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Record Information
Version3.6
Creation Date2006-08-15 21:24:16 UTC
Update Date2016-05-13 20:58:12 UTC
HMDB IDHMDB00547
Secondary Accession NumbersNone
Metabolite Identification
Common NameMagnesium
DescriptionMagnesium salts are essential in nutrition, being required for the activity of many enzymes, especially those concerned with oxidative phosphorylation. Physiologically, it exists as an ion in the body. It is a component of both intra- and extracellular fluids and is excreted in the urine and feces. Deficiency causes irritability of the nervous system with tetany, vasodilatation, convulsions, tremors, depression, and psychotic behavior. Magnesium ion in large amounts is an ionic laxative, and magnesium sulfate (Epsom salts) is sometimes used for this purpose. So-called "milk of magnesia" is a water suspension of one of the few insoluble magnesium compounds, magnesium hydroxide; the undissolved particles give rise to its appearance and name. Milk of magnesia is a mild base, and is commonly used as an antacid.
Structure
Thumb
Synonyms
ValueSource
MAGNESIUM ionChEBI
Magnesium, doubly charged positive ionChEBI
Magnesium, ion (MG(2+))ChEBI
MG(2+)ChEBI
MG2+ChEBI
Magnesium ionsHMDB
Chemical FormulaMg
Average Molecular Weight24.305
Monoisotopic Molecular Weight23.985041898
IUPAC Namemagnesium(2+) ion
Traditional Namemagnesium(2+) ion
CAS Registry Number7439-95-4
SMILES
[Mg++]
InChI Identifier
InChI=1S/Mg/q+2
InChI KeyInChIKey=JLVVSXFLKOJNIY-UHFFFAOYSA-N
Chemical Taxonomy
DescriptionThis compound belongs to the class of inorganic compounds known as homogeneous alkaline earth metal compounds. These are inorganic compounds containing only metal atoms,with the largest atom being a alkaline earth metal atom.
KingdomInorganic compounds
Super ClassHomogeneous metal compounds
ClassHomogeneous alkaline earth metal compounds
Sub ClassNot Available
Direct ParentHomogeneous alkaline earth metal compounds
Alternative ParentsNot Available
Substituents
  • Homogeneous alkaline earth metal
  • Acyclic compound
Molecular FrameworkAcyclic compounds
External Descriptors
Ontology
StatusDetected and Quantified
Origin
  • Drug
  • Food
Biofunction
  • Enzyme co-factor
  • Essential minerals
  • Protein component
ApplicationNot Available
Cellular locations
  • Cytoplasm (predicted from logP)
Physical Properties
StateSolid
Experimental Properties
PropertyValueReference
Melting Point651 °CNot Available
Boiling PointNot AvailableNot Available
Water SolubilityNot AvailableNot Available
LogPNot AvailableNot Available
Predicted Properties
PropertyValueSource
logP-0.57ChemAxon
Physiological Charge2ChemAxon
Hydrogen Acceptor Count0ChemAxon
Hydrogen Donor Count0ChemAxon
Polar Surface Area0 Å2ChemAxon
Rotatable Bond Count0ChemAxon
Refractivity0 m3·mol-1ChemAxon
Polarizability1.78 Å3ChemAxon
Number of Rings0ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
SpectraNot Available
Biological Properties
Cellular Locations
  • Cytoplasm (predicted from logP)
Biofluid Locations
  • Blood
  • Cerebrospinal Fluid (CSF)
  • Saliva
  • Urine
Tissue Location
  • Brain
  • Erythrocyte
  • Hair
  • Kidney
  • Liver
  • Lymphocyte
  • Muscle
  • Platelet
  • Skeletal Muscle
Pathways
NameSMPDB LinkKEGG Link
2-Hydroxyglutric Aciduria (D And L Form)SMP00136Not Available
2-ketoglutarate dehydrogenase complex deficiencySMP00549Not Available
3-Phosphoglycerate dehydrogenase deficiencySMP00721Not Available
4-Hydroxybutyric Aciduria/Succinic Semialdehyde Dehydrogenase DeficiencySMP00243Not Available
Acebutolol PathwaySMP00296Not Available
Acetaminophen Action PathwaySMP00710Not Available
Acetylsalicylic Acid PathwaySMP00083Not Available
Adefovir Dipivoxil Metabolism PathwaySMP00629Not Available
Adenine phosphoribosyltransferase deficiency (APRT)SMP00535Not Available
Adenosine Deaminase DeficiencySMP00144Not Available
Adenylosuccinate Lyase DeficiencySMP00167Not Available
Adrenoleukodystrophy, X-linkedSMP00516Not Available
AICA-RibosiduriaSMP00168Not Available
Alendronate pathwaySMP00095Not Available
AlkaptonuriaSMP00169Not Available
Alprenolol PathwaySMP00297Not Available
Amino Sugar MetabolismSMP00045map00520
Amiodarone Action PathwaySMP00665Not Available
Amlodipine PathwaySMP00376Not Available
Ammonia RecyclingSMP00009map00910
Antipyrine Action PathwaySMP00692Not Available
Antrafenine Action PathwaySMP00693Not Available
Arachidonic Acid MetabolismSMP00075map00590
Arbutamine Action PathwaySMP00664Not Available
Aspartate MetabolismSMP00067map00250
Atenolol PathwaySMP00298Not Available
Atorvastatin PathwaySMP00131Not Available
Azathioprine PathwaySMP00427Not Available
Beta Oxidation of Very Long Chain Fatty AcidsSMP00052map01040
Beta Ureidopropionase DeficiencySMP00172Not Available
Betaine MetabolismSMP00123map00260
Betaxolol PathwaySMP00299Not Available
Bevantolol Action PathwaySMP00668Not Available
Bisoprolol PathwaySMP00300Not Available
Bopindolol Action PathwaySMP00657Not Available
Bromfenac PathwaySMP00102Not Available
Bupranolol Action PathwaySMP00670Not Available
Butyrate MetabolismSMP00073map00650
Canavan DiseaseSMP00175Not Available
Carnitine palmitoyl transferase deficiency (I)SMP00538Not Available
Carnitine palmitoyl transferase deficiency (II)SMP00541Not Available
Carnitine-acylcarnitine translocase deficiencySMP00517Not Available
Carprofen Action PathwaySMP00694Not Available
Carteolol Action PathwaySMP00658Not Available
Carvedilol PathwaySMP00367Not Available
Celecoxib PathwaySMP00096Not Available
Cerivastatin PathwaySMP00111Not Available
CHILD SyndromeSMP00387Not Available
Cholesteryl ester storage diseaseSMP00508Not Available
Chondrodysplasia Punctata II, X Linked Dominant (CDPX2)SMP00388Not Available
Citric Acid CycleSMP00057map00020
Congenital disorder of glycosylation CDG-IIdSMP00579Not Available
Congenital lactic acidosisSMP00546Not Available
Corticotropin Activation of Cortisol ProductionSMP00310Not Available
Cystathionine Beta-Synthase DeficiencySMP00177Not Available
DesmosterolosisSMP00386Not Available
Diclofenac PathwaySMP00093Not Available
Diflunisal PathwaySMP00289Not Available
Dihydropyrimidinase DeficiencySMP00178Not Available
Dihydropyrimidine Dehydrogenase Deficiency (DHPD)SMP00179Not Available
Diltiazem PathwaySMP00359Not Available
Dimethylglycine Dehydrogenase DeficiencySMP00242Not Available
Dimethylglycine Dehydrogenase DeficiencySMP00484Not Available
Disopyramide PathwaySMP00325Not Available
Disulfiram PathwaySMP00429Not Available
Dobutamine Action PathwaySMP00662Not Available
Dopamine Activation of Neurological Reward SystemSMP00308Not Available
Dopamine beta-hydroxylase deficiencySMP00498Not Available
Epinephrine Action PathwaySMP00661Not Available
Esmolol PathwaySMP00301Not Available
Ethylmalonic EncephalopathySMP00181Not Available
Etodolac PathwaySMP00084Not Available
Etoposide Metabolism PathwaySMP00601Not Available
Etoposide PathwaySMP00442Not Available
Etoricoxib Action PathwaySMP00695Not Available
Excitatory Neural Signalling Through 5-HTR 4 and SerotoninSMP00309Not Available
Excitatory Neural Signalling Through 5-HTR 6 and Serotonin SMP00312Not Available
Excitatory Neural Signalling Through 5-HTR 7 and Serotonin SMP00311Not Available
Fabry diseaseSMP00525Not Available
Fanconi-bickel syndromeSMP00572Not Available
Fatty acid MetabolismSMP00051map00071
Fc Epsilon Receptor I Signaling in Mast CellsSMP00358Not Available
Felodipine PathwaySMP00377Not Available
Fenoprofen Action PathwaySMP00696Not Available
Flecainide PathwaySMP00331Not Available
Flurbiprofen Action PathwaySMP00697Not Available
Fluvastatin PathwaySMP00119Not Available
Folate malabsorption, hereditarySMP00724Not Available
Folate MetabolismSMP00053map00670
Fosphenytoin (Antiarrhythmic) PathwaySMP00326Not Available
Fructose and Mannose DegradationSMP00064map00051
Fructose intolerance, hereditarySMP00725Not Available
Fructose-1,6-diphosphatase deficiencySMP00562Not Available
FructosuriaSMP00561Not Available
Fumarase deficiencySMP00547Not Available
G(M2)-Gangliosidosis: Variant B, Tay-sachs diseaseSMP00534Not Available
Galactose MetabolismSMP00043map00052
GalactosemiaSMP00182Not Available
Galactosemia II (GALK)SMP00495Not Available
Galactosemia IIISMP00496Not Available
Gaucher DiseaseSMP00349Not Available
Gemcitabine Metabolism PathwaySMP00603Not Available
Gemcitabine PathwaySMP00446Not Available
Globoid Cell LeukodystrophySMP00348Not Available
GluconeogenesisSMP00128map00010
Glucose-6-phosphate dehydrogenase deficiencySMP00518Not Available
GLUT-1 deficiency syndromeSMP00580Not Available
Glutamate MetabolismSMP00072map00250
Glutaminolysis and CancerSMP02298Not Available
Glutaric Aciduria Type ISMP00185Not Available
Glycine and Serine MetabolismSMP00004map00260
Glycine N-methyltransferase DeficiencySMP00222Not Available
Glycogen Storage Disease Type 1A (GSD1A) or Von Gierke DiseaseSMP00374Not Available
Glycogen synthetase deficiencySMP00552Not Available
Glycogenosis, Type IA. Von gierke diseaseSMP00581Not Available
Glycogenosis, Type IBSMP00573Not Available
Glycogenosis, Type ICSMP00574Not Available
Glycogenosis, Type III. Cori disease, Debrancher glycogenosisSMP00553Not Available
Glycogenosis, Type IV. Amylopectinosis, Anderson diseaseSMP00554Not Available
Glycogenosis, Type VI. Hers diseaseSMP00555Not Available
Glycogenosis, Type VII. Tarui diseaseSMP00531Not Available
GlycolysisSMP00040map00010
Gout or Kelley-Seegmiller SyndromeSMP00365Not Available
HawkinsinuriaSMP00190Not Available
HomocarnosinosisSMP00385Not Available
Homocystinuria-megaloblastic anemia due to defect in cobalamin metabolism, cblG complementation typeSMP00570Not Available
Hyper-IgD syndromeSMP00509Not Available
HypercholesterolemiaSMP00209Not Available
Hyperglycinemia, non-ketoticSMP00485Not Available
Hyperinsulinism-Hyperammonemia SyndromeSMP00339Not Available
HypermethioninemiaSMP00341Not Available
HypoacetylaspartiaSMP00192Not Available
HypophosphatasiaSMP00503Not Available
Ibandronate PathwaySMP00079Not Available
Ibuprofen PathwaySMP00086Not Available
Ibutilide PathwaySMP00332Not Available
Indomethacin PathwaySMP00104Not Available
Inositol MetabolismSMP00011map00562
Inositol Phosphate MetabolismSMP00462map00562
Insulin SignallingSMP00391Not Available
Intracellular Signalling Through Adenosine Receptor A2a and AdenosineSMP00320Not Available
Intracellular Signalling Through Adenosine Receptor A2b and AdenosineSMP00321Not Available
Intracellular Signalling Through FSH Receptor and Follicle Stimulating HormoneSMP00333Not Available
Intracellular Signalling Through Histamine H2 Receptor and HistamineSMP00335Not Available
Intracellular Signalling Through LHCGR Receptor and Luteinizing Hormone/ChoriogonadotropinSMP00338Not Available
Intracellular Signalling Through PGD2 receptor and Prostaglandin D2SMP00343Not Available
Intracellular Signalling Through Prostacyclin Receptor and ProstacyclinSMP00354Not Available
Isoprenaline Action PathwaySMP00663Not Available
Isradipine PathwaySMP00378Not Available
Joubert syndromeSMP00582Not Available
Ketoprofen PathwaySMP00085Not Available
Ketorolac PathwaySMP00098Not Available
Krabbe diseaseSMP00526Not Available
Labetalol PathwaySMP00368Not Available
Lactose SynthesisSMP00444Not Available
Lamivudine Metabolism PathwaySMP00649Not Available
Leigh SyndromeSMP00196Not Available
Lesch-Nyhan Syndrome (LNS)SMP00364Not Available
Leukotriene C4 Synthesis DeficiencySMP00353Not Available
Levobunolol Action PathwaySMP00666Not Available
Lidocaine (Antiarrhythmic) PathwaySMP00328Not Available
Long chain acyl-CoA dehydrogenase deficiency (LCAD)SMP00539Not Available
Lornoxicam Action PathwaySMP00700Not Available
Lovastatin PathwaySMP00099Not Available
Lumiracoxib Action PathwaySMP00699Not Available
Lysosomal Acid Lipase Deficiency (Wolman Disease)SMP00319Not Available
Magnesium salicylate Action PathwaySMP00698Not Available
Medium chain acyl-coa dehydrogenase deficiency (MCAD)SMP00542Not Available
Mefanamic Acid PathwaySMP00109Not Available
Meloxicam PathwaySMP00106Not Available
Mercaptopurine Metabolism PathwaySMP00609Not Available
Mercaptopurine PathwaySMP00428Not Available
Metachromatic Leukodystrophy (MLD)SMP00347Not Available
Methionine Adenosyltransferase DeficiencySMP00221Not Available
Methionine MetabolismSMP00033map00270
Methotrexate PathwaySMP00432Not Available
Methylenetetrahydrofolate Reductase Deficiency (MTHFRD)SMP00543Not Available
Methylenetetrahydrofolate Reductase Deficiency (MTHFRD)SMP00340Not Available
Metipranolol Action PathwaySMP00667Not Available
Metoprolol PathwaySMP00302Not Available
Mevalonic aciduriaSMP00510Not Available
Mexiletine PathwaySMP00329Not Available
Mitochondrial Beta-Oxidation of Long Chain Saturated Fatty AcidsSMP00482Not Available
Mitochondrial Beta-Oxidation of Medium Chain Saturated Fatty AcidsSMP00481Not Available
Mitochondrial complex II deficiencySMP00548Not Available
Mitochondrial DNA depletion syndromeSMP00536Not Available
MNGIE (Mitochondrial Neurogastrointestinal Encephalopathy)SMP00202Not Available
Molybdenum Cofactor DeficiencySMP00203Not Available
Monoamine oxidase-a deficiency (MAO-A)SMP00533Not Available
Mucopolysaccharidosis VI. Sly syndromeSMP00556Not Available
Muscle/Heart ContractionSMP00588Not Available
Myoadenylate deaminase deficiencySMP00537Not Available
Nabumetone PathwaySMP00114Not Available
Nadolol PathwaySMP00303Not Available
Naproxen PathwaySMP00120Not Available
Nebivolol PathwaySMP00366Not Available
Nepafenac Action PathwaySMP00702Not Available
Nicotinate and Nicotinamide MetabolismSMP00048map00760
Nifedipine PathwaySMP00379Not Available
Nimodipine PathwaySMP00380Not Available
Nisoldipine PathwaySMP00381Not Available
Nitrendipine PathwaySMP00382Not Available
Non Ketotic HyperglycinemiaSMP00223Not Available
Nucleotide Sugars MetabolismSMP00010map00520
Oxaprozin PathwaySMP00113Not Available
Oxidation of Branched Chain Fatty AcidsSMP00030Not Available
Oxprenolol PathwaySMP00304Not Available
Pamidronate PathwaySMP00117Not Available
Penbutolol PathwaySMP00305Not Available
Pentose Phosphate PathwaySMP00031map00030
Phenylacetate MetabolismSMP00126map00360
Phenylalanine and Tyrosine MetabolismSMP00008map00360
Phenylbutazone Action PathwaySMP00701Not Available
PhenylketonuriaSMP00206Not Available
Phenytoin (Antiarrhythmic) PathwaySMP00327Not Available
Phosphatidylinositol Phosphate MetabolismSMP00463map00562
Phosphoenolpyruvate carboxykinase deficiency 1 (PEPCK1)SMP00560Not Available
Phospholipid BiosynthesisSMP00025map00564
Phytanic Acid Peroxisomal OxidationSMP00450Not Available
Pindolol PathwaySMP00306Not Available
Piroxicam PathwaySMP00077Not Available
Plasmalogen SynthesisSMP00479Not Available
Practolol Action PathwaySMP00669Not Available
Pravastatin PathwaySMP00089Not Available
Primary hyperoxaluria II, PH2SMP00558Not Available
Procainamide (Antiarrhythmic) PathwaySMP00324Not Available
Propranolol PathwaySMP00307Not Available
Purine MetabolismSMP00050map00230
Purine Nucleoside Phosphorylase DeficiencySMP00210Not Available
Pyrimidine MetabolismSMP00046map00240
Pyruvate Decarboxylase E1 Component Deficiency (PDHE1 Deficiency)SMP00334Not Available
Pyruvate Dehydrogenase Complex DeficiencySMP00212Not Available
Pyruvate dehydrogenase deficiency (E2)SMP00551Not Available
Pyruvate dehydrogenase deficiency (E3)SMP00550Not Available
Pyruvate kinase deficiencySMP00559Not Available
Pyruvate MetabolismSMP00060map00620
Quinidine PathwaySMP00323Not Available
Refsum DiseaseSMP00451Not Available
Riboflavin MetabolismSMP00070map00740
Ribose-5-phosphate isomerase deficiencySMP00519Not Available
Risedronate PathwaySMP00112Not Available
Rofecoxib PathwaySMP00087Not Available
Rosuvastatin PathwaySMP00092Not Available
S-Adenosylhomocysteine (SAH) Hydrolase DeficiencySMP00214Not Available
Salicylate-sodium Action PathwaySMP00708Not Available
Salicylic Acid Action PathwaySMP00709Not Available
Salla Disease/Infantile Sialic Acid Storage DiseaseSMP00240Not Available
Salsalate Action PathwaySMP00707Not Available
sarcosine oncometabolite pathway SMP02313Not Available
SarcosinemiaSMP00244Not Available
Short Chain Acyl CoA Dehydrogenase Deficiency (SCAD Deficiency)SMP00235Not Available
Sialuria or French Type SialuriaSMP00216Not Available
Sialuria or French Type SialuriaSMP00217Not Available
Simvastatin Action PathwaySMP00082Not Available
Smith-Lemli-Opitz Syndrome (SLOS)SMP00389Not Available
Sotalol Action PathwaySMP00660Not Available
Spermidine and Spermine BiosynthesisSMP00445Not Available
Sphingolipid MetabolismSMP00034map00500
Starch and Sucrose MetabolismSMP00058map00500
Steroid BiosynthesisSMP00023map00100
Succinic semialdehyde dehydrogenase deficiencySMP00567Not Available
Sucrase-isomaltase deficiencySMP00557Not Available
Sulfate/Sulfite MetabolismSMP00041map00920
Sulfite oxidase deficiencySMP00532Not Available
Sulindac PathwaySMP00094Not Available
Suprofen PathwaySMP00101Not Available
Tay-Sachs DiseaseSMP00390Not Available
Teniposide Metabolism PathwaySMP00602Not Available
Teniposide PathwaySMP00443Not Available
Tenofovir Metabolism PathwaySMP00630Not Available
Tenoxicam Action PathwaySMP00706Not Available
The oncogenic action of 2-hydroxyglutarateSMP02291Not Available
The oncogenic action of D-2-hydroxyglutarate in Hydroxygluaricaciduria SMP02359Not Available
The oncogenic action of FumarateSMP02295Not Available
The oncogenic action of L-2-hydroxyglutarate in HydroxygluaricaciduriaSMP02358Not Available
The oncogenic action of SuccinateSMP02292Not Available
Thioguanine Metabolism PathwaySMP00647Not Available
Thioguanine PathwaySMP00430Not Available
Tiaprofenic Acid Action PathwaySMP00705Not Available
Timolol Action PathwaySMP00659Not Available
Tocainide PathwaySMP00330Not Available
Tolmetin Action PathwaySMP00704Not Available
Transaldolase deficiencySMP00520Not Available
Trifunctional protein deficiencySMP00545Not Available
Triosephosphate isomeraseSMP00563Not Available
Trisalicylate-choline Action PathwaySMP00703Not Available
Tyrosine MetabolismSMP00006map00350
Tyrosinemia Type 2 (or Richner-Hanhart syndrome)SMP00369Not Available
Tyrosinemia Type 3 (TYRO3)SMP00370Not Available
Tyrosinemia Type ISMP00218Not Available
Tyrosinemia, transient, of the newbornSMP00494Not Available
UMP Synthase Deiciency (Orotic Aciduria)SMP00219Not Available
Valdecoxib PathwaySMP00116Not Available
Valproic Acid Metabolism PathwaySMP00635Not Available
Vasopressin Regulation of Water HomeostasisSMP00322Not Available
Verapamil PathwaySMP00375Not Available
Very-long-chain acyl coa dehydrogenase deficiency (VLCAD)SMP00540Not Available
Vitamin B6 MetabolismSMP00017map00750
Warburg EffectSMP00654Not Available
Wolman diseaseSMP00511Not Available
Xanthine Dehydrogenase Deficiency (Xanthinuria)SMP00220Not Available
Xanthinuria type ISMP00512Not Available
Xanthinuria type IISMP00513Not Available
Zoledronate PathwaySMP00107Not Available
Normal Concentrations
BiofluidStatusValueAgeSexConditionReferenceDetails
BloodDetected and Quantified717 +/- 74.3 uMElderly (>65 years old)BothNormal details
BloodDetected and Quantified700.0 +/- 130.0 uMNewborn (0-30 days old)BothNormal
    • Geigy Scientific ...
details
BloodDetected and Quantified780.0 +/- 50.0 uMChildren (1-13 years old)BothNormal
    • Geigy Scientific ...
details
BloodDetected and Quantified833.0 +/- 208.0 uMAdult (>18 years old)FemaleNormal details
BloodDetected and Quantified833.0 +/- 250.0 uMAdult (>18 years old)MaleNormal details
BloodDetected and Quantified818.76-1621.07 uMNewborn (0 - <14 days old)Both
Normal
    • CALIPER Paediatri...
details
BloodDetected and Quantified810.53-1271.34 uMInfant (15 days - <1 year old)Both
Normal
    • CALIPER Paediatri...
details
BloodDetected and Quantified859.91-1168.48 uMChildren (1 - <19 years old)Both
Normal
    • CALIPER Paediatri...
details
Cerebrospinal Fluid (CSF)Detected and Quantified954 +/- 207 uMAdult (>18 years old)Not SpecifiedNormal details
Cerebrospinal Fluid (CSF)Detected and Quantified890.0 (550.0-1230.0) uMAdult (>18 years old)BothNormal
    • Geigy Scientific ...
details
SalivaDetected and Quantified440.92 +/- 290.50 uMAdult (>18 years old)BothNormal
    • Zerihun T. Dame, ...
details
SalivaDetected and Quantified7.0438 +/- 5.822 uMAdult (>18 years old)Male
Normal
details
SalivaDetected and Quantified4.1-49.4 uMAdult (>18 years old)Both
Normal
details
SalivaDetected and Quantified4.1-49.4 uMAdult (>18 years old)Both
Normal
details
SalivaDetected and Quantified4.1-49.4 uMAdult (>18 years old)Both
Normal
details
SalivaDetected and Quantified4.1-41.1 uMAdult (>18 years old)Both
Normal
details
SalivaDetected and Quantified389.220 +/- 85.168 uMAdult (>18 years old)Not SpecifiedNormal
    • Natheer H. Al-Raw...
details
SalivaDetected and Quantified8.0436 +/- 4.604 uMAdult (>18 years old)Male
Normal
details
SalivaDetected and Quantified387.163 +/- 254.680 uMAdult (>18 years old)Male
Normal
details
SalivaDetected and Quantified484.674 +/- 308.167 uMAdult (>18 years old)Male
Normal
details
SalivaDetected and Quantified10.401 +/- 2.765 uMAdult (>18 years old)Male
Normal
details
SalivaDetected and Quantified7.130 +/- 3.361 uMAdult (>18 years old)Male
Normal
details
UrineDetected and Quantified262 (42-1189) umol/mmol creatinineAdult (>18 years old)Both
Normal
details
UrineDetected and Quantified355.0 +/- 98.0 umol/mmol creatinineAdult (>18 years old)MaleNormal
    • Geigy Scientific ...
    • West Cadwell, N.J...
    • Basel, Switzerlan...
details
UrineDetected and Quantified289.0 +/- 92.0 umol/mmol creatinineAdult (>18 years old)FemaleNormal
    • Geigy Scientific ...
    • West Cadwell, N.J...
    • Basel, Switzerlan...
details
Abnormal Concentrations
BiofluidStatusValueAgeSexConditionReferenceDetails
BloodDetected and Quantified1534 +/- 242 uMAdult (>18 years old)BothMultiple sclerosis details
BloodDetected and Quantified793 +/- 134 uMAdult (>18 years old)BothParkinson's disease details
BloodDetected and Quantified220.00 (150.00-300.00) uMChildren (1-13 years old)BothPrimary Hypomagnesemia details
BloodDetected and Quantified850.00 (700.00-1000.00) uMAdult (>18 years old)BothPrimary hypomagnesemia details
BloodDetected and Quantified763 +/- 100 uMAdult (>18 years old)BothAlzheimer's disease details
SalivaDetected and Quantified167.0438 +/- 43.612 uMAdult (>18 years old)Not SpecifiedOral squamous cell carcinoma
    • Natheer H. Al-Raw...
details
SalivaDetected and Quantified167.867 +/- 61.304 uMAdult (>18 years old)Not Specified
Oral squamous cell carcinoma
    • Natheer H. Al-Raw...
details
SalivaDetected and Quantified226.291 +/- 16.869 uMAdult (>18 years old)Not Specified
Oral squamous cell carcinoma
    • Natheer H. Al-Raw...
details
Associated Disorders and Diseases
Disease References
Alzheimer's disease
  1. Bocca B, Forte G, Petrucci F, Pino A, Marchione F, Bomboi G, Senofonte O, Giubilei F, Alimonti A: Monitoring of chemical elements and oxidative damage in patients affected by Alzheimer's disease. Ann Ist Super Sanita. 2005;41(2):197-203. [16244393 ]
Multiple sclerosis
  1. Forte G, Visconti A, Santucci S, Ghazaryan A, Figa-Talamanca L, Cannoni S, Bocca B, Pino A, Violante N, Alimonti A, Salvetti M, Ristori G: Quantification of chemical elements in blood of patients affected by multiple sclerosis. Ann Ist Super Sanita. 2005;41(2):213-6. [16244395 ]
Parkinson's disease
  1. Forte G, Alimonti A, Pino A, Stanzione P, Brescianini S, Brusa L, Sancesario G, Violante N, Bocca B: Metals and oxidative stress in patients with Parkinson's disease. Ann Ist Super Sanita. 2005;41(2):189-95. [16244392 ]
Primary hypomagnesemia
  1. MetaGene [Link]
Associated OMIM IDs
DrugBank IDNot Available
DrugBank Metabolite IDNot Available
Phenol Explorer Compound IDNot Available
Phenol Explorer Metabolite IDNot Available
FoodDB IDFDB003518
KNApSAcK IDNot Available
Chemspider ID865
KEGG Compound IDC00305
BioCyc IDMG%2b2
BiGG IDNot Available
Wikipedia LinkMagnesium
NuGOwiki LinkHMDB00547
Metagene LinkHMDB00547
METLIN IDNot Available
PubChem Compound888
PDB IDMG
ChEBI ID18420
References
Synthesis ReferenceNot Available
Material Safety Data Sheet (MSDS)Download (PDF)
General References
  1. Rakicioglu N, Samur G, Topcu A, Topcu AA: The effect of Ramadan on maternal nutrition and composition of breast milk. Pediatr Int. 2006 Jun;48(3):278-83. [16732795 ]
  2. Fowler AJ, Moskowitz DG, Wong A, Cohen SP, Williams ML, Heyman MB: Nutritional status and gastrointestinal structure and function in children with ichthyosis and growth failure. J Pediatr Gastroenterol Nutr. 2004 Feb;38(2):164-9. [14734878 ]
  3. Siqueira WL, de Oliveira E, Mustacchi Z, Nicolau J: Electrolyte concentrations in saliva of children aged 6-10 years with Down syndrome. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2004 Jul;98(1):76-9. [15243474 ]
  4. Abbasciano V, Sartori S, Trevisani L, Girometti R, Ranzini M, Nielsen I, Mazzotta D, Vecchiatti G, Bononi A, Guglielmini C: Comparison of magnesium concentration in serum, erythrocytes and gastric tissue in two groups of patients affected by chronic gastritis, Helicobacter pylori negative and positive. Magnes Res. 2003 Dec;16(4):281-6. [14979638 ]
  5. Kielczykowska M, Pasternak K, Musik I: The influence of lithium on calcium and magnesium homeostasis in serum and tissues of rats. Ann Univ Mariae Curie Sklodowska [Med]. 2003;58(2):281-4. [15323205 ]
  6. Resnick LM, Barbagallo M, Bardicef M, Bardicef O, Sorokin Y, Evelhoch J, Dominguez LJ, Mason BA, Cotton DB: Cellular-free magnesium depletion in brain and muscle of normal and preeclamptic pregnancy: a nuclear magnetic resonance spectroscopic study. Hypertension. 2004 Sep;44(3):322-6. Epub 2004 Jul 19. [15262910 ]
  7. Korycinska A, Dabrowski W, Rzecki Z, Dragan M, Pozarowski P, Wronska J, Stazka J, Pasternak K, Rolinski J: The degree of lymphocytic mitochondrial transmembrane potential and blood magnesium concentrations during coronary artery bypass grafting. Magnes Res. 2005 Dec;18(4):253-60. [16548140 ]
  8. Wang FJ, Cao J, Ma LP, Jin ZX: [Study on cellular and serum concentration of calcium and magnesium in peripheral blood cells of cirrhosis] Zhonghua Gan Zang Bing Za Zhi. 2004 Mar;12(3):144-7. [15059297 ]
  9. Kedzierska E: [Concentrations of selected bioelements and toxic metals and their influence on health status of children and youth residing in Szczecin] Ann Acad Med Stetin. 2003;49:131-43. [15552844 ]
  10. Mendez DR, Corbett R, Macias C, Laptook A: Total and ionized plasma magnesium concentrations in children after traumatic brain injury. Pediatr Res. 2005 Mar;57(3):347-52. Epub 2004 Dec 7. [15585675 ]
  11. Bologa C, Rusu M, Ianovici N, Tetraru C, Hurjui J, Petris O, Lionte C: [Role of calcium and magnesium ions in cerebrospinal fluid in alcoholic-traumatic coma] Rev Med Chir Soc Med Nat Iasi. 2003 Oct-Dec;107(4):809-12. [14756024 ]
  12. Nielsen FH, Milne DB: A moderately high intake compared to a low intake of zinc depresses magnesium balance and alters indices of bone turnover in postmenopausal women. Eur J Clin Nutr. 2004 May;58(5):703-10. [15116072 ]
  13. Miyamoto Y, Yamamoto H, Murakami H, Kamiyama N, Fukuda M: Studies on cerebrospinal fluid ionized calcium and magnesium concentrations in convulsive children. Pediatr Int. 2004 Aug;46(4):394-7. [15310301 ]
  14. Guo H, Lee JD, Guo M, Lu Y, Tang F, Ueda T: Status of intracellular and extracellular magnesium concentration in patients with cardiac syndrome X. Acta Cardiol. 2005 Jun;60(3):259-63. [15999464 ]
  15. Wang W, Kumar P, Minhas S, Ralph D: Proposals or findings for a new approach about how to define and diagnose premature ejaculation. Eur Urol. 2005 Sep;48(3):418-23. [15967566 ]
  16. Guo H, Cheng J, Lee JD, Ueda T, Shan J, Wang J: Relationship between the degree of intracellular magnesium deficiency and the frequency of chest pain in women with variant angina. Herz. 2004 May;29(3):299-303. [15167956 ]
  17. Bryant RE, Crouse R, Deagen JT: Zinc, iron, copper, selenium, lactoferrin, and ferritin in human pus. Am J Med Sci. 2004 Feb;327(2):73-6. [14770022 ]
  18. Gortzak-Uzan L, Mezad D, Smolin A, Friger M, Huleihel M, Hallak M: Increasing amniotic fluid magnesium concentrations with stable maternal serum levels: a prospective clinical trial. J Reprod Med. 2005 Nov;50(11):817-20. [16419627 ]
  19. Postnikova LB, Alekseeva OP, Kubysheva NI, Gorshkova TN, Ishanova OS: [Significance of biochemical parameters of saliva in the diagnosis of chronic obstructive pulmonary disease at exacerbation] Klin Lab Diagn. 2004 Oct;(10):16-8. [15584394 ]
  20. Simsek E, Karabay M, Kocabay K: Assessment of magnesium status in newly diagnosed diabetic children: measurement of erythrocyte magnesium level and magnesium tolerance testing. Turk J Pediatr. 2005 Apr-Jun;47(2):132-7. [16052852 ]

Only showing the first 50 proteins. There are 463 proteins in total.

Enzymes

General function:
Involved in ATP binding
Specific function:
Catalyzes specific phosphoryl transfer from ATP to UMP and CMP.
Gene Name:
CMPK1
Uniprot ID:
P30085
Molecular weight:
20180.12
General function:
Involved in nucleotide binding
Specific function:
Dephosphorylates the 5' and 2'(3')-phosphates of deoxyribonucleotides. Helps to regulate adenosine levels (By similarity).
Gene Name:
NT5C1B
Uniprot ID:
Q96P26
Molecular weight:
68803.055
General function:
Involved in nucleotide binding
Specific function:
Dephosphorylates the 5' and 2'(3')-phosphates of deoxyribonucleotides and has a broad substrate specificity. Helps to regulate adenosine levels in heart during ischemia and hypoxia.
Gene Name:
NT5C1A
Uniprot ID:
Q9BXI3
Molecular weight:
41020.145
General function:
Involved in metal ion binding
Specific function:
Dephosphorylates the 5' and 2'(3')-phosphates of deoxyribonucleotides, with a preference for dUMP and dTMP, intermediate activity towards dGMP, and low activity towards dCMP and dAMP.
Gene Name:
NT5C
Uniprot ID:
Q8TCD5
Molecular weight:
Not Available
General function:
Involved in phosphatase activity
Specific function:
Dephosphorylates specifically the 5' and 2'(3')-phosphates of uracil and thymine deoxyribonucleotides, and so protects mitochondrial DNA replication from excess dTTP. Has only marginal activity towards dIMP and dGMP.
Gene Name:
NT5M
Uniprot ID:
Q9NPB1
Molecular weight:
Not Available
General function:
Involved in hydrolase activity
Specific function:
In the nervous system, could hydrolyze ATP and other nucleotides to regulate purinergic neurotransmission. Could also be implicated in the prevention of platelet aggregation by hydrolyzing platelet-activating ADP to AMP. Hydrolyzes ATP and ADP equally well.
Gene Name:
ENTPD1
Uniprot ID:
P49961
Molecular weight:
58706.0
General function:
Involved in hydrolase activity
Specific function:
Has a threefold preference for the hydrolysis of ATP over ADP.
Gene Name:
ENTPD3
Uniprot ID:
O75355
Molecular weight:
59104.76
General function:
Involved in catalytic activity
Specific function:
Not Available
Gene Name:
ALPP
Uniprot ID:
P05187
Molecular weight:
57953.31
General function:
Involved in catalytic activity
Specific function:
Not Available
Gene Name:
ALPI
Uniprot ID:
P09923
Molecular weight:
56811.695
General function:
Involved in catalytic activity
Specific function:
This isozyme may play a role in skeletal mineralization.
Gene Name:
ALPL
Uniprot ID:
P05186
Molecular weight:
57304.435
General function:
Involved in catalytic activity
Specific function:
Not Available
Gene Name:
ALPPL2
Uniprot ID:
P10696
Molecular weight:
57376.515
General function:
Involved in nucleoside diphosphate kinase activity
Specific function:
Major role in the synthesis of nucleoside triphosphates other than ATP (By similarity).
Gene Name:
NME4
Uniprot ID:
O00746
Molecular weight:
20658.45
General function:
Involved in nucleoside diphosphate kinase activity
Specific function:
Major role in the synthesis of nucleoside triphosphates other than ATP. Possesses nucleoside-diphosphate kinase, serine/threonine-specific protein kinase, geranyl and farnesyl pyrophosphate kinase, histidine protein kinase and 3'-5' exonuclease activities. Involved in cell proliferation, differentiation and development, signal transduction, G protein-coupled receptor endocytosis, and gene expression. Required for neural development including neural patterning and cell fate determination.
Gene Name:
NME1
Uniprot ID:
P15531
Molecular weight:
17148.635
General function:
Involved in nucleoside diphosphate kinase activity
Specific function:
Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.
Gene Name:
NME7
Uniprot ID:
Q9Y5B8
Molecular weight:
42491.365
General function:
Involved in nucleoside diphosphate kinase activity
Specific function:
Major role in the synthesis of nucleoside triphosphates other than ATP. Negatively regulates Rho activity by interacting with AKAP13/LBC. Acts as a transcriptional activator of the MYC gene; binds DNA non-specifically (PubMed:8392752). Exhibits histidine protein kinase activity.
Gene Name:
NME2
Uniprot ID:
P22392
Molecular weight:
30136.92
General function:
Involved in nucleoside diphosphate kinase activity
Specific function:
Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Probably has a role in normal hematopoiesis by inhibition of granulocyte differentiation and induction of apoptosis.
Gene Name:
NME3
Uniprot ID:
Q13232
Molecular weight:
19014.85
General function:
Involved in nucleoside diphosphate kinase activity
Specific function:
Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Inhibitor of p53-induced apoptosis.
Gene Name:
NME6
Uniprot ID:
O75414
Molecular weight:
22002.965
General function:
Involved in flavin-containing monooxygenase activity
Specific function:
Catalyzes the N-oxidation of certain primary alkylamines to their oximes via an N-hydroxylamine intermediate. Inactive toward certain tertiary amines, such as imipramine or chloropromazine. Can catalyze the S-oxidation of methimazole. The truncated form is catalytically inactive.
Gene Name:
FMO2
Uniprot ID:
Q99518
Molecular weight:
53643.29
General function:
Involved in transferase activity
Specific function:
Not Available
Gene Name:
FDFT1
Uniprot ID:
P37268
Molecular weight:
48114.87
General function:
Involved in magnesium ion binding
Specific function:
Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol.
Gene Name:
COMT
Uniprot ID:
P21964
Molecular weight:
30036.77
General function:
Involved in catalytic activity
Specific function:
Hydrolyzes cerebroside sulfate.
Gene Name:
ARSA
Uniprot ID:
P15289
Molecular weight:
53805.87
General function:
Involved in 6-phosphogluconolactonase activity
Specific function:
Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.
Gene Name:
PGLS
Uniprot ID:
O95336
Molecular weight:
27546.495
General function:
Involved in 6-phosphogluconolactonase activity
Specific function:
Oxidizes glucose-6-phosphate and glucose, as well as other hexose-6-phosphates.
Gene Name:
H6PD
Uniprot ID:
O95479
Molecular weight:
88891.99
General function:
Involved in amidophosphoribosyltransferase activity
Specific function:
Not Available
Gene Name:
PPAT
Uniprot ID:
Q06203
Molecular weight:
57398.52
General function:
Involved in nucleotidyltransferase activity
Specific function:
Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP. Can also use the deamidated form; nicotinic acid mononucleotide (NaMN) as substrate with the same efficiency. Can use triazofurin monophosphate (TrMP) as substrate. Also catalyzes the reverse reaction, i.e. the pyrophosphorolytic cleavage of NAD(+). For the pyrophosphorolytic activity, prefers NAD(+) and NAAD as substrates and degrades NADH, nicotinic acid adenine dinucleotide phosphate (NHD) and nicotinamide guanine dinucleotide (NGD) less effectively. Fails to cleave phosphorylated dinucleotides NADP(+), NADPH and NAADP(+). Protects against axonal degeneration following mechanical or toxic insults.
Gene Name:
NMNAT1
Uniprot ID:
Q9HAN9
Molecular weight:
31932.22
General function:
Involved in nucleotidyltransferase activity
Specific function:
Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP. Can also use the deamidated form; nicotinic acid mononucleotide (NaMN) as substrate but with a lower efficiency. Cannot use triazofurin monophosphate (TrMP) as substrate. Also catalyzes the reverse reaction, i.e. the pyrophosphorolytic cleavage of NAD(+). For the pyrophosphorolytic activity prefers NAD(+), NADH and NAAD as substrates and degrades nicotinic acid adenine dinucleotide phosphate (NHD) less effectively. Fails to cleave phosphorylated dinucleotides NADP(+), NADPH and NAADP(+).
Gene Name:
NMNAT2
Uniprot ID:
Q9BZQ4
Molecular weight:
34438.38
General function:
Involved in inositol or phosphatidylinositol phosphatase activity
Specific function:
Converts adenosine 3'-phosphate 5'-phosphosulfate (PAPS) to adenosine 5'-phosphosulfate (APS) and 3'(2')-phosphoadenosine 5'- phosphate (PAP) to AMP. Has 1000-fold lower activity towards inositol 1,4-bisphosphate (Ins(1,4)P2) and inositol 1,3,4-trisphosphate (Ins(1,3,4)P3), but does not hydrolyze Ins(1)P, Ins(3,4)P2, Ins(1,3,4,5)P4 or InsP6.
Gene Name:
BPNT1
Uniprot ID:
O95861
Molecular weight:
33392.035
General function:
Involved in inositol or phosphatidylinositol phosphatase activity
Specific function:
Not Available
Gene Name:
INPP1
Uniprot ID:
P49441
Molecular weight:
43997.62
General function:
Involved in phosphotransferase activity, alcohol group as acceptor
Specific function:
Catalyzes the phosphorylation of D-glucose to D-glucose 6-phosphate using ADP as the phosphate donor. GDP and CDP can replace ADP, but with reduced efficiency (By similarity).
Gene Name:
ADPGK
Uniprot ID:
Q9BRR6
Molecular weight:
53960.185
General function:
Involved in methionine adenosyltransferase activity
Specific function:
Catalyzes the formation of S-adenosylmethionine from methionine and ATP.
Gene Name:
MAT2A
Uniprot ID:
P31153
Molecular weight:
43660.37
General function:
Involved in methionine adenosyltransferase activity
Specific function:
Catalyzes the formation of S-adenosylmethionine from methionine and ATP.
Gene Name:
MAT1A
Uniprot ID:
Q00266
Molecular weight:
43647.6
General function:
Involved in hydrolase activity
Specific function:
Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triposphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions.
Gene Name:
ITPA
Uniprot ID:
Q9BY32
Molecular weight:
16833.23
General function:
Involved in hydrolase activity
Specific function:
This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.
Gene Name:
DUT
Uniprot ID:
P33316
Molecular weight:
26562.975
General function:
Involved in deoxyribonuclease activity
Specific function:
Among other functions, seems to be involved in cell death by apoptosis. Binds specifically to G-actin and blocks actin polymerization
Gene Name:
DNASE1
Uniprot ID:
P24855
Molecular weight:
31433.4
General function:
Involved in hypoxanthine phosphoribosyltransferase activity
Specific function:
Converts guanine to guanosine monophosphate, and hypoxanthine to inosine monophosphate. Transfers the 5-phosphoribosyl group from 5-phosphoribosylpyrophosphate onto the purine. Plays a central role in the generation of purine nucleotides through the purine salvage pathway.
Gene Name:
HPRT1
Uniprot ID:
P00492
Molecular weight:
24579.155
General function:
Involved in magnesium ion binding
Specific function:
Catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis.
Gene Name:
PRPS1L1
Uniprot ID:
P21108
Molecular weight:
34838.915
General function:
Involved in catalytic activity
Specific function:
Activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Preferentially uses arachidonate and eicosapentaenoate as substrates.
Gene Name:
ACSL4
Uniprot ID:
O60488
Molecular weight:
74435.495
General function:
Involved in catalytic activity
Specific function:
Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in maintaining basal levels of the cyclic nucleotide and/or in the cAMP regulation of germ cell development.
Gene Name:
PDE8A
Uniprot ID:
O60658
Molecular weight:
86047.88
General function:
Involved in catalytic activity
Specific function:
Activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Preferentially uses palmitoleate, oleate and linoleate.
Gene Name:
ACSL1
Uniprot ID:
P33121
Molecular weight:
77942.685
General function:
Involved in catalytic activity
Specific function:
Cleaves A-5'-PPP-5'A to yield AMP and ADP. Possible tumor suppressor for specific tissues.
Gene Name:
FHIT
Uniprot ID:
P49789
Molecular weight:
16858.11
General function:
Involved in catalytic activity
Specific function:
Activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Plays an important role in fatty acid metabolism in brain and the acyl-CoAs produced may be utilized exclusively for the synthesis of the brain lipid.
Gene Name:
ACSL6
Uniprot ID:
Q9UKU0
Molecular weight:
80609.765
General function:
Involved in hydrolase activity
Specific function:
Hydrolyzes with similar activities ADP-ribose ADP-mannose, ADP-glucose, 8-oxo-GDP and 8-oxo-dGDP. Can also hydrolyze other nucleotide sugars with low activity.
Gene Name:
NUDT5
Uniprot ID:
Q9UKK9
Molecular weight:
24327.41
General function:
Involved in magnesium ion binding
Specific function:
Catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis.
Gene Name:
PRPS1
Uniprot ID:
P60891
Molecular weight:
12324.195
General function:
Involved in magnesium ion binding
Specific function:
Catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis.
Gene Name:
PRPS2
Uniprot ID:
P11908
Molecular weight:
35054.06
General function:
Involved in catalytic activity
Specific function:
Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes.
Gene Name:
PDE4D
Uniprot ID:
Q08499
Molecular weight:
91114.1
General function:
Involved in hydrolase activity
Specific function:
Hydrolyzes ADP-ribose (ADPR) to AMP and ribose 5'-phosphate.
Gene Name:
NUDT9
Uniprot ID:
Q9BW91
Molecular weight:
35448.725
General function:
Involved in adenosine kinase activity
Specific function:
ATP dependent phosphorylation of adenosine and other related nucleoside analogs to monophosphate derivatives. Serves as a potential regulator of concentrations of extracellular adenosine and intracellular adenine nucleotides.
Gene Name:
ADK
Uniprot ID:
P55263
Molecular weight:
38702.93
General function:
Involved in catalytic activity
Specific function:
Acyl-CoA synthetases (ACSL) activate long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. ACSL5 may activate fatty acids from exogenous sources for the synthesis of triacylglycerol destined for intracellular storage (By similarity). Utilizes a wide range of saturated fatty acids with a preference for C16-C18 unsaturated fatty acids (By similarity). It was suggested that it may also stimulate fatty acid oxidation (By similarity). At the villus tip of the crypt-villus axis of the small intestine may sensitize epithelial cells to apoptosis specifically triggered by the death ligand TRAIL. May have a role in the survival of glioma cells.
Gene Name:
ACSL5
Uniprot ID:
Q9ULC5
Molecular weight:
82262.19
General function:
Involved in catalytic activity
Specific function:
Acyl-CoA synthetases (ACSL) activates long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. ACSL3 mediates hepatic lipogenesis (By similarity). Preferentially uses myristate, laurate, arachidonate and eicosapentaenoate as substrates (By similarity). Has mainly an anabolic role in energy metabolism. Required for the incorporation of fatty acids into phosphatidylcholine, the major phospholipid located on the surface of VLDL (very low density lipoproteins).
Gene Name:
ACSL3
Uniprot ID:
O95573
Molecular weight:
80419.415
General function:
Involved in catalytic activity
Specific function:
Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This phosphodiesterase catalyzes the specific hydrolysis of cGMP to 5'-GMP.
Gene Name:
PDE5A
Uniprot ID:
O76074
Molecular weight:
99984.14

Only showing the first 50 proteins. There are 463 proteins in total.