Human Metabolome Database Version 3.5

Showing metabocard for Acetyl-CoA (HMDB01206)

Record Information
Version 3.5
Creation Date 2005-11-16 08:48:42 -0700
Update Date 2013-02-08 17:10:06 -0700
HMDB ID HMDB01206
Secondary Accession Numbers None
Metabolite Identification
Common Name Acetyl-CoA
Description The main function of coenzyme A is to carry acyl groups (such as the acetyl group) or thioesters. Acetyl-CoA is an important molecule itself. It is the precursor to HMG CoA, which is a vital component in cholesterol and ketone synthesis. (wikipedia). acetyl CoA participates in the biosynthesis of fatty acids and sterols, in the oxidation of fatty acids and in the metabolism of many amino acids. It also acts as a biological acetylating agent.
Structure Thumb
Download: MOL | SDF | PDB | SMILES | InChI
Display: 2D Structure | 3D Structure
Synonyms
  1. Ac-CoA
  2. Ac-Coenzyme A
  3. Ac-S-CoA
  4. Ac-S-Coenzyme A
  5. Acetyl coenzyme-A
  6. Acetyl-CoA
  7. Acetyl-Coenzyme A
  8. Acetyl-S-CoA
  9. Acetyl-S-Coenzyme A
  10. Acetylcoenzyme-A
  11. S-Acetate CoA
  12. S-Acetate Coenzyme A
  13. S-Acetyl coenzyme A
Chemical Formula C23H38N7O17P3S
Average Molecular Weight 809.571
Monoisotopic Molecular Weight 809.125773051
IUPAC Name {[(2R,3S,4R,5R)-2-({[({[(3R)-3-[(2-{[2-(acetylsulfanyl)ethyl]carbamoyl}ethyl)carbamoyl]-3-hydroxy-2,2-dimethylpropoxy](hydroxy)phosphoryl}oxy)(hydroxy)phosphoryl]oxy}methyl)-5-(6-amino-9H-purin-9-yl)-4-hydroxyoxolan-3-yl]oxy}phosphonic acid
Traditional IUPAC Name [(2R,3S,4R,5R)-2-[({[(3R)-3-[(2-{[2-(acetylsulfanyl)ethyl]carbamoyl}ethyl)carbamoyl]-3-hydroxy-2,2-dimethylpropoxy(hydroxy)phosphoryl]oxy(hydroxy)phosphoryl}oxy)methyl]-5-(6-aminopurin-9-yl)-4-hydroxyoxolan-3-yl]oxyphosphonic acid
CAS Registry Number 72-89-9
SMILES CC(=O)SCCNC(=O)CCNC(=O)[C@H](O)C(C)(C)COP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP(O)(O)=O)N1C=NC2=C1N=CN=C2N
InChI Identifier InChI=1S/C23H38N7O17P3S/c1-12(31)51-7-6-25-14(32)4-5-26-21(35)18(34)23(2,3)9-44-50(41,42)47-49(39,40)43-8-13-17(46-48(36,37)38)16(33)22(45-13)30-11-29-15-19(24)27-10-28-20(15)30/h10-11,13,16-18,22,33-34H,4-9H2,1-3H3,(H,25,32)(H,26,35)(H,39,40)(H,41,42)(H2,24,27,28)(H2,36,37,38)/t13-,16-,17-,18+,22-/m1/s1
InChI Key ZSLZBFCDCINBPY-ZSJPKINUSA-N
Chemical Taxonomy
Kingdom Organic Compounds
Super Class Lipids
Class Fatty Acid Esters
Sub Class Acyl CoAs
Other Descriptors
  • Aromatic Heteropolycyclic Compounds
  • acyl-CoA(ChEBI)
Substituents
  • 1 Phosphoribosyl Imidazole
  • Aminopyrimidine
  • Carboxamide Group
  • Carboxylic Thioester
  • Coenzyme A
  • Glycosyl Compound
  • Imidazole
  • Imidazopyrimidine
  • Monosaccharide Phosphate
  • N Glycosyl Compound
  • Organic Hypophosphite
  • Organic Phosphite
  • Organic Pyrophosphate
  • Oxolane
  • Pentose Monosaccharide
  • Phosphoric Acid Ester
  • Purine
  • Purine Ribonucleoside 3',5' Bisphosphate
  • Pyrimidine
  • Saccharide
  • Secondary Alcohol
  • Secondary Carboxylic Acid Amide
  • Thiocarboxylic Acid Ester
Direct Parent Acyl CoAs
Ontology
Status Expected and Not Quantified
Origin
  • Endogenous
  • Food
Biofunction
  • Cell signaling
  • Component of Alanine and aspartate metabolism
  • Component of Aminosugars metabolism
  • Component of Arginine and proline metabolism
  • Component of Bile acid biosynthesis
  • Component of Butanoate metabolism
  • Component of Fatty acid metabolism
  • Component of Glutamate metabolism
  • Component of Glycerophospholipid metabolism
  • Component of Glycine, serine and threonine metabolism
  • Component of Glyoxylate and dicarboxylate metabolism
  • Component of Propanoate metabolism
  • Component of Pyruvate metabolism
  • Component of Tetracycline biosynthesis
  • Component of Tryptophan metabolism
  • Component of beta-Alanine metabolism
  • Fuel and energy storage
  • Fuel or energy source
  • Membrane integrity/stability
Application
  • Nutrients
  • Stabilizers
  • Surfactants and Emulsifiers
Cellular locations
  • Cytoplasm
  • Extracellular
  • Membrane
  • Mitochondria
  • Nucleus
  • Endoplasmic reticulum
  • Golgi apparatus
  • Peroxisome
Physical Properties
State Solid
Experimental Properties
Property Value Reference
Melting Point Not Available Not Available
Boiling Point Not Available Not Available
Water Solubility Not Available Not Available
LogP Not Available Not Available
Predicted Properties
Property Value Source
Water Solubility 4.3 g/L ALOGPS
LogP -0.58 ALOGPS
LogP -7 ChemAxon
LogS -2.27 ALOGPS
pKa (strongest acidic) 0.83 ChemAxon
pKa (strongest basic) 4.95 ChemAxon
Hydrogen Acceptor Count 17 ChemAxon
Hydrogen Donor Count 9 ChemAxon
Polar Surface Area 363.63 A2 ChemAxon
Rotatable Bond Count 20 ChemAxon
Refractivity 172.21 ChemAxon
Polarizability 71.4 ChemAxon
Formal Charge 0 ChemAxon
Physiological Charge -4 ChemAxon
Spectra
Not Available
Biological Properties
Cellular Locations
  • Cytoplasm
  • Extracellular
  • Membrane
  • Mitochondria
  • Nucleus
  • Endoplasmic reticulum
  • Golgi apparatus
  • Peroxisome
Biofluid Locations Not Available
Tissue Location
  • Muscle
  • Skeletal Muscle
  • Brain
  • Prostate
  • Adipose Tissue
  • Platelet
  • Spleen
Pathways
Name SMPDB Link KEGG Link
Butyrate Metabolism SMP00073 map00650 Link_out
Fatty acid Metabolism SMP00051 map00071 Link_out
Valine, Leucine and Isoleucine Degradation SMP00032 map00280 Link_out
Citric Acid Cycle SMP00057 map00020 Link_out
Propanoate Metabolism SMP00016 map00640 Link_out
Steroid Biosynthesis SMP00023 map00100 Link_out
Lysine Degradation SMP00037 map00310 Link_out
Ketone Body Metabolism SMP00071 map00072 Link_out
Pyruvate Metabolism SMP00060 map00620 Link_out
Beta-Alanine Metabolism SMP00007 map00410 Link_out
Beta Oxidation of Very Long Chain Fatty Acids SMP00052 map01040 Link_out
Oxidation of Branched Chain Fatty Acids SMP00030 Not Available
Phytanic Acid Peroxisomal Oxidation SMP00450 Not Available
Ethanol Degradation SMP00449 Not Available
Fatty Acid Biosynthesis SMP00456 Not Available
Transfer of Acetyl Groups into Mitochondria SMP00466 Not Available
Amino Sugar Metabolism SMP00045 map00520 Link_out
Mitochondrial Beta-Oxidation of Short Chain Saturated Fatty Acids SMP00480 Not Available
Glycine and Serine Metabolism SMP00004 map00260 Link_out
Mitochondrial Beta-Oxidation of Medium Chain Saturated Fatty Acids SMP00481 Not Available
Mitochondrial Beta-Oxidation of Long Chain Saturated Fatty Acids SMP00482 Not Available
Normal Concentrations
Not Available
Abnormal Concentrations
Not Available
Associated Disorders and Diseases
Disease References None
Associated OMIM IDs None
DrugBank ID Not Available
DrugBank Metabolite ID Not Available
Phenol Explorer Compound ID Not Available
Phenol Explorer Metabolite ID Not Available
FoodDB ID FDB022491
KNApSAcK ID Not Available
Chemspider ID 392413 Link_out
KEGG Compound ID C00024 Link_out
BioCyc ID ACETYL-COA Link_out
BiGG ID 33558 Link_out
Wikipedia Link Acetyl-CoA Link_out
NuGOwiki Link HMDB01206 Link_out
Metagene Link HMDB01206 Link_out
METLIN ID 6082 Link_out
PubChem Compound 444493 Link_out
PDB ID ACO Link_out
ChEBI ID 15351 Link_out
References
Synthesis Reference Tucek, S. The synthesis of acetyl coenzyme A and acetylcholine from citrate and acetate in the nerve endings of mammalian brain. Biochimica et Biophysica Acta, General Subjects (1966), 117(1), 278-80.
Material Safety Data Sheet (MSDS) Not Available
General References
  1. Michno A, Skibowska A, Raszeja-Specht A, Cwikowska J, Szutowicz A: The role of adenosine triphosphate citrate lyase in the metabolism of acetyl coenzyme a and function of blood platelets in diabetes mellitus. Metabolism. 2004 Jan;53(1):66-72. Pubmed: 14681844 Link_out
  2. Al-Buheissi SZ, Patel HR, Meinl W, Hewer A, Bryan RL, Glatt H, Miller RA, Phillips DH: N-Acetyltransferase and sulfotransferase activity in human prostate: potential for carcinogen activation. Pharmacogenet Genomics. 2006 Jun;16(6):391-9. Pubmed: 16708048 Link_out
  3. Griffin MJ, Sul HS: Insulin regulation of fatty acid synthase gene transcription: roles of USF and SREBP-1c. IUBMB Life. 2004 Oct;56(10):595-600. Pubmed: 15814457 Link_out
  4. Putman CT, Spriet LL, Hultman E, Dyck DJ, Heigenhauser GJ: Skeletal muscle pyruvate dehydrogenase activity during acetate infusion in humans. Am J Physiol. 1995 May;268(5 Pt 1):E1007-17. Pubmed: 7762627 Link_out
  5. Szutowicz A, Tomaszewicz M, Jankowska A, Madziar B, Bielarczyk H: [Mechanisms of selective vulnerability of cholinergic neurons to neurotoxic stimuli] Postepy Hig Med Dosw. 1999;53(2):263-75. Pubmed: 10355292 Link_out
  6. Ingebretsen OC, Bakken AM, Farstad M: The content of coenzyme A, acetyl-CoA and long-chain acyl-CoA in human blood platelets. Clin Chim Acta. 1982 Dec 23;126(3):307-13. Pubmed: 7151284 Link_out
  7. Michno A, Raszeja-Specht A, Jankowska-Kulawy A, Pawelczyk T, Szutowicz A: Effect of L-carnitine on acetyl-CoA content and activity of blood platelets in healthy and diabetic persons. Clin Chem. 2005 Sep;51(9):1673-82. Epub 2005 Jul 14. Pubmed: 16020499 Link_out
  8. Constantin-Teodosiu D, Peirce NS, Fox J, Greenhaff PL: Muscle pyruvate availability can limit the flux, but not activation, of the pyruvate dehydrogenase complex during submaximal exercise in humans. J Physiol. 2004 Dec 1;561(Pt 2):647-55. Epub 2004 Oct 7. Pubmed: 15579544 Link_out
  9. Crystal HA, Davies P: Cortical substance P-like immunoreactivity in cases of Alzheimer's disease and senile dementia of the Alzheimer type. J Neurochem. 1982 Jun;38(6):1781-4. Pubmed: 6176686 Link_out
  10. Wysocki SJ, Wilkinson SP, Hahnel R, Wong CY, Panegyres PK: 3-Hydroxy-3-methylglutaric aciduria, combined with 3-methylglutaconic aciduria. Clin Chim Acta. 1976 Aug 2;70(3):399-406. Pubmed: 947633 Link_out
  11. Evans MK, Savasi I, Heigenhauser GJ, Spriet LL: Effects of acetate infusion and hyperoxia on muscle substrate phosphorylation after onset of moderate exercise. Am J Physiol Endocrinol Metab. 2001 Dec;281(6):E1144-50. Pubmed: 11701427 Link_out
  12. Peters SJ: Regulation of PDH activity and isoform expression: diet and exercise. Biochem Soc Trans. 2003 Dec;31(Pt 6):1274-80. Pubmed: 14641042 Link_out
  13. Roe CR, Sweetman L, Roe DS, David F, Brunengraber H: Treatment of cardiomyopathy and rhabdomyolysis in long-chain fat oxidation disorders using an anaplerotic odd-chain triglyceride. J Clin Invest. 2002 Jul;110(2):259-69. Pubmed: 12122118 Link_out
  14. Skibowska A, Raszeja-Specht A, Szutowicz A: Platelet function and acetyl-coenzyme A metabolism in type 1 diabetes mellitus. Clin Chem Lab Med. 2003 Sep;41(9):1136-43. Pubmed: 14598862 Link_out
  15. Girard J: [Contribution of free fatty acids to impairment of insulin secretion and action. mechanism of beta-cell lipotoxicity] Med Sci (Paris). 2005 Dec;21 Spec No:19-25. Pubmed: 16598900 Link_out
  16. Szutowicz A, Jankowska A, Tomaszewicz M: [Disturbances of glucose metabolism in epilepsy and other neurodegenerative diseases] Neurol Neurochir Pol. 2000;34 Suppl 8:59-66. Pubmed: 11780590 Link_out
  17. Spriet LL, MacLean DA, Dyck DJ, Hultman E, Cederblad G, Graham TE: Caffeine ingestion and muscle metabolism during prolonged exercise in humans. Am J Physiol. 1992 Jun;262(6 Pt 1):E891-8. Pubmed: 1616022 Link_out
  18. Constantin-Teodosiu D, Carlin JI, Cederblad G, Harris RC, Hultman E: Acetyl group accumulation and pyruvate dehydrogenase activity in human muscle during incremental exercise. Acta Physiol Scand. 1991 Dec;143(4):367-72. Pubmed: 1815472 Link_out
  19. Boden G, Jadali F, White J, Liang Y, Mozzoli M, Chen X, Coleman E, Smith C: Effects of fat on insulin-stimulated carbohydrate metabolism in normal men. J Clin Invest. 1991 Sep;88(3):960-6. Pubmed: 1885781 Link_out
  20. Blank ML, Smith ZL, Fitzgerald V, Snyder F: The CoA-independent transacylase in PAF biosynthesis: tissue distribution and molecular species selectivity. Biochim Biophys Acta. 1995 Feb 9;1254(3):295-301. Pubmed: 7857969 Link_out

Enzymes

Show all enzymes and transporters Important Only showing the first 50 enzymes. There are 178 enzymes in total.

Name: Hydroxymethylglutaryl-CoA lyase, mitochondrial
Reactions:
3-Hydroxy-3-methylglutaryl-CoA unknown Acetyl-CoA + Acetoacetic acid details
Gene Name: HMGCL
Uniprot ID: P35914 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: ATP-citrate synthase
Reactions:
ADP + Phosphoric acid + Acetyl-CoA + Oxalacetic acid unknown Adenosine triphosphate + Citric acid + Coenzyme A details
Adenosine triphosphate + Citric acid + Coenzyme A unknown ADP + Phosphoric acid + Acetyl-CoA + Oxalacetic acid details
Gene Name: ACLY
Uniprot ID: P53396 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Histone acetyltransferase p300
Reactions:
Acetyl-CoA + [histone] unknown Coenzyme A + acetyl-[histone] details
Gene Name: EP300
Uniprot ID: Q09472 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Pyruvate dehydrogenase E1 component subunit beta, mitochondrial
Reactions: Not Available
Gene Name: PDHB
Uniprot ID: P11177 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Acetyl-CoA acetyltransferase, cytosolic
Reactions:
Acetyl-CoA unknown Coenzyme A + Acetoacetyl-CoA details
Acetyl-CoA + Butyryl-CoA unknown Coenzyme A + 3-Oxohexanoyl-CoA details
Gene Name: ACAT2
Uniprot ID: Q9BWD1 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: CREB-binding protein
Reactions:
Acetyl-CoA + [histone] unknown Coenzyme A + acetyl-[histone] details
Gene Name: CREBBP
Uniprot ID: Q92793 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Diamine acetyltransferase 2
Reactions:
Acetyl-CoA + an alkane-alpha,omega-diamine unknown Coenzyme A + an N-acetyldiamine details
Acetyl-CoA + Putrescine unknown Coenzyme A + N-Acetylputrescine details
Gene Name: SAT2
Uniprot ID: Q96F10 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Malonyl-CoA decarboxylase, mitochondrial
Reactions:
Malonyl-CoA unknown Acetyl-CoA + CO(2) details
Malonyl-CoA unknown Acetyl-CoA + Carbon dioxide details
Gene Name: MLYCD
Uniprot ID: O95822 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Acetyl-CoA carboxylase 2
Reactions:
Adenosine triphosphate + Acetyl-CoA + Carbonic acid unknown ADP + Phosphoric acid + Malonyl-CoA details
Acetyl-CoA + Carboxybiotin-carboxyl-carrier protein unknown Malonyl-CoA + Holo-[carboxylase] details
Gene Name: ACACB
Uniprot ID: O00763 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Pyruvate carboxylase, mitochondrial
Reactions: Not Available
Gene Name: PC
Uniprot ID: P11498 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Arylamine N-acetyltransferase 1
Reactions:
Acetyl-CoA + an arylamine unknown Coenzyme A + an N-acetylarylamine details
2,4-Diamino-6-nitrotoluene + Acetyl-CoA unknown 4-Acetamido-2-amino-6-nitrotoluene + Coenzyme A details
Acetyl-CoA + Isoniazid unknown Coenzyme A + Acetylisoniazid details
Acetyl-CoA + Acetylhydrazine unknown Coenzyme A + N,N'-Diacetylhydrazine details
Gene Name: NAT1
Uniprot ID: P18440 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Arylamine N-acetyltransferase 2
Reactions:
Acetyl-CoA + an arylamine unknown Coenzyme A + an N-acetylarylamine details
2,4-Diamino-6-nitrotoluene + Acetyl-CoA unknown 4-Acetamido-2-amino-6-nitrotoluene + Coenzyme A details
Acetyl-CoA + Isoniazid unknown Coenzyme A + Acetylisoniazid details
Acetyl-CoA + Acetylhydrazine unknown Coenzyme A + N,N'-Diacetylhydrazine details
Gene Name: NAT2
Uniprot ID: P11245 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: 5-aminolevulinate synthase, nonspecific, mitochondrial
Reactions: Not Available
Gene Name: ALAS1
Uniprot ID: P13196 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: General transcription factor 3C polypeptide 4
Reactions:
Acetyl-CoA + [histone] unknown Coenzyme A + acetyl-[histone] details
Gene Name: GTF3C4
Uniprot ID: Q9UKN8 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Acyl-coenzyme A thioesterase 12
Reactions:
Acetyl-CoA + Water unknown Coenzyme A + Acetic acid details
Gene Name: ACOT12
Uniprot ID: Q8WYK0 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Choline O-acetyltransferase
Reactions:
Acetyl-CoA + Choline unknown Coenzyme A + Acetylcholine details
Gene Name: CHAT
Uniprot ID: P28329 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Nuclear receptor coactivator 3
Reactions:
Acetyl-CoA + [histone] unknown Coenzyme A + acetyl-[histone] details
Gene Name: NCOA3
Uniprot ID: Q9Y6Q9 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Histone acetyltransferase KAT2B
Reactions:
Acetyl-CoA + [histone] unknown Coenzyme A + acetyl-[histone] details
Gene Name: KAT2B
Uniprot ID: Q92831 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Carnitine O-acetyltransferase
Reactions:
Acetyl-CoA + L-Carnitine unknown Coenzyme A + L-Acetylcarnitine details
Gene Name: CRAT
Uniprot ID: P43155 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Diamine acetyltransferase 1
Reactions:
Acetyl-CoA + an alkane-alpha,omega-diamine unknown Coenzyme A + an N-acetyldiamine details
Acetyl-CoA + Putrescine unknown Coenzyme A + N-Acetylputrescine details
Gene Name: SAT1
Uniprot ID: P21673 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Serotonin N-acetyltransferase
Reactions:
Acetyl-CoA + a 2-arylethylamine unknown Coenzyme A + an N-acetyl-2-arylethylamine details
Acetyl-CoA + Serotonin unknown Coenzyme A + N-Acetylserotonin details
Gene Name: AANAT
Uniprot ID: Q16613 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: 3-ketoacyl-CoA thiolase, mitochondrial
Reactions:
Acyl-CoA + Acetyl-CoA unknown Coenzyme A + 3-oxoacyl-CoA details
Acyl-CoA + Acetyl-CoA unknown Coenzyme A + 3-Oxoacyl-CoA details
Succinyl-CoA + Acetyl-CoA unknown Coenzyme A + 3-Oxoadipyl-CoA details
Propionyl-CoA + Acetyl-CoA unknown Coenzyme A + 2-Methylacetoacetyl-CoA details
Acetyl-CoA + Butyryl-CoA unknown Coenzyme A + 3-Oxohexanoyl-CoA details
Octanoyl-CoA + Acetyl-CoA unknown Coenzyme A + 3-Oxodecanoyl-CoA details
Lauroyl-CoA + Acetyl-CoA unknown Coenzyme A + 3-Oxotetradecanoyl-CoA details
Tetradecanoyl-CoA + Acetyl-CoA unknown Coenzyme A + 3-Oxohexadecanoyl-CoA details
Decanoyl-CoA (n-C10:0CoA) + Acetyl-CoA unknown Coenzyme A + 3-Oxododecanoyl-CoA details
Hexanoyl-CoA + Acetyl-CoA unknown Coenzyme A + 3-Oxooctanoyl-CoA details
Gene Name: ACAA2
Uniprot ID: P42765 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Testis-specific chromodomain protein Y 1
Reactions:
Acetyl-CoA + [histone] unknown Coenzyme A + acetyl-[histone] details
Gene Name: CDY1
Uniprot ID: Q9Y6F8 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Fatty acid synthase
Reactions:
Acetyl-CoA + n malonyl-CoA + 2n NADPH unknown a long-chain fatty acid + (n+1) CoA + n CO(2) + 2n NADP(+) details
Acetyl-CoA + [acyl-carrier-protein] unknown Coenzyme A + acetyl-[acyl-carrier-protein] details
Acetyl-CoA + Acyl-carrier protein unknown Coenzyme A + Acetyl-[acyl-carrier protein] details
Gene Name: FASN
Uniprot ID: P49327 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Histone acetyltransferase KAT5
Reactions:
Acetyl-CoA + [histone] unknown Coenzyme A + acetyl-[histone] details
Gene Name: KAT5
Uniprot ID: Q92993 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Acetyl-coenzyme A synthetase, cytoplasmic
Reactions:
Adenosine triphosphate + Acetic acid + Coenzyme A unknown Adenosine monophosphate + Pyrophosphate + Acetyl-CoA details
Acetyl adenylate + Coenzyme A unknown Adenosine monophosphate + Acetyl-CoA details
Gene Name: ACSS2
Uniprot ID: Q9NR19 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Acetyl-CoA acetyltransferase, mitochondrial
Reactions:
Acetyl-CoA unknown Coenzyme A + Acetoacetyl-CoA details
Acetyl-CoA + Butyryl-CoA unknown Coenzyme A + 3-Oxohexanoyl-CoA details
Gene Name: ACAT1
Uniprot ID: P24752 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Nuclear receptor coactivator 1
Reactions:
Acetyl-CoA + [histone] unknown Coenzyme A + acetyl-[histone] details
Gene Name: NCOA1
Uniprot ID: Q15788 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Hydroxymethylglutaryl-CoA synthase, mitochondrial
Reactions:
Acetyl-CoA + Water + Acetoacetyl-CoA unknown 3-Hydroxy-3-methylglutaryl-CoA + Coenzyme A details
3-Hydroxy-3-methylglutaryl-CoA + Coenzyme A unknown Acetyl-CoA + Water + Acetoacetyl-CoA details
Gene Name: HMGCS2
Uniprot ID: P54868 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Acetyl-coenzyme A synthetase 2-like, mitochondrial
Reactions:
Adenosine triphosphate + Acetic acid + Coenzyme A unknown Adenosine monophosphate + Pyrophosphate + Acetyl-CoA details
Acetyl adenylate + Coenzyme A unknown Adenosine monophosphate + Acetyl-CoA details
Gene Name: ACSS1
Uniprot ID: Q9NUB1 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Citrate synthase, mitochondrial
Reactions:
Acetyl-CoA + Water + Oxalacetic acid unknown Citric acid + Coenzyme A details
Citric acid + Coenzyme A unknown Acetyl-CoA + Water + Oxalacetic acid details
Gene Name: CS
Uniprot ID: O75390 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Testis-specific chromodomain protein Y 2
Reactions:
Acetyl-CoA + [histone] unknown Coenzyme A + acetyl-[histone] details
Gene Name: CDY2A
Uniprot ID: Q9Y6F7 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: 3-ketoacyl-CoA thiolase, peroxisomal
Reactions:
Acyl-CoA + Acetyl-CoA unknown Coenzyme A + 3-oxoacyl-CoA details
Succinyl-CoA + Acetyl-CoA unknown Coenzyme A + 3-Oxoadipyl-CoA details
Propionyl-CoA + Acetyl-CoA unknown Coenzyme A + 2-Methylacetoacetyl-CoA details
Acetyl-CoA + Butyryl-CoA unknown Coenzyme A + 3-Oxohexanoyl-CoA details
Octanoyl-CoA + Acetyl-CoA unknown Coenzyme A + 3-Oxodecanoyl-CoA details
Lauroyl-CoA + Acetyl-CoA unknown Coenzyme A + 3-Oxotetradecanoyl-CoA details
Tetradecanoyl-CoA + Acetyl-CoA unknown Coenzyme A + 3-Oxohexadecanoyl-CoA details
Decanoyl-CoA (n-C10:0CoA) + Acetyl-CoA unknown Coenzyme A + 3-Oxododecanoyl-CoA details
Hexanoyl-CoA + Acetyl-CoA unknown Coenzyme A + 3-Oxooctanoyl-CoA details
OPC6-CoA + Acetyl-CoA unknown Coenzyme A + 3-Oxo-OPC8-CoA details
OPC4-CoA + Acetyl-CoA unknown Coenzyme A + 3-Oxo-OPC6-CoA details
(+)-7-Isojasmonic acid CoA + Acetyl-CoA unknown Coenzyme A + 3-Oxo-OPC4-CoA details
Cervonyl coenzyme A + Acetyl-CoA unknown Coenzyme A + (6Z,9Z,12Z,15Z,18Z,21Z)-3-Oxotetracosahexa-6,9,12,15,18,21-enoyl-CoA details
Docosa-4,7,10,13,16-pentaenoyl CoA + Acetyl-CoA unknown Coenzyme A + (6Z,9Z,12Z,15Z,18Z)-3-Oxotetracosapenta-6,9,12,15,18-enoyl-CoA details
Gene Name: ACAA1
Uniprot ID: P09110 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial
Reactions: Not Available
Gene Name: PDHA1
Uniprot ID: P08559 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Acetyl-CoA carboxylase 1
Reactions:
Adenosine triphosphate + Acetyl-CoA + Carbonic acid unknown ADP + Phosphoric acid + Malonyl-CoA details
Acetyl-CoA + Carboxybiotin-carboxyl-carrier protein unknown Malonyl-CoA + Holo-[carboxylase] details
Gene Name: ACACA
Uniprot ID: Q13085 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Trifunctional enzyme subunit beta, mitochondrial
Reactions:
Acyl-CoA + Acetyl-CoA unknown Coenzyme A + 3-oxoacyl-CoA details
Acyl-CoA + Acetyl-CoA unknown Coenzyme A + 3-Oxoacyl-CoA details
Succinyl-CoA + Acetyl-CoA unknown Coenzyme A + 3-Oxoadipyl-CoA details
Propionyl-CoA + Acetyl-CoA unknown Coenzyme A + 2-Methylacetoacetyl-CoA details
Acetyl-CoA + Butyryl-CoA unknown Coenzyme A + 3-Oxohexanoyl-CoA details
Octanoyl-CoA + Acetyl-CoA unknown Coenzyme A + 3-Oxodecanoyl-CoA details
Lauroyl-CoA + Acetyl-CoA unknown Coenzyme A + 3-Oxotetradecanoyl-CoA details
Tetradecanoyl-CoA + Acetyl-CoA unknown Coenzyme A + 3-Oxohexadecanoyl-CoA details
Decanoyl-CoA (n-C10:0CoA) + Acetyl-CoA unknown Coenzyme A + 3-Oxododecanoyl-CoA details
Hexanoyl-CoA + Acetyl-CoA unknown Coenzyme A + 3-Oxooctanoyl-CoA details
Gene Name: HADHB
Uniprot ID: P55084 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: 2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial
Reactions:
Acetyl-CoA + Glycine unknown Coenzyme A + L-2-Amino-3-oxobutanoic acid details
Acetyl-CoA + Glycine unknown Coenzyme A + L-2-Amino-3-oxobutanoic acid details
Gene Name: GCAT
Uniprot ID: O75600 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Pyruvate dehydrogenase E1 component subunit alpha, testis-specific form, mitochondrial
Reactions: Not Available
Gene Name: PDHA2
Uniprot ID: P29803 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial
Reactions:
Malonic semialdehyde + Coenzyme A + NAD(P)(+) unknown Acetyl-CoA + CO(2) + NAD(P)H details
Malonic semialdehyde + Coenzyme A + NAD unknown Acetyl-CoA + Carbon dioxide + NADH + Hydrogen Ion details
Malonic semialdehyde + Coenzyme A + NADP unknown Acetyl-CoA + Carbon dioxide + NADPH + Hydrogen Ion details
Gene Name: ALDH6A1
Uniprot ID: Q02252 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Glucosamine 6-phosphate N-acetyltransferase
Reactions:
Acetyl-CoA + Glucosamine 6-phosphate unknown Coenzyme A + N-Acetyl-D-Glucosamine 6-Phosphate details
Gene Name: GNPNAT1
Uniprot ID: Q96EK6 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Hydroxymethylglutaryl-CoA synthase, cytoplasmic
Reactions:
Acetyl-CoA + Water + Acetoacetyl-CoA unknown 3-Hydroxy-3-methylglutaryl-CoA + Coenzyme A details
3-Hydroxy-3-methylglutaryl-CoA + Coenzyme A unknown Acetyl-CoA + Water + Acetoacetyl-CoA details
Gene Name: HMGCS1
Uniprot ID: Q01581 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Dihydrolipoyl dehydrogenase, mitochondrial
Reactions: Not Available
Gene Name: DLD
Uniprot ID: P09622 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial
Reactions:
Acetyl-CoA + enzyme N(6)-(dihydrolipoyl)lysine unknown Coenzyme A + enzyme N(6)-(S-acetyldihydrolipoyl)lysine details
Acetyl-CoA + Enzyme N6-(dihydrolipoyl)lysine unknown Coenzyme A + [Dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine details
Gene Name: DLAT
Uniprot ID: P10515 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Long-chain specific acyl-CoA dehydrogenase, mitochondrial
Reactions: Not Available
Gene Name: ACADL
Uniprot ID: P28330 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Short-chain specific acyl-CoA dehydrogenase, mitochondrial
Reactions: Not Available
Gene Name: ACADS
Uniprot ID: P16219 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Medium-chain specific acyl-CoA dehydrogenase, mitochondrial
Reactions: Not Available
Gene Name: ACADM
Uniprot ID: P11310 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Peroxisomal acyl-coenzyme A oxidase 1
Reactions: Not Available
Gene Name: ACOX1
Uniprot ID: Q15067 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Peroxisomal acyl-coenzyme A oxidase 2
Reactions: Not Available
Gene Name: ACOX2
Uniprot ID: Q99424 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Isovaleryl-CoA dehydrogenase, mitochondrial
Reactions: Not Available
Gene Name: IVD
Uniprot ID: P26440 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Name: Peroxisomal acyl-coenzyme A oxidase 3
Reactions: Not Available
Gene Name: ACOX3
Uniprot ID: O15254 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
Transporters
Name: Long-chain fatty acid transport protein 1
Reactions: Not Available
Gene Name: SLC27A1
Uniprot ID: Q6PCB7 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA