Human Metabolome Database Version 3.5

Showing metabocard for Adenosine triphosphate (HMDB00538)

Record Information
Version 3.5
Creation Date 2005-11-16 08:48:42 -0700
Update Date 2013-05-29 13:27:29 -0600
HMDB ID HMDB00538
Secondary Accession Numbers None
Metabolite Identification
Common Name Adenosine triphosphate
Description Adenosine triphosphate (ATP) is a nucleotide consisting of a purine base (adenine) attached to the first carbon atom of ribose (a pentose sugar). Three phosphate groups are esterified at the fifth carbon atom of the ribose. ATP is incorporated into nucleic acids by polymerases in the processes of DNA replication and transcription. ATP contributes to cellular energy charge and participates in overall energy balance, maintaining cellular homeostasis. ATP can act as an extracellular signaling molecule via interactions with specific purinergic receptors to mediate a wide variety of processes as diverse as neurotransmission, inflammation, apoptosis, and bone remodelling. Extracellular ATP and its metabolite adenosine have also been shown to exert a variety of effects on nearly every cell type in human skin, and ATP seems to play a direct role in triggering skin inflammatory, regenerative, and fibrotic responses to mechanical injury, an indirect role in melanocyte proliferation and apoptosis, and a complex role in Langerhans cell-directed adaptive immunity. During exercise, intracellular homeostasis depends on the matching of adenosine triphosphate (ATP) supply and ATP demand. Metabolites play a useful role in communicating the extent of ATP demand to the metabolic supply pathways. Effects as different as proliferation or differentiation, chemotaxis, release of cytokines or lysosomal constituents, and generation of reactive oxygen or nitrogen species are elicited upon stimulation of blood cells with extracellular ATP. The increased concentration of adenosine triphosphate (ATP) in erythrocytes from patients with chronic renal failure (CRF) has been observed in many studies but the mechanism leading to these abnormalities still is controversial. (PMID: 15490415 Link_out, 15129319 Link_out, 14707763 Link_out, 14696970 Link_out, 11157473 Link_out).
Structure Thumb
Download: MOL | SDF | PDB | SMILES | InChI
Display: 2D Structure | 3D Structure
Synonyms
  1. 5'-(Tetrahydrogen triphosphate) Adenosine
  2. 5'-ATP
  3. Adenosine 5'-triphosphate
  4. Adenosine 5'-triphosphorate
  5. Adenosine 5'-triphosphoric acid
  6. Adenosine triphosphate
  7. Adenylpyrophosphorate
  8. Adenylpyrophosphoric acid
  9. Adephos
  10. Adetol
  11. Adynol
  12. Atipi
  13. ATP
  14. Atriphos
  15. Cardenosine
  16. Fosfobion
  17. Glucobasin
  18. Myotriphos
  19. Phosphobion
  20. Striadyne
  21. Triadenyl
  22. Triphosphaden
  23. Triphosphoric acid adenosine ester
Chemical Formula C10H16N5O13P3
Average Molecular Weight 507.181
Monoisotopic Molecular Weight 506.995745159
IUPAC Name ({[({[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy](hydroxy)phosphoryl}oxy)phosphonic acid
Traditional IUPAC Name ({[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy(hydroxy)phosphoryl}oxy(hydroxy)phosphoryl)oxyphosphonic acid
CAS Registry Number 56-65-5
SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O
InChI Identifier InChI=1S/C10H16N5O13P3/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(26-10)1-25-30(21,22)28-31(23,24)27-29(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H,23,24)(H2,11,12,13)(H2,18,19,20)/t4-,6-,7-,10-/m1/s1
InChI Key ZKHQWZAMYRWXGA-KQYNXXCUSA-N
Chemical Taxonomy
Kingdom Organic Compounds
Super Class Nucleosides, Nucleotides, and Analogues
Class Purine Nucleotides
Sub Class Purine Ribonucleotides
Other Descriptors
  • Aromatic Heteropolycyclic Compounds
  • Coenzymes(KEGG)
  • Ribonucleotides(KEGG)
  • adenosine 5'-phosphate(ChEBI)
  • purine ribonucleoside 5'-triphosphate(ChEBI)
Substituents
  • 1,2 Diol
  • 1 Phosphoribosyl Imidazole
  • Aminopyrimidine
  • Glycosyl Compound
  • Imidazole
  • Imidazopyrimidine
  • Monosaccharide Phosphate
  • N Glycosyl Compound
  • Organic Hypophosphite
  • Organic Phosphite
  • Organic Pyrophosphate
  • Oxolane
  • Pentose Monosaccharide
  • Phosphoric Acid Ester
  • Purine
  • Pyrimidine
  • Saccharide
  • Secondary Alcohol
Direct Parent Purine Ribonucleoside Triphosphates
Ontology
Status Detected and Quantified
Origin
  • Endogenous
Biofunction
  • Component of Aminosugars metabolism
  • Component of Fructose and mannose metabolism
  • Component of Galactose metabolism
  • Component of Starch and sucrose metabolism
  • Component of Streptomycin biosynthesis
Application Not Available
Cellular locations
  • Cytoplasm
  • Extracellular
  • Mitochondria
  • Nucleus
  • Endoplasmic reticulum
  • Peroxisome
Physical Properties
State Solid
Experimental Properties
Property Value Reference
Melting Point Not Available Not Available
Boiling Point Not Available Not Available
Water Solubility 1000.0 mg/mL; 862 mg/mL (magnesium salt) MERCK INDEX (1996); Human Metabolome Project (salt)
LogP Not Available Not Available
Predicted Properties
Property Value Source
Water Solubility 4.49 g/L ALOGPS
LogP -0.84 ALOGPS
LogP -6.2 ChemAxon
LogS -2.05 ALOGPS
pKa (strongest acidic) 0.9 ChemAxon
pKa (strongest basic) 5 ChemAxon
Hydrogen Acceptor Count 14 ChemAxon
Hydrogen Donor Count 7 ChemAxon
Polar Surface Area 279.13 A2 ChemAxon
Rotatable Bond Count 8 ChemAxon
Refractivity 95.81 ChemAxon
Polarizability 38.76 ChemAxon
Formal Charge 0 ChemAxon
Physiological Charge -3 ChemAxon
Spectra
13C NMR Spectrum
1H NMR Spectrum
MS/MS Spectrum LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientific )
MS/MS Spectrum LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientific )
MS/MS Spectrum LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientific )
[1H,13C] 2D NMR Spectrum
Biological Properties
Cellular Locations
  • Cytoplasm
  • Extracellular
  • Mitochondria
  • Nucleus
  • Endoplasmic reticulum
  • Peroxisome
Biofluid Locations
  • Blood
  • Cellular Cytoplasm
  • Cerebrospinal Fluid (CSF)
Tissue Location
  • Muscle
  • Skeletal Muscle
  • Bladder
  • Fibroblasts
  • Intestine
  • Neuron
  • Pancreas
  • Kidney
  • Myelin
  • Adipose Tissue
  • Nerve Cells
  • Platelet
Pathways
Name SMPDB Link KEGG Link
Citric Acid Cycle SMP00057 map00020 Link_out
Gluconeogenesis SMP00128 map00010 Link_out
Transcription/Translation SMP00019 Not Available
Purine Metabolism SMP00050 map00230 Link_out
Urea Cycle SMP00059 map00330 Link_out
Mitochondrial Electron Transport Chain SMP00355 map00190 Link_out
Histidine Metabolism SMP00044 map00340 Link_out
Methionine Metabolism SMP00033 map00270 Link_out
Lactose Synthesis SMP00444 Not Available
Glycerolipid Metabolism SMP00039 map00561 Link_out
Ammonia Recycling SMP00009 map00910 Link_out
Glycolysis SMP00040 map00010 Link_out
Spermidine and Spermine Biosynthesis SMP00445 Not Available
Phytanic Acid Peroxisomal Oxidation SMP00450 Not Available
Ethanol Degradation SMP00449 Not Available
Threonine and 2-Oxobutanoate Degradation SMP00452 Not Available
Lactose Degradation SMP00457 Not Available
Phosphatidylinositol Phosphate Metabolism SMP00463 map00562 Link_out
Inositol Phosphate Metabolism SMP00462 map00562 Link_out
Transfer of Acetyl Groups into Mitochondria SMP00466 Not Available
Trehalose Degradation SMP00467 Not Available
DNA Replication Fork SMP00477 Not Available
Amino Sugar Metabolism SMP00045 map00520 Link_out
Mitochondrial Beta-Oxidation of Short Chain Saturated Fatty Acids SMP00480 Not Available
Glycine and Serine Metabolism SMP00004 map00260 Link_out
Folate Metabolism SMP00053 map00670 Link_out
Mitochondrial Beta-Oxidation of Long Chain Saturated Fatty Acids SMP00482 Not Available
Mitochondrial Beta-Oxidation of Medium Chain Saturated Fatty Acids SMP00481 Not Available
Normal Concentrations
Biofluid Status Value Age Sex Condition Reference
Blood Detected and Quantified
1077.0 +/- 210.0 uM Newborn (0-30 days old) Both Normal
  • Geigy Scient...
Blood Detected and Quantified
1552.0 +/- 161.0 uM Adult (>18 years old) Male Normal
  • Geigy Scient...
Blood Detected and Quantified
1390.0 +/- 170.0 uM Adult (>18 years old) Both Normal
  • Geigy Scient...
Blood Detected and Quantified
3152.0 +/- 1698.0 uM Adult (>18 years old) Both Normal
Cellular Cytoplasm Detected and Quantified
1540 (1290-1790) uM Adult (>18 years old) Both Normal
Cerebrospinal Fluid (CSF) Detected and Quantified
1.85 +/- 0.03 uM Adult (>18 years old) Both Normal
Abnormal Concentrations
Biofluid Status Value Age Sex Condition Reference
Cerebrospinal Fluid (CSF) Detected and Quantified 0.23 +/- 0.19 uM Adult (>18 years old) Both Rachialgia
Cerebrospinal Fluid (CSF) Detected and Quantified 0.80 +/- 0.63 uM Adult (>18 years old) Both Subarachnoid hemorrhage
Cerebrospinal Fluid (CSF) Detected and Quantified 1.08 +/- 0.77 uM Adult (>18 years old) Both Epilepsy
Cerebrospinal Fluid (CSF) Detected and Quantified 0.26 +/- 0.11 uM Adult (>18 years old) Both Comment Stroke
Cerebrospinal Fluid (CSF) Detected and Quantified 1.09 +/- 0.76 uM Adult (>18 years old) Both Neuroinfection
Associated Disorders and Diseases
Disease References
Rachialgia
  • Czarnecka J, Cieslak M, Michal K: Application of solid phase extraction and high-performance liquid chromatography to qualitative and quantitative analysis of nucleotides and nucleosides in human cerebrospinal fluid. J Chromatogr B Analyt Technol Biomed Life Sci. 2005 Aug 5;822(1-2):85-90. Pubmed: 15993662 Link_out
      Subarachnoid hemorrhage
      • Czarnecka J, Cieslak M, Michal K: Application of solid phase extraction and high-performance liquid chromatography to qualitative and quantitative analysis of nucleotides and nucleosides in human cerebrospinal fluid. J Chromatogr B Analyt Technol Biomed Life Sci. 2005 Aug 5;822(1-2):85-90. Pubmed: 15993662 Link_out
          Epilepsy
          • Czarnecka J, Cieslak M, Michal K: Application of solid phase extraction and high-performance liquid chromatography to qualitative and quantitative analysis of nucleotides and nucleosides in human cerebrospinal fluid. J Chromatogr B Analyt Technol Biomed Life Sci. 2005 Aug 5;822(1-2):85-90. Pubmed: 15993662 Link_out
              Stroke
              • Czarnecka J, Cieslak M, Michal K: Application of solid phase extraction and high-performance liquid chromatography to qualitative and quantitative analysis of nucleotides and nucleosides in human cerebrospinal fluid. J Chromatogr B Analyt Technol Biomed Life Sci. 2005 Aug 5;822(1-2):85-90. Pubmed: 15993662 Link_out
                  Neuroinfection
                  • Czarnecka J, Cieslak M, Michal K: Application of solid phase extraction and high-performance liquid chromatography to qualitative and quantitative analysis of nucleotides and nucleosides in human cerebrospinal fluid. J Chromatogr B Analyt Technol Biomed Life Sci. 2005 Aug 5;822(1-2):85-90. Pubmed: 15993662 Link_out
                      Associated OMIM IDs
                      DrugBank ID Not Available
                      DrugBank Metabolite ID Not Available
                      Phenol Explorer Compound ID Not Available
                      Phenol Explorer Metabolite ID Not Available
                      FoodDB ID FDB021813
                      KNApSAcK ID Not Available
                      Chemspider ID 5742 Link_out
                      KEGG Compound ID C00002 Link_out
                      BioCyc ID ATP Link_out
                      BiGG ID 33477 Link_out
                      Wikipedia Link Adenosine triphosphate Link_out
                      NuGOwiki Link HMDB00538 Link_out
                      Metagene Link HMDB00538 Link_out
                      METLIN ID 5523 Link_out
                      PubChem Compound 5957 Link_out
                      PDB ID ATP Link_out
                      ChEBI ID 15422 Link_out
                      References
                      Synthesis Reference Clark, V. M.; Kirby, G. W.; Todd, Alexander. Phosphorylation. XV. Use of phosphoramidic esters in acylation-new preparation of adenosine 5'-pyrophosphate and adenosine 5'-triphosphate. Journal of the Chemical Society (1957), 1497-1501.
                      Material Safety Data Sheet (MSDS) Not Available
                      General References
                      1. Gottlieb C, Svanborg K, Eneroth P, Bygdeman M: Effect of prostaglandins on human sperm function in vitro and seminal adenosine triphosphate content. Fertil Steril. 1988 Feb;49(2):322-7. Pubmed: 3338588 Link_out
                      2. Mahmoud AM, Comhaire FH, Vermeulen L, Andreou E: Comparison of the resazurin test, adenosine triphosphate in semen, and various sperm parameters. Hum Reprod. 1994 Sep;9(9):1688-93. Pubmed: 7836519 Link_out
                      3. Kadmon M, Klunemann C, Bohme M, Ishikawa T, Gorgas K, Otto G, Herfarth C, Keppler D: Inhibition by cyclosporin A of adenosine triphosphate-dependent transport from the hepatocyte into bile. Gastroenterology. 1993 May;104(5):1507-14. Pubmed: 7683296 Link_out
                      4. Sun Y, MaLossi J, Jacobs SC, Chai TC: Effect of doxazosin on stretch-activated adenosine triphosphate release in bladder urothelial cells from patients with benign prostatic hyperplasia. Urology. 2002 Aug;60(2):351-6. Pubmed: 12137852 Link_out
                      5. Ryan LM, Rachow JW, McCarty BA, McCarty DJ: Adenosine triphosphate levels in human plasma. J Rheumatol. 1996 Feb;23(2):214-9. Pubmed: 8882021 Link_out
                      6. Nakayama Y, Kinoshita A, Tomita M: Dynamic simulation of red blood cell metabolism and its application to the analysis of a pathological condition. Theor Biol Med Model. 2005 May 9;2(1):18. Pubmed: 15882454 Link_out
                      7. Yoshida M, Miyamae K, Iwashita H, Otani M, Inadome A: Management of detrusor dysfunction in the elderly: changes in acetylcholine and adenosine triphosphate release during aging. Urology. 2004 Mar;63(3 Suppl 1):17-23. Pubmed: 15013648 Link_out
                      8. Bar-Meir M, Elpeleg ON, Saada A: Effect of various agents on adenosine triphosphate synthesis in mitochondrial complex I deficiency. J Pediatr. 2001 Dec;139(6):868-70. Pubmed: 11743516 Link_out
                      9. Mannucci L, Pastore A, Rizzo C, Piemonte F, Rizzoni G, Emma F: Impaired activity of the gamma-glutamyl cycle in nephropathic cystinosis fibroblasts. Pediatr Res. 2006 Feb;59(2):332-5. Pubmed: 16439602 Link_out
                      10. Livingston JH, Brown JK, Harkness RA, McCreanor GM: Cerebrospinal fluid nucleotide metabolites following non-convulsive status epilepticus. Dev Med Child Neurol. 1989 Apr;31(2):168-73. Pubmed: 2737369 Link_out
                      11. Rutkowski B, Swierczynski J, Slominska E, Szolkiewicz M, Smolenski RT, Marlewski M, Butto B, Rutkowski P: Disturbances of purine nucleotide metabolism in uremia. Semin Nephrol. 2004 Sep;24(5):479-83. Pubmed: 15490415 Link_out
                      12. Holzer AM, Granstein RD: Role of extracellular adenosine triphosphate in human skin. J Cutan Med Surg. 2004 Mar-Apr;8(2):90-6. Epub 2004 May 3. Pubmed: 15129319 Link_out
                      13. Myburgh KH: Can any metabolites partially alleviate fatigue manifestations at the cross-bridge? Med Sci Sports Exerc. 2004 Jan;36(1):20-7. Pubmed: 14707763 Link_out
                      14. Gartland A, Buckley KA, Hipskind RA, Bowler WB, Gallagher JA: P2 receptors in bone--modulation of osteoclast formation and activity via P2X7 activation. Crit Rev Eukaryot Gene Expr. 2003;13(2-4):237-42. Pubmed: 14696970 Link_out
                      15. Di Virgilio F, Chiozzi P, Ferrari D, Falzoni S, Sanz JM, Morelli A, Torboli M, Bolognesi G, Baricordi OR: Nucleotide receptors: an emerging family of regulatory molecules in blood cells. Blood. 2001 Feb 1;97(3):587-600. Pubmed: 11157473 Link_out

                      Enzymes

                      Show all enzymes and transporters Important Only showing the first 50 enzymes. There are 1037 enzymes in total.

                      Name: UMP-CMP kinase
                      Reactions:
                      Adenosine triphosphate + (d)CMP unknown ADP + (d)CDP details
                      Adenosine triphosphate + Uridine 5'-monophosphate unknown ADP + Uridine 5'-diphosphate details
                      Adenosine triphosphate + Cytidine monophosphate unknown ADP + CDP details
                      Adenosine triphosphate + dCMP unknown ADP + dCDP details
                      Gene Name: CMPK1
                      Uniprot ID: P30085 Link_out
                      Protein Sequence: FASTA
                      Gene Sequence: FASTA
                      Name: Deoxycytidine kinase
                      Reactions:
                      Adenosine triphosphate + Adenosine unknown ADP + Adenosine monophosphate details
                      Adenosine triphosphate + Deoxycytidine unknown ADP + dCMP details
                      Gene Name: DCK
                      Uniprot ID: P27707 Link_out
                      Protein Sequence: FASTA
                      Gene Sequence: FASTA
                      Name: ATP-citrate synthase
                      Reactions:
                      ADP + Phosphoric acid + Acetyl-CoA + Oxalacetic acid unknown Adenosine triphosphate + Citric acid + Coenzyme A details
                      Adenosine triphosphate + Citric acid + Coenzyme A unknown ADP + Phosphoric acid + Acetyl-CoA + Oxalacetic acid details
                      Gene Name: ACLY
                      Uniprot ID: P53396 Link_out
                      Protein Sequence: FASTA
                      Gene Sequence: FASTA
                      Name: Acetyl-CoA carboxylase 2
                      Reactions:
                      Adenosine triphosphate + Acetyl-CoA + Carbonic acid unknown ADP + Phosphoric acid + Malonyl-CoA details
                      Adenosine triphosphate + biotin-[carboxyl-carrier-protein] + CO(2) unknown ADP + Phosphoric acid + carboxy-biotin-[carboxyl-carrier-protein] details
                      Adenosine triphosphate + Holo-[carboxylase] + Carbonic acid unknown ADP + Phosphoric acid + Carboxybiotin-carboxyl-carrier protein details
                      Gene Name: ACACB
                      Uniprot ID: O00763 Link_out
                      Protein Sequence: FASTA
                      Gene Sequence: FASTA
                      Name: Pyruvate carboxylase, mitochondrial
                      Reactions:
                      Adenosine triphosphate + Pyruvic acid + Carbonic acid unknown ADP + Phosphoric acid + Oxalacetic acid details
                      Gene Name: PC
                      Uniprot ID: P11498 Link_out
                      Protein Sequence: FASTA
                      Gene Sequence: FASTA
                      Name: Acetyl-coenzyme A synthetase, cytoplasmic
                      Reactions:
                      Adenosine triphosphate + Acetic acid + Coenzyme A unknown Adenosine monophosphate + Pyrophosphate + Acetyl-CoA details
                      Adenosine triphosphate + Acetic acid unknown Pyrophosphate + Acetyl adenylate details
                      Adenosine triphosphate + Propionic acid unknown Pyrophosphate + Propinol adenylate details
                      Gene Name: ACSS2
                      Uniprot ID: Q9NR19 Link_out
                      Protein Sequence: FASTA
                      Gene Sequence: FASTA
                      Name: Acetyl-coenzyme A synthetase 2-like, mitochondrial
                      Reactions:
                      Adenosine triphosphate + Acetic acid + Coenzyme A unknown Adenosine monophosphate + Pyrophosphate + Acetyl-CoA details
                      Adenosine triphosphate + Acetic acid unknown Pyrophosphate + Acetyl adenylate details
                      Adenosine triphosphate + Propionic acid unknown Pyrophosphate + Propinol adenylate details
                      Gene Name: ACSS1
                      Uniprot ID: Q9NUB1 Link_out
                      Protein Sequence: FASTA
                      Gene Sequence: FASTA
                      Name: Acetyl-CoA carboxylase 1
                      Reactions:
                      Adenosine triphosphate + Acetyl-CoA + Carbonic acid unknown ADP + Phosphoric acid + Malonyl-CoA details
                      Adenosine triphosphate + biotin-[carboxyl-carrier-protein] + CO(2) unknown ADP + Phosphoric acid + carboxy-biotin-[carboxyl-carrier-protein] details
                      Adenosine triphosphate + Holo-[carboxylase] + Carbonic acid unknown ADP + Phosphoric acid + Carboxybiotin-carboxyl-carrier protein details
                      Gene Name: ACACA
                      Uniprot ID: Q13085 Link_out
                      Protein Sequence: FASTA
                      Gene Sequence: FASTA
                      Name: Thymidylate kinase
                      Reactions:
                      Adenosine triphosphate + 5-Thymidylic acid unknown ADP + dTDP details
                      Adenosine triphosphate + dUMP unknown ADP + dUDP details
                      Gene Name: DTYMK
                      Uniprot ID: P23919 Link_out
                      Protein Sequence: FASTA
                      Gene Sequence: FASTA
                      Name: Ectonucleoside triphosphate diphosphohydrolase 1
                      Reactions:
                      Adenosine triphosphate + Water unknown Adenosine monophosphate + Phosphoric acid details
                      Adenosine triphosphate + Water unknown ADP + Phosphoric acid details
                      Gene Name: ENTPD1
                      Uniprot ID: P49961 Link_out
                      Protein Sequence: FASTA
                      Gene Sequence: FASTA
                      Name: Soluble calcium-activated nucleotidase 1
                      Reactions: Not Available
                      Gene Name: CANT1
                      Uniprot ID: Q8WVQ1 Link_out
                      Protein Sequence: FASTA
                      Gene Sequence: FASTA
                      Name: Ectonucleoside triphosphate diphosphohydrolase 3
                      Reactions:
                      Adenosine triphosphate + Water unknown Adenosine monophosphate + Phosphoric acid details
                      Adenosine triphosphate + Water unknown ADP + Phosphoric acid details
                      Gene Name: ENTPD3
                      Uniprot ID: O75355 Link_out
                      Protein Sequence: FASTA
                      Gene Sequence: FASTA
                      Name: Serum paraoxonase/lactonase 3
                      Reactions: Not Available
                      Gene Name: PON3
                      Uniprot ID: Q15166 Link_out
                      Protein Sequence: FASTA
                      Gene Sequence: FASTA
                      Name: Uridine-cytidine kinase 1
                      Reactions:
                      Adenosine triphosphate + Uridine unknown ADP + Uridine 5'-monophosphate details
                      Adenosine triphosphate + Cytidine unknown ADP + Cytidine monophosphate details
                      5-Fluorouridine + Adenosine triphosphate unknown 5-Fluorouridine monophosphate + ADP details
                      Gene Name: UCK1
                      Uniprot ID: Q9HA47 Link_out
                      Protein Sequence: FASTA
                      Gene Sequence: FASTA
                      Name: Nucleoside diphosphate kinase, mitochondrial
                      Reactions:
                      Adenosine triphosphate + nucleoside diphosphate unknown ADP + nucleoside triphosphate details
                      Adenosine triphosphate + ADP unknown ADP + Adenosine triphosphate details
                      Adenosine triphosphate + Uridine 5'-diphosphate unknown ADP + Uridine triphosphate details
                      Adenosine triphosphate + Guanosine diphosphate unknown ADP + Guanosine triphosphate details
                      Adenosine triphosphate + CDP unknown ADP + Cytidine triphosphate details
                      Adenosine triphosphate + IDP unknown ADP + Inosine triphosphate details
                      Adenosine triphosphate + dADP unknown ADP + Deoxyadenosine triphosphate details
                      Adenosine triphosphate + dGDP unknown ADP + dGTP details
                      Adenosine triphosphate + dTDP unknown ADP + Thymidine 5'-triphosphate details
                      Adenosine triphosphate + dCDP unknown ADP + dCTP details
                      Adenosine triphosphate + dUDP unknown ADP + Deoxyuridine triphosphate details
                      Adenosine triphosphate + dIDP unknown ADP + 2'-Deoxyinosine triphosphate details
                      Gene Name: NME4
                      Uniprot ID: O00746 Link_out
                      Protein Sequence: FASTA
                      Gene Sequence: FASTA
                      Name: Ribonucleoside-diphosphate reductase large subunit
                      Reactions: Not Available
                      Gene Name: RRM1
                      Uniprot ID: P23921 Link_out
                      Protein Sequence: FASTA
                      Gene Sequence: FASTA
                      Name: Nucleoside diphosphate kinase A
                      Reactions:
                      Adenosine triphosphate + nucleoside diphosphate unknown ADP + nucleoside triphosphate details
                      Adenosine triphosphate + ADP unknown ADP + Adenosine triphosphate details
                      Adenosine triphosphate + Uridine 5'-diphosphate unknown ADP + Uridine triphosphate details
                      Adenosine triphosphate + Guanosine diphosphate unknown ADP + Guanosine triphosphate details
                      Adenosine triphosphate + CDP unknown ADP + Cytidine triphosphate details
                      Adenosine triphosphate + IDP unknown ADP + Inosine triphosphate details
                      Adenosine triphosphate + dADP unknown ADP + Deoxyadenosine triphosphate details
                      Adenosine triphosphate + dGDP unknown ADP + dGTP details
                      Adenosine triphosphate + dTDP unknown ADP + Thymidine 5'-triphosphate details
                      Adenosine triphosphate + dCDP unknown ADP + dCTP details
                      Adenosine triphosphate + dUDP unknown ADP + Deoxyuridine triphosphate details
                      Adenosine triphosphate + dIDP unknown ADP + 2'-Deoxyinosine triphosphate details
                      Gene Name: NME1
                      Uniprot ID: P15531 Link_out
                      Protein Sequence: FASTA
                      Gene Sequence: FASTA
                      Name: Nucleoside diphosphate kinase 7
                      Reactions:
                      Adenosine triphosphate + nucleoside diphosphate unknown ADP + nucleoside triphosphate details
                      Adenosine triphosphate + ADP unknown ADP + Adenosine triphosphate details
                      Adenosine triphosphate + Uridine 5'-diphosphate unknown ADP + Uridine triphosphate details
                      Adenosine triphosphate + Guanosine diphosphate unknown ADP + Guanosine triphosphate details
                      Adenosine triphosphate + CDP unknown ADP + Cytidine triphosphate details
                      Adenosine triphosphate + IDP unknown ADP + Inosine triphosphate details
                      Adenosine triphosphate + dADP unknown ADP + Deoxyadenosine triphosphate details
                      Adenosine triphosphate + dGDP unknown ADP + dGTP details
                      Adenosine triphosphate + dTDP unknown ADP + Thymidine 5'-triphosphate details
                      Adenosine triphosphate + dCDP unknown ADP + dCTP details
                      Adenosine triphosphate + dUDP unknown ADP + Deoxyuridine triphosphate details
                      Adenosine triphosphate + dIDP unknown ADP + 2'-Deoxyinosine triphosphate details
                      Gene Name: NME7
                      Uniprot ID: Q9Y5B8 Link_out
                      Protein Sequence: FASTA
                      Gene Sequence: FASTA
                      Name: Ribonucleoside-diphosphate reductase subunit M2
                      Reactions: Not Available
                      Gene Name: RRM2
                      Uniprot ID: P31350 Link_out
                      Protein Sequence: FASTA
                      Gene Sequence: FASTA
                      Name: Nucleoside diphosphate kinase B
                      Reactions:
                      Adenosine triphosphate + nucleoside diphosphate unknown ADP + nucleoside triphosphate details
                      Adenosine triphosphate + protein L-histidine unknown ADP + protein N-phospho-L-histidine details
                      Adenosine triphosphate + ADP unknown ADP + Adenosine triphosphate details
                      Adenosine triphosphate + Uridine 5'-diphosphate unknown ADP + Uridine triphosphate details
                      Adenosine triphosphate + Guanosine diphosphate unknown ADP + Guanosine triphosphate details
                      Adenosine triphosphate + CDP unknown ADP + Cytidine triphosphate details
                      Adenosine triphosphate + IDP unknown ADP + Inosine triphosphate details
                      Adenosine triphosphate + dADP unknown ADP + Deoxyadenosine triphosphate details
                      Adenosine triphosphate + dGDP unknown ADP + dGTP details
                      Adenosine triphosphate + dTDP unknown ADP + Thymidine 5'-triphosphate details
                      Adenosine triphosphate + dCDP unknown ADP + dCTP details
                      Adenosine triphosphate + dUDP unknown ADP + Deoxyuridine triphosphate details
                      Adenosine triphosphate + dIDP unknown ADP + 2'-Deoxyinosine triphosphate details
                      Gene Name: NME2
                      Uniprot ID: P22392 Link_out
                      Protein Sequence: FASTA
                      Gene Sequence: FASTA
                      Name: Nucleoside diphosphate kinase 3
                      Reactions:
                      Adenosine triphosphate + nucleoside diphosphate unknown ADP + nucleoside triphosphate details
                      Adenosine triphosphate + ADP unknown ADP + Adenosine triphosphate details
                      Adenosine triphosphate + Uridine 5'-diphosphate unknown ADP + Uridine triphosphate details
                      Adenosine triphosphate + Guanosine diphosphate unknown ADP + Guanosine triphosphate details
                      Adenosine triphosphate + CDP unknown ADP + Cytidine triphosphate details
                      Adenosine triphosphate + IDP unknown ADP + Inosine triphosphate details
                      Adenosine triphosphate + dADP unknown ADP + Deoxyadenosine triphosphate details
                      Adenosine triphosphate + dGDP unknown ADP + dGTP details
                      Adenosine triphosphate + dTDP unknown ADP + Thymidine 5'-triphosphate details
                      Adenosine triphosphate + dCDP unknown ADP + dCTP details
                      Adenosine triphosphate + dUDP unknown ADP + Deoxyuridine triphosphate details
                      Adenosine triphosphate + dIDP unknown ADP + 2'-Deoxyinosine triphosphate details
                      Gene Name: NME3
                      Uniprot ID: Q13232 Link_out
                      Protein Sequence: FASTA
                      Gene Sequence: FASTA
                      Name: Nucleoside diphosphate kinase 6
                      Reactions:
                      Adenosine triphosphate + nucleoside diphosphate unknown ADP + nucleoside triphosphate details
                      Adenosine triphosphate + ADP unknown ADP + Adenosine triphosphate details
                      Adenosine triphosphate + Uridine 5'-diphosphate unknown ADP + Uridine triphosphate details
                      Adenosine triphosphate + Guanosine diphosphate unknown ADP + Guanosine triphosphate details
                      Adenosine triphosphate + CDP unknown ADP + Cytidine triphosphate details
                      Adenosine triphosphate + IDP unknown ADP + Inosine triphosphate details
                      Adenosine triphosphate + dADP unknown ADP + Deoxyadenosine triphosphate details
                      Adenosine triphosphate + dGDP unknown ADP + dGTP details
                      Adenosine triphosphate + dTDP unknown ADP + Thymidine 5'-triphosphate details
                      Adenosine triphosphate + dCDP unknown ADP + dCTP details
                      Adenosine triphosphate + dUDP unknown ADP + Deoxyuridine triphosphate details
                      Adenosine triphosphate + dIDP unknown ADP + 2'-Deoxyinosine triphosphate details
                      Gene Name: NME6
                      Uniprot ID: O75414 Link_out
                      Protein Sequence: FASTA
                      Gene Sequence: FASTA
                      Name: Glucokinase
                      Reactions:
                      Adenosine triphosphate + D-Glucose unknown ADP + Glucose 6-phosphate details
                      Adenosine triphosphate + Beta-D-Glucose unknown ADP + Beta-D-Glucose 6-phosphate details
                      Adenosine triphosphate + Alpha-D-Glucose unknown ADP + Glucose 6-phosphate details
                      Gene Name: GCK
                      Uniprot ID: P35557 Link_out
                      Protein Sequence: FASTA
                      Gene Sequence: FASTA
                      Name: Hexokinase-3
                      Reactions:
                      Adenosine triphosphate + D-Galactose unknown ADP + Glucose 6-phosphate details
                      Adenosine triphosphate + D-Glucose unknown ADP + Glucose 6-phosphate details
                      Adenosine triphosphate + D-Fructose unknown ADP + Beta-D-Fructose 6-phosphate details
                      Adenosine triphosphate + D-Mannose unknown ADP + Mannose 6-phosphate details
                      Adenosine triphosphate + Beta-D-Glucose unknown ADP + Beta-D-Glucose 6-phosphate details
                      Adenosine triphosphate + Alpha-D-Glucose unknown ADP + Glucose 6-phosphate details
                      Adenosine triphosphate + Glucosamine unknown ADP + Glucosamine 6-phosphate details
                      Adenosine triphosphate + D-Fructose unknown ADP + Beta-D-Fructose 6-phosphate details
                      Gene Name: HK3
                      Uniprot ID: P52790 Link_out
                      Protein Sequence: FASTA
                      Gene Sequence: FASTA
                      Name: Hexokinase-2
                      Reactions:
                      Adenosine triphosphate + D-Galactose unknown ADP + Glucose 6-phosphate details
                      Adenosine triphosphate + D-Glucose unknown ADP + Glucose 6-phosphate details
                      Adenosine triphosphate + D-Fructose unknown ADP + Beta-D-Fructose 6-phosphate details
                      Adenosine triphosphate + D-Mannose unknown ADP + Mannose 6-phosphate details
                      Adenosine triphosphate + Beta-D-Glucose unknown ADP + Beta-D-Glucose 6-phosphate details
                      Adenosine triphosphate + Alpha-D-Glucose unknown ADP + Glucose 6-phosphate details
                      Adenosine triphosphate + Glucosamine unknown ADP + Glucosamine 6-phosphate details
                      Adenosine triphosphate + D-Fructose unknown ADP + Beta-D-Fructose 6-phosphate details
                      Gene Name: HK2
                      Uniprot ID: P52789 Link_out
                      Protein Sequence: FASTA
                      Gene Sequence: FASTA
                      Name: Hexokinase-1
                      Reactions:
                      Adenosine triphosphate + D-Galactose unknown ADP + Glucose 6-phosphate details
                      Adenosine triphosphate + D-Glucose unknown ADP + Glucose 6-phosphate details
                      Adenosine triphosphate + D-Fructose unknown ADP + Beta-D-Fructose 6-phosphate details
                      Adenosine triphosphate + D-Mannose unknown ADP + Mannose 6-phosphate details
                      Adenosine triphosphate + Beta-D-Glucose unknown ADP + Beta-D-Glucose 6-phosphate details
                      Adenosine triphosphate + Alpha-D-Glucose unknown ADP + Glucose 6-phosphate details
                      Adenosine triphosphate + Glucosamine unknown ADP + Glucosamine 6-phosphate details
                      Adenosine triphosphate + D-Fructose unknown ADP + Beta-D-Fructose 6-phosphate details
                      Gene Name: HK1
                      Uniprot ID: P19367 Link_out
                      Protein Sequence: FASTA
                      Gene Sequence: FASTA
                      Name: Diacylglycerol kinase theta
                      Reactions: Not Available
                      Gene Name: DGKQ
                      Uniprot ID: P52824 Link_out
                      Protein Sequence: FASTA
                      Gene Sequence: FASTA
                      Name: Diacylglycerol kinase alpha
                      Reactions: Not Available
                      Gene Name: DGKA
                      Uniprot ID: P23743 Link_out
                      Protein Sequence: FASTA
                      Gene Sequence: FASTA
                      Name: Diacylglycerol kinase delta
                      Reactions: Not Available
                      Gene Name: DGKD
                      Uniprot ID: Q16760 Link_out
                      Protein Sequence: FASTA
                      Gene Sequence: FASTA
                      Name: Diacylglycerol kinase beta
                      Reactions: Not Available
                      Gene Name: DGKB
                      Uniprot ID: Q9Y6T7 Link_out
                      Protein Sequence: FASTA
                      Gene Sequence: FASTA
                      Name: Diacylglycerol kinase iota
                      Reactions: Not Available
                      Gene Name: DGKI
                      Uniprot ID: O75912 Link_out
                      Protein Sequence: FASTA
                      Gene Sequence: FASTA
                      Name: Diacylglycerol kinase zeta
                      Reactions: Not Available
                      Gene Name: DGKZ
                      Uniprot ID: Q13574 Link_out
                      Protein Sequence: FASTA
                      Gene Sequence: FASTA
                      Name: L-fucose kinase
                      Reactions:
                      Adenosine triphosphate + L-Fucose unknown ADP + Fucose 1-phosphate details
                      Gene Name: FUK
                      Uniprot ID: Q8N0W3 Link_out
                      Protein Sequence: FASTA
                      Gene Sequence: FASTA
                      Name: Propionyl-CoA carboxylase beta chain, mitochondrial
                      Reactions:
                      Adenosine triphosphate + Propionyl-CoA + Carbonic acid unknown ADP + Phosphoric acid + S-Methylmalonyl-CoA details
                      Gene Name: PCCB
                      Uniprot ID: P05166 Link_out
                      Protein Sequence: FASTA
                      Gene Sequence: FASTA
                      Name: Propionyl-CoA carboxylase alpha chain, mitochondrial
                      Reactions:
                      Adenosine triphosphate + Propionyl-CoA + Carbonic acid unknown ADP + Phosphoric acid + S-Methylmalonyl-CoA details
                      Gene Name: PCCA
                      Uniprot ID: P05165 Link_out
                      Protein Sequence: FASTA
                      Gene Sequence: FASTA
                      Name: Phenylalanine--tRNA ligase alpha subunit
                      Reactions:
                      Adenosine triphosphate + L-Phenylalanine + tRNA(Phe) unknown Adenosine monophosphate + Pyrophosphate + L-phenylalanyl-tRNA(Phe) details
                      Adenosine triphosphate + L-Phenylalanine + tRNA(Phe) unknown Adenosine monophosphate + Pyrophosphate + L-Phenylalanyl-tRNA(Phe) details
                      Gene Name: FARSA
                      Uniprot ID: Q9Y285 Link_out
                      Protein Sequence: FASTA
                      Gene Sequence: FASTA
                      Name: Phenylalanine--tRNA ligase, mitochondrial
                      Reactions:
                      Adenosine triphosphate + L-Phenylalanine + tRNA(Phe) unknown Adenosine monophosphate + Pyrophosphate + L-phenylalanyl-tRNA(Phe) details
                      Adenosine triphosphate + L-Phenylalanine + tRNA(Phe) unknown Adenosine monophosphate + Pyrophosphate + L-Phenylalanyl-tRNA(Phe) details
                      Gene Name: FARS2
                      Uniprot ID: O95363 Link_out
                      Protein Sequence: FASTA
                      Gene Sequence: FASTA
                      Name: Alpha-aminoadipic semialdehyde dehydrogenase
                      Reactions:
                      Aminoadipic acid + Adenosine triphosphate unknown L-2-Aminoadipate adenylate + Pyrophosphate details
                      Gene Name: ALDH7A1
                      Uniprot ID: P49419 Link_out
                      Protein Sequence: FASTA
                      Gene Sequence: FASTA
                      Name: Trifunctional purine biosynthetic protein adenosine-3
                      Reactions:
                      Adenosine triphosphate + 5-Phosphoribosylamine + Glycine unknown ADP + Phosphoric acid + Glycineamideribotide details
                      Adenosine triphosphate + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine unknown ADP + Phosphoric acid + 5-Aminoimidazole ribonucleotide details
                      Adenosine triphosphate + 5-Phosphoribosylamine + Glycine unknown ADP + Phosphoric acid + Glycineamideribotide details
                      Adenosine triphosphate + Phosphoribosylformylglycineamidine unknown ADP + Phosphoric acid + 5-Aminoimidazole ribonucleotide details
                      Gene Name: GART
                      Uniprot ID: P22102 Link_out
                      Protein Sequence: FASTA
                      Gene Sequence: FASTA
                      Name: Bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase
                      Reactions:
                      Adenosine triphosphate + N-acyl-D-mannosamine unknown ADP + N-acyl-D-mannosamine 6-phosphate details
                      Adenosine triphosphate + N-Acetylmannosamine unknown ADP + N-Acetyl-D-mannosamine 6-phosphate details
                      Gene Name: GNE
                      Uniprot ID: Q9Y223 Link_out
                      Protein Sequence: FASTA
                      Gene Sequence: FASTA
                      Name: N-acylglucosamine 2-epimerase
                      Reactions: Not Available
                      Gene Name: RENBP
                      Uniprot ID: P51606 Link_out
                      Protein Sequence: FASTA
                      Gene Sequence: FASTA
                      Name: Nicotinamide mononucleotide adenylyltransferase 1
                      Reactions:
                      Adenosine triphosphate + beta-nicotinamide D-ribonucleotide unknown Pyrophosphate + NAD details
                      Adenosine triphosphate + beta-nicotinate-D-ribonucleotide unknown Pyrophosphate + Nicotinic acid adenine dinucleotide details
                      Adenosine triphosphate + nicotinate beta-D-ribonucleotide unknown Pyrophosphate + Nicotinic acid adenine dinucleotide details
                      Gene Name: NMNAT1
                      Uniprot ID: Q9HAN9 Link_out
                      Protein Sequence: FASTA
                      Gene Sequence: FASTA
                      Name: Nicotinamide mononucleotide adenylyltransferase 3
                      Reactions:
                      Adenosine triphosphate + beta-nicotinamide D-ribonucleotide unknown Pyrophosphate + NAD details
                      Adenosine triphosphate + beta-nicotinate-D-ribonucleotide unknown Pyrophosphate + Nicotinic acid adenine dinucleotide details
                      Adenosine triphosphate + nicotinate beta-D-ribonucleotide unknown Pyrophosphate + Nicotinic acid adenine dinucleotide details
                      Gene Name: NMNAT3
                      Uniprot ID: Q96T66 Link_out
                      Protein Sequence: FASTA
                      Gene Sequence: FASTA
                      Name: Nicotinamide mononucleotide adenylyltransferase 2
                      Reactions:
                      Adenosine triphosphate + beta-nicotinamide D-ribonucleotide unknown Pyrophosphate + NAD details
                      Adenosine triphosphate + beta-nicotinate-D-ribonucleotide unknown Pyrophosphate + Nicotinic acid adenine dinucleotide details
                      Adenosine triphosphate + nicotinate beta-D-ribonucleotide unknown Pyrophosphate + Nicotinic acid adenine dinucleotide details
                      Gene Name: NMNAT2
                      Uniprot ID: Q9BZQ4 Link_out
                      Protein Sequence: FASTA
                      Gene Sequence: FASTA
                      Name: Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1
                      Reactions:
                      Adenosine triphosphate + Oat gum unknown Pyrophosphate + Adenosine phosphosulfate details
                      Adenosine triphosphate + Adenosine phosphosulfate unknown ADP + Phosphoadenosine phosphosulfate details
                      Adenosine triphosphate + Adenylylselenate unknown ADP + 3-Phosphoadenylylselenate details
                      Adenosine triphosphate + Selenocystathionine unknown Pyrophosphate + Adenylylselenate details
                      Gene Name: PAPSS1
                      Uniprot ID: O43252 Link_out
                      Protein Sequence: FASTA
                      Gene Sequence: FASTA
                      Name: Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2
                      Reactions:
                      Adenosine triphosphate + Oat gum unknown Pyrophosphate + Adenosine phosphosulfate details
                      Adenosine triphosphate + Adenosine phosphosulfate unknown ADP + Phosphoadenosine phosphosulfate details
                      Adenosine triphosphate + Adenylylselenate unknown ADP + 3-Phosphoadenylylselenate details
                      Adenosine triphosphate + Selenocystathionine unknown Pyrophosphate + Adenylylselenate details
                      Gene Name: PAPSS2
                      Uniprot ID: O95340 Link_out
                      Protein Sequence: FASTA
                      Gene Sequence: FASTA
                      Name: Carbamoyl-phosphate synthase [ammonia], mitochondrial
                      Reactions:
                      Adenosine triphosphate + Ammonia + CO(2) + Water unknown ADP + Phosphoric acid + Carbamoyl phosphate details
                      Adenosine triphosphate + Ammonia + Carbon dioxide + Water unknown ADP + Phosphoric acid + Carbamoyl phosphate details
                      Gene Name: CPS1
                      Uniprot ID: P31327 Link_out
                      Protein Sequence: FASTA
                      Gene Sequence: FASTA
                      Name: S-adenosylmethionine synthase isoform type-2
                      Reactions:
                      Adenosine triphosphate + L-Methionine + Water unknown Phosphoric acid + Pyrophosphate + S-Adenosylmethionine details
                      Phosphoric acid + Pyrophosphate + S-Adenosylmethionine unknown Adenosine triphosphate + L-Methionine + Water details
                      Adenosine triphosphate + Selenomethionine + Water unknown Phosphoric acid + Pyrophosphate + Se-Adenosylselenomethionine details
                      Gene Name: MAT2A
                      Uniprot ID: P31153 Link_out
                      Protein Sequence: FASTA
                      Gene Sequence: FASTA
                      Name: S-adenosylmethionine synthase isoform type-1
                      Reactions:
                      Adenosine triphosphate + L-Methionine + Water unknown Phosphoric acid + Pyrophosphate + S-Adenosylmethionine details
                      Phosphoric acid + Pyrophosphate + S-Adenosylmethionine unknown Adenosine triphosphate + L-Methionine + Water details
                      Adenosine triphosphate + Selenomethionine + Water unknown Phosphoric acid + Pyrophosphate + Se-Adenosylselenomethionine details
                      Gene Name: MAT1A
                      Uniprot ID: Q00266 Link_out
                      Protein Sequence: FASTA
                      Gene Sequence: FASTA
                      Name: Inosine triphosphate pyrophosphatase
                      Reactions: Not Available
                      Gene Name: ITPA
                      Uniprot ID: Q9BY32 Link_out
                      Protein Sequence: FASTA
                      Gene Sequence: FASTA
                      Transporters
                      Name: Copper-transporting ATPase 2
                      Reactions: Not Available
                      Gene Name: ATP7B
                      Uniprot ID: P35670 Link_out
                      Protein Sequence: FASTA
                      Gene Sequence: FASTA
                      Name: Copper-transporting ATPase 1
                      Reactions: Not Available
                      Gene Name: ATP7A
                      Uniprot ID: Q04656 Link_out
                      Protein Sequence: FASTA
                      Gene Sequence: FASTA
                      Name: Antigen peptide transporter 1
                      Reactions: Not Available
                      Gene Name: TAP1
                      Uniprot ID: Q03518 Link_out
                      Protein Sequence: FASTA
                      Gene Sequence: FASTA