Record Information
Version3.6
Creation Date2006-08-16 13:22:34 UTC
Update Date2013-02-08 18:20:51 UTC
HMDB IDHMDB01333
Secondary Accession NumbersNone
Metabolite Identification
Common NameManganese
DescriptionManganese is an essential trace nutrient in all forms of life. Physiologically, it. exists as an ion in the body. It is concentrated in cell mitochondria, mostly in the pituitary gland, liver, pancreas, kidney, and bone, influences the synthesis of mucopolysaccharides, stimulates hepatic synthesis of cholesterol and fatty acids, and is a cofactor in many enzymes, including arginase and alkaline phosphatase in the liver.
Structure
Thumb
Synonyms
  1. Manganese
Chemical FormulaMn
Average Molecular Weight54.938045
Monoisotopic Molecular Weight54.938049636
IUPAC Namemanganese(2+) ion
Traditional IUPAC Namemanganese(II)
CAS Registry Number7439-96-5
SMILES
[Mn++]
InChI Identifier
InChI=1S/Mn/q+2
InChI KeyWAEMQWOKJMHJLA-UHFFFAOYSA-N
Chemical Taxonomy
KingdomInorganic Compounds
Super ClassHomogeneous Metal Compounds
ClassHomogeneous Transition Metal Compounds
Sub ClassN/A
Other Descriptors
  • a cation(Cyc)
  • divalent metal cation(ChEBI)
  • manganese cation(ChEBI)
  • monoatomic dication(ChEBI)
Substituents
  • N/A
Direct ParentHomogeneous Transition Metal Compounds
Ontology
StatusDetected and Quantified
Origin
  • Food
  • Toxin/Pollutant
Biofunction
  • Enzyme co-factor
  • Essential minerals
ApplicationNot Available
Cellular locationsNot Available
Physical Properties
StateSolid
Experimental Properties
PropertyValueReference
Melting Point1244 °CNot Available
Boiling PointNot AvailableNot Available
Water SolubilityNot AvailableNot Available
LogPNot AvailableNot Available
Predicted Properties
PropertyValueSource
logP-0.16ChemAxon
physiological charge2ChemAxon
hydrogen acceptor count0ChemAxon
hydrogen donor count0ChemAxon
polar surface area0ChemAxon
rotatable bond count0ChemAxon
refractivity0ChemAxon
polarizability1.78ChemAxon
Spectra
SpectraNot Available
Biological Properties
Cellular LocationsNot Available
Biofluid Locations
  • Blood
  • Cerebrospinal Fluid (CSF)
  • Urine
Tissue Location
  • Basal Ganglia
  • Brain
  • Central Nervous System
  • Hair
  • Liver
PathwaysNot Available
Normal Concentrations
BiofluidStatusValueAgeSexConditionReference
BloodDetected and Quantified0.18858(0.18020-0.19659) uMNot AvailableBothNormal
  • Report on Hu...
BloodDetected and Quantified0.17292(0.16382-0.18202) uMAdult (>18 years old)BothNormal
  • Report on Hu...
BloodDetected and Quantified0.012 +/- 0.0044 uMElderly (>65 years old)BothNormal
BloodDetected and Quantified0.01 (0.007 - 0.019) uMAdult (>18 years old)BothNormal
  • Geigy Scient...
Cerebrospinal Fluid (CSF)Detected and Quantified0.0218 +/- 0.0309 uMElderly (>65 years old)BothNormal
Cerebrospinal Fluid (CSF)Detected and Quantified0.149 +/- 0.177 uMAdult (>18 years old)Not SpecifiedNormal
Cerebrospinal Fluid (CSF)Detected and Quantified0.021 (0.015 - 0.027) uMAdult (>18 years old)BothNormal
  • Geigy Scient...
UrineDetected and Quantified0.00058 (0.00023-0.00101) umol/mmol creatinineNot AvailableBothNormal
  • Report on Hu...
UrineDetected and Quantified0.00043 (0.00029-0.00056) umol/mmol creatinineAdult (>18 years old)BothNormal
  • Report on Hu...
UrineDetected and Quantified0.013 (0.002-0.051) umol/mmol creatinineAdult (>18 years old)BothCommentNormal
UrineDetected and Quantified0.011 (0.0-0.023) umol/mmol creatinineAdult (>18 years old)MaleNormal
  • Geigy Scient...
  • West Cadwell...
  • Basel, Switz...
Abnormal Concentrations
BiofluidStatusValueAgeSexConditionReference
BloodDetected and Quantified0.15 +/- .072 uMAdult (>18 years old)BothMultiple sclerosis
BloodDetected and Quantified0.012 +/- 0.0044 uMAdult (>18 years old)BothParkinson's disease
BloodDetected and Quantified0.011 +/- 0 .004 uMElderly (>65 years old)BothAlzheimer's disease
Cerebrospinal Fluid (CSF)Detected and Quantified0.0346 +/- 0.0182 uMAdult (>18 years old)Not Specifiedcontrol
Cerebrospinal Fluid (CSF)Detected and Quantified0.0400 +/- 0.0273 uMAdult (>18 years old)Not Specifiedamyotrophic lateral sclerosis
Cerebrospinal Fluid (CSF)Detected and Quantified0.0400 +/- 0.0255 uMAdult (>18 years old)Not Specifiedamyotrophic lateral sclerosis (classic)
Cerebrospinal Fluid (CSF)Detected and Quantified0.0419 +/- 0.0291 uMAdult (>18 years old)Not Specifiedamyotrophic lateral sclerosis (bulbar)
Cerebrospinal Fluid (CSF)Detected and Quantified0.0328 +/- 0.0164 uMAdult (>18 years old)Not SpecifiedAlzheimer's disease
Cerebrospinal Fluid (CSF)Detected and Quantified0.0218 +/- 0.00546 uMAdult (>18 years old)Not SpecifiedAlzheimer's disease (early-onset)
Cerebrospinal Fluid (CSF)Detected and Quantified0.0382 +/- 0.0182 uMAdult (>18 years old)Not SpecifiedAlzheimer's disease (late-onset)
Cerebrospinal Fluid (CSF)Detected and Quantified0.0546 +/- 0.0382 uMAdult (>18 years old)Not SpecifiedParkinson's disease
Cerebrospinal Fluid (CSF)Detected and Quantified0.0146 +/- 0.0146 uMElderly (>65 years old)BothAlzheimer's disease
Cerebrospinal Fluid (CSF)Detected and Quantified14.6 +/- 13.7 uMElderly (>65 years old)Not SpecifiedAlzheimer's disease
Associated Disorders and Diseases
Disease References
Alzheimer's disease
  • Molina JA, Jimenez-Jimenez FJ, Aguilar MV, Meseguer I, Mateos-Vega CJ, Gonzalez-Munoz MJ, de Bustos F, Porta J, Orti-Pareja M, Zurdo M, Barrios E, Martinez-Para MC: Cerebrospinal fluid levels of transition metals in patients with Alzheimer's disease. J Neural Transm. 1998;105(4-5):479-88. Pubmed: 9720975
  • Bocca B, Forte G, Petrucci F, Pino A, Marchione F, Bomboi G, Senofonte O, Giubilei F, Alimonti A: Monitoring of chemical elements and oxidative damage in patients affected by Alzheimer's disease. Ann Ist Super Sanita. 2005;41(2):197-203. Pubmed: 16244393
Multiple sclerosis
  • Forte G, Visconti A, Santucci S, Ghazaryan A, Figa-Talamanca L, Cannoni S, Bocca B, Pino A, Violante N, Alimonti A, Salvetti M, Ristori G: Quantification of chemical elements in blood of patients affected by multiple sclerosis. Ann Ist Super Sanita. 2005;41(2):213-6. Pubmed: 16244395
Parkinson's disease
  • Forte G, Alimonti A, Pino A, Stanzione P, Brescianini S, Brusa L, Sancesario G, Violante N, Bocca B: Metals and oxidative stress in patients with Parkinson's disease. Ann Ist Super Sanita. 2005;41(2):189-95. Pubmed: 16244392
Associated OMIM IDs
DrugBank IDNot Available
DrugBank Metabolite IDNot Available
Phenol Explorer Compound IDNot Available
Phenol Explorer Metabolite IDNot Available
FoodDB IDFDB003636
KNApSAcK IDNot Available
Chemspider ID25916
KEGG Compound IDC19610
BioCyc IDMN%2b3
BiGG IDNot Available
Wikipedia LinkManganese
NuGOwiki LinkHMDB01333
Metagene LinkHMDB01333
METLIN IDNot Available
PubChem Compound27854
PDB IDMN
ChEBI ID29035
References
Synthesis ReferenceNot Available
Material Safety Data Sheet (MSDS)Download (PDF)
General References
  1. Ikeda S, Sera Y, Yoshida M, Ohshiro H, Uchino S, Oka Y, Lee KJ, Kotera A: Manganese deposits in patients with biliary atresia after hepatic porto-enterostomy. J Pediatr Surg. 2000 Mar;35(3):450-3. Pubmed: 10726687
  2. Greger JL: Nutrition versus toxicology of manganese in humans: evaluation of potential biomarkers. Neurotoxicology. 1999 Apr-Jun;20(2-3):205-12. Pubmed: 10385884
  3. Lander F, Kristiansen J, Lauritsen JM: Manganese exposure in foundry furnacemen and scrap recycling workers. Int Arch Occup Environ Health. 1999 Nov;72(8):546-50. Pubmed: 10592008
  4. Mizoguchi N, Nishimura Y, Ono H, Sakura N: Manganese elevations in blood of children with congenital portosystemic shunts. Eur J Pediatr. 2001 Apr;160(4):247-50. Pubmed: 11317649
  5. Woolf A, Wright R, Amarasiriwardena C, Bellinger D: A child with chronic manganese exposure from drinking water. Environ Health Perspect. 2002 Jun;110(6):613-6. Pubmed: 12055054
  6. Ikeda S, Yamaguchi Y, Sera Y, Ohshiro H, Uchino S, Yamashita Y, Ogawa M: Manganese deposition in the globus pallidus in patients with biliary atresia. Transplantation. 2000 Jun 15;69(11):2339-43. Pubmed: 10868637
  7. Wardle CA, Forbes A, Roberts NB, Jawhari AV, Shenkin A: Hypermanganesemia in long-term intravenous nutrition and chronic liver disease. JPEN J Parenter Enteral Nutr. 1999 Nov-Dec;23(6):350-5. Pubmed: 10574484
  8. Mergler D, Baldwin M, Belanger S, Larribe F, Beuter A, Bowler R, Panisset M, Edwards R, de Geoffroy A, Sassine MP, Hudnell K: Manganese neurotoxicity, a continuum of dysfunction: results from a community based study. Neurotoxicology. 1999 Apr-Jun;20(2-3):327-42. Pubmed: 10385894
  9. Butterworth RF: Hepatic encephalopathy. Alcohol Res Health. 2003;27(3):240-6. Pubmed: 15535452
  10. Herynek V, Babis M, Trunecka P, Filip K, Vymazal J, Dezortova M, Hajek M: Chronic liver disease: relaxometry in the brain after liver transplantation. MAGMA. 2001 Mar;12(1):10-5. Pubmed: 11255087
  11. Miranda M, Caballero L: [Chronic hepatic encephalopathy: the role of high serum manganese levels and its relation with basal ganglia lesions in nuclear magnetic resonance of the brain. Clinical case] Rev Med Chil. 2001 Sep;129(9):1051-5. Pubmed: 11725469
  12. Barceloux DG: Manganese. J Toxicol Clin Toxicol. 1999;37(2):293-307. Pubmed: 10382563
  13. Bader M, Dietz MC, Ihrig A, Triebig G: Biomonitoring of manganese in blood, urine and axillary hair following low-dose exposure during the manufacture of dry cell batteries. Int Arch Occup Environ Health. 1999 Nov;72(8):521-7. Pubmed: 10592004
  14. Kao HJ, Chen WH, Liu JS: Rapid progression of parkinsonism associated with an increase of blood manganese. Kaohsiung J Med Sci. 1999 May;15(5):297-301. Pubmed: 10375873
  15. Melo TM, Larsen C, White LR, Aasly J, Sjobakk TE, Flaten TP, Sonnewald U, Syversen T: Manganese, copper, and zinc in cerebrospinal fluid from patients with multiple sclerosis. Biol Trace Elem Res. 2003 Summer;93(1-3):1-8. Pubmed: 12835484
  16. Lees-Haley PR, Rohling ML, Langhinrichsen-Rohling J: A meta-analysis of the neuropsychological effects of occupational exposure to manganese. Clin Neuropsychol. 2006 Feb;20(1):90-107. Pubmed: 16393922
  17. Sadek AH, Rauch R, Schulz PE: Parkinsonism due to manganism in a welder. Int J Toxicol. 2003 Sep-Oct;22(5):393-401. Pubmed: 14555414
  18. Wang X, Li GJ, Zheng W: Upregulation of DMT1 expression in choroidal epithelia of the blood-CSF barrier following manganese exposure in vitro. Brain Res. 2006 Jun 30;1097(1):1-10. Epub 2006 May 26. Pubmed: 16729984
  19. Takeda A: Manganese action in brain function. Brain Res Brain Res Rev. 2003 Jan;41(1):79-87. Pubmed: 12505649
  20. Baldwin M, Mergler D, Larribe F, Belanger S, Tardif R, Bilodeau L, Hudnell K: Bioindicator and exposure data for a population based study of manganese. Neurotoxicology. 1999 Apr-Jun;20(2-3):343-53. Pubmed: 10385895

Only showing the first 50 proteins. There are 194 proteins in total.

Enzymes

Gene Name:
ACACB
Uniprot ID:
O00763
Gene Name:
ACACA
Uniprot ID:
Q13085
Gene Name:
ARG1
Uniprot ID:
P05089
Gene Name:
B4GALT2
Uniprot ID:
O60909
Gene Name:
B4GALT1
Uniprot ID:
P15291
Gene Name:
ANPEP
Uniprot ID:
P15144
Gene Name:
FHIT
Uniprot ID:
P49789
Gene Name:
ME1
Uniprot ID:
P48163
Gene Name:
LAP3
Uniprot ID:
P28838
Gene Name:
POMT1
Uniprot ID:
Q9Y6A1
Gene Name:
POMT2
Uniprot ID:
Q9UKY4
Gene Name:
POLL
Uniprot ID:
Q9UGP5
Gene Name:
POLH
Uniprot ID:
Q9Y253
Gene Name:
POLK
Uniprot ID:
Q9UBT6
Gene Name:
GALNT7
Uniprot ID:
Q86SF2

Only showing the first 50 proteins. There are 194 proteins in total.