATP binding
Specific function:
Required for the phosphorylation of the deoxyribonucleosides deoxycytidine (dC), deoxyguanosine (dG) and deoxyadenosine (dA). Has broad substrate specificity, and does not display selectivity based on the chirality of the substrate. It is also an essential enzyme for the phosphorylation of numerous nucleoside analogs widely employed as antiviral and chemotherapeutic agents.
Gene Name:
DCK
Uniprot ID:
P27707
Molecular weight:
30518.315
Reactions
Adenosine triphosphate + Adenosine → ADP + Adenosine monophosphatedetails
Adenosine triphosphate + Deoxycytidine → ADP + dCMPdetails
General function:
Involved in ATP binding
Specific function:
Plays a key role in the repair of DNA damage, functioning as part of both the non-homologous end-joining (NHEJ) and base excision repair (BER) pathways. Through its two catalytic activities, PNK ensures that DNA termini are compatible with extension and ligation by either removing 3'-phosphates from, or by phosphorylating 5'-hydroxyl groups on, the ribose sugar of the DNA backbone.
Gene Name:
PNKP
Uniprot ID:
Q96T60
Molecular weight:
57075.9
Reactions
Adenosine triphosphate + 5'-dephospho-DNA → ADP + 5'-phospho-DNAdetails
General function:
Cell wall/membrane/envelope biogenesis
Specific function:
Highly specific for ethanolamine phosphorylation. May be a rate-controlling step in phosphatidylethanolamine biosynthesis.
Gene Name:
ETNK1
Uniprot ID:
Q9HBU6
Molecular weight:
27994.955
Reactions
Adenosine triphosphate + Ethanolamine → ADP + O-Phosphoethanolaminedetails

Transporters

General function:
Involved in ATP binding
Specific function:
Involved in the export of copper out of the cells, such as the efflux of hepatic copper into the bile.
Gene Name:
ATP7B
Uniprot ID:
P35670
Molecular weight:
157261.34
General function:
Involved in ATP binding
Specific function:
Involved in the transport of antigens from the cytoplasm to the endoplasmic reticulum for association with MHC class I molecules. Also acts as a molecular scaffold for the final stage of MHC class I folding, namely the binding of peptide. Nascent MHC class I molecules associate with TAP via tapasin. Inhibited by the covalent attachment of herpes simplex virus ICP47 protein, which blocks the peptide-binding site of TAP. Inhibited by human cytomegalovirus US6 glycoprotein, which binds to the lumenal side of the TAP complex and inhibits peptide translocation by specifically blocking ATP-binding to TAP1 and prevents the conformational rearrangement of TAP induced by peptide binding. Inhibited by human adenovirus E3-19K glycoprotein, which binds the TAP complex and acts as a tapasin inhibitor, preventing MHC class I/TAP association. Expression of TAP1 is down-regulated by human Epstein-Barr virus vIL-10 protein, thereby affecting the transport of peptides into the endoplasmic reticulum and subsequent peptide loading by MHC class I molecules
Gene Name:
TAP1
Uniprot ID:
Q03518
Molecular weight:
87216.9
General function:
Involved in ATP binding
Specific function:
May supply copper to copper-requiring proteins within the secretory pathway, when localized in the trans-Golgi network. Under conditions of elevated extracellular copper, it relocalized to the plasma membrane where it functions in the efflux of copper from cells.
Gene Name:
ATP7A
Uniprot ID:
Q04656
Molecular weight:
163372.275

Only showing the first 50 proteins. There are 1040 proteins in total.