Human Metabolome Database Version 3.5

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Showing metabocard for Manganese (HMDB01333)

enzymes (194)

Blood
Urine

Record Information

Version

3.5

Creation Date

2006-08-16 07:22:34 -0600

Update Date

2013-02-08 11:20:51 -0700

HMDB ID

HMDB01333

Secondary Accession Numbers

None

Metabolite Identification

Common Name

Manganese

Description

Manganese is an essential trace nutrient in all forms of life. Physiologically, it. exists as an ion in the body. It is concentrated in cell mitochondria, mostly in the pituitary gland, liver, pancreas, kidney, and bone, influences the synthesis of mucopolysaccharides, stimulates hepatic synthesis of cholesterol and fatty acids, and is a cofactor in many enzymes, including arginase and alkaline phosphatase in the liver.

Structure

Download: MOL | SDF | SMILES | InChI
Display: 2D Structure | 3D Structure

Synonyms

Manganese

Chemical Formula

Average Molecular Weight

54.938045

Monoisotopic Molecular Weight

54.938049636

IUPAC Name

manganese(2+) ion

Traditional IUPAC Name

manganese(II)

CAS Registry Number

7439-96-5

SMILES

[Mn++]

InChI Identifier

InChI=1S/Mn/q+2

InChI Key

WAEMQWOKJMHJLA-UHFFFAOYSA-N

Chemical Taxonomy

Kingdom

Inorganic Compounds

Super Class

Homogeneous Metal Compounds

Class

Homogeneous Transition Metal Compounds

Sub Class

N/A

Other Descriptors

a cation(Cyc)
divalent metal cation(ChEBI)
manganese cation(ChEBI)
monoatomic dication(ChEBI)

Substituents

Direct Parent

Homogeneous Transition Metal Compounds

Ontology

Status

Detected and Quantified

Origin

Food

Toxin/Pollutant

Biofunction

Enzyme co-factor
Essential minerals

Application

Not Available

Cellular locations

Not Available

Physical Properties

State

Solid

Experimental Properties

Property	Value	Reference
Melting Point	1244 °C	Not Available
Boiling Point	Not Available	Not Available
Water Solubility	Not Available	Not Available
LogP	Not Available	Not Available

Predicted Properties

Property	Value	Source
LogP	-0.16	ChemAxon
Hydrogen Acceptor Count	0	ChemAxon
Hydrogen Donor Count	0	ChemAxon
Polar Surface Area	0 A²	ChemAxon
Rotatable Bond Count	0	ChemAxon
Refractivity	0	ChemAxon
Polarizability	1.78	ChemAxon
Formal Charge	2	ChemAxon
Physiological Charge	2	ChemAxon

Spectra

Not Available

Biological Properties

Cellular Locations

Not Available

Biofluid Locations

Blood
Cerebrospinal Fluid (CSF)
Urine

Tissue Location

Liver
Brain
Basal Ganglia
Central Nervous System
Hair

Pathways

Not Available

Normal Concentrations

Biofluid	Status	Value	Age	Sex	Condition	Comments
Blood	Detected and Quantified	0.18858(0.18020-0.19659) uM	Not Available	Both	Normal	Not Available
Blood	Detected and Quantified	0.17292(0.16382-0.18202) uM	Adult (>18 years old)	Both	Normal	Not Available
Blood	Detected and Quantified	0.012 +/- 0.0044 uM	Elderly (>65 years old)	Both	Normal	Not Available
Blood	Detected and Quantified	0.01 (0.007 - 0.019) uM	Adult (>18 years old)	Both	Normal	Not Available
Cerebrospinal Fluid (CSF)	Detected and Quantified	0.0218 +/- 0.0309 uM	Elderly (>65 years old)	Both	Normal	Not Available
Cerebrospinal Fluid (CSF)	Detected and Quantified	0.149 +/- 0.177 uM	Adult (>18 years old)	Not Specified	Normal	Not Available
Cerebrospinal Fluid (CSF)	Detected and Quantified	0.021 (0.015 - 0.027) uM	Adult (>18 years old)	Both	Normal	Not Available
Urine	Detected and Quantified	0.00058(0.00023-0.00101) umol/mmol creatinine	Not Available	Both	Normal	Not Available
Urine	Detected and Quantified	0.00043(0.00029-0.00056) umol/mmol creatinine	Adult (>18 years old)	Both	Normal	Not Available
Urine	Detected and Quantified	0.013(0.002-0.051) umol/mmol creatinine	Adult (>18 years old)	Both	Normal	by ICP MS
Urine	Detected and Quantified	0.011 (0.0-0.023) umol/mmol creatinine	Adult (>18 years old)	Male	Normal	Not Available

Abnormal Concentrations

Biofluid	Status	Value	Age	Sex	Condition	Comments
Blood	Detected and Quantified	0.15 +/- .072 uM	Adult (>18 years old)	Both	Multiple sclerosis	Not Available
Blood	Detected and Quantified	0.012 +/- 0.0044 uM	Adult (>18 years old)	Both	Parkinson's disease	Not Available
Blood	Detected and Quantified	0.011 +/- 0 .004 uM	Elderly (>65 years old)	Both	Alzheimer's disease	Not Available
Cerebrospinal Fluid (CSF)	Detected and Quantified	0.0346 +/- 0.0182 uM	Adult (>18 years old)	Not Specified	control	Not Available
Cerebrospinal Fluid (CSF)	Detected and Quantified	0.0400 +/- 0.0273 uM	Adult (>18 years old)	Not Specified	amyotrophic lateral sclerosis	Not Available
Cerebrospinal Fluid (CSF)	Detected and Quantified	0.0400 +/- 0.0255 uM	Adult (>18 years old)	Not Specified	amyotrophic lateral sclerosis (classic)	Not Available
Cerebrospinal Fluid (CSF)	Detected and Quantified	0.0419 +/- 0.0291 uM	Adult (>18 years old)	Not Specified	amyotrophic lateral sclerosis (bulbar)	Not Available
Cerebrospinal Fluid (CSF)	Detected and Quantified	0.0328 +/- 0.0164 uM	Adult (>18 years old)	Not Specified	Alzheimer's disease	Not Available
Cerebrospinal Fluid (CSF)	Detected and Quantified	0.0218 +/- 0.00546 uM	Adult (>18 years old)	Not Specified	Alzheimer's disease (early-onset)	Not Available
Cerebrospinal Fluid (CSF)	Detected and Quantified	0.0382 +/- 0.0182 uM	Adult (>18 years old)	Not Specified	Alzheimer's disease (late-onset)	Not Available
Cerebrospinal Fluid (CSF)	Detected and Quantified	0.0546 +/- 0.0382 uM	Adult (>18 years old)	Not Specified	Parkinson's disease	Not Available
Cerebrospinal Fluid (CSF)	Detected and Quantified	0.0146 +/- 0.0146 uM	Elderly (>65 years old)	Both	Alzheimer's disease	Not Available
Cerebrospinal Fluid (CSF)	Detected and Quantified	14.6 +/- 13.7 uM	Elderly (>65 years old)	Not Specified	Alzheimer's disease	Not Available

Associated Disorders and Diseases

Disease References

Alzheimer's disease
Molina JA, Jimenez-Jimenez FJ, Aguilar MV, Meseguer I, Mateos-Vega CJ, Gonzalez-Munoz MJ, de Bustos F, Porta J, Orti-Pareja M, Zurdo M, Barrios E, Martinez-Para MC: Cerebrospinal fluid levels of transition metals in patients with Alzheimer's disease. J Neural Transm. 1998;105(4-5):479-88. Pubmed: 9720975 Bocca B, Forte G, Petrucci F, Pino A, Marchione F, Bomboi G, Senofonte O, Giubilei F, Alimonti A: Monitoring of chemical elements and oxidative damage in patients affected by Alzheimer's disease. Ann Ist Super Sanita. 2005;41(2):197-203. Pubmed: 16244393
Multiple sclerosis
Forte G, Visconti A, Santucci S, Ghazaryan A, Figa-Talamanca L, Cannoni S, Bocca B, Pino A, Violante N, Alimonti A, Salvetti M, Ristori G: Quantification of chemical elements in blood of patients affected by multiple sclerosis. Ann Ist Super Sanita. 2005;41(2):213-6. Pubmed: 16244395
Parkinson's disease
Forte G, Alimonti A, Pino A, Stanzione P, Brescianini S, Brusa L, Sancesario G, Violante N, Bocca B: Metals and oxidative stress in patients with Parkinson's disease. Ann Ist Super Sanita. 2005;41(2):189-95. Pubmed: 16244392

Associated OMIM IDs

104300 (Alzheimer's disease)
126200 (Multiple sclerosis)
168600 (Parkinson's disease)

External Links

DrugBank ID

Not Available

Phenol Explorer Compound ID

Not Available

Phenol Explorer Metabolite ID

Not Available

FoodDB ID

FDB003636

KNApSAcK ID

Not Available

Chemspider ID

25916

KEGG Compound ID

C19610

BioCyc ID

MN%2b3

BiGG ID

Not Available

Wikipedia Link

Manganese

NuGOwiki Link

HMDB01333

Metagene Link

HMDB01333

METLIN ID

Not Available

PubChem Compound

27854

PDB ID

ChEBI ID

29035

References

Synthesis Reference

Not Available

Material Safety Data Sheet (MSDS)

Download (PDF)

General References

Ikeda S, Sera Y, Yoshida M, Ohshiro H, Uchino S, Oka Y, Lee KJ, Kotera A: Manganese deposits in patients with biliary atresia after hepatic porto-enterostomy. J Pediatr Surg. 2000 Mar;35(3):450-3. Pubmed: 10726687
Greger JL: Nutrition versus toxicology of manganese in humans: evaluation of potential biomarkers. Neurotoxicology. 1999 Apr-Jun;20(2-3):205-12. Pubmed: 10385884
Lander F, Kristiansen J, Lauritsen JM: Manganese exposure in foundry furnacemen and scrap recycling workers. Int Arch Occup Environ Health. 1999 Nov;72(8):546-50. Pubmed: 10592008
Mizoguchi N, Nishimura Y, Ono H, Sakura N: Manganese elevations in blood of children with congenital portosystemic shunts. Eur J Pediatr. 2001 Apr;160(4):247-50. Pubmed: 11317649
Woolf A, Wright R, Amarasiriwardena C, Bellinger D: A child with chronic manganese exposure from drinking water. Environ Health Perspect. 2002 Jun;110(6):613-6. Pubmed: 12055054
Ikeda S, Yamaguchi Y, Sera Y, Ohshiro H, Uchino S, Yamashita Y, Ogawa M: Manganese deposition in the globus pallidus in patients with biliary atresia. Transplantation. 2000 Jun 15;69(11):2339-43. Pubmed: 10868637
Wardle CA, Forbes A, Roberts NB, Jawhari AV, Shenkin A: Hypermanganesemia in long-term intravenous nutrition and chronic liver disease. JPEN J Parenter Enteral Nutr. 1999 Nov-Dec;23(6):350-5. Pubmed: 10574484
Mergler D, Baldwin M, Belanger S, Larribe F, Beuter A, Bowler R, Panisset M, Edwards R, de Geoffroy A, Sassine MP, Hudnell K: Manganese neurotoxicity, a continuum of dysfunction: results from a community based study. Neurotoxicology. 1999 Apr-Jun;20(2-3):327-42. Pubmed: 10385894
Butterworth RF: Hepatic encephalopathy. Alcohol Res Health. 2003;27(3):240-6. Pubmed: 15535452
Herynek V, Babis M, Trunecka P, Filip K, Vymazal J, Dezortova M, Hajek M: Chronic liver disease: relaxometry in the brain after liver transplantation. MAGMA. 2001 Mar;12(1):10-5. Pubmed: 11255087
Miranda M, Caballero L: [Chronic hepatic encephalopathy: the role of high serum manganese levels and its relation with basal ganglia lesions in nuclear magnetic resonance of the brain. Clinical case] Rev Med Chil. 2001 Sep;129(9):1051-5. Pubmed: 11725469
Barceloux DG: Manganese. J Toxicol Clin Toxicol. 1999;37(2):293-307. Pubmed: 10382563
Bader M, Dietz MC, Ihrig A, Triebig G: Biomonitoring of manganese in blood, urine and axillary hair following low-dose exposure during the manufacture of dry cell batteries. Int Arch Occup Environ Health. 1999 Nov;72(8):521-7. Pubmed: 10592004
Kao HJ, Chen WH, Liu JS: Rapid progression of parkinsonism associated with an increase of blood manganese. Kaohsiung J Med Sci. 1999 May;15(5):297-301. Pubmed: 10375873
Melo TM, Larsen C, White LR, Aasly J, Sjobakk TE, Flaten TP, Sonnewald U, Syversen T: Manganese, copper, and zinc in cerebrospinal fluid from patients with multiple sclerosis. Biol Trace Elem Res. 2003 Summer;93(1-3):1-8. Pubmed: 12835484
Lees-Haley PR, Rohling ML, Langhinrichsen-Rohling J: A meta-analysis of the neuropsychological effects of occupational exposure to manganese. Clin Neuropsychol. 2006 Feb;20(1):90-107. Pubmed: 16393922
Sadek AH, Rauch R, Schulz PE: Parkinsonism due to manganism in a welder. Int J Toxicol. 2003 Sep-Oct;22(5):393-401. Pubmed: 14555414
Wang X, Li GJ, Zheng W: Upregulation of DMT1 expression in choroidal epithelia of the blood-CSF barrier following manganese exposure in vitro. Brain Res. 2006 Jun 30;1097(1):1-10. Epub 2006 May 26. Pubmed: 16729984
Takeda A: Manganese action in brain function. Brain Res Brain Res Rev. 2003 Jan;41(1):79-87. Pubmed: 12505649
Baldwin M, Mergler D, Larribe F, Belanger S, Tardif R, Bilodeau L, Hudnell K: Bioindicator and exposure data for a population based study of manganese. Neurotoxicology. 1999 Apr-Jun;20(2-3):343-53. Pubmed: 10385895

Enzymes

Name:	Acetyl-CoA carboxylase 2
Reactions:	ATP + acetyl-CoA + HCO3- = ADP + phosphate + malonyl-CoA [RN:R00742]
Gene Name:	ACACB
Uniprot ID:	O00763
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Pyruvate carboxylase, mitochondrial
Reactions:	ATP + pyruvate + HCO3- = ADP + phosphate + oxaloacetate [RN:R00344]
Gene Name:	PC
Uniprot ID:	P11498
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Acetyl-CoA carboxylase 1
Reactions:	ATP + acetyl-CoA + HCO3- = ADP + phosphate + malonyl-CoA [RN:R00742]
Gene Name:	ACACA
Uniprot ID:	Q13085
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Arginase-1
Reactions:	L-arginine + H2O = L-ornithine + urea [RN:R00551]
Gene Name:	ARG1
Uniprot ID:	P05089
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Beta-1,4-galactosyltransferase 2
Reactions:	UDP-galactose + N-acetyl-D-glucosamine = UDP + N-acetyllactosamine [RN:R01205 R06055]
Gene Name:	B4GALT2
Uniprot ID:	O60909
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Beta-1,4-galactosyltransferase 1
Reactions:	UDP-galactose + N-acetyl-D-glucosamine = UDP + N-acetyllactosamine [RN:R01205 R06055]
Gene Name:	B4GALT1
Uniprot ID:	P15291
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Globoside alpha-1,3-N-acetylgalactosaminyltransferase 1
Reactions:
Gene Name:	GBGT1
Uniprot ID:	Q8N5D6
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Aminopeptidase N
Reactions:	Release of an N-terminal amino acid, Xaa!Yaa- from a peptide, amide or arylamide. Xaa is preferably Ala, but may be most amino acids including Pro (slow action). When a terminal hydrophobic residue is followed by a prolyl residue, the two may be released as an intact Xaa-Pro dipeptide ALL_REAC (other) R00899 R04951 COFACTOR Manganese [CPD:C00034] Zinc [CPD:C00038]
Gene Name:	ANPEP
Uniprot ID:	P15144
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A
Reactions:	nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate [RN:R03259]
Gene Name:	PDE8A
Uniprot ID:	O60658
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Bis(5'-adenosyl)-triphosphatase
Reactions:	P1,P3-bis(5'-adenosyl) triphosphate + H2O = ADP + AMP [RN:R00187]
Gene Name:	FHIT
Uniprot ID:	P49789
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A
Reactions:	guanosine 3',5'-cyclic phosphate + H2O = guanosine 5'-phosphate [RN:R01234]
Gene Name:	PDE9A
Uniprot ID:	O76083
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	cAMP-specific 3',5'-cyclic phosphodiesterase 4D
Reactions:	nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate [RN:R03259]
Gene Name:	PDE4D
Uniprot ID:	Q08499
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	ADP-ribose pyrophosphatase, mitochondrial
Reactions:	ADP-ribose + H2O = AMP + D-ribose 5-phosphate [RN:R01054]
Gene Name:	NUDT9
Uniprot ID:	Q9BW91
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	cGMP-specific 3',5'-cyclic phosphodiesterase
Reactions:	guanosine 3',5'-cyclic phosphate + H2O = guanosine 5'-phosphate [RN:R01234]
Gene Name:	PDE5A
Uniprot ID:	O76074
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	CDP-diacylglycerol--inositol 3-phosphatidyltransferase
Reactions:	CDP-diacylglycerol + myo-inositol = CMP + phosphatidyl-1D-myo-inositol [RN:R01802]
Gene Name:	CDIPT
Uniprot ID:	O14735
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	NADP-dependent malic enzyme
Reactions:	(S)-malate + NADP+ = pyruvate + CO2 + NADPH [RN:R00216]
Gene Name:	ME1
Uniprot ID:	P48163
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	NADP-dependent malic enzyme, mitochondrial
Reactions:	(S)-malate + NADP+ = pyruvate + CO2 + NADPH [RN:R00216]
Gene Name:	ME3
Uniprot ID:	Q16798
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	NAD-dependent malic enzyme, mitochondrial
Reactions:	(S)-malate + NAD+ = pyruvate + CO2 + NADH [RN:R00214]
Gene Name:	ME2
Uniprot ID:	P23368
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Cytosol aminopeptidase
Reactions:	Release of N-terminal proline from a peptide ALL_REAC (other) R00135 COFACTOR Manganese [CPD:C00034]
Gene Name:	LAP3
Uniprot ID:	P28838
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Phosphoenolpyruvate carboxykinase [GTP], mitochondrial
Reactions:	GTP + oxaloacetate = GDP + phosphoenolpyruvate + CO2 [RN:R00431]
Gene Name:	PCK2
Uniprot ID:	Q16822
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Isocitrate dehydrogenase [NADP], mitochondrial
Reactions:	(1) isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH + H+ (overall reaction) [RN:R00267] (2) (1a) isocitrate + NADP+ = oxalosuccinate + NADPH + H+ [RN:R01899] (3) (1b) oxalosuccinate = 2-oxoglutarate + CO2 [RN:R00268]
Gene Name:	IDH2
Uniprot ID:	P48735
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial
Reactions:	isocitrate + NAD+ = 2-oxoglutarate + CO2 + NADH [RN:R00709]
Gene Name:	IDH3B
Uniprot ID:	O43837
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Isocitrate dehydrogenase [NADP] cytoplasmic
Reactions:	(1) isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH + H+ (overall reaction) [RN:R00267] (2) (1a) isocitrate + NADP+ = oxalosuccinate + NADPH + H+ [RN:R01899] (3) (1b) oxalosuccinate = 2-oxoglutarate + CO2 [RN:R00268]
Gene Name:	IDH1
Uniprot ID:	O75874
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial
Reactions:	isocitrate + NAD+ = 2-oxoglutarate + CO2 + NADH [RN:R00709]
Gene Name:	IDH3A
Uniprot ID:	P50213
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial
Reactions:	isocitrate + NAD+ = 2-oxoglutarate + CO2 + NADH [RN:R00709]
Gene Name:	IDH3G
Uniprot ID:	P51553
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3
Reactions:	UDP-glucuronate + 3-beta-D-galactosyl-4-beta-D-galactosyl-O-beta-D-xylosylprotein = UDP + 3-beta-D-glucuronosyl-3-beta-D-galactosyl-4-beta-D-galactosyl-O- beta-D-xylosylprotein [RN:R04607 R05928]
Gene Name:	B3GAT3
Uniprot ID:	O94766
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 2
Reactions:	UDP-glucuronate + 3-beta-D-galactosyl-4-beta-D-galactosyl-O-beta-D-xylosylprotein = UDP + 3-beta-D-glucuronosyl-3-beta-D-galactosyl-4-beta-D-galactosyl-O- beta-D-xylosylprotein [RN:R04607 R05928]
Gene Name:	B3GAT2
Uniprot ID:	Q9NPZ5
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1
Reactions:	UDP-glucuronate + 3-beta-D-galactosyl-4-beta-D-galactosyl-O-beta-D-xylosylprotein = UDP + 3-beta-D-glucuronosyl-3-beta-D-galactosyl-4-beta-D-galactosyl-O- beta-D-xylosylprotein [RN:R04607 R05928]
Gene Name:	B3GAT1
Uniprot ID:	Q9P2W7
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Protein O-mannosyl-transferase 1
Reactions:	dolichyl phosphate D-mannose + protein = dolichyl phosphate + O-D-mannosylprotein [RN:R04072 R07620]
Gene Name:	POMT1
Uniprot ID:	Q9Y6A1
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Protein O-mannosyl-transferase 2
Reactions:	dolichyl phosphate D-mannose + protein = dolichyl phosphate + O-D-mannosylprotein [RN:R04072 R07620]
Gene Name:	POMT2
Uniprot ID:	Q9UKY4
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	DNA polymerase lambda
Reactions:	deoxynucleoside triphosphate + DNAn = diphosphate + DNAn+1 [RN:R00379]
Gene Name:	POLL
Uniprot ID:	Q9UGP5
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	DNA polymerase eta
Reactions:	deoxynucleoside triphosphate + DNAn = diphosphate + DNAn+1 [RN:R00379]
Gene Name:	POLH
Uniprot ID:	Q9Y253
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	DNA polymerase kappa
Reactions:	deoxynucleoside triphosphate + DNAn = diphosphate + DNAn+1 [RN:R00379]
Gene Name:	POLK
Uniprot ID:	Q9UBT6
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Polypeptide N-acetylgalactosaminyltransferase 11
Reactions:	UDP-N-acetyl-D-galactosamine + polypeptide = UDP + N-acetyl-D-galactosaminyl-polypeptide [RN:R02183]
Gene Name:	GALNT11
Uniprot ID:	Q8NCW6
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Polypeptide N-acetylgalactosaminyltransferase 4
Reactions:	UDP-N-acetyl-D-galactosamine + polypeptide = UDP + N-acetyl-D-galactosaminyl-polypeptide [RN:R02183]
Gene Name:	GALNT4
Uniprot ID:	Q8N4A0
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Polypeptide N-acetylgalactosaminyltransferase 3
Reactions:	UDP-N-acetyl-D-galactosamine + polypeptide = UDP + N-acetyl-D-galactosaminyl-polypeptide [RN:R02183]
Gene Name:	GALNT3
Uniprot ID:	Q14435
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Probable polypeptide N-acetylgalactosaminyltransferase 8
Reactions:	UDP-N-acetyl-D-galactosamine + polypeptide = UDP + N-acetyl-D-galactosaminyl-polypeptide [RN:R02183]
Gene Name:	GALNT8
Uniprot ID:	Q9NY28
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Polypeptide N-acetylgalactosaminyltransferase-like protein 2
Reactions:	UDP-N-acetyl-D-galactosamine + polypeptide = UDP + N-acetyl-D-galactosaminyl-polypeptide [RN:R02183]
Gene Name:	GALNTL2
Uniprot ID:	Q8N3T1
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Putative polypeptide N-acetylgalactosaminyltransferase-like protein 1
Reactions:	UDP-N-acetyl-D-galactosamine + polypeptide = UDP + N-acetyl-D-galactosaminyl-polypeptide [RN:R02183]
Gene Name:	GALNTL1
Uniprot ID:	Q8N428
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Polypeptide N-acetylgalactosaminyltransferase 10
Reactions:	UDP-N-acetyl-D-galactosamine + polypeptide = UDP + N-acetyl-D-galactosaminyl-polypeptide [RN:R02183]
Gene Name:	GALNT10
Uniprot ID:	Q86SR1
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Polypeptide N-acetylgalactosaminyltransferase 13
Reactions:	UDP-N-acetyl-D-galactosamine + polypeptide = UDP + N-acetyl-D-galactosaminyl-polypeptide [RN:R02183]
Gene Name:	GALNT13
Uniprot ID:	Q8IUC8
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Putative polypeptide N-acetylgalactosaminyltransferase-like protein 3
Reactions:	UDP-N-acetyl-D-galactosamine + polypeptide = UDP + N-acetyl-D-galactosaminyl-polypeptide [RN:R02183]
Gene Name:	WBSCR17
Uniprot ID:	Q6IS24
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Putative polypeptide N-acetylgalactosaminyltransferase-like protein 4
Reactions:	UDP-N-acetyl-D-galactosamine + polypeptide = UDP + N-acetyl-D-galactosaminyl-polypeptide [RN:R02183]
Gene Name:	GALNTL4
Uniprot ID:	Q6P9A2
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	N-acetylgalactosaminyltransferase 7
Reactions:
Gene Name:	GALNT7
Uniprot ID:	Q86SF2
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Polypeptide N-acetylgalactosaminyltransferase 6
Reactions:	UDP-N-acetyl-D-galactosamine + polypeptide = UDP + N-acetyl-D-galactosaminyl-polypeptide [RN:R02183]
Gene Name:	GALNT6
Uniprot ID:	Q8NCL4
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Polypeptide N-acetylgalactosaminyltransferase 14
Reactions:	UDP-N-acetyl-D-galactosamine + polypeptide = UDP + N-acetyl-D-galactosaminyl-polypeptide [RN:R02183]
Gene Name:	GALNT14
Uniprot ID:	Q96FL9
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Polypeptide N-acetylgalactosaminyltransferase 2
Reactions:	UDP-N-acetyl-D-galactosamine + polypeptide = UDP + N-acetyl-D-galactosaminyl-polypeptide [RN:R02183]
Gene Name:	GALNT2
Uniprot ID:	Q10471
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Polypeptide N-acetylgalactosaminyltransferase 12
Reactions:	UDP-N-acetyl-D-galactosamine + polypeptide = UDP + N-acetyl-D-galactosaminyl-polypeptide [RN:R02183]
Gene Name:	GALNT12
Uniprot ID:	Q8IXK2
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Polypeptide N-acetylgalactosaminyltransferase 1
Reactions:	UDP-N-acetyl-D-galactosamine + polypeptide = UDP + N-acetyl-D-galactosaminyl-polypeptide [RN:R02183]
Gene Name:	GALNT1
Uniprot ID:	Q10472
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Polypeptide N-acetylgalactosaminyltransferase 5
Reactions:	UDP-N-acetyl-D-galactosamine + polypeptide = UDP + N-acetyl-D-galactosaminyl-polypeptide [RN:R02183]
Gene Name:	GALNT5
Uniprot ID:	Q7Z7M9
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Cob(I)yrinic acid a,c-diamide adenosyltransferase, mitochondrial
Reactions:	(1) ATP + cob(I)yrinic acid a,c-diamide = triphosphate + adenosylcob(III)yrinic acid a,c-diamide [RN:R05220] (2) ATP + cobinamide = triphosphate + adenosylcobinamide [RN:R07268]
Gene Name:	MMAB
Uniprot ID:	Q96EY8
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Beta-1,4-galactosyltransferase 3
Reactions:	UDP-galactose + N-acetyl-D-glucosamine = UDP + N-acetyllactosamine [RN:R01205 R06055]
Gene Name:	B4GALT3
Uniprot ID:	O60512
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Beta-1,4-galactosyltransferase 4
Reactions:	UDP-galactose + N-acetyl-D-glucosamine = UDP + N-acetyllactosamine [RN:R01205 R06055]
Gene Name:	B4GALT4
Uniprot ID:	O60513
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Arginase-2, mitochondrial
Reactions:	L-arginine + H2O = L-ornithine + urea [RN:R00551]
Gene Name:	ARG2
Uniprot ID:	P78540
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Guanylate cyclase soluble subunit beta-1
Reactions:	GTP = 3',5'-cyclic GMP + diphosphate [RN:R00434]
Gene Name:	GUCY1B3
Uniprot ID:	Q02153
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Guanylate cyclase soluble subunit alpha-3
Reactions:	GTP = 3',5'-cyclic GMP + diphosphate [RN:R00434]
Gene Name:	GUCY1A3
Uniprot ID:	Q02108
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Guanylate cyclase soluble subunit alpha-2
Reactions:	GTP = 3',5'-cyclic GMP + diphosphate [RN:R00434]
Gene Name:	GUCY1A2
Uniprot ID:	P33402
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Guanylate cyclase soluble subunit beta-2
Reactions:	GTP = 3',5'-cyclic GMP + diphosphate [RN:R00434]
Gene Name:	GUCY1B2
Uniprot ID:	O75343
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Glycogenin-1
Reactions:	UDP-alpha-D-glucose + glycogenin = UDP + alpha-D-glucosylglycogenin [RN:R03681]
Gene Name:	GYG1
Uniprot ID:	P46976
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Glycogenin-2
Reactions:	UDP-alpha-D-glucose + glycogenin = UDP + alpha-D-glucosylglycogenin [RN:R03681]
Gene Name:	GYG2
Uniprot ID:	O15488
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Beta-1,4-galactosyltransferase 5
Reactions:
Gene Name:	B4GALT5
Uniprot ID:	O43286
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Histo-blood group ABO system transferase
Reactions:	UDP-N-acetyl-D-galactosamine + glycoprotein-alpha-L-fucosyl-(1->2)-D-galactose = UDP + glycoprotein-N-acetyl-alpha-D-galactosaminyl-(1->3)-[alpha-L- fucosyl-(1->2)]-D-galactose [RN:R04423]
Gene Name:	ABO
Uniprot ID:	P16442
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Chondroitin sulfate synthase 3
Reactions:	UDP-alpha-D-glucuronate + N-acetyl-beta-D-galactosaminyl-(1->4)-beta-D-glucuronosyl- proteoglycan = UDP + beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-galactosaminyl-(1->4)- beta-D-glucuronosyl-proteoglycan [RN:R07336]
Gene Name:	CHSY3
Uniprot ID:	Q70JA7
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Chondroitin sulfate synthase 2
Reactions:	UDP-alpha-D-glucuronate + N-acetyl-beta-D-galactosaminyl-(1->4)-beta-D-glucuronosyl- proteoglycan = UDP + beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-galactosaminyl-(1->4)- beta-D-glucuronosyl-proteoglycan [RN:R07336]
Gene Name:	CHPF
Uniprot ID:	Q8IZ52
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Chondroitin sulfate synthase 1
Reactions:	UDP-alpha-D-glucuronate + N-acetyl-beta-D-galactosaminyl-(1->4)-beta-D-glucuronosyl- proteoglycan = UDP + beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-galactosaminyl-(1->4)- beta-D-glucuronosyl-proteoglycan [RN:R07336]
Gene Name:	CHSY1
Uniprot ID:	Q86X52
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Activin receptor type-2B
Reactions:	ATP + [receptor-protein] = ADP + [receptor-protein] phosphate
Gene Name:	ACVR2B
Uniprot ID:	Q13705
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Activin receptor type-1
Reactions:	ATP + [receptor-protein] = ADP + [receptor-protein] phosphate
Gene Name:	ACVR1
Uniprot ID:	Q04771
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Dual specificity testis-specific protein kinase 2
Reactions:	ATP + a protein = ADP + a phosphoprotein [RN:R00162]
Gene Name:	TESK2
Uniprot ID:	Q96S53
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Bone morphogenetic protein receptor type-1A
Reactions:	ATP + [receptor-protein] = ADP + [receptor-protein] phosphate
Gene Name:	BMPR1A
Uniprot ID:	P36894
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Serine/threonine-protein kinase receptor R3
Reactions:	ATP + [receptor-protein] = ADP + [receptor-protein] phosphate
Gene Name:	ACVRL1
Uniprot ID:	P37023
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Bone morphogenetic protein receptor type-1B
Reactions:	ATP + [receptor-protein] = ADP + [receptor-protein] phosphate
Gene Name:	BMPR1B
Uniprot ID:	O00238
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	TGF-beta receptor type-2
Reactions:	ATP + [receptor-protein] = ADP + [receptor-protein] phosphate
Gene Name:	TGFBR2
Uniprot ID:	P37173
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing subunit beta
Reactions:	ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate [RN:R05795]
Gene Name:	PIK3C2B
Uniprot ID:	O00750
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Proto-oncogene serine/threonine-protein kinase pim-1
Reactions:	ATP + a protein = ADP + a phosphoprotein [RN:R00162]
Gene Name:	PIM1
Uniprot ID:	P11309
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	TGF-beta receptor type-1
Reactions:	ATP + [receptor-protein] = ADP + [receptor-protein] phosphate
Gene Name:	TGFBR1
Uniprot ID:	P36897
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Serine/threonine-protein kinase Nek9
Reactions:	ATP + a protein = ADP + a phosphoprotein [RN:R00162]
Gene Name:	NEK9
Uniprot ID:	Q8TD19
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Serine/threonine-protein kinase ATR
Reactions:	ATP + a protein = ADP + a phosphoprotein [RN:R00162]
Gene Name:	ATR
Uniprot ID:	Q13535
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Dual specificity tyrosine-phosphorylation-regulated kinase 2
Reactions:	ATP + a protein = ADP + a phosphoprotein [RN:R00162]
Gene Name:	DYRK2
Uniprot ID:	Q92630
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Tyrosine-protein kinase Fyn
Reactions:	ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate [RN:R02584]
Gene Name:	FYN
Uniprot ID:	P06241
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Tyrosine-protein kinase ABL2
Reactions:	ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate [RN:R02584]
Gene Name:	ABL2
Uniprot ID:	P42684
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Serine/threonine-protein kinase 24
Reactions:	ATP + a protein = ADP + a phosphoprotein [RN:R00162]
Gene Name:	STK24
Uniprot ID:	Q9Y6E0
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Tyrosine-protein kinase ABL1
Reactions:	ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate [RN:R02584]
Gene Name:	ABL1
Uniprot ID:	P00519
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Activin receptor type-1B
Reactions:	ATP + [receptor-protein] = ADP + [receptor-protein] phosphate
Gene Name:	ACVR1B
Uniprot ID:	P36896
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Bone morphogenetic protein receptor type-2
Reactions:	ATP + [receptor-protein] = ADP + [receptor-protein] phosphate
Gene Name:	BMPR2
Uniprot ID:	Q13873
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Serine/threonine-protein kinase 19
Reactions:	ATP + a protein = ADP + a phosphoprotein [RN:R00162]
Gene Name:	STK19
Uniprot ID:	P49842
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Activin receptor type-2A
Reactions:	ATP + [receptor-protein] = ADP + [receptor-protein] phosphate
Gene Name:	ACVR2A
Uniprot ID:	P27037
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Anti-Muellerian hormone type-2 receptor
Reactions:	ATP + [receptor-protein] = ADP + [receptor-protein] phosphate
Gene Name:	AMHR2
Uniprot ID:	Q16671
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Serine/threonine-protein kinase 11
Reactions:	ATP + a protein = ADP + a phosphoprotein [RN:R00162]
Gene Name:	STK11
Uniprot ID:	Q15831
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Catalase
Reactions:	2 H2O2 = O2 + 2 H2O [RN:R00009]
Gene Name:	CAT
Uniprot ID:	P04040
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Beta-1,3-galactosyltransferase 2
Reactions:
Gene Name:	B3GALT2
Uniprot ID:	O43825
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit
Reactions:
Gene Name:	OGT
Uniprot ID:	O15294
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Elastin
Reactions:
Gene Name:	ELN
Uniprot ID:	P15502
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Xaa-Pro dipeptidase
Reactions:	Hydrolysis of Xaa!Pro dipeptides also acts on aminoacyl-hydroxyproline analogs. No action on Pro-Pro COFACTOR Manganese [CPD:C00034] EFFECTOR Thiol [CPD:C00145]
Gene Name:	PEPD
Uniprot ID:	P12955
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Serine/threonine-protein phosphatase PP1-beta catalytic subunit
Reactions:	a phosphoprotein + H2O = a protein + phosphate [RN:R00164]
Gene Name:	PPP1CB
Uniprot ID:	P62140
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Serine/threonine-protein phosphatase PP1-gamma catalytic subunit
Reactions:	a phosphoprotein + H2O = a protein + phosphate [RN:R00164]
Gene Name:	PPP1CC
Uniprot ID:	P36873
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Superoxide dismutase [Mn], mitochondrial
Reactions:	2 O2.- + 2 H+ = O2 + H2O2 [RN:R00275]
Gene Name:	SOD2
Uniprot ID:	P04179
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Superoxide dismutase [Cu-Zn]
Reactions:	2 O2.- + 2 H+ = O2 + H2O2 [RN:R00275]
Gene Name:	SOD1
Uniprot ID:	P00441
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform
Reactions:	a phosphoprotein + H2O = a protein + phosphate [RN:R00164]
Gene Name:	PPP2CA
Uniprot ID:	P67775
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Ribonuclease H2 subunit A
Reactions:	Endonucleolytic cleavage to 5'-phosphomonoester
Gene Name:	RNASEH2A
Uniprot ID:	O75792
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Agmatinase, mitochondrial
Reactions:	agmatine + H2O = putrescine + urea [RN:R01157]
Gene Name:	AGMAT
Uniprot ID:	Q9BSE5
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Cholinephosphotransferase 1
Reactions:	CDP-choline + 1,2-diacyl-sn-glycerol = CMP + a phosphatidylcholine [RN:R01321]
Gene Name:	CHPT1
Uniprot ID:	Q8WUD6
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Beta-1,4-galactosyltransferase 7
Reactions:	UDP-galactose + O-beta-D-xylosylprotein = UDP + 4-beta-D-galactosyl-O-beta-D-xylosylprotein [RN:R05926]
Gene Name:	B4GALT7
Uniprot ID:	Q9UBV7
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Polypeptide N-acetylgalactosaminyltransferase 13
Reactions:
Gene Name:	GALNT13
Uniprot ID:	Q68VI8
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing subunit alpha
Reactions:	ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate [RN:R05795]
Gene Name:	PIK3C2A
Uniprot ID:	O00443
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Extracellular superoxide dismutase [Cu-Zn]
Reactions:	2 O2.- + 2 H+ = O2 + H2O2 [RN:R00275]
Gene Name:	SOD3
Uniprot ID:	P08294
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Chondroitin sulfate N-acetylgalactosaminyltransferase 2
Reactions:	UDP-N-acetyl-D-galactosamine + beta-D-glucuronyl-(1->3)-D-galactosyl-proteoglycan = UDP + N-acetyl-D-galactosaminyl-(1->4)-beta-D-glucuronyl-(1->3)-beta-D- galactosylproteoglycan [RN:R05929]
Gene Name:	CSGALNACT2
Uniprot ID:	Q8N6G5
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Beta-1,3-N-acetylglucosaminyltransferase bGnT-2
Reactions:	--- []
Gene Name:	bGnT-2
Uniprot ID:	Q9NY97
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Beta-1,3-galactosyltransferase 6
Reactions:	UDP-galactose + 4-beta-D-galactosyl-O-beta-D-xylosylprotein = UDP + 3-beta-D-galactosyl-4-beta-D-galactosyl-O-beta-D-xylosylprotein [RN:R05927]
Gene Name:	B3GALT6
Uniprot ID:	Q96L58
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Choline/ethanolaminephosphotransferase 1
Reactions:	CDP-choline + 1,2-diacyl-sn-glycerol = CMP + a phosphatidylcholine [RN:R01321]
Gene Name:	CEPT1
Uniprot ID:	Q9Y6K0
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Phosphatidylinositol 3-kinase catalytic subunit type 3
Reactions:	ATP + 1-phosphatidyl-1D-myo-inositol = ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate [RN:R03362]
Gene Name:	PIK3C3
Uniprot ID:	Q8NEB9
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Adenylate cyclase type 10
Reactions:	ATP = 3',5'-cyclic AMP + diphosphate [RN:R00089]
Gene Name:	ADCY10
Uniprot ID:	Q96PN6
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Polypeptide N-acetylgalactosaminyltransferase 9
Reactions:	UDP-N-acetyl-D-galactosamine + polypeptide = UDP + N-acetyl-D-galactosaminyl-polypeptide [RN:R02183]
Gene Name:	GALNT9
Uniprot ID:	Q9HCQ5
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Beta-1,4-galactosyltransferase 6
Reactions:
Gene Name:	B4GALT6
Uniprot ID:	Q9UBX8
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Ethanolaminephosphotransferase 1
Reactions:	CDP-ethanolamine + 1,2-diacyl-sn-glycerol = CMP + a phosphatidylethanolamine [RN:R02057]
Gene Name:	EPT1
Uniprot ID:	Q9C0D9
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	UDP-glucose:glycoprotein glucosyltransferase 2
Reactions:
Gene Name:	UGGT2
Uniprot ID:	Q9NYU1
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Peroxisomal NADH pyrophosphatase NUDT12
Reactions:	NAD+ + H2O = AMP + NMN [RN:R00103]
Gene Name:	NUDT12
Uniprot ID:	Q9BQG2
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Putative uncharacterized protein PGD
Reactions:
Gene Name:	PGD
Uniprot ID:	A9Z1X1
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Anthrax toxin receptor 2
Reactions:
Gene Name:	ANTXR2
Uniprot ID:	P58335
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Polypeptide N-acetylgalactosaminyltransferase-like 6
Reactions:	UDP-N-acetyl-D-galactosamine + polypeptide = UDP + N-acetyl-D-galactosaminyl-polypeptide [RN:R02183]
Gene Name:	GALNTL6
Uniprot ID:	Q49A17
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Putative polypeptide N-acetylgalactosaminyltransferase-like protein 5
Reactions:
Gene Name:	GALNTL5
Uniprot ID:	Q7Z4T8
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Mitochondrial intermediate peptidase
Reactions:	Release of an N-terminal octapeptide as second stage of processing of some proteins imported into the mitochondrion
Gene Name:	MIPEP
Uniprot ID:	Q99797
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Serine/threonine-protein phosphatase with EF-hands 1
Reactions:	a phosphoprotein + H2O = a protein + phosphate [RN:R00164]
Gene Name:	PPEF1
Uniprot ID:	O14829
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Serine/threonine-protein phosphatase with EF-hands 2
Reactions:	a phosphoprotein + H2O = a protein + phosphate [RN:R00164]
Gene Name:	PPEF2
Uniprot ID:	O14830
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Tau-tubulin kinase 1
Reactions:	ATP + a protein = ADP + a phosphoprotein [RN:R00162]
Gene Name:	TTBK1
Uniprot ID:	Q5TCY1
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	UDP-glucose:glycoprotein glucosyltransferase 1
Reactions:
Gene Name:	UGGT1
Uniprot ID:	Q9NYU2
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Protein prune homolog
Reactions:	diphosphate + H2O = 2 phosphate [RN:R00004]
Gene Name:	PRUNE
Uniprot ID:	Q86TP1
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	U8 snoRNA-decapping enzyme
Reactions:
Gene Name:	NUDT16
Uniprot ID:	Q96DE0
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Exocyst complex component 2
Reactions:
Gene Name:	EXOC2
Uniprot ID:	Q96KP1
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Leucine-rich repeat serine/threonine-protein kinase 1
Reactions:	ATP + a protein = ADP + a phosphoprotein [RN:R00162]
Gene Name:	LRRK1
Uniprot ID:	Q38SD2
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Secretion-regulating guanine nucleotide exchange factor
Reactions:
Gene Name:	SERGEF
Uniprot ID:	Q9UGK8
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Natural resistance-associated macrophage protein 1
Reactions:
Gene Name:	SLC11A1
Uniprot ID:	P49279
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Serine/threonine-protein phosphatase PP1-alpha catalytic subunit
Reactions:	a phosphoprotein + H2O = a protein + phosphate [RN:R00164]
Gene Name:	PPP1CA
Uniprot ID:	P62136
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform
Reactions:	a phosphoprotein + H2O = a protein + phosphate [RN:R00164]
Gene Name:	PPP2CB
Uniprot ID:	P62714
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Serine/threonine-protein phosphatase 4 catalytic subunit
Reactions:	a phosphoprotein + H2O = a protein + phosphate [RN:R00164]
Gene Name:	PPP4C
Uniprot ID:	P60510
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Serine/threonine-protein phosphatase 5
Reactions:	a phosphoprotein + H2O = a protein + phosphate [RN:R00164]
Gene Name:	PPP5C
Uniprot ID:	P53041
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Serine/threonine-protein phosphatase 6 catalytic subunit
Reactions:	a phosphoprotein + H2O = a protein + phosphate [RN:R00164]
Gene Name:	PPP6C
Uniprot ID:	O00743
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Acyl-coenzyme A synthetase ACSM2A, mitochondrial
Reactions:	ATP + an acid + CoA = AMP + diphosphate + an acyl-CoA [RN:R00389]
Gene Name:	ACSM2A
Uniprot ID:	Q08AH3
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Acyl-coenzyme A synthetase ACSM2B, mitochondrial
Reactions:	ATP + an acid + CoA = AMP + diphosphate + an acyl-CoA [RN:R00389]
Gene Name:	ACSM2B
Uniprot ID:	Q68CK6
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Acyl-coenzyme A synthetase ACSM5, mitochondrial
Reactions:	ATP + an acid + CoA = AMP + diphosphate + an acyl-CoA [RN:R00389]
Gene Name:	ACSM5
Uniprot ID:	Q6NUN0
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Activin receptor type-1C
Reactions:	ATP + [receptor-protein] = ADP + [receptor-protein] phosphate
Gene Name:	ACVR1C
Uniprot ID:	Q8NER5
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	mRNA-decapping enzyme 2
Reactions:
Gene Name:	DCP2
Uniprot ID:	Q8IU60
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	DNA helicase B
Reactions:	ATP + H2O = ADP + phosphate
Gene Name:	HELB
Uniprot ID:	Q8NG08
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Integrin-linked kinase-associated serine/threonine phosphatase 2C
Reactions:	a phosphoprotein + H2O = a protein + phosphate [RN:R00164]
Gene Name:	ILKAP
Uniprot ID:	Q9H0C8
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Serine/threonine-protein kinase Nek11
Reactions:	ATP + a protein = ADP + a phosphoprotein [RN:R00162]
Gene Name:	NEK11
Uniprot ID:	Q8NG66
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Endonuclease G, mitochondrial
Reactions:
Gene Name:	ENDOG
Uniprot ID:	Q14249
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Diphosphoinositol polyphosphate phosphohydrolase 3-alpha
Reactions:	diphospho-myo-inositol polyphosphate + H2O = myo-inositol polyphosphate + phosphate [RN:R05777]
Gene Name:	NUDT10
Uniprot ID:	Q8NFP7
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Diphosphoinositol polyphosphate phosphohydrolase 3-beta
Reactions:	diphospho-myo-inositol polyphosphate + H2O = myo-inositol polyphosphate + phosphate [RN:R05777]
Gene Name:	NUDT11
Uniprot ID:	Q96G61
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Probable 7,8-dihydro-8-oxoguanine triphosphatase NUDT15
Reactions:
Gene Name:	NUDT15
Uniprot ID:	Q9NV35
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Nucleoside diphosphate-linked moiety X motif 17
Reactions:
Gene Name:	NUDT17
Uniprot ID:	P0C025
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Nucleoside diphosphate-linked moiety X motif 18
Reactions:
Gene Name:	NUDT18
Uniprot ID:	Q6ZVK8
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Nucleoside diphosphate-linked moiety X motif 19, mitochondrial
Reactions:
Gene Name:	NUDT19
Uniprot ID:	A8MXV4
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Diphosphoinositol polyphosphate phosphohydrolase 2
Reactions:	diphospho-myo-inositol polyphosphate + H2O = myo-inositol polyphosphate + phosphate [RN:R05777]
Gene Name:	NUDT4
Uniprot ID:	Q9NZJ9
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Peroxisomal coenzyme A diphosphatase NUDT7
Reactions:
Gene Name:	NUDT7
Uniprot ID:	P0C024
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Nucleoside diphosphate-linked moiety X motif 8, mitochondrial
Reactions:
Gene Name:	NUDT8
Uniprot ID:	Q8WV74
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Protein phosphatase 1A
Reactions:	a phosphoprotein + H2O = a protein + phosphate [RN:R00164]
Gene Name:	PPM1A
Uniprot ID:	P35813
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Protein phosphatase 1B
Reactions:	a phosphoprotein + H2O = a protein + phosphate [RN:R00164]
Gene Name:	PPM1B
Uniprot ID:	O75688
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Protein phosphatase 1D
Reactions:	a phosphoprotein + H2O = a protein + phosphate [RN:R00164]
Gene Name:	PPM1D
Uniprot ID:	O15297
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Protein phosphatase 1E
Reactions:	a phosphoprotein + H2O = a protein + phosphate [RN:R00164]
Gene Name:	PPM1E
Uniprot ID:	Q8WY54
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Protein phosphatase 1F
Reactions:	a phosphoprotein + H2O = a protein + phosphate [RN:R00164]
Gene Name:	PPM1F
Uniprot ID:	P49593
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Protein phosphatase 1G
Reactions:	a phosphoprotein + H2O = a protein + phosphate [RN:R00164]
Gene Name:	PPM1G
Uniprot ID:	O15355
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Protein phosphatase 1K, mitochondrial
Reactions:	a phosphoprotein + H2O = a protein + phosphate [RN:R00164]
Gene Name:	PPM1K
Uniprot ID:	Q8N3J5
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Protein phosphatase 1L
Reactions:	a phosphoprotein + H2O = a protein + phosphate [RN:R00164]
Gene Name:	PPM1L
Uniprot ID:	Q5SGD2
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Protein phosphatase 1M
Reactions:	a phosphoprotein + H2O = a protein + phosphate [RN:R00164]
Gene Name:	PPM1M
Uniprot ID:	Q96MI6
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Protein phosphatase PTC7 homolog
Reactions:	a phosphoprotein + H2O = a protein + phosphate [RN:R00164]
Gene Name:	PPTC7
Uniprot ID:	Q8NI37
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	V(D)J recombination-activating protein 1
Reactions:
Gene Name:	RAG1
Uniprot ID:	P15918
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	2-5A-dependent ribonuclease
Reactions:
Gene Name:	RNASEL
Uniprot ID:	Q05823
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Ribonuclease H1
Reactions:	Endonucleolytic cleavage to 5'-phosphomonoester
Gene Name:	RNASEH1
Uniprot ID:	O60930
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	ATP-dependent RNA helicase SUPV3L1, mitochondrial
Reactions:	ATP + H2O = ADP + phosphate
Gene Name:	SUPV3L1
Uniprot ID:	Q8IYB8
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Dual specificity testis-specific protein kinase 1
Reactions:	ATP + a protein = ADP + a phosphoprotein [RN:R00162]
Gene Name:	TESK1
Uniprot ID:	Q15569
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Beta-1,3-galactosyltransferase 1
Reactions:
Gene Name:	B3GALT1
Uniprot ID:	Q9Y5Z6
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	PP2C-like domain-containing protein C3orf48
Reactions:
Gene Name:	C3orf48
Uniprot ID:	A8MPX8
Protein Sequence:	FASTA

Name:	Dermcidin
Reactions:
Gene Name:	DCD
Uniprot ID:	P81605
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Dual specificity protein phosphatase 18
Reactions:	protein tyrosine phosphate + H2O = protein tyrosine + phosphate [RN:R02585]
Gene Name:	DUSP18
Uniprot ID:	Q8NEJ0
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Interferon-induced, double-stranded RNA-activated protein kinase
Reactions:	ATP + a protein = ADP + a phosphoprotein [RN:R00162]
Gene Name:	EIF2AK2
Uniprot ID:	P19525
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Telomerase-binding protein EST1A
Reactions:
Gene Name:	SMG6
Uniprot ID:	Q86US8
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Galactose-3-O-sulfotransferase 4
Reactions:
Gene Name:	GAL3ST4
Uniprot ID:	Q96RP7
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Interferon-stimulated gene 20 kDa protein
Reactions:	Exonucleolytic cleavage in the 3'- to 5'-direction to yield nucleoside 5'-phosphates
Gene Name:	ISG20
Uniprot ID:	Q96AZ6
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Carnosine synthase 1
Reactions:	ATP + L-histidine + beta-alanine = ADP + phosphate + carnosine [RN:R01164]
Gene Name:	CARNS1
Uniprot ID:	A5YM72
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Double-strand break repair protein MRE11A
Reactions:
Gene Name:	MRE11A
Uniprot ID:	P49959
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	GDP-fucose protein O-fucosyltransferase 1
Reactions:	transfers an alpha-L-fucosyl residue from GDP-beta-L-fucose to the serine hydroxy group of a protein acceptor
Gene Name:	POFUT1
Uniprot ID:	Q9H488
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Oligoribonuclease, mitochondrial
Reactions:
Gene Name:	REXO2
Uniprot ID:	Q9Y3B8
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Probable aminopeptidase NPEPL1
Reactions:
Gene Name:	NPEPL1
Uniprot ID:	Q8NDH3
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	PH domain leucine-rich repeat-containing protein phosphatase 2
Reactions:	a phosphoprotein + H2O = a protein + phosphate [RN:R00164]
Gene Name:	PHLPP2
Uniprot ID:	Q6ZVD8
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	PH domain leucine-rich repeat-containing protein phosphatase 1
Reactions:	a phosphoprotein + H2O = a protein + phosphate [RN:R00164]
Gene Name:	PHLPP1
Uniprot ID:	O60346
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Phosphoinositide 3-kinase regulatory subunit 4
Reactions:	ATP + a protein = ADP + a phosphoprotein [RN:R00162]
Gene Name:	PIK3R4
Uniprot ID:	Q99570
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Protein O-linked-mannose beta-1,2-N-acetylglucosaminyltransferase 1
Reactions:
Gene Name:	POMGNT1
Uniprot ID:	Q8WZA1
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Ribosomal protein S6 modification-like protein A
Reactions:
Gene Name:	RIMKLA
Uniprot ID:	Q8IXN7
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Ribosomal protein S6 modification-like protein B
Reactions:
Gene Name:	RIMKLB
Uniprot ID:	Q9ULI2
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Serine/threonine-protein kinase SMG1
Reactions:	ATP + a protein = ADP + a phosphoprotein [RN:R00162]
Gene Name:	SMG1
Uniprot ID:	Q96Q15
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Xaa-Pro aminopeptidase 1
Reactions:	Release of any N-terminal amino acid, including proline, that is linked to proline, even from a dipeptide or tripeptide COFACTOR Manganese [CPD:C00034] Cobalt ion [CPD:C00175]
Gene Name:	XPNPEP1
Uniprot ID:	Q9NQW7
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Xaa-Pro aminopeptidase 2
Reactions:	Release of any N-terminal amino acid, including proline, that is linked to proline, even from a dipeptide or tripeptide COFACTOR Manganese [CPD:C00034] Cobalt ion [CPD:C00175]
Gene Name:	XPNPEP2
Uniprot ID:	O43895
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Probable Xaa-Pro aminopeptidase 3
Reactions:	Release of any N-terminal amino acid, including proline, that is linked to proline, even from a dipeptide or tripeptide COFACTOR Manganese [CPD:C00034] Cobalt ion [CPD:C00175]
Gene Name:	XPNPEP3
Uniprot ID:	Q9NQH7
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Acyl-coenzyme A synthetase ACSM4, mitochondrial
Reactions:	ATP + an acid + CoA = AMP + diphosphate + an acyl-CoA [RN:R00389]
Gene Name:	ACSM4
Uniprot ID:	P0C7M7
Protein Sequence:	FASTA
Gene Sequence:	FASTA

Name:	Pp-GalNAc-transferase 20
Reactions:
Gene Name:	GALNT20
Uniprot ID:	Q2L4S5
Protein Sequence:	FASTA
Gene Sequence:	FASTA