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Record Information
Version3.6
Creation Date2006-08-15 22:06:05 UTC
Update Date2016-02-11 01:02:59 UTC
HMDB IDHMDB00586
Secondary Accession NumbersNone
Metabolite Identification
Common NamePotassium
DescriptionPotassium is an essential electrolyte. Potassium balance is crucial for regulating the excitability of nerves and muscles and so critical for regulating contractility of cardiac muscle. Although the most important changes seen in the presence of deranged potassium are cardiac, smooth muscle is also affected with increasing muscle weakness, a feature of both hyperkalaemia and hypokalaemia. Physiologically, it exists as an ion in the body. Potassium (K+) is a positively charged electrolyte, cation, which is present throughout the body in both intracellular and extracellular fluids. The majority of body potassium, >90%, are intracellular. It moves freely from intracellular fluid (ICF) to extracellular fluid (ECF) and vice versa when adenosine triphosphate increases the permeability of the cell membrane. It is mainly replaced inside or outside the cells by another cation, sodium (Na+). The movement of potassium into or out of the cells is linked to certain body hormones and also to certain physiological states. Standard laboratory tests measure ECF potassium. Potassium enters the body rapidly during food ingestion. Insulin is produced when a meal is eaten; this causes the temporary movement of potassium from ECF to ICF. Over the ensuing hours, the kidneys excrete the ingested potassium and homeostasis is returned. In the critically ill patient, suffering from hyperkalaemia, this mechanism can be manipulated beneficially by administering high concentration (50%) intravenous glucose. Insulin can be added to the glucose, but glucose alone will stimulate insulin production and cause movement of potassium from ECF to ICF. The stimulation of alpha receptors causes increased movement of potassium from ICF to ECF. A noradrenaline infusion can elevate serum potassium levels. An adrenaline infusion, or elevated adrenaline levels, can lower serum potassium levels. Metabolic acidosis causes a rise in extracellular potassium levels. In this situation, excess of hydrogen ions (H+) are exchanged for intracellular potassium ions, probably as a result of the cellular response to a falling blood pH. Metabolic alkalosis causes the opposite effect, with potassium moving into the cells. (PMID: 17883675 ).
Structure
Thumb
Synonyms
  1. K+
  2. Kalium
  3. Potassium
  4. Potassium (ion)
  5. Potassium (K+)
  6. Potassium cation
  7. Potassium ion
  8. Potassium ion (K+)
  9. Potassium ion (K1+)
  10. Potassium ion(+)
  11. Potassium ion(1+)
  12. Potassium monocation
  13. Potassium(+)
  14. Potassium(1+)
  15. Potassium(1+) ion
  16. Potassium(I) cation
Chemical FormulaK
Average Molecular Weight39.0983
Monoisotopic Molecular Weight38.963706861
IUPAC Namepotassium(1+) ion
Traditional Namepotassium(1+) ion
CAS Registry Number7440-09-7
SMILES
[K+]
InChI Identifier
InChI=1S/K/q+1
InChI KeyInChIKey=NPYPAHLBTDXSSS-UHFFFAOYSA-N
Chemical Taxonomy
DescriptionThis compound belongs to the class of inorganic compounds known as homogeneous alkali metal compounds. These are inorganic compounds containing only metal atoms,with the largest atom being a alkali metal atom.
KingdomInorganic compounds
Super ClassHomogeneous metal compounds
ClassHomogeneous alkali metal compounds
Sub ClassNot Available
Direct ParentHomogeneous alkali metal compounds
Alternative ParentsNot Available
Substituents
  • Homogeneous alkali metal
  • Acyclic compound
Molecular FrameworkAcyclic compounds
External Descriptors
Ontology
StatusDetected and Quantified
Origin
Biofunction
  • Essential minerals
ApplicationNot Available
Cellular locations
  • Extracellular
  • Golgi apparatus
Physical Properties
StateSolid
Experimental Properties
PropertyValueReference
Melting Point63.2 °CNot Available
Boiling PointNot AvailableNot Available
Water SolubilityNot AvailableNot Available
LogPNot AvailableNot Available
Predicted Properties
PropertyValueSource
logP0.2ChemAxon
Physiological Charge1ChemAxon
Hydrogen Acceptor Count0ChemAxon
Hydrogen Donor Count0ChemAxon
Polar Surface Area0 Å2ChemAxon
Rotatable Bond Count0ChemAxon
Refractivity0 m3·mol-1ChemAxon
Polarizability1.78 Å3ChemAxon
Number of Rings0ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Spectra
Spectrum TypeDescriptionSplash Key
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, Positivesplash10-z000000000-560fc6f738e9570ec8a2View in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, Positivesplash10-z000000000-560fc6f738e9570ec8a2View in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, Positivesplash10-z000000000-560fc6f738e9570ec8a2View in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, Negativesplash10-z000000000-bcbe5ea7d5d32f6a9598View in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, Negativesplash10-z000000000-bcbe5ea7d5d32f6a9598View in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, Negativesplash10-z000000000-bcbe5ea7d5d32f6a9598View in MoNA
Biological Properties
Cellular Locations
  • Extracellular
  • Golgi apparatus
Biofluid Locations
  • Blood
  • Cerebrospinal Fluid (CSF)
  • Saliva
  • Urine
Tissue LocationNot Available
Pathways
NameSMPDB LinkKEGG Link
3-Methylthiofentanyl Action PathwaySMP00679Not Available
Acebutolol PathwaySMP00296Not Available
Adenine phosphoribosyltransferase deficiency (APRT)SMP00535Not Available
Adenosine Deaminase DeficiencySMP00144Not Available
Adenylosuccinate Lyase DeficiencySMP00167Not Available
AICA-RibosiduriaSMP00168Not Available
Alfentanil PathwaySMP00413Not Available
Alprenolol PathwaySMP00297Not Available
Alvimopan Action PathwaySMP00685Not Available
Amiloride PathwaySMP00133Not Available
Amiodarone Action PathwaySMP00665Not Available
Amlodipine PathwaySMP00376Not Available
Anileridine Action PathwaySMP00674Not Available
Arbutamine Action PathwaySMP00664Not Available
Atenolol PathwaySMP00298Not Available
Azathioprine PathwaySMP00427Not Available
Bendroflumethiazide PathwaySMP00090Not Available
Benzocaine PathwaySMP00392Not Available
Betaine MetabolismSMP00123map00260
Betaxolol PathwaySMP00299Not Available
Betazole Action PathwaySMP00736Not Available
Bevantolol Action PathwaySMP00668Not Available
Bisoprolol PathwaySMP00300Not Available
Blue diaper syndromeSMP00583Not Available
Bopindolol Action PathwaySMP00657Not Available
Bumetanide PathwaySMP00088Not Available
Bupivacaine PathwaySMP00393Not Available
Bupranolol Action PathwaySMP00670Not Available
Buprenorphine Action PathwaySMP00684Not Available
Carfentanil PathwaySMP00414Not Available
Carteolol Action PathwaySMP00658Not Available
Carvedilol PathwaySMP00367Not Available
Chloroprocaine PathwaySMP00394Not Available
Chlorothiazide PathwaySMP00078Not Available
Chlorthalidone PathwaySMP00122Not Available
Cimetidine PathwaySMP00232Not Available
Citalopram PathwaySMP00424Not Available
Cocaine PathwaySMP00395Not Available
Codeine PathwaySMP00405Not Available
Cyclothiazide PathwaySMP00103Not Available
Cystathionine Beta-Synthase DeficiencySMP00177Not Available
CystinuriaSMP00723Not Available
Desipramine PathwaySMP00423Not Available
Dezocine Action PathwaySMP00676Not Available
Dibucaine PathwaySMP00396Not Available
Dihydromorphine Action PathwaySMP00689Not Available
Diltiazem PathwaySMP00359Not Available
Dimethylthiambutene Action PathwaySMP00680Not Available
Diphenoxylate Action PathwaySMP00675Not Available
Disopyramide PathwaySMP00325Not Available
Dobutamine Action PathwaySMP00662Not Available
Epinephrine Action PathwaySMP00661Not Available
Eplerenone PathwaySMP00135Not Available
Escitalopram PathwaySMP00425Not Available
Esmolol PathwaySMP00301Not Available
Esomeprazole PathwaySMP00225Not Available
Ethacrynic Acid pathwaySMP00097Not Available
Ethylmorphine Action PathwaySMP00681Not Available
Famotidine PathwaySMP00231Not Available
Fanconi-bickel syndromeSMP00572Not Available
Felodipine PathwaySMP00377Not Available
Fentanyl PathwaySMP00415Not Available
Flecainide PathwaySMP00331Not Available
Fluoxetine PathwaySMP00426Not Available
Fosphenytoin (Antiarrhythmic) PathwaySMP00326Not Available
Furosemide PathwaySMP00115Not Available
Gastric Acid ProductionSMP00589Not Available
Glibenclamide PathwaySMP00460Not Available
Gliclazide PathwaySMP00461Not Available
Glucose Transporter Defect (SGLT2)SMP00184Not Available
Glucose Transporter Defect (SGLT2)SMP00245Not Available
Glycine N-methyltransferase DeficiencySMP00222Not Available
Glycogenosis, Type VII. Tarui diseaseSMP00531Not Available
GlycolysisSMP00040map00010
Gout or Kelley-Seegmiller SyndromeSMP00365Not Available
Hartnup DisorderSMP00189Not Available
Heroin PathwaySMP00407Not Available
Homocystinuria-megaloblastic anemia due to defect in cobalamin metabolism, cblG complementation typeSMP00570Not Available
Hydrochlorothiazide PathwaySMP00100Not Available
Hydrocodone PathwaySMP00411Not Available
Hydroflumethiazide PathwaySMP00108Not Available
Hydromorphone PathwaySMP00410Not Available
HypermethioninemiaSMP00341Not Available
Ibutilide PathwaySMP00332Not Available
IminoglycinuriaSMP00193Not Available
Imipramine PathwaySMP00422Not Available
Indapamide PathwaySMP00110Not Available
Isoprenaline Action PathwaySMP00663Not Available
Isradipine PathwaySMP00378Not Available
Ketobemidone Action PathwaySMP00690Not Available
Kidney FunctionSMP00483Not Available
Labetalol PathwaySMP00368Not Available
Lactose DegradationSMP00457Not Available
Lactose IntoleranceSMP00458Not Available
Lansoprazole PathwaySMP00227Not Available
Leigh SyndromeSMP00196Not Available
Lesch-Nyhan Syndrome (LNS)SMP00364Not Available
Levallorphan Action PathwaySMP00683Not Available
Levobunolol Action PathwaySMP00666Not Available
Levobupivacaine PathwaySMP00397Not Available
Levomethadyl Acetate Action Action PathwaySMP00677Not Available
Levorphanol Action PathwaySMP00673Not Available
Lidocaine (Antiarrhythmic) PathwaySMP00328Not Available
Lidocaine (Local Anaesthetic) PathwaySMP00398Not Available
Lysinuric Protein IntoleranceSMP00197Not Available
Lysinuric protein intolerance (LPI)SMP00585Not Available
Mepivacaine PathwaySMP00399Not Available
Mercaptopurine Metabolism PathwaySMP00609Not Available
Mercaptopurine PathwaySMP00428Not Available
Methadone PathwaySMP00408Not Available
Methadyl Acetate Action PathwaySMP00678Not Available
Methionine Adenosyltransferase DeficiencySMP00221Not Available
Methionine MetabolismSMP00033map00270
Methyclothiazide PathwaySMP00081Not Available
Methylenetetrahydrofolate Reductase Deficiency (MTHFRD)SMP00340Not Available
Metiamide Action PathwaySMP00735Not Available
Metipranolol Action PathwaySMP00667Not Available
Metolazone PathwaySMP00105Not Available
Metoprolol PathwaySMP00302Not Available
Mexiletine PathwaySMP00329Not Available
Mitochondrial DNA depletion syndromeSMP00536Not Available
Molybdenum Cofactor DeficiencySMP00203Not Available
Morphine PathwaySMP00406Not Available
Muscle/Heart ContractionSMP00588Not Available
Mycophenolic Acid Metabolism PathwaySMP00652Not Available
Myoadenylate deaminase deficiencySMP00537Not Available
Nadolol PathwaySMP00303Not Available
Nalbuphine Action PathwaySMP00691Not Available
Naloxone Action PathwaySMP00688Not Available
Naltrexone Action PathwaySMP00687Not Available
Nateglinide PathwaySMP00453Not Available
Nebivolol PathwaySMP00366Not Available
Nicotine PathwaySMP00431Not Available
Nifedipine PathwaySMP00379Not Available
Nimodipine PathwaySMP00380Not Available
Nisoldipine PathwaySMP00381Not Available
Nitrendipine PathwaySMP00382Not Available
Nizatidine PathwaySMP00233Not Available
Omeprazole PathwaySMP00226Not Available
Oxprenolol PathwaySMP00304Not Available
Oxybuprocaine PathwaySMP00400Not Available
Oxycodone PathwaySMP00409Not Available
Oxymorphone PathwaySMP00412Not Available
Pancreas FunctionSMP00643Not Available
Pantoprazole PathwaySMP00228Not Available
Penbutolol PathwaySMP00305Not Available
Pentazocine Action PathwaySMP00686Not Available
Phenytoin (Antiarrhythmic) PathwaySMP00327Not Available
Pindolol PathwaySMP00306Not Available
Pirenzepine PathwaySMP00246Not Available
Polythiazide PathwaySMP00080Not Available
Practolol Action PathwaySMP00669Not Available
Prilocaine PathwaySMP00401Not Available
Primary hyperoxaluria II, PH2SMP00558Not Available
Procainamide (Antiarrhythmic) PathwaySMP00324Not Available
Procaine PathwaySMP00402Not Available
Proparacaine PathwaySMP00403Not Available
Propoxyphene Action PathwaySMP00672Not Available
Propranolol PathwaySMP00307Not Available
Purine MetabolismSMP00050map00230
Purine Nucleoside Phosphorylase DeficiencySMP00210Not Available
Pyruvate Decarboxylase E1 Component Deficiency (PDHE1 Deficiency)SMP00334Not Available
Pyruvate Dehydrogenase Complex DeficiencySMP00212Not Available
Pyruvate kinase deficiencySMP00559Not Available
Pyruvate MetabolismSMP00060map00620
Quinethazone PathwaySMP00091Not Available
Quinidine PathwaySMP00323Not Available
Rabeprazole PathwaySMP00229Not Available
Ranitidine PathwaySMP00230Not Available
Remifentanil PathwaySMP00416Not Available
Repaglinide PathwaySMP00454Not Available
Ropivacaine PathwaySMP00404Not Available
Roxatidine acetate Action PathwaySMP00734Not Available
S-Adenosylhomocysteine (SAH) Hydrolase DeficiencySMP00214Not Available
sarcosine oncometabolite pathway SMP02313Not Available
Sotalol Action PathwaySMP00660Not Available
Spermidine and Spermine BiosynthesisSMP00445Not Available
Spironolactone PathwaySMP00134Not Available
Sufentanil PathwaySMP00417Not Available
Thioguanine PathwaySMP00430Not Available
Timolol Action PathwaySMP00659Not Available
Tocainide PathwaySMP00330Not Available
Torsemide PathwaySMP00118Not Available
Tramadol Action Action PathwaySMP00671Not Available
Trehalose DegradationSMP00467Not Available
Triamterene PathwaySMP00132Not Available
Trichlormethiazide PathwaySMP00121Not Available
Verapamil PathwaySMP00375Not Available
Warburg EffectSMP00654Not Available
Xanthine Dehydrogenase Deficiency (Xanthinuria)SMP00220Not Available
Xanthinuria type ISMP00512Not Available
Xanthinuria type IISMP00513Not Available
Normal Concentrations
BiofluidStatusValueAgeSexConditionReferenceDetails
BloodDetected and Quantified4600.0 +/- 500.0 uMChildren (1-13 years old)Both
Normal
    • Geigy Scientific ...
details
BloodDetected and Quantified4200.0 (3600.0-4800.0) uMAdult (>18 years old)BothNormal
    • Geigy Scientific ...
details
BloodDetected and Quantified4100.0 (3600.0-4600.0) uMAdult (>18 years old)Female
Normal
    • Geigy Scientific ...
details
BloodDetected and Quantified4560.0 +/- 560.0 uMNewborn (0-30 days old)Not Specified
Normal
    • Geigy Scientific ...
details
Cerebrospinal Fluid (CSF)Detected and Quantified2960.0 (2620.0-3300.0) uMAdult (>18 years old)BothNormal
    • Geigy Scientific ...
details
Cerebrospinal Fluid (CSF)Detected and Quantified2163 +/- 274 uMAdult (>18 years old)Not SpecifiedNormal details
SalivaDetected and Quantified24800 +/- 9900 uMNot SpecifiedBoth
Normal
details
SalivaDetected and Quantified21830 +/- 2080 uMAdult (>18 years old)Not Specified
Normal
details
SalivaDetected and Quantified20250 +/- 2770 uMAdult (>18 years old)Not Specified
Normal
details
SalivaDetected and Quantified19009.26 +/- 7828.18 uMAdult (>18 years old)BothNormal
    • Zerihun T. Dame, ...
details
UrineDetected and Quantified3593.14 (553.33-8078.58) umol/mmol creatinineAdult (>18 years old)Both
Normal
details
UrineDetected and Quantified4605.2 (2631.5 - 6578.9) umol/mmol creatinineAdult (>18 years old)BothNormal
    • Geigy Scientific ...
details
UrineDetected and Quantified4407.8 +/- 131.5 umol/mmol creatinineAdult (>18 years old)FemaleNormal details
UrineDetected and Quantified5460.00 +/- 197.00 umol/mmol creatinineAdult (>18 years old)MaleNormal details
Abnormal Concentrations
BiofluidStatusValueAgeSexConditionReferenceDetails
BloodDetected and Quantified4500.00 (3500.00-5500.00) uMAdult (>18 years old)BothRenal tubular acidosis, distal, RTA type 1 details
BloodDetected and Quantified2750.00 (2500.00-3000.00) uMChildren (1-13 years old)BothRenal tubular acidosis, distal, RTA type 1 details
Associated Disorders and Diseases
Disease References
Renal tubular acidosis, distal, RTA type 1
  1. MetaGene [Link]
Associated OMIM IDs
  • 179800 (Renal tubular acidosis, distal, RTA type 1)
DrugBank IDDB01345
DrugBank Metabolite IDNot Available
Phenol Explorer Compound IDNot Available
Phenol Explorer Metabolite IDNot Available
FoodDB IDFDB003521
KNApSAcK IDNot Available
Chemspider IDNot Available
KEGG Compound IDC00238
BioCyc IDK%2b
BiGG ID34349
Wikipedia LinkPotassium
NuGOwiki LinkHMDB00586
Metagene LinkHMDB00586
METLIN ID3197
PubChem CompoundNot Available
PDB IDNot Available
ChEBI ID26216
References
Synthesis ReferenceAlberti, Augusto. Recovering potassium salts from the refuse liquor of the manufacture of tartaric acid. (1910), US 957295 19100510 CAN 4:13164 AN 1910:13164
Material Safety Data Sheet (MSDS)Download (PDF)
General References
  1. Schaafsma A, de Vries PJ, Saris WH: Delay of natural bone loss by higher intakes of specific minerals and vitamins. Crit Rev Food Sci Nutr. 2001 May;41(4):225-49. [11401244 ]
  2. Preuss HG: Diet, genetics and hypertension. J Am Coll Nutr. 1997 Aug;16(4):296-305. [9263178 ]
  3. Beede DK: Mineral and water nutrition. Vet Clin North Am Food Anim Pract. 1991 Jul;7(2):373-90. [1893277 ]
  4. Brooks G: Potassium additive algorithm for use in continuous renal replacement therapy. Nurs Crit Care. 2006 Nov-Dec;11(6):273-80. [17883675 ]

Only showing the first 50 proteins. There are 55 proteins in total.

Enzymes

General function:
Involved in oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
Specific function:
The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3).
Gene Name:
BCKDHA
Uniprot ID:
P12694
Molecular weight:
50470.58
General function:
Involved in methionine adenosyltransferase activity
Specific function:
Catalyzes the formation of S-adenosylmethionine from methionine and ATP.
Gene Name:
MAT2A
Uniprot ID:
P31153
Molecular weight:
43660.37
General function:
Involved in methionine adenosyltransferase activity
Specific function:
Catalyzes the formation of S-adenosylmethionine from methionine and ATP.
Gene Name:
MAT1A
Uniprot ID:
Q00266
Molecular weight:
43647.6
General function:
Involved in magnesium ion binding
Specific function:
Glycolytic enzyme that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP. Stimulates POU5F1-mediated transcriptional activation. Plays a general role in caspase independent cell death of tumor cells. The ratio betwween the highly active tetrameric form and nearly inactive dimeric form determines whether glucose carbons are channeled to biosynthetic processes or used for glycolytic ATP production. The transition between the 2 forms contributes to the control of glycolysis and is important for tumor cell proliferation and survival.
Gene Name:
PKM
Uniprot ID:
P14618
Molecular weight:
65930.14
General function:
Involved in magnesium ion binding
Specific function:
Plays a key role in glycolysis (By similarity).
Gene Name:
PKLR
Uniprot ID:
P30613
Molecular weight:
61829.575
General function:
Involved in catalytic activity
Specific function:
Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors.
Gene Name:
IMPDH2
Uniprot ID:
P12268
Molecular weight:
55804.495
General function:
Involved in catalytic activity
Specific function:
Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors.
Gene Name:
IMPDH1
Uniprot ID:
P20839
Molecular weight:
63252.24
General function:
Involved in pyridoxal kinase activity
Specific function:
Required for synthesis of pyridoxal-5-phosphate from vitamin B6.
Gene Name:
PDXK
Uniprot ID:
O00764
Molecular weight:
35102.105
General function:
Involved in sodium:potassium-exchanging ATPase activity
Specific function:
This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The exact function of the beta-3 subunit is not known
Gene Name:
ATP1B3
Uniprot ID:
P54709
Molecular weight:
31512.3
General function:
Involved in sodium:potassium-exchanging ATPase activity
Specific function:
This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The exact function of the beta-2 subunit is not known
Gene Name:
ATP1B2
Uniprot ID:
P14415
Molecular weight:
33366.9
General function:
Involved in sodium:potassium-exchanging ATPase activity
Specific function:
This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane
Gene Name:
ATP1B1
Uniprot ID:
P05026
Molecular weight:
35061.1
General function:
Involved in ATP binding
Specific function:
Catalyzes the hydrolysis of ATP coupled with the exchange of H(+) and K(+) ions across the plasma membrane. Responsible for potassium absorption in various tissues.
Gene Name:
ATP12A
Uniprot ID:
P54707
Molecular weight:
116052.03
General function:
Involved in sodium:potassium-exchanging ATPase activity
Specific function:
May act as a transcriptional coregulator during muscle development through its interaction with SNW1. Has lost its ancestral function as a Na,K-ATPase beta-subunit
Gene Name:
ATP1B4
Uniprot ID:
Q9UN42
Molecular weight:
41597.4
General function:
Involved in ATP binding
Specific function:
This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients.
Gene Name:
ATP1A1
Uniprot ID:
P05023
Molecular weight:
112895.01
General function:
Involved in ATP binding
Specific function:
This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients.
Gene Name:
ATP1A3
Uniprot ID:
P13637
Molecular weight:
113132.965
General function:
Involved in sodium:potassium-exchanging ATPase activity
Specific function:
Not Available
Gene Name:
ATP4B
Uniprot ID:
P51164
Molecular weight:
33367.0
General function:
Involved in ATP binding
Specific function:
Catalyzes the hydrolysis of ATP coupled with the exchange of H(+) and K(+) ions across the plasma membrane. Responsible for acid production in the stomach.
Gene Name:
ATP4A
Uniprot ID:
P20648
Molecular weight:
114117.74
General function:
Involved in ATP binding
Specific function:
This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium, providing the energy for active transport of various nutrients.
Gene Name:
ATP1A2
Uniprot ID:
P50993
Molecular weight:
112264.385
General function:
Involved in ion channel activity
Specific function:
Potassium channel activated by both membrane depolarization or increase in cytosolic Ca(2+) that mediates export of K(+). It is also activated by the concentration of cytosolic Mg(2+). Its activation dampens the excitatory events that elevate the cytosolic Ca(2+) concentration and/or depolarize the cell membrane. It therefore contributes to repolarization of the membrane potential. Plays a key role in controlling excitability in a number of systems, such as regulation of the contraction of smooth muscle, the tuning of hair cells in the cochlea, regulation of transmitter release, and innate immunity. In smooth muscles, its activation by high level of Ca(2+), caused by ryanodine receptors in the sarcoplasmic reticulum, regulates the membrane potential. In cochlea cells, its number and kinetic properties partly determine the characteristic frequency of each hair cell and thereby helps to establish a tonotopic map. Kinetics of KCNMA1 channels are determined by alternative splicing, phosphorylation status and its combination with modulating beta subunits. Highly sensitive to both iberiotoxin (IbTx) and charybdotoxin (CTX)
Gene Name:
KCNMA1
Uniprot ID:
Q12791
Molecular weight:
137558.1
General function:
Involved in ion channel activity
Specific function:
Pore-forming (alpha) subunit of voltage-gated inwardly rectifying potassium channel. Channel properties are modulated by cAMP and subunit assembly. Mediates the rapidly activating component of the delayed rectifying potassium current in heart (IKr). Isoform 3 has no channel activity by itself, but modulates channel characteristics when associated with isoform 1
Gene Name:
KCNH2
Uniprot ID:
Q12809
Molecular weight:
126653.5
General function:
Involved in calcium ion binding
Specific function:
Required for constitutive membrane traffic. Inhibits GTPase-stimulated Na(+)/H(+) exchange. Also inhibits calcineurin phosphatase activity. Required for activity of SLC9A1/NHE1
Gene Name:
CHP
Uniprot ID:
Q99653
Molecular weight:
22456.0
General function:
Involved in G-protein coupled receptor activity
Specific function:
Isoform 1E function may be to regulate the availability of functional GABA-B-R1A/GABA-B-R2 heterodimers by competing for GABA-B-R2 dimerization. This could explain the observation that certain small molecule ligands exhibit differential affinity for central versus peripheral sites
Gene Name:
GABBR1
Uniprot ID:
Q9UBS5
Molecular weight:
108319.4
General function:
Involved in inward rectifier potassium channel activity
Specific function:
Probably participates in establishing action potential waveform and excitability of neuronal and muscle tissues. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium or cesium
Gene Name:
KCNJ2
Uniprot ID:
P63252
Molecular weight:
48287.8
General function:
Involved in ion channel activity
Specific function:
Probably important in cardiac repolarization. Associates with KCNE1 (MinK) to form the I(Ks) cardiac potassium current. Elicits a rapidly activating, potassium-selective outward current. Muscarinic agonist oxotremorine-M strongly suppresses KCNQ1/KCNE1 current in CHO cells in which cloned KCNQ1/KCNE1 channels were coexpressed with M1 muscarinic receptors. May associate also with KCNE3 (MiRP2) to form the potassium channel that is important for cyclic AMP-stimulated intestinal secretion of chloride ions, which is reduced in cystic fibrosis and pathologically stimulated in cholera and other forms of secretory diarrhea
Gene Name:
KCNQ1
Uniprot ID:
P51787
Molecular weight:
74697.9
General function:
Involved in inward rectifier potassium channel activity
Specific function:
In the kidney, probably plays a major role in potassium homeostasis. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. This channel is activated by internal ATP and can be blocked by external barium
Gene Name:
KCNJ1
Uniprot ID:
P48048
Molecular weight:
44794.6
General function:
Involved in calcium ion binding
Specific function:
May play a role in the regulation of PSEN2 proteolytic processing and apoptosis. Together with PSEN2 involved in modulation of beta-amyloid formation
Gene Name:
KCNIP3
Uniprot ID:
Q9Y2W7
Molecular weight:
29231.0
General function:
Involved in inward rectifier potassium channel activity
Specific function:
This receptor is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium
Gene Name:
KCNJ11
Uniprot ID:
Q14654
Molecular weight:
43540.4
General function:
Involved in sequence-specific DNA binding transcription factor activity
Specific function:
Transcriptional activator. Seems to be essential for sexual differentiation and formation of the primary steroidogenic tissues. Binds to the Ad4 site found in the promoter region of steroidogenic P450 genes such as CYP11A, CYP11B and CYP21B. Also regulates the AMH/Muellerian inhibiting substance gene as well as the AHCH and STAR genes. 5'-YCAAGGYC-3' and 5'-RRAGGTCA-3' are the consensus sequences for the recognition by NR5A1. The SFPQ-NONO- NR5A1 complex binds to the CYP17 promoter and regulates basal and cAMP-dependent transcriptional avtivity. Binds phosphatidylcholine. Binds phospholipids with a phosphatidylinositol (PI) headgroup, in particular PI(3,4)P2 and PI(3,4,5)P3
Gene Name:
NR5A1
Uniprot ID:
Q13285
Molecular weight:
51635.5
General function:
Involved in ATP binding
Specific function:
This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients. Plays a role in sperm motility.
Gene Name:
ATP1A4
Uniprot ID:
Q13733
Molecular weight:
19608.69
General function:
Involved in calcium ion binding
Specific function:
Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels. Probably modulates channels density, inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner. In vitro, modulates KCND1/Kv4.1 and KCND2/Kv4.2 currents. Seems to be involved in KCND2 trafficking to the cell surface
Gene Name:
KCNIP1
Uniprot ID:
Q9NZI2
Molecular weight:
26817.3
General function:
Involved in calcium ion binding
Specific function:
Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels. Probably modulates channels density, inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner. In vitro, modulates KCND2/Kv4.2 and KCND3/Kv4.3 currents. Involved in KCND2 and KCND3 trafficking to the cell surface
Gene Name:
KCNIP2
Uniprot ID:
Q9NS61
Molecular weight:
30918.6
General function:
Involved in calcium-activated potassium channel activity
Specific function:
Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Alters the functional properties of the current expressed by the KCNMA1 channel. Isoform 2, isoform 3 and isoform 4 partially inactivate the current of KCNBMA. Isoform 4 induces a fast and incomplete inactivation of KCNMA1 channel that is detectable only at large depolarizations. In contrast, isoform 1 does not induce detectable inactivation of KCNMA1. Two or more subunits of KCNMB3 are required to block the KCNMA1 tetramer
Gene Name:
KCNMB3
Uniprot ID:
Q9NPA1
Molecular weight:
31603.3
General function:
Involved in voltage-gated potassium channel activity
Specific function:
Ancillary protein that assembles as a beta subunit with a voltage-gated potassium channel complex of pore-forming alpha subunits. Modulates the gating kinetics and enhances stability of the channel complex. Associated with KCNC4/Kv3.4 is proposed to form the subthreshold voltage-gated potassium channel in skeletal muscle and to establish the resting membrane potential (RMP) in muscle cells. Associated with KCNQ1/KCLQT1 may form the intestinal cAMP-stimulated potassium channel involved in chloride secretion
Gene Name:
KCNE3
Uniprot ID:
Q9Y6H6
Molecular weight:
11710.3
General function:
Involved in ion channel activity
Specific function:
Pore-forming (alpha) subunit of voltage-gated non- inactivating delayed rectifier potassium channel. Channel properties may be modulated by cAMP and subunit assembly. Mediates IK(NI) current in myoblasts
Gene Name:
KCNH1
Uniprot ID:
O95259
Molecular weight:
111421.8
General function:
Involved in oxidoreductase activity
Specific function:
Oxidoreductase that catalyzes the NADP-dependent reduction of cytochrome c and one-electron acceptors, such as doxorubicin, potassium ferricyanide and menadione (in vitro)
Gene Name:
NDOR1
Uniprot ID:
Q9UHB4
Molecular weight:
66761.9
General function:
Involved in catalytic activity
Specific function:
Has medium-chain fatty acid:CoA ligase activity with broad substrate specificity (in vitro). Acts on acids from C(4) to C(11) and on the corresponding 3-hydroxy- and 2,3- or 3,4-unsaturated acids (in vitro).
Gene Name:
ACSM2B
Uniprot ID:
Q68CK6
Molecular weight:
64270.78
General function:
Involved in catalytic activity
Specific function:
Catalyzes the post-translational addition of a tyrosine to the C-terminal end of detyrosinated alpha-tubulin (By similarity).
Gene Name:
TTL
Uniprot ID:
Q8NG68
Molecular weight:
43211.94
General function:
Involved in magnesium ion binding
Specific function:
ATP + pyruvate = ADP + phosphoenolpyruvate
Gene Name:
Not Available
Uniprot ID:
Q16715
Molecular weight:
63260.1
General function:
Involved in magnesium ion binding
Specific function:
ATP + pyruvate = ADP + phosphoenolpyruvate
Gene Name:
Not Available
Uniprot ID:
Q16716
Molecular weight:
60963.6
General function:
Involved in magnesium ion binding
Specific function:
ATP + pyruvate = ADP + phosphoenolpyruvate
Gene Name:
PKM2
Uniprot ID:
Q504U3
Molecular weight:
40163.2
General function:
Involved in magnesium ion binding
Specific function:
ATP + pyruvate = ADP + phosphoenolpyruvate
Gene Name:
PKM2
Uniprot ID:
Q8WUW7
Molecular weight:
37275.8
General function:
Involved in voltage-gated potassium channel activity
Specific function:
Ancillary protein that assembles as a beta subunit with a voltage-gated potassium channel complex of pore-forming alpha subunits. Modulates the gating kinetics and enhances stability of the channel complex. Assembled with KCNQ1/KVLQT1 is proposed to form the slowly activating delayed rectifier cardiac potassium (IKs) channel. The outward current reaches its steady state only after 50 seconds. Assembled with KCNH2/HERG may modulate the rapidly activating component of the delayed rectifying potassium current in heart (IKr)
Gene Name:
KCNE1
Uniprot ID:
P15382
Molecular weight:
14674.7
General function:
Involved in potassium channel activity
Specific function:
Probably important in the regulation of neuronal excitability. Associates with KCNQ3 to form a potassium channel with essentially identical properties to the channel underlying the native M-current, a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons as well as the responsiveness to synaptic inputs. KCNQ2/KCNQ3 current is blocked by linopirdine and XE991, and activated by the anticonvulsant retigabine. Muscarinic agonist oxotremorine-M strongly suppress KCNQ2/KCNQ3 current in cells in which cloned KCNQ2/KCNQ3 channels were coexpressed with M1 muscarinic receptors
Gene Name:
KCNQ2
Uniprot ID:
O43526
Molecular weight:
95846.6
General function:
Involved in protein binding
Specific function:
Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient
Gene Name:
KCNA1
Uniprot ID:
Q09470
Molecular weight:
56465.0
General function:
Involved in potassium channel activity
Specific function:
Probably important in the regulation of neuronal excitability. Associates with KCNQ2 or KCNQ5 to form a potassium channel with essentially identical properties to the channel underlying the native M-current, a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons as well as the responsiveness to synaptic inputs
Gene Name:
KCNQ3
Uniprot ID:
O43525
Molecular weight:
96741.5
General function:
Involved in voltage-gated potassium channel activity
Specific function:
Ancillary protein that assembles as a beta subunit with a voltage-gated potassium channel complex of pore-forming alpha subunits. Modulates the gating kinetics and enhances stability of the channel complex. Associated with KCNH2/HERG is proposed to form the rapidly activating component of the delayed rectifying potassium current in heart (IKr). May associate with KCNQ2 and/or KCNQ3 and modulate the native M-type current. May associate with KCNQ1/KVLTQ1 and elicit a voltage-independent current. May associate with HCN1 and HCN2 and increase potassium current
Gene Name:
KCNE2
Uniprot ID:
Q9Y6J6
Molecular weight:
14471.4
General function:
Involved in protein binding
Specific function:
Pore-forming (alpha) subunit of voltage-gated rapidly inactivating A-type potassium channels. May contribute to I(To) current in heart and I(Sa) current in neurons. Channel properties are modulated by interactions with other alpha subunits and with regulatory subunits
Gene Name:
KCND2
Uniprot ID:
Q9NZV8
Molecular weight:
70535.8
General function:
Involved in protein binding
Specific function:
Pore-forming (alpha) subunit of voltage-gated rapidly inactivating A-type potassium channels. May contribute to I(To) current in heart and I(Sa) current in neurons. Channel properties are modulated by interactions with other alpha subunits and with regulatory subunits
Gene Name:
KCND3
Uniprot ID:
Q9UK17
Molecular weight:
73450.5
General function:
Involved in ion channel activity
Specific function:
Probably important in the regulation of neuronal excitability. Associates with KCNQ3 to form a potassium channel which contributes to M-type current, a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons. May contribute, with other potassium channels, to the molecular diversity of an heterogeneous population of M-channels, varying in kinetic and pharmacological properties, which underlie this physiologically important current. Insensitive to tetraethylammonium, but inhibited by barium, linopirdine and XE991. Activated by niflumic acid and the anticonvulsant retigabine. Muscarine suppresses KCNQ5 current in Xenopus oocytes in which cloned KCNQ5 channels were coexpressed with M(1) muscarinic receptors
Gene Name:
KCNQ5
Uniprot ID:
Q9NR82
Molecular weight:
102178.0
General function:
Involved in protein binding
Specific function:
Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient
Gene Name:
KCNA4
Uniprot ID:
P22459
Molecular weight:
73287.6

Only showing the first 50 proteins. There are 55 proteins in total.