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Human Metabolome Database Version 3.5

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Showing metabocard for Acetyl-CoA (HMDB01206)

Record Information
Version 3.5
Creation Date 2005-11-16 08:48:42 -0700
Update Date 2013-02-08 17:10:06 -0700
HMDB ID HMDB01206
Secondary Accession Numbers None
Metabolite Identification
Common Name Acetyl-CoA
Description The main function of coenzyme A is to carry acyl groups (such as the acetyl group) or thioesters. Acetyl-CoA is an important molecule itself. It is the precursor to HMG CoA, which is a vital component in cholesterol and ketone synthesis. (wikipedia). acetyl CoA participates in the biosynthesis of fatty acids and sterols, in the oxidation of fatty acids and in the metabolism of many amino acids. It also acts as a biological acetylating agent.
Structure Thumb
Download: MOL | SDF | SMILES | InChI
Display: 2D Structure | 3D Structure
Synonyms
  1. Ac-CoA
  2. Ac-Coenzyme A
  3. Ac-S-CoA
  4. Ac-S-Coenzyme A
  5. Acetyl coenzyme-A
  6. Acetyl-CoA
  7. Acetyl-Coenzyme A
  8. Acetyl-S-CoA
  9. Acetyl-S-Coenzyme A
  10. Acetylcoenzyme-A
  11. S-Acetate CoA
  12. S-Acetate Coenzyme A
  13. S-Acetyl coenzyme A
Chemical Formula C23H38N7O17P3S
Average Molecular Weight 809.571
Monoisotopic Molecular Weight 809.125773051
IUPAC Name {[(2R,3S,4R,5R)-2-({[({[(3R)-3-[(2-{[2-(acetylsulfanyl)ethyl]carbamoyl}ethyl)carbamoyl]-3-hydroxy-2,2-dimethylpropoxy](hydroxy)phosphoryl}oxy)(hydroxy)phosphoryl]oxy}methyl)-5-(6-amino-9H-purin-9-yl)-4-hydroxyoxolan-3-yl]oxy}phosphonic acid
Traditional IUPAC Name [(2R,3S,4R,5R)-2-[({[(3R)-3-[(2-{[2-(acetylsulfanyl)ethyl]carbamoyl}ethyl)carbamoyl]-3-hydroxy-2,2-dimethylpropoxy(hydroxy)phosphoryl]oxy(hydroxy)phosphoryl}oxy)methyl]-5-(6-aminopurin-9-yl)-4-hydroxyoxolan-3-yl]oxyphosphonic acid
CAS Registry Number 72-89-9
SMILES CC(=O)SCCNC(=O)CCNC(=O)[C@H](O)C(C)(C)COP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP(O)(O)=O)N1C=NC2=C1N=CN=C2N
InChI Identifier InChI=1S/C23H38N7O17P3S/c1-12(31)51-7-6-25-14(32)4-5-26-21(35)18(34)23(2,3)9-44-50(41,42)47-49(39,40)43-8-13-17(46-48(36,37)38)16(33)22(45-13)30-11-29-15-19(24)27-10-28-20(15)30/h10-11,13,16-18,22,33-34H,4-9H2,1-3H3,(H,25,32)(H,26,35)(H,39,40)(H,41,42)(H2,24,27,28)(H2,36,37,38)/t13-,16-,17-,18+,22-/m1/s1
InChI Key ZSLZBFCDCINBPY-ZSJPKINUSA-N
Chemical Taxonomy
Kingdom Organic Compounds
Super Class Lipids
Class Fatty Acid Esters
Sub Class Acyl CoAs
Other Descriptors
  • Aromatic Heteropolycyclic Compounds
  • acyl-CoA(ChEBI)
Substituents
  • 1 Phosphoribosyl Imidazole
  • Aminopyrimidine
  • Carboxamide Group
  • Carboxylic Thioester
  • Coenzyme A
  • Glycosyl Compound
  • Imidazole
  • Imidazopyrimidine
  • Monosaccharide Phosphate
  • N Glycosyl Compound
  • Organic Hypophosphite
  • Organic Phosphite
  • Organic Pyrophosphate
  • Oxolane
  • Pentose Monosaccharide
  • Phosphoric Acid Ester
  • Purine
  • Purine Ribonucleoside 3',5' Bisphosphate
  • Pyrimidine
  • Saccharide
  • Secondary Alcohol
  • Secondary Carboxylic Acid Amide
  • Thiocarboxylic Acid Ester
Direct Parent Acyl CoAs
Ontology
Status Expected and Not Quantified
Origin
  • Endogenous
  • Food
Biofunction
  • Cell signaling
  • Component of Alanine and aspartate metabolism
  • Component of Aminosugars metabolism
  • Component of Arginine and proline metabolism
  • Component of Bile acid biosynthesis
  • Component of Butanoate metabolism
  • Component of Fatty acid metabolism
  • Component of Glutamate metabolism
  • Component of Glycerophospholipid metabolism
  • Component of Glycine, serine and threonine metabolism
  • Component of Glyoxylate and dicarboxylate metabolism
  • Component of Propanoate metabolism
  • Component of Pyruvate metabolism
  • Component of Tetracycline biosynthesis
  • Component of Tryptophan metabolism
  • Component of beta-Alanine metabolism
  • Fuel and energy storage
  • Fuel or energy source
  • Membrane integrity/stability
Application
  • Nutrients
  • Stabilizers
  • Surfactants and Emulsifiers
Cellular locations
  • Cytoplasm
  • Extracellular
  • Membrane
  • Mitochondria
  • Nucleus
  • Endoplasmic reticulum
  • Golgi apparatus
  • Peroxisome
Physical Properties
State Solid
Experimental Properties
Property Value Reference
Melting Point Not Available Not Available
Boiling Point Not Available Not Available
Water Solubility Not Available Not Available
LogP Not Available Not Available
Predicted Properties
Property Value Source
Water Solubility 4.3 g/L ALOGPS
LogP -0.58 ALOGPS
LogP -7 ChemAxon
LogS -2.27 ALOGPS
pKa (strongest acidic) 0.83 ChemAxon
pKa (strongest basic) 4.95 ChemAxon
Hydrogen Acceptor Count 17 ChemAxon
Hydrogen Donor Count 9 ChemAxon
Polar Surface Area 363.63 A2 ChemAxon
Rotatable Bond Count 20 ChemAxon
Refractivity 172.21 ChemAxon
Polarizability 71.4 ChemAxon
Formal Charge 0 ChemAxon
Physiological Charge -4 ChemAxon
Spectra
Not Available
Biological Properties
Cellular Locations
  • Cytoplasm
  • Extracellular
  • Membrane
  • Mitochondria
  • Nucleus
  • Endoplasmic reticulum
  • Golgi apparatus
  • Peroxisome
Biofluid Locations Not Available
Tissue Location
  • Muscle
  • Skeletal Muscle
  • Brain
  • Prostate
  • Adipose Tissue
  • Platelet
  • Spleen
Pathways
Name SMPDB Link KEGG Link
Butyrate Metabolism SMP00073 map00650 Link_out
Fatty acid Metabolism SMP00051 map00071 Link_out
Valine, Leucine and Isoleucine Degradation SMP00032 map00280 Link_out
Citric Acid Cycle SMP00057 map00020 Link_out
Propanoate Metabolism SMP00016 map00640 Link_out
Steroid Biosynthesis SMP00023 map00100 Link_out
Lysine Degradation SMP00037 map00310 Link_out
Ketone Body Metabolism SMP00071 map00072 Link_out
Pyruvate Metabolism SMP00060 map00620 Link_out
Beta-Alanine Metabolism SMP00007 map00410 Link_out
Beta Oxidation of Very Long Chain Fatty Acids SMP00052 map01040 Link_out
Oxidation of Branched Chain Fatty Acids SMP00030 Not Available
Phytanic Acid Peroxisomal Oxidation SMP00450 Not Available
Ethanol Degradation SMP00449 Not Available
Fatty Acid Biosynthesis SMP00456 Not Available
Transfer of Acetyl Groups into Mitochondria SMP00466 Not Available
Amino Sugar Metabolism SMP00045 map00520 Link_out
Mitochondrial Beta-Oxidation of Short Chain Saturated Fatty Acids SMP00480 Not Available
Glycine and Serine Metabolism SMP00004 map00260 Link_out
Mitochondrial Beta-Oxidation of Medium Chain Saturated Fatty Acids SMP00481 Not Available
Mitochondrial Beta-Oxidation of Long Chain Saturated Fatty Acids SMP00482 Not Available
Normal Concentrations
Not Available
Abnormal Concentrations
Not Available
Associated Disorders and Diseases
Disease References None
Associated OMIM IDs None
DrugBank ID Not Available
Phenol Explorer Compound ID Not Available
Phenol Explorer Metabolite ID Not Available
FoodDB ID FDB022491
KNApSAcK ID Not Available
Chemspider ID 392413 Link_out
KEGG Compound ID C00024 Link_out
BioCyc ID ACETYL-COA Link_out
BiGG ID 33558 Link_out
Wikipedia Link Acetyl-CoA Link_out
NuGOwiki Link HMDB01206 Link_out
Metagene Link HMDB01206 Link_out
METLIN ID 6082 Link_out
PubChem Compound 444493 Link_out
PDB ID ACO Link_out
ChEBI ID 15351 Link_out
References
Synthesis Reference Tucek, S. The synthesis of acetyl coenzyme A and acetylcholine from citrate and acetate in the nerve endings of mammalian brain. Biochimica et Biophysica Acta, General Subjects (1966), 117(1), 278-80.
Material Safety Data Sheet (MSDS) Not Available
General References
  1. Michno A, Skibowska A, Raszeja-Specht A, Cwikowska J, Szutowicz A: The role of adenosine triphosphate citrate lyase in the metabolism of acetyl coenzyme a and function of blood platelets in diabetes mellitus. Metabolism. 2004 Jan;53(1):66-72. Pubmed: 14681844 Link_out
  2. Al-Buheissi SZ, Patel HR, Meinl W, Hewer A, Bryan RL, Glatt H, Miller RA, Phillips DH: N-Acetyltransferase and sulfotransferase activity in human prostate: potential for carcinogen activation. Pharmacogenet Genomics. 2006 Jun;16(6):391-9. Pubmed: 16708048 Link_out
  3. Griffin MJ, Sul HS: Insulin regulation of fatty acid synthase gene transcription: roles of USF and SREBP-1c. IUBMB Life. 2004 Oct;56(10):595-600. Pubmed: 15814457 Link_out
  4. Putman CT, Spriet LL, Hultman E, Dyck DJ, Heigenhauser GJ: Skeletal muscle pyruvate dehydrogenase activity during acetate infusion in humans. Am J Physiol. 1995 May;268(5 Pt 1):E1007-17. Pubmed: 7762627 Link_out
  5. Szutowicz A, Tomaszewicz M, Jankowska A, Madziar B, Bielarczyk H: [Mechanisms of selective vulnerability of cholinergic neurons to neurotoxic stimuli] Postepy Hig Med Dosw. 1999;53(2):263-75. Pubmed: 10355292 Link_out
  6. Ingebretsen OC, Bakken AM, Farstad M: The content of coenzyme A, acetyl-CoA and long-chain acyl-CoA in human blood platelets. Clin Chim Acta. 1982 Dec 23;126(3):307-13. Pubmed: 7151284 Link_out
  7. Michno A, Raszeja-Specht A, Jankowska-Kulawy A, Pawelczyk T, Szutowicz A: Effect of L-carnitine on acetyl-CoA content and activity of blood platelets in healthy and diabetic persons. Clin Chem. 2005 Sep;51(9):1673-82. Epub 2005 Jul 14. Pubmed: 16020499 Link_out
  8. Constantin-Teodosiu D, Peirce NS, Fox J, Greenhaff PL: Muscle pyruvate availability can limit the flux, but not activation, of the pyruvate dehydrogenase complex during submaximal exercise in humans. J Physiol. 2004 Dec 1;561(Pt 2):647-55. Epub 2004 Oct 7. Pubmed: 15579544 Link_out
  9. Crystal HA, Davies P: Cortical substance P-like immunoreactivity in cases of Alzheimer's disease and senile dementia of the Alzheimer type. J Neurochem. 1982 Jun;38(6):1781-4. Pubmed: 6176686 Link_out
  10. Wysocki SJ, Wilkinson SP, Hahnel R, Wong CY, Panegyres PK: 3-Hydroxy-3-methylglutaric aciduria, combined with 3-methylglutaconic aciduria. Clin Chim Acta. 1976 Aug 2;70(3):399-406. Pubmed: 947633 Link_out
  11. Evans MK, Savasi I, Heigenhauser GJ, Spriet LL: Effects of acetate infusion and hyperoxia on muscle substrate phosphorylation after onset of moderate exercise. Am J Physiol Endocrinol Metab. 2001 Dec;281(6):E1144-50. Pubmed: 11701427 Link_out
  12. Peters SJ: Regulation of PDH activity and isoform expression: diet and exercise. Biochem Soc Trans. 2003 Dec;31(Pt 6):1274-80. Pubmed: 14641042 Link_out
  13. Roe CR, Sweetman L, Roe DS, David F, Brunengraber H: Treatment of cardiomyopathy and rhabdomyolysis in long-chain fat oxidation disorders using an anaplerotic odd-chain triglyceride. J Clin Invest. 2002 Jul;110(2):259-69. Pubmed: 12122118 Link_out
  14. Skibowska A, Raszeja-Specht A, Szutowicz A: Platelet function and acetyl-coenzyme A metabolism in type 1 diabetes mellitus. Clin Chem Lab Med. 2003 Sep;41(9):1136-43. Pubmed: 14598862 Link_out
  15. Girard J: [Contribution of free fatty acids to impairment of insulin secretion and action. mechanism of beta-cell lipotoxicity] Med Sci (Paris). 2005 Dec;21 Spec No:19-25. Pubmed: 16598900 Link_out
  16. Szutowicz A, Jankowska A, Tomaszewicz M: [Disturbances of glucose metabolism in epilepsy and other neurodegenerative diseases] Neurol Neurochir Pol. 2000;34 Suppl 8:59-66. Pubmed: 11780590 Link_out
  17. Spriet LL, MacLean DA, Dyck DJ, Hultman E, Cederblad G, Graham TE: Caffeine ingestion and muscle metabolism during prolonged exercise in humans. Am J Physiol. 1992 Jun;262(6 Pt 1):E891-8. Pubmed: 1616022 Link_out
  18. Constantin-Teodosiu D, Carlin JI, Cederblad G, Harris RC, Hultman E: Acetyl group accumulation and pyruvate dehydrogenase activity in human muscle during incremental exercise. Acta Physiol Scand. 1991 Dec;143(4):367-72. Pubmed: 1815472 Link_out
  19. Boden G, Jadali F, White J, Liang Y, Mozzoli M, Chen X, Coleman E, Smith C: Effects of fat on insulin-stimulated carbohydrate metabolism in normal men. J Clin Invest. 1991 Sep;88(3):960-6. Pubmed: 1885781 Link_out
  20. Blank ML, Smith ZL, Fitzgerald V, Snyder F: The CoA-independent transacylase in PAF biosynthesis: tissue distribution and molecular species selectivity. Biochim Biophys Acta. 1995 Feb 9;1254(3):295-301. Pubmed: 7857969 Link_out

Enzymes
Name: Hydroxymethylglutaryl-CoA lyase, mitochondrial
Reactions:
  • (S)-3-hydroxy-3-methylglutaryl-CoA = acetyl-CoA + acetoacetate [RN:R01360]
Gene Name: HMGCL
Uniprot ID: P35914 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: ATP-citrate synthase
Reactions:
  • ADP + phosphate + acetyl-CoA + oxaloacetate = ATP + citrate + CoA [RN:R00352]
Gene Name: ACLY
Uniprot ID: P53396 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Histone acetyltransferase p300
Reactions:
  • acetyl-CoA + histone = CoA + acetylhistone
Gene Name: EP300
Uniprot ID: Q09472 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Pyruvate dehydrogenase E1 component subunit beta, mitochondrial
Reactions:
  • pyruvate + [dihydrolipoyllysine-residue acetyltransferase] lipoyllysine = [dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine + CO2 [RN:R01699]
Gene Name: PDHB
Uniprot ID: P11177 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Acetyl-CoA acetyltransferase, cytosolic
Reactions:
  • 2 acetyl-CoA = CoA + acetoacetyl-CoA [RN:R00238]
Gene Name: ACAT2
Uniprot ID: Q9BWD1 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: CREB-binding protein
Reactions:
  • acetyl-CoA + histone = CoA + acetylhistone
Gene Name: CREBBP
Uniprot ID: Q92793 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Diamine acetyltransferase 2
Reactions:
  • acetyl-CoA + an alkane-alpha,omega-diamine = CoA + an N-acetyldiamine [RN:R03910]
Gene Name: SAT2
Uniprot ID: Q96F10 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Malonyl-CoA decarboxylase, mitochondrial
Reactions:
  • malonyl-CoA = acetyl-CoA + CO2 [RN:R00233]
Gene Name: MLYCD
Uniprot ID: O95822 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Acetyl-CoA carboxylase 2
Reactions:
  • ATP + acetyl-CoA + HCO3- = ADP + phosphate + malonyl-CoA [RN:R00742]
Gene Name: ACACB
Uniprot ID: O00763 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Pyruvate carboxylase, mitochondrial
Reactions:
  • ATP + pyruvate + HCO3- = ADP + phosphate + oxaloacetate [RN:R00344]
Gene Name: PC
Uniprot ID: P11498 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Arylamine N-acetyltransferase 1
Reactions:
  • acetyl-CoA + an arylamine = CoA + an N-acetylarylamine [RN:R02387]
Gene Name: NAT1
Uniprot ID: P18440 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: 5-aminolevulinate synthase, nonspecific, mitochondrial
Reactions:
  • succinyl-CoA + glycine = 5-aminolevulinate + CoA + CO2 [RN:R00830]
Gene Name: ALAS1
Uniprot ID: P13196 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: General transcription factor 3C polypeptide 4
Reactions:
  • acetyl-CoA + histone = CoA + acetylhistone
Gene Name: GTF3C4
Uniprot ID: Q9UKN8 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Acyl-coenzyme A thioesterase 12
Reactions:
  • acetyl-CoA + H2O = CoA + acetate [RN:R00227]
Gene Name: ACOT12
Uniprot ID: Q8WYK0 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Choline O-acetyltransferase
Reactions:
  • acetyl-CoA + choline = CoA + O-acetylcholine [RN:R01023]
Gene Name: CHAT
Uniprot ID: P28329 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Nuclear receptor coactivator 3
Reactions:
  • acetyl-CoA + histone = CoA + acetylhistone
Gene Name: NCOA3
Uniprot ID: Q9Y6Q9 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Histone acetyltransferase KAT2B
Reactions:
  • acetyl-CoA + histone = CoA + acetylhistone
Gene Name: KAT2B
Uniprot ID: Q92831 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Carnitine O-acetyltransferase
Reactions:
  • acetyl-CoA + carnitine = CoA + O-acetylcarnitine [RN:R02396]
Gene Name: CRAT
Uniprot ID: P43155 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Diamine acetyltransferase 1
Reactions:
  • acetyl-CoA + an alkane-alpha,omega-diamine = CoA + an N-acetyldiamine [RN:R03910]
Gene Name: SAT1
Uniprot ID: P21673 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Serotonin N-acetyltransferase
Reactions:
  • acetyl-CoA + a 2-arylethylamine = CoA + an N-acetyl-2-arylethylamine [RN:R03760]
Gene Name: AANAT
Uniprot ID: Q16613 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: 3-ketoacyl-CoA thiolase, mitochondrial
Reactions:
  • acyl-CoA + acetyl-CoA = CoA + 3-oxoacyl-CoA [RN:R00391]
Gene Name: ACAA2
Uniprot ID: P42765 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Testis-specific chromodomain protein Y 1
Reactions:
  • acetyl-CoA + histone = CoA + acetylhistone
Gene Name: CDY1
Uniprot ID: Q9Y6F8 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Fatty acid synthase
Reactions:
  • a (3R)-3-hydroxypalmitoyl-[acyl-carrier protein] = a hexadec-2-enoyl-[acyl-carrier protein] + H2O [RN:R04462]
Gene Name: FASN
Uniprot ID: P49327 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Histone acetyltransferase KAT5
Reactions:
  • acetyl-CoA + histone = CoA + acetylhistone
Gene Name: KAT5
Uniprot ID: Q92993 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Acetyl-coenzyme A synthetase, cytoplasmic
Reactions:
  • ATP + acetate + CoA = AMP + diphosphate + acetyl-CoA [RN:R00235]
Gene Name: ACSS2
Uniprot ID: Q9NR19 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Acetyl-CoA acetyltransferase, mitochondrial
Reactions:
  • 2 acetyl-CoA = CoA + acetoacetyl-CoA [RN:R00238]
Gene Name: ACAT1
Uniprot ID: P24752 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Nuclear receptor coactivator 1
Reactions:
  • acetyl-CoA + histone = CoA + acetylhistone
Gene Name: NCOA1
Uniprot ID: Q15788 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Hydroxymethylglutaryl-CoA synthase, mitochondrial
Reactions:
  • acetyl-CoA + H2O + acetoacetyl-CoA = (S)-3-hydroxy-3-methylglutaryl-CoA + CoA [RN:R01978]
Gene Name: HMGCS2
Uniprot ID: P54868 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Acetyl-coenzyme A synthetase 2-like, mitochondrial
Reactions:
  • ATP + acetate + CoA = AMP + diphosphate + acetyl-CoA [RN:R00235]
Gene Name: ACSS1
Uniprot ID: Q9NUB1 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Citrate synthase, mitochondrial
Reactions:
  • acetyl-CoA + H2O + oxaloacetate = citrate + CoA [RN:R00351]
Gene Name: CS
Uniprot ID: O75390 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Testis-specific chromodomain protein Y 2
Reactions:
  • acetyl-CoA + histone = CoA + acetylhistone
Gene Name: CDY2A
Uniprot ID: Q9Y6F7 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: 3-ketoacyl-CoA thiolase, peroxisomal
Reactions:
  • acyl-CoA + acetyl-CoA = CoA + 3-oxoacyl-CoA [RN:R00391]
Gene Name: ACAA1
Uniprot ID: P09110 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial
Reactions:
  • pyruvate + [dihydrolipoyllysine-residue acetyltransferase] lipoyllysine = [dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine + CO2 [RN:R01699]
Gene Name: PDHA1
Uniprot ID: P08559 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Acetyl-CoA carboxylase 1
Reactions:
  • ATP + acetyl-CoA + HCO3- = ADP + phosphate + malonyl-CoA [RN:R00742]
Gene Name: ACACA
Uniprot ID: Q13085 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Trifunctional enzyme subunit beta, mitochondrial
Reactions:
  • acyl-CoA + acetyl-CoA = CoA + 3-oxoacyl-CoA [RN:R00391]
Gene Name: HADHB
Uniprot ID: P55084 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: 2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial
Reactions:
  • acetyl-CoA + glycine = CoA + L-2-amino-3-oxobutanoate [RN:R00371]
Gene Name: GCAT
Uniprot ID: O75600 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Pyruvate dehydrogenase E1 component subunit alpha, testis-specific form, mitochondrial
Reactions:
  • pyruvate + [dihydrolipoyllysine-residue acetyltransferase] lipoyllysine = [dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine + CO2 [RN:R01699]
Gene Name: PDHA2
Uniprot ID: P29803 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial
Reactions:
  • 2-methyl-3-oxopropanoate + CoA + H2O + NAD+ = propanoyl-CoA + HCO3- + NADH [RN:R00922]
Gene Name: ALDH6A1
Uniprot ID: Q02252 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Glucosamine 6-phosphate N-acetyltransferase
Reactions:
  • acetyl-CoA + D-glucosamine 6-phosphate = CoA + N-acetyl-D-glucosamine 6-phosphate [RN:R02058]
Gene Name: GNPNAT1
Uniprot ID: Q96EK6 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Hydroxymethylglutaryl-CoA synthase, cytoplasmic
Reactions:
  • acetyl-CoA + H2O + acetoacetyl-CoA = (S)-3-hydroxy-3-methylglutaryl-CoA + CoA [RN:R01978]
Gene Name: HMGCS1
Uniprot ID: Q01581 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Dihydrolipoyl dehydrogenase, mitochondrial
Reactions:
  • protein N6-(dihydrolipoyl)lysine + NAD+ = protein N6-(lipoyl)lysine + NADH + H+ [RN:R08550]
Gene Name: DLD
Uniprot ID: P09622 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial
Reactions:
  • acetyl-CoA + enzyme N6-(dihydrolipoyl)lysine = CoA + enzyme N6-(S-acetyldihydrolipoyl)lysine [RN:R02569]
Gene Name: DLAT
Uniprot ID: P10515 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Long-chain specific acyl-CoA dehydrogenase, mitochondrial
Reactions:
  • acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor [RN:R00392]
Gene Name: ACADL
Uniprot ID: P28330 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Short-chain specific acyl-CoA dehydrogenase, mitochondrial
Reactions:
  • butanoyl-CoA + acceptor = 2-butenoyl-CoA + reduced acceptor [RN:R01178]
Gene Name: ACADS
Uniprot ID: P16219 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Medium-chain specific acyl-CoA dehydrogenase, mitochondrial
Reactions:
  • acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor [RN:R00392]
Gene Name: ACADM
Uniprot ID: P11310 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Peroxisomal acyl-coenzyme A oxidase 1
Reactions:
  • acyl-CoA + O2 = trans-2,3-dehydroacyl-CoA + H2O2 [RN:R00388]
Gene Name: ACOX1
Uniprot ID: Q15067 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Peroxisomal acyl-coenzyme A oxidase 2
Reactions:
  • (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA + H2O + acceptor = (24R,25R)-3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestan-26- oyl-CoA + reduced acceptor [RN:R07374]
Gene Name: ACOX2
Uniprot ID: Q99424 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Isovaleryl-CoA dehydrogenase, mitochondrial
Reactions:
  • 3-methylbutanoyl-CoA + acceptor = 3-methylbut-2-enoyl-CoA + reduced acceptor [RN:R04096]
Gene Name: IVD
Uniprot ID: P26440 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Peroxisomal acyl-coenzyme A oxidase 3
Reactions:
  • acyl-CoA + O2 = trans-2,3-dehydroacyl-CoA + H2O2 [RN:R00388]
Gene Name: ACOX3
Uniprot ID: O15254 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Glutaryl-CoA dehydrogenase, mitochondrial
Reactions:
  • glutaryl-CoA + acceptor = crotonoyl-CoA + CO2 + reduced acceptor [RN:R02488]
Gene Name: GCDH
Uniprot ID: Q92947 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Hepatic triacylglycerol lipase
Reactions:
  • triacylglycerol + H2O = diacylglycerol + a carboxylate [RN:R01369]
Gene Name: LIPC
Uniprot ID: P11150 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Diacylglycerol O-acyltransferase 1
Reactions:
  • acyl-CoA + 1,2-diacyl-sn-glycerol = CoA + triacylglycerol [RN:R02251]
Gene Name: DGAT1
Uniprot ID: O75907 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: 2-oxoisovalerate dehydrogenase subunit beta, mitochondrial
Reactions:
  • 3-methyl-2-oxobutanoate + [dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] lipoyllysine = [dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] S-(2-methylpropanoyl)dihydrolipoyllysine + CO2 [RN:R01701]
Gene Name: BCKDHB
Uniprot ID: P21953 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: 2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial
Reactions:
  • 3-methyl-2-oxobutanoate + [dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] lipoyllysine = [dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] S-(2-methylpropanoyl)dihydrolipoyllysine + CO2 [RN:R01701]
Gene Name: BCKDHA
Uniprot ID: P12694 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Acyl-CoA desaturase
Reactions:
  • stearoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+ = oleoyl-CoA + 2 ferricytochrome b5 + 2 H2O [RN:R02222]
Gene Name: SCD
Uniprot ID: O00767 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Trifunctional enzyme subunit alpha, mitochondrial
Reactions:
  • (3S)-3-hydroxyacyl-CoA = trans-2(or 3)-enoyl-CoA + H2O [RN:R02685 R07314]
Gene Name: HADHA
Uniprot ID: P40939 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Sterol O-acyltransferase 2
Reactions:
  • acyl-CoA + cholesterol = CoA + cholesterol ester [RN:R01461]
Gene Name: SOAT2
Uniprot ID: O75908 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Sterol O-acyltransferase 1
Reactions:
  • acyl-CoA + cholesterol = CoA + cholesterol ester [RN:R01461]
Gene Name: SOAT1
Uniprot ID: P35610 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: N-acetylglutamate synthase, mitochondrial
Reactions:
  • acetyl-CoA + L-glutamate = CoA + N-acetyl-L-glutamate [RN:R00259]
Gene Name: NAGS
Uniprot ID: Q8N159 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Bile acid-CoA:amino acid N-acyltransferase
Reactions:
  • palmitoyl-CoA + H2O = CoA + palmitate [RN:R01274]
Gene Name: BAAT
Uniprot ID: Q14032 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Long-chain-fatty-acid--CoA ligase 4
Reactions:
  • ATP + a long-chain carboxylic acid + CoA = AMP + diphosphate + an acyl-CoA [RN:R00390]
Gene Name: ACSL4
Uniprot ID: O60488 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Long-chain-fatty-acid--CoA ligase 1
Reactions:
  • ATP + a long-chain carboxylic acid + CoA = AMP + diphosphate + an acyl-CoA [RN:R00390]
Gene Name: ACSL1
Uniprot ID: P33121 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Long-chain-fatty-acid--CoA ligase 6
Reactions:
  • ATP + a long-chain carboxylic acid + CoA = AMP + diphosphate + an acyl-CoA [RN:R00390]
Gene Name: ACSL6
Uniprot ID: Q9UKU0 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Long-chain-fatty-acid--CoA ligase 5
Reactions:
  • ATP + a long-chain carboxylic acid + CoA = AMP + diphosphate + an acyl-CoA [RN:R00390]
Gene Name: ACSL5
Uniprot ID: Q9ULC5 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Long-chain-fatty-acid--CoA ligase 3
Reactions:
  • ATP + a long-chain carboxylic acid + CoA = AMP + diphosphate + an acyl-CoA [RN:R00390]
Gene Name: ACSL3
Uniprot ID: O95573 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Glycerol-3-phosphate acyltransferase 1, mitochondrial
Reactions:
  • acyl-CoA + sn-glycerol 3-phosphate = CoA + 1-acyl-sn-glycerol 3-phosphate [RN:R00851]
Gene Name: GPAM
Uniprot ID: Q9HCL2 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Trans-2-enoyl-CoA reductase, mitochondrial
Reactions:
  • acyl-CoA + NADP+ = trans-2,3-dehydroacyl-CoA + NADPH + H+ [RN:R07162]
Gene Name: MECR
Uniprot ID: Q9BV79 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Peroxisomal trans-2-enoyl-CoA reductase
Reactions:
  • acyl-CoA + NADP+ = trans-2,3-dehydroacyl-CoA + NADPH + H+ [RN:R07162]
Gene Name: PECR
Uniprot ID: Q9BY49 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Cytosolic acyl coenzyme A thioester hydrolase
Reactions:
  • palmitoyl-CoA + H2O = CoA + palmitate [RN:R01274]
Gene Name: ACOT7
Uniprot ID: O00154 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Acyl-coenzyme A thioesterase 2, mitochondrial
Reactions:
  • palmitoyl-CoA + H2O = CoA + palmitate [RN:R01274]
Gene Name: ACOT2
Uniprot ID: P49753 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Acyl-coenzyme A thioesterase 4
Reactions:
  • palmitoyl-CoA + H2O = CoA + palmitate [RN:R01274]
Gene Name: ACOT4
Uniprot ID: Q8N9L9 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Acyl-coenzyme A thioesterase 8
Reactions:
  • choloyl-CoA + H2O = cholate + CoA [RN:R07296]
Gene Name: ACOT8
Uniprot ID: O14734 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Dihydroxyacetone phosphate acyltransferase
Reactions:
  • acyl-CoA + glycerone phosphate = CoA + acylglycerone phosphate [RN:R01013]
Gene Name: GNPAT
Uniprot ID: O15228 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: 1-acyl-sn-glycerol-3-phosphate acyltransferase gamma
Reactions:
  • acyl-CoA + 1-acyl-sn-glycerol 3-phosphate = CoA + 1,2-diacyl-sn-glycerol 3-phosphate [RN:R02241]
Gene Name: AGPAT3
Uniprot ID: Q9NRZ7 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: 1-acyl-sn-glycerol-3-phosphate acyltransferase beta
Reactions:
  • acyl-CoA + 1-acyl-sn-glycerol 3-phosphate = CoA + 1,2-diacyl-sn-glycerol 3-phosphate [RN:R02241]
Gene Name: AGPAT2
Uniprot ID: O15120 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: 1-acyl-sn-glycerol-3-phosphate acyltransferase alpha
Reactions:
  • acyl-CoA + 1-acyl-sn-glycerol 3-phosphate = CoA + 1,2-diacyl-sn-glycerol 3-phosphate [RN:R02241]
Gene Name: AGPAT1
Uniprot ID: Q99943 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial
Reactions:
  • --- []
Gene Name: ACADSB
Uniprot ID: P45954 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Very long-chain acyl-CoA synthetase
Reactions:
  • ATP + a long-chain carboxylic acid + CoA = AMP + diphosphate + an acyl-CoA [RN:R00390]
Gene Name: SLC27A2
Uniprot ID: O14975 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Peroxisome proliferator-activated receptor gamma
Reactions:
  • --- []
Gene Name: PPARG
Uniprot ID: P37231 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Peroxisome proliferator-activated receptor alpha
Reactions:
    Gene Name: PPARA
    Uniprot ID: Q07869 Link_out
    Protein Sequence: FASTA
    Gene Sequence: FASTA
    Name: Peroxisome proliferator-activated receptor delta
    Reactions:
      Gene Name: PPARD
      Uniprot ID: Q03181 Link_out
      Protein Sequence: FASTA
      Gene Sequence: FASTA
      Name: Acyl-CoA-binding protein
      Reactions:
        Gene Name: DBI
        Uniprot ID: P07108 Link_out
        Protein Sequence: FASTA
        Gene Sequence: FASTA
        Name: Histone acetyltransferase KAT2A
        Reactions:
        • acetyl-CoA + histone = CoA + acetylhistone
        Gene Name: KAT2A
        Uniprot ID: Q92830 Link_out
        Protein Sequence: FASTA
        Gene Sequence: FASTA
        Name: Fatty acid-binding protein, heart
        Reactions:
          Gene Name: FABP3
          Uniprot ID: P05413 Link_out
          Protein Sequence: FASTA
          Gene Sequence: FASTA
          Name: 1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon
          Reactions:
          • acyl-CoA + 1-acyl-sn-glycerol 3-phosphate = CoA + 1,2-diacyl-sn-glycerol 3-phosphate [RN:R02241]
          Gene Name: AGPAT5
          Uniprot ID: Q9NUQ2 Link_out
          Protein Sequence: FASTA
          Gene Sequence: FASTA
          Name: Acetyl-coenzyme A transporter 1
          Reactions:
            Gene Name: SLC33A1
            Uniprot ID: O00400 Link_out
            Protein Sequence: FASTA
            Gene Sequence: FASTA
            Name: Bile acyl-CoA synthetase
            Reactions:
            • (1) ATP + cholate + CoA = AMP + diphosphate + choloyl-CoA [RN:R02794]
            • (2) ATP + (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate + CoA = AMP + diphosphate + (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl-CoA [RN:R04580]
            Gene Name: SLC27A5
            Uniprot ID: Q9Y2P5 Link_out
            Protein Sequence: FASTA
            Gene Sequence: FASTA
            Name: Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial
            Reactions:
            • 2-methylpropanoyl-CoA + enzyme N6-(dihydrolipoyl)lysine = CoA + enzyme N6-(S-[2-methylpropanoyl]dihydrolipoyl)lysine [RN:R02662]
            Gene Name: DBT
            Uniprot ID: P11182 Link_out
            Protein Sequence: FASTA
            Gene Sequence: FASTA
            Name: 2-acylglycerol O-acyltransferase 2
            Reactions:
            • acyl-CoA + 2-acylglycerol = CoA + diacylglycerol [RN:R01368]
            Gene Name: MOGAT2
            Uniprot ID: Q3SYC2 Link_out
            Protein Sequence: FASTA
            Gene Sequence: FASTA
            Name: Long-chain fatty acid transport protein 3
            Reactions:
              Gene Name: SLC27A3
              Uniprot ID: Q5K4L6 Link_out
              Protein Sequence: FASTA
              Gene Sequence: FASTA
              Name: Acyl-CoA dehydrogenase family member 10
              Reactions:
                Gene Name: ACAD10
                Uniprot ID: Q6JQN1 Link_out
                Protein Sequence: FASTA
                Gene Sequence: FASTA
                Name: Acyl-CoA dehydrogenase family member 11
                Reactions:
                  Gene Name: ACAD11
                  Uniprot ID: Q709F0 Link_out
                  Protein Sequence: FASTA
                  Gene Sequence: FASTA
                  Name: Glycerol-3-phosphate acyltransferase 4
                  Reactions:
                  • acyl-CoA + sn-glycerol 3-phosphate = CoA + 1-acyl-sn-glycerol 3-phosphate [RN:R00851]
                  Gene Name: AGPAT6
                  Uniprot ID: Q86UL3 Link_out
                  Protein Sequence: FASTA
                  Gene Sequence: FASTA
                  Name: Acyl-coenzyme A synthetase ACSM1, mitochondrial
                  Reactions:
                  • ATP + an acid + CoA = AMP + diphosphate + an acyl-CoA [RN:R00389]
                  Gene Name: ACSM1
                  Uniprot ID: Q08AH1 Link_out
                  Protein Sequence: FASTA
                  Gene Sequence: FASTA
                  Name: Diacylglycerol O-acyltransferase 2
                  Reactions:
                  • acyl-CoA + 1,2-diacyl-sn-glycerol = CoA + triacylglycerol [RN:R02251]
                  Gene Name: DGAT2
                  Uniprot ID: Q96PD7 Link_out
                  Protein Sequence: FASTA
                  Gene Sequence: FASTA
                  Name: 1-acyl-sn-glycerol-3-phosphate acyltransferase delta
                  Reactions:
                  • acyl-CoA + 1-acyl-sn-glycerol 3-phosphate = CoA + 1,2-diacyl-sn-glycerol 3-phosphate [RN:R02241]
                  Gene Name: AGPAT4
                  Uniprot ID: Q9NRZ5 Link_out
                  Protein Sequence: FASTA
                  Gene Sequence: FASTA
                  Name: 2-acylglycerol O-acyltransferase 1
                  Reactions:
                  • acyl-CoA + 2-acylglycerol = CoA + diacylglycerol [RN:R01368]
                  Gene Name: MOGAT1
                  Uniprot ID: Q96PD6 Link_out
                  Protein Sequence: FASTA
                  Gene Sequence: FASTA
                  Name: Isobutyryl-CoA dehydrogenase, mitochondrial
                  Reactions:
                    Gene Name: ACAD8
                    Uniprot ID: Q9UKU7 Link_out
                    Protein Sequence: FASTA
                    Gene Sequence: FASTA
                    Name: Acyl-CoA dehydrogenase family member 9, mitochondrial
                    Reactions:
                      Gene Name: ACAD9
                      Uniprot ID: Q9H845 Link_out
                      Protein Sequence: FASTA
                      Gene Sequence: FASTA
                      Name: Long-chain fatty acid transport protein 4
                      Reactions:
                        Gene Name: SLC27A4
                        Uniprot ID: Q6P1M0 Link_out
                        Protein Sequence: FASTA
                        Gene Sequence: FASTA
                        Name: Fatty acyl-CoA reductase 1
                        Reactions:
                          Gene Name: FAR1
                          Uniprot ID: Q8WVX9 Link_out
                          Protein Sequence: FASTA
                          Gene Sequence: FASTA
                          Name: Fatty acyl-CoA reductase 2
                          Reactions:
                            Gene Name: FAR2
                            Uniprot ID: Q96K12 Link_out
                            Protein Sequence: FASTA
                            Gene Sequence: FASTA
                            Name: Acyl-CoA wax alcohol acyltransferase 1
                            Reactions:
                            • acyl-CoA + a long-chain alcohol = CoA + a long-chain ester [RN:R01999]
                            Gene Name: AWAT1
                            Uniprot ID: Q58HT5 Link_out
                            Protein Sequence: FASTA
                            Gene Sequence: FASTA
                            Name: Acyl-CoA wax alcohol acyltransferase 2
                            Reactions:
                            • acyl-CoA + a long-chain alcohol = CoA + a long-chain ester [RN:R01999]
                            Gene Name: AWAT2
                            Uniprot ID: Q6E213 Link_out
                            Protein Sequence: FASTA
                            Gene Sequence: FASTA
                            Name: Diacylglycerol O-acyltransferase 2-like protein 6
                            Reactions:
                              Gene Name: DGAT2L6
                              Uniprot ID: Q6ZPD8 Link_out
                              Protein Sequence: FASTA
                              Gene Sequence: FASTA
                              Name: Putative diacylglycerol O-acyltransferase 2-like protein 7
                              Reactions:
                                Gene Name: DGAT2L7
                                Uniprot ID: Q6IED9 Link_out
                                Protein Sequence: FASTA
                                Name: 2-acylglycerol O-acyltransferase 3
                                Reactions:
                                • acyl-CoA + 2-acylglycerol = CoA + diacylglycerol [RN:R01368]
                                Gene Name: MOGAT3
                                Uniprot ID: Q86VF5 Link_out
                                Protein Sequence: FASTA
                                Gene Sequence: FASTA
                                Name: Lysophospholipid acyltransferase 5
                                Reactions:
                                • acyl-CoA + 1-acyl-sn-glycero-3-phosphocholine = CoA + 1,2-diacyl-sn-glycero-3-phosphocholine [RN:R01318]
                                Gene Name: LPCAT3
                                Uniprot ID: Q6P1A2 Link_out
                                Protein Sequence: FASTA
                                Gene Sequence: FASTA
                                Name: Lysophosphatidylcholine acyltransferase 1
                                Reactions:
                                • acetyl-CoA + 1-alkyl-sn-glycero-3-phosphocholine = CoA + 2-acetyl-1-alkyl-sn-glycero-3-phosphocholine [RN:R03437]
                                Gene Name: LPCAT1
                                Uniprot ID: Q8NF37 Link_out
                                Protein Sequence: FASTA
                                Gene Sequence: FASTA
                                Name: Lysocardiolipin acyltransferase 1
                                Reactions:
                                • acyl-CoA + 1-acyl-sn-glycerol 3-phosphate = CoA + 1,2-diacyl-sn-glycerol 3-phosphate [RN:R02241]
                                Gene Name: LCLAT1
                                Uniprot ID: Q6UWP7 Link_out
                                Protein Sequence: FASTA
                                Gene Sequence: FASTA
                                Name: Lysophospholipid acyltransferase LPCAT4
                                Reactions:
                                  Gene Name: LPCAT4
                                  Uniprot ID: Q643R3 Link_out
                                  Protein Sequence: FASTA
                                  Gene Sequence: FASTA
                                  Name: Glycerol-3-phosphate acyltransferase 3
                                  Reactions:
                                  • acyl-CoA + sn-glycerol 3-phosphate = CoA + 1-acyl-sn-glycerol 3-phosphate [RN:R00851]
                                  Gene Name: AGPAT9
                                  Uniprot ID: Q53EU6 Link_out
                                  Protein Sequence: FASTA
                                  Gene Sequence: FASTA
                                  Name: Glycine N-acyltransferase
                                  Reactions:
                                  • acyl-CoA + glycine = CoA + N-acylglycine [RN:R00395]
                                  Gene Name: GLYAT
                                  Uniprot ID: Q6IB77 Link_out
                                  Protein Sequence: FASTA
                                  Gene Sequence: FASTA
                                  Name: Glycine N-acyltransferase-like protein 1
                                  Reactions:
                                  • acyl-CoA + glycine = CoA + N-acylglycine [RN:R00395]
                                  Gene Name: GLYATL1
                                  Uniprot ID: Q969I3 Link_out
                                  Protein Sequence: FASTA
                                  Gene Sequence: FASTA
                                  Name: Glycine N-acyltransferase-like protein 2
                                  Reactions:
                                  • acyl-CoA + glycine = CoA + N-acylglycine [RN:R00395]
                                  Gene Name: GLYATL2
                                  Uniprot ID: Q8WU03 Link_out
                                  Protein Sequence: FASTA
                                  Gene Sequence: FASTA
                                  Name: Dihydrolipoamide S-acetyltransferase
                                  Reactions:
                                    Gene Name: DLAT
                                    Uniprot ID: Q86YI5 Link_out
                                    Protein Sequence: FASTA
                                    Gene Sequence: FASTA
                                    Name: Arylamine N-acetyltransferase 2
                                    Reactions:
                                      Gene Name: NAT2
                                      Uniprot ID: A4Z6T7 Link_out
                                      Protein Sequence: FASTA
                                      Gene Sequence: FASTA
                                      Name: Peroxisomal 3,2-trans-enoyl-CoA isomerase
                                      Reactions:
                                      • (3Z)-dodec-3-enoyl-CoA = (2E)-dodec-2-enoyl-CoA [RN:R04100]
                                      Gene Name: PECI
                                      Uniprot ID: O75521 Link_out
                                      Protein Sequence: FASTA
                                      Gene Sequence: FASTA
                                      Name: Acyl-CoA synthetase family member 4
                                      Reactions:
                                        Gene Name: AASDH
                                        Uniprot ID: Q4L235 Link_out
                                        Protein Sequence: FASTA
                                        Gene Sequence: FASTA
                                        Name: ACSS2 protein
                                        Reactions:
                                          Gene Name: ACSS2
                                          Uniprot ID: Q96FY7 Link_out
                                          Protein Sequence: FASTA
                                          Gene Sequence: FASTA
                                          Name: Very long-chain specific acyl-CoA dehydrogenase, mitochondrial
                                          Reactions:
                                            Gene Name: ACADVL
                                            Uniprot ID: P49748 Link_out
                                            Protein Sequence: FASTA
                                            Gene Sequence: FASTA
                                            Name: Acyl-coenzyme A oxidase-like protein
                                            Reactions:
                                              Gene Name: ACOXL
                                              Uniprot ID: Q9NUZ1 Link_out
                                              Protein Sequence: FASTA
                                              Name: Acyl-coenzyme A synthetase ACSM6, mitochondrial
                                              Reactions:
                                              • ATP + an acid + CoA = AMP + diphosphate + an acyl-CoA [RN:R00389]
                                              Gene Name: ACSM6
                                              Uniprot ID: Q6P461 Link_out
                                              Protein Sequence: FASTA
                                              Gene Sequence: FASTA
                                              Name: Acyl-coenzyme A synthetase ACSM2A, mitochondrial
                                              Reactions:
                                              • ATP + an acid + CoA = AMP + diphosphate + an acyl-CoA [RN:R00389]
                                              Gene Name: ACSM2A
                                              Uniprot ID: Q08AH3 Link_out
                                              Protein Sequence: FASTA
                                              Gene Sequence: FASTA
                                              Name: Acyl-coenzyme A synthetase ACSM2B, mitochondrial
                                              Reactions:
                                              • ATP + an acid + CoA = AMP + diphosphate + an acyl-CoA [RN:R00389]
                                              Gene Name: ACSM2B
                                              Uniprot ID: Q68CK6 Link_out
                                              Protein Sequence: FASTA
                                              Gene Sequence: FASTA
                                              Name: Acyl-coenzyme A synthetase ACSM3, mitochondrial
                                              Reactions:
                                              • ATP + an acid + CoA = AMP + diphosphate + an acyl-CoA [RN:R00389]
                                              Gene Name: ACSM3
                                              Uniprot ID: Q53FZ2 Link_out
                                              Protein Sequence: FASTA
                                              Gene Sequence: FASTA
                                              Name: Acyl-coenzyme A synthetase ACSM5, mitochondrial
                                              Reactions:
                                              • ATP + an acid + CoA = AMP + diphosphate + an acyl-CoA [RN:R00389]
                                              Gene Name: ACSM5
                                              Uniprot ID: Q6NUN0 Link_out
                                              Protein Sequence: FASTA
                                              Gene Sequence: FASTA
                                              Name: Peroxisomal coenzyme A diphosphatase NUDT7
                                              Reactions:
                                                Gene Name: NUDT7
                                                Uniprot ID: P0C024 Link_out
                                                Protein Sequence: FASTA
                                                Gene Sequence: FASTA
                                                Name: Elongator complex protein 3
                                                Reactions:
                                                • acetyl-CoA + histone = CoA + acetylhistone
                                                Gene Name: ELP3
                                                Uniprot ID: Q9H9T3 Link_out
                                                Protein Sequence: FASTA
                                                Gene Sequence: FASTA
                                                Name: Acyl-coenzyme A synthetase ACSM4, mitochondrial
                                                Reactions:
                                                • ATP + an acid + CoA = AMP + diphosphate + an acyl-CoA [RN:R00389]
                                                Gene Name: ACSM4
                                                Uniprot ID: P0C7M7 Link_out
                                                Protein Sequence: FASTA
                                                Gene Sequence: FASTA
                                                Name: 3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial
                                                Reactions:
                                                • an acyl-[acyl-carrier protein] + a malonyl-[acyl-carrier protein] = a 3-oxoacyl-[acyl-carrier protein] + CO2 + an [acyl-carrier protein] [RN:R02768]
                                                Gene Name: OXSM
                                                Uniprot ID: Q9NWU1 Link_out
                                                Protein Sequence: FASTA
                                                Gene Sequence: FASTA
                                                Name: Histone acetyltransferase MYST4
                                                Reactions:
                                                • acetyl-CoA + histone = CoA + acetylhistone
                                                Gene Name: MYST4
                                                Uniprot ID: Q8WYB5 Link_out
                                                Protein Sequence: FASTA
                                                Gene Sequence: FASTA
                                                Name: MYST3 protein
                                                Reactions:
                                                  Gene Name: MYST3
                                                  Uniprot ID: A5PKX7 Link_out
                                                  Protein Sequence: FASTA
                                                  Gene Sequence: FASTA
                                                  Name: Probable histone acetyltransferase MYST1
                                                  Reactions:
                                                  • acetyl-CoA + histone = CoA + acetylhistone
                                                  Gene Name: MYST1
                                                  Uniprot ID: Q9H7Z6 Link_out
                                                  Protein Sequence: FASTA
                                                  Gene Sequence: FASTA
                                                  Name: Histone acetyltransferase 1
                                                  Reactions:
                                                    Gene Name: HAT1
                                                    Uniprot ID: O14929 Link_out
                                                    Protein Sequence: FASTA
                                                    Gene Sequence: FASTA
                                                    Name: Glycerol-3-phosphate acyltransferase 2, mitochondrial
                                                    Reactions:
                                                    • acyl-CoA + sn-glycerol 3-phosphate = CoA + 1-acyl-sn-glycerol 3-phosphate [RN:R00851]
                                                    Gene Name: GPAT2
                                                    Uniprot ID: Q6NUI2 Link_out
                                                    Protein Sequence: FASTA
                                                    Gene Sequence: FASTA
                                                    Name: Chromodomain Y-like protein
                                                    Reactions:
                                                    • acetyl-CoA + histone = CoA + acetylhistone
                                                    Gene Name: CDYL
                                                    Uniprot ID: Q9Y232 Link_out
                                                    Protein Sequence: FASTA
                                                    Gene Sequence: FASTA
                                                    Name: Peroxisomal D3,D2-enoyl-CoA isomerase isoform 1 variant
                                                    Reactions:
                                                      Gene Name: Not Available
                                                      Uniprot ID: Q53GC8 Link_out
                                                      Protein Sequence: FASTA
                                                      Gene Sequence: FASTA
                                                      Name: Peroxisomal D3,D2-enoyl-CoA isomerase isoform 1 variant
                                                      Reactions:
                                                        Gene Name: Not Available
                                                        Uniprot ID: Q53HG3 Link_out
                                                        Protein Sequence: FASTA
                                                        Gene Sequence: FASTA
                                                        Name: Nef-associated protein 1
                                                        Reactions:
                                                          Gene Name: C9orf156
                                                          Uniprot ID: Q9BU70 Link_out
                                                          Protein Sequence: FASTA
                                                          Gene Sequence: FASTA
                                                          Name: Peroxisomal D3,D2-enoyl-CoA isomerase isoform 1 variant
                                                          Reactions:
                                                            Gene Name: Not Available
                                                            Uniprot ID: Q59E94 Link_out
                                                            Protein Sequence: FASTA
                                                            Gene Sequence: FASTA
                                                            Name: Acyl-coenzyme A thioesterase 9, mitochondrial
                                                            Reactions:
                                                              Gene Name: ACOT9
                                                              Uniprot ID: Q9Y305 Link_out
                                                              Protein Sequence: FASTA
                                                              Gene Sequence: FASTA
                                                              Name: Acyl-CoA synthetase family member 3, mitochondrial
                                                              Reactions:
                                                                Gene Name: ACSF3
                                                                Uniprot ID: Q4G176 Link_out
                                                                Protein Sequence: FASTA
                                                                Gene Sequence: FASTA
                                                                Name: Acyl-coenzyme A thioesterase 1
                                                                Reactions:
                                                                • palmitoyl-CoA + H2O = CoA + palmitate [RN:R01274]
                                                                Gene Name: ACOT1
                                                                Uniprot ID: Q86TX2 Link_out
                                                                Protein Sequence: FASTA
                                                                Gene Sequence: FASTA
                                                                Name: Cytosolic acyl coenzyme A thioester hydrolase-like
                                                                Reactions:
                                                                • palmitoyl-CoA + H2O = CoA + palmitate [RN:R01274]
                                                                Gene Name: ACOT7L
                                                                Uniprot ID: Q6ZUV0 Link_out
                                                                Protein Sequence: FASTA
                                                                Gene Sequence: FASTA
                                                                Name: Acyl-CoA synthetase family member 2, mitochondrial
                                                                Reactions:
                                                                  Gene Name: ACSF2
                                                                  Uniprot ID: Q96CM8 Link_out
                                                                  Protein Sequence: FASTA
                                                                  Gene Sequence: FASTA
                                                                  Name: Acyl-coenzyme A thioesterase 11
                                                                  Reactions:
                                                                    Gene Name: ACOT11
                                                                    Uniprot ID: Q8WXI4 Link_out
                                                                    Protein Sequence: FASTA
                                                                    Gene Sequence: FASTA
                                                                    Name: Long-chain-fatty-acid--CoA ligase ACSBG2
                                                                    Reactions:
                                                                    • ATP + a long-chain carboxylic acid + CoA = AMP + diphosphate + an acyl-CoA [RN:R00390]
                                                                    Gene Name: ACSBG2
                                                                    Uniprot ID: Q5FVE4 Link_out
                                                                    Protein Sequence: FASTA
                                                                    Gene Sequence: FASTA
                                                                    Name: Long-chain-fatty-acid--CoA ligase ACSBG1
                                                                    Reactions:
                                                                    • ATP + a long-chain carboxylic acid + CoA = AMP + diphosphate + an acyl-CoA [RN:R00390]
                                                                    Gene Name: ACSBG1
                                                                    Uniprot ID: Q96GR2 Link_out
                                                                    Protein Sequence: FASTA
                                                                    Gene Sequence: FASTA
                                                                    Name: Golgi resident protein GCP60
                                                                    Reactions:
                                                                      Gene Name: ACBD3
                                                                      Uniprot ID: Q9H3P7 Link_out
                                                                      Protein Sequence: FASTA
                                                                      Gene Sequence: FASTA
                                                                      Name: Acyl-CoA-binding domain-containing protein 4
                                                                      Reactions:
                                                                        Gene Name: ACBD4
                                                                        Uniprot ID: Q8NC06 Link_out
                                                                        Protein Sequence: FASTA
                                                                        Gene Sequence: FASTA
                                                                        Name: Acyl-CoA-binding domain-containing protein 5
                                                                        Reactions:
                                                                          Gene Name: ACBD5
                                                                          Uniprot ID: Q5T8D3 Link_out
                                                                          Protein Sequence: FASTA
                                                                          Gene Sequence: FASTA
                                                                          Name: ACAD11 protein
                                                                          Reactions:
                                                                            Gene Name: ACAD11
                                                                            Uniprot ID: Q08AE9 Link_out
                                                                            Protein Sequence: FASTA
                                                                            Gene Sequence: FASTA
                                                                            Name: Putative uncharacterized protein HADHA
                                                                            Reactions:
                                                                              Gene Name: HADHA
                                                                              Uniprot ID: Q53T69 Link_out
                                                                              Protein Sequence: FASTA
                                                                              Gene Sequence: FASTA
                                                                              Name: KIAA1996 protein
                                                                              Reactions:
                                                                                Gene Name: KIAA1996
                                                                                Uniprot ID: Q8NCM9 Link_out
                                                                                Protein Sequence: FASTA
                                                                                Gene Sequence: FASTA
                                                                                Name: Benzodiazepine receptor ligand
                                                                                Reactions:
                                                                                  Gene Name: BRL
                                                                                  Uniprot ID: Q71U42 Link_out
                                                                                  Protein Sequence: FASTA
                                                                                  Gene Sequence: FASTA
                                                                                  Name: Putative uncharacterized protein HADHA
                                                                                  Reactions:
                                                                                    Gene Name: HADHA
                                                                                    Uniprot ID: Q53TA2 Link_out
                                                                                    Protein Sequence: FASTA
                                                                                    Gene Sequence: FASTA
                                                                                    Name: Acyl-CoA-binding domain-containing protein 6
                                                                                    Reactions:
                                                                                      Gene Name: ACBD6
                                                                                      Uniprot ID: Q9BR61 Link_out
                                                                                      Protein Sequence: FASTA
                                                                                      Gene Sequence: FASTA
                                                                                      Name: PECI protein
                                                                                      Reactions:
                                                                                        Gene Name: PECI
                                                                                        Uniprot ID: Q6IBN4 Link_out
                                                                                        Protein Sequence: FASTA
                                                                                        Gene Sequence: FASTA
                                                                                        Name: Acyl-Coenzyme A binding domain containing 5
                                                                                        Reactions:
                                                                                          Gene Name: ACBD5
                                                                                          Uniprot ID: Q5T8E0 Link_out
                                                                                          Protein Sequence: FASTA
                                                                                          Gene Sequence: FASTA
                                                                                          Name: Acyl-CoA-binding domain-containing protein 7
                                                                                          Reactions:
                                                                                            Gene Name: ACBD7
                                                                                            Uniprot ID: Q8N6N7 Link_out
                                                                                            Protein Sequence: FASTA
                                                                                            Gene Sequence: FASTA
                                                                                            Name: Fatty acid-binding protein, intestinal
                                                                                            Reactions:
                                                                                              Gene Name: FABP2
                                                                                              Uniprot ID: P12104 Link_out
                                                                                              Protein Sequence: FASTA
                                                                                              Gene Sequence: FASTA
                                                                                              Name: Circadian locomoter output cycles protein kaput
                                                                                              Reactions:
                                                                                              • acetyl-CoA + histone = CoA + acetylhistone
                                                                                              Gene Name: CLOCK
                                                                                              Uniprot ID: O15516 Link_out
                                                                                              Protein Sequence: FASTA
                                                                                              Gene Sequence: FASTA
                                                                                              Name: Histone acetyltransferase MYST2
                                                                                              Reactions:
                                                                                              • acetyl-CoA + histone = CoA + acetylhistone
                                                                                              Gene Name: MYST2
                                                                                              Uniprot ID: O95251 Link_out
                                                                                              Protein Sequence: FASTA
                                                                                              Gene Sequence: FASTA
                                                                                              Transporters
                                                                                              Name: Long-chain fatty acid transport protein 1
                                                                                              Reactions:
                                                                                              • --- []
                                                                                              Gene Name: SLC27A1
                                                                                              Uniprot ID: Q6PCB7 Link_out
                                                                                              Protein Sequence: FASTA
                                                                                              Gene Sequence: FASTA