Record Information
Version3.6
Creation Date2005-11-16 15:48:42 UTC
Update Date2013-05-29 19:28:31 UTC
HMDB IDHMDB00696
Secondary Accession NumbersNone
Metabolite Identification
Common NameL-Methionine
DescriptionMethionine is a dietary indispensable amino acid required for normal growth and development of humans, other mammals, and avian species. In addition to being a substrate for protein synthesis, it is an intermediate in transmethylation reactions, serving as the major methyl group donor in vivo, including the methyl groups for DNA and RNA intermediates. Methionine is a methyl acceptor for 5-methyltetrahydrofolate-homocysteine methyl transferase (methionine synthase), the only reaction that allows for the recycling of this form of folate, and is also a methyl acceptor for the catabolism of betaine. Methionine is also required for synthesis of cysteine. Methionine is accepted as the metabolic precursor for cysteine. Only the sulfur atom from methionine is transferred to cysteine; the carbon skeleton of cysteine is donated by serine. (PMID 16702340 ). The adequacy range of dietary requirements of specific amino acids in disease states is difficult to determine. Requirements may not be similar in disease with regard to protein synthesis. Requirements for this purpose can be assessed only when such a function can be measured and related to clinical outcome. There is apparent consensus concerning normal sulfur amino acid (SAA) requirements. WHO recommendations amount to 13 mg/kg per 24 h in healthy adults. This amount is roughly doubled in artificial nutrition regimens. In disease or after trauma, requirements may be altered for methionine, cysteine, and taurine. Although in specific cases of congenital enzyme deficiency, prematurity, or diminished liver function, hypermethionemia or hyperhomocysteinemia may occur, SAA supplementation can be considered safe in amounts exceeding 2-3 times the minimal recommended daily intake. Apart from some very specific indications (e.g., acetaminophen poisoning) the usefulness of SAA supplementation is not yet established.(PMID 16702341 ). Methionine is known to exacerbate psychopathological symptoms in schizophrenic patients, there is no evidence of similar effects in healthy subjects. The role of methionine as a precursor of homocysteine is the most notable cause for concern. A "loading dose" of methionine (0.1 g/kg) has been given, and the resultant acute increase in plasma homocysteine has been used as an index of the susceptibility to cardiovascular disease. Although this procedure results in vascular dysfunction, this is acute and unlikely to result in permanent damage. However, a 10-fold larger dose, given mistakenly, resulted in death. Longer-term studies in adults have indicated no adverse consequences of moderate fluctuations in dietary methionine intake, but intakes higher than 5 times normal resulted in elevated homocysteine levels. These effects of methionine on homocysteine and vascular function are moderated by supplements of vitamins B-6, B-12, C, and folic acid. In infants, methionine intakes of 2 to 5 times normal resulted in impaired growth and extremely high plasma methionine levels, but no adverse long-term consequences were observed. (PMID 16702346 ).
Structure
Thumb
Synonyms
  1. (2S)-2-amino-4-(methylsulfanyl)butanoate
  2. (2S)-2-amino-4-(methylsulfanyl)butanoic acid
  3. (L)-methionine
  4. (S)-(+)-methionine
  5. (S)-2-amino-4-(methylthio)-Butanoate
  6. (S)-2-amino-4-(methylthio)-Butanoic acid
  7. (S)-2-Amino-4-(methylthio)butanoate
  8. (S)-2-Amino-4-(methylthio)butanoic acid
  9. (S)-2-amino-4-(methylthio)butyric acid
  10. (S)-methionine
  11. 2-Amino-4-(methylthio)butyrate
  12. 2-Amino-4-(methylthio)butyric acid
  13. 2-Amino-4-methylthiobutanoate
  14. 2-Amino-4-methylthiobutanoic acid
  15. A-Amino-g-methylmercaptobutyrate
  16. A-Amino-g-methylmercaptobutyric acid
  17. Acimethin
  18. alpha-Amino-alpha-aminobutyric acid
  19. alpha-Amino-gamma-methylmercaptobutyrate
  20. alpha-Amino-gamma-methylmercaptobutyric acid
  21. Cymethion
  22. G-Methylthio-a-aminobutyrate
  23. G-Methylthio-a-aminobutyric acid
  24. gamma-Methylthio-alpha-aminobutyrate
  25. gamma-Methylthio-alpha-aminobutyric acid
  26. H-Met-h
  27. H-Met-oh
  28. L(-)-Amino-alpha-amino-alpha-aminobutyric acid
  29. L(-)-Amino-gamma-methylthiobutyric acid
  30. L-(-)-Methionine
  31. L-2-Amino-4-(methylthio)butyric acid
  32. L-2-Amino-4-methylthiobutyric acid
  33. L-a-Amino-g-methylthiobutyrate
  34. L-a-Amino-g-methylthiobutyric acid
  35. L-alpha-Amino-gamma-methylmercaptobutyric acid
  36. L-alpha-Amino-gamma-methylthiobutyrate
  37. L-alpha-Amino-gamma-methylthiobutyric acid
  38. L-gamma-Methylthio-alpha-aminobutyric acid
  39. L-Methionin
  40. L-Methionine
  41. L-Methioninum
  42. Liquimeth
  43. Mepron
  44. MET
  45. Methilanin
  46. Methionine
  47. Methioninum
  48. Metionina
  49. Neo-methidin
  50. Poly-L-methionine
  51. Polymethionine
  52. S-Methionine
  53. S-Methyl-L-homocysteine
  54. Toxin WAR
Chemical FormulaC5H11NO2S
Average Molecular Weight149.211
Monoisotopic Molecular Weight149.051049291
IUPAC Name(2S)-2-amino-4-(methylsulfanyl)butanoic acid
Traditional IUPAC NameL-methionine
CAS Registry Number63-68-3
SMILES
CSCC[C@H](N)C(O)=O
InChI Identifier
InChI=1S/C5H11NO2S/c1-9-3-2-4(6)5(7)8/h4H,2-3,6H2,1H3,(H,7,8)/t4-/m0/s1
InChI KeyFFEARJCKVFRZRR-BYPYZUCNSA-N
Chemical Taxonomy
KingdomOrganic Compounds
Super ClassAmino Acids, Peptides, and Analogues
ClassAmino Acids and Derivatives
Sub ClassAlpha Amino Acids and Derivatives
Other Descriptors
  • Aliphatic Acyclic Compounds
  • Common amino acids(KEGG)
  • amino acid zwitterion(ChEBI)
Substituents
  • Carboxylic Acid
  • Primary Aliphatic Amine (Alkylamine)
  • Thioether
Direct ParentAlpha Amino Acids and Derivatives
Ontology
StatusDetected and Quantified
Origin
  • Drug metabolite
  • Food
Biofunction
  • Component of Aminoacyl-tRNA biosynthesis
  • Component of Glycine, serine and threonine metabolism
  • Component of Histidine metabolism
  • Component of Methionine metabolism
  • Component of Selenoamino acid metabolism
  • Component of Tyrosine metabolism
  • Essential amino acids
  • Waste products
ApplicationNot Available
Cellular locations
  • Extracellular
Physical Properties
StateSolid
Experimental Properties
PropertyValueReference
Melting Point284 °CNot Available
Boiling PointNot AvailableNot Available
Water Solubility56.6 mg/mLYALKOWSKY,SH & DANNENFELSER,RM (1992)
LogP-1.87HANSCH,C ET AL. (1995)
Predicted Properties
PropertyValueSource
water solubility23.9 g/LALOGPS
logP-1.9ALOGPS
logP-2.2ChemAxon
logS-0.8ALOGPS
pKa (strongest acidic)2.53ChemAxon
pKa (strongest basic)9.5ChemAxon
physiological charge0ChemAxon
hydrogen acceptor count3ChemAxon
hydrogen donor count2ChemAxon
polar surface area63.32ChemAxon
rotatable bond count4ChemAxon
refractivity37.59ChemAxon
polarizability15.5ChemAxon
Spectra
Spectra
Biological Properties
Cellular Locations
  • Extracellular
Biofluid Locations
  • Blood
  • Cerebrospinal Fluid (CSF)
  • Urine
Tissue Location
  • Fibroblasts
  • Kidney
  • Liver
  • Muscle
  • Pancreas
  • Prostate
  • Spleen
Pathways
NameSMPDB LinkKEGG Link
Betaine MetabolismSMP00123map00260
Glycine and Serine MetabolismSMP00004map00260
Methionine MetabolismSMP00033map00270
Spermidine and Spermine BiosynthesisSMP00445Not Available
Transcription/TranslationSMP00019Not Available
Normal Concentrations
BiofluidStatusValueAgeSexConditionReference
BloodDetected and Quantified25.0 (21.0-29.0) uMAdult (>18 years old)BothNormal
BloodDetected and Quantified33.4 +/- 9 uMAdult (>18 years old)Not SpecifiedNormal
BloodDetected and Quantified35.0 +/- 5.0 uMNewborn (0-30 days old)Not SpecifiedNormal
  • Geigy Scient...
BloodDetected and Quantified27.0 +/- 5.0 uMChildren (1-13 year old)MaleNormal
  • Geigy Scient...
BloodDetected and Quantified32.0 +/- 6.0 uMAdult (>18 years old)MaleNormal
  • Geigy Scient...
BloodDetected and Quantified27.0 +/- 5.0 uMAdult (>18 years old)FemaleNormal
  • Geigy Scient...
BloodDetected and Quantified20.00 (10.00-30.00) uMAdult (>18 years old)BothNormal
BloodDetected and Quantified29.8 +/- 6.3 uMAdult (>18 years old)Not SpecifiedNormal
Cerebrospinal Fluid (CSF)Detected and Quantified5 +/- 4 uMNot SpecifiedBothNormal
Cerebrospinal Fluid (CSF)Detected and Quantified3.6 +/- 0.98 uMAdult (>18 years old)Not SpecifiedNormal
Cerebrospinal Fluid (CSF)Detected and Quantified2.9 +/- 0.69 uMAdult (>18 years old)BothNormal
Cerebrospinal Fluid (CSF)Detected and Quantified1.9 +/- 0.7 uMAdult (>18 years old)BothNormal
  • Geigy Scient...
Cerebrospinal Fluid (CSF)Detected and Quantified6.1 +/- 3.1 uMAdult (>18 years old)Not SpecifiedNormal
Cerebrospinal Fluid (CSF)Detected and Quantified4.3 +/- 2.5 uMAdult (>18 years old)Not SpecifiedNormal
Cerebrospinal Fluid (CSF)Detected and Quantified4.07 (3.00-5.14) uMAdult (>18 years old)BothNormal
UrineDetected and Quantified1.0 umol/mmol creatinineAdult (>18 years old)BothNormal
UrineDetected and Quantified2.303 (0.658-3.947) umol/mmol creatinineAdult (>18 years old)BothNormal
    UrineDetected but not QuantifiedNot ApplicableAdult (>18 years old)MaleCommentNormal
    UrineDetected but not QuantifiedNot ApplicableAdult (>18 years old)MaleCommentNormal
    UrineDetected and Quantified1.70 +/- 1.01 umol/mmol creatinineAdult (>18 years old)BothNormal
    UrineDetected and Quantified0.065 (0.0-0.13) umol/mmol creatinineNewborn (0-30 days old)BothNormal
    • Geigy Scient...
    • West Cadwell...
    • Basel, Switz...
    UrineDetected and Quantified0.8 (0.4-1.6) umol/mmol creatinineAdult (>18 years old)BothCommentNormal
    UrineDetected and Quantified0.611 +/- 0.45 umol/mmol creatinineChildren (1-13 year old)MaleNormal
    • Geigy Scient...
    • West Cadwell...
    • Basel, Switz...
    UrineDetected and Quantified1.3 +/- 0.97 umol/mmol creatinineAdult (>18 years old)MaleNormal
    • Geigy Scient...
    • West Cadwell...
    • Basel, Switz...
    UrineDetected and Quantified1.12 +/- 0.97 umol/mmol creatinineAdult (>18 years old)FemaleNormal
    • Geigy Scient...
    • West Cadwell...
    • Basel, Switz...
    UrineDetected and Quantified1.4 (0.5-2.5) umol/mmol creatinineAdult (>18 years old)BothCommentNormal
    UrineDetected and Quantified0.4 umol/mmol creatinineAdult (>18 years old)BothNormal
    UrineDetected and Quantified1.21 +/- 1.20 umol/mmol creatinineInfant (0-1 year old)BothNormal
    Abnormal Concentrations
    BiofluidStatusValueAgeSexConditionReference
    BloodDetected and Quantified17.8 (17.0-18.6) uMAdult (>18 years old)BothCommentEpilepsy
    BloodDetected and Quantified775.00 (250.00-1300.00) uMChildren (1-13 year old)BothMethionine adenosyl transferase deficiency
    BloodDetected and Quantified17.3 +/- 9.5 uMAdult (>18 years old)Not SpecifiedHeart Transplant
    BloodDetected and Quantified518.5 (37.00-1000.00) uMChildren (1-13 year old)BothS-Adenosylhomocysteine hydrolase deficiency
    BloodDetected and Quantified750.0 (500.00-1000.00) uMChildren (1-13 year old)BothGlycine N-Methyltransferase deficiency
    BloodDetected and Quantified9.00 (0.00-18.00) uMChildren (1-13 year old)BothHomocystinuria
    BloodDetected and Quantified415.0 +/- 7.0 uMAdult (>18 years old)BothCommentHeart failure
    Cerebrospinal Fluid (CSF)Detected and Quantified2.7 +/- 0.67 uMAdult (>18 years old)BothSchizophrenia
    Cerebrospinal Fluid (CSF)Detected and Quantified6.0 +/- 5.3 uMChildren (1-13 year old)Not SpecifiedLeukemia
    Cerebrospinal Fluid (CSF)Detected and Quantified3.5 +/- 0.4 uMChildren (1-13 year old)Not SpecifiedCommentLeukemia
    Associated Disorders and Diseases
    Disease References
    Epilepsy
    • Rainesalo S, Keranen T, Palmio J, Peltola J, Oja SS, Saransaari P: Plasma and cerebrospinal fluid amino acids in epileptic patients. Neurochem Res. 2004 Jan;29(1):319-24. Pubmed: 14992292
    Schizophrenia
    • Do KQ, Lauer CJ, Schreiber W, Zollinger M, Gutteck-Amsler U, Cuenod M, Holsboer F: gamma-Glutamylglutamine and taurine concentrations are decreased in the cerebrospinal fluid of drug-naive patients with schizophrenic disorders. J Neurochem. 1995 Dec;65(6):2652-62. Pubmed: 7595563
    Heart failure
    • Norrelund H, Wiggers H, Halbirk M, Frystyk J, Flyvbjerg A, Botker HE, Schmitz O, Jorgensen JO, Christiansen JS, Moller N: Abnormalities of whole body protein turnover, muscle metabolism and levels of metabolic hormones in patients with chronic heart failure. J Intern Med. 2006 Jul;260(1):11-21. Pubmed: 16789974
    Homocystinuria
    Hypermethioninemia
    Leukemia
    • Peng CT, Wu KH, Lan SJ, Tsai JJ, Tsai FJ, Tsai CH: Amino acid concentrations in cerebrospinal fluid in children with acute lymphoblastic leukemia undergoing chemotherapy. Eur J Cancer. 2005 May;41(8):1158-63. Epub 2005 Apr 14. Pubmed: 15911239
    Methionine adenosyltransferase deficiency
    Glycine N-methyltransferase deficiency
    Homocystinuria due to defect of N(5,10)-methylene THF deficiency
    Associated OMIM IDs
      181500 (Schizophrenia)606664 (Glycine N-methyltransferase deficiency)236250 (Homocystinuria due to defect of N(5,10)-methylene THF deficiency)236200 (Homocystinuria)250850 (Methionine adenosyltransferase deficiency)613752 (Hypermethioninemia)
    DrugBank IDDB00134
    DrugBank Metabolite IDDBMET00506
    Phenol Explorer Compound IDNot Available
    Phenol Explorer Metabolite IDNot Available
    FoodDB IDFDB012683
    KNApSAcK IDC00001379
    Chemspider ID5907
    KEGG Compound IDC00073
    BioCyc IDMET
    BiGG ID33753
    Wikipedia LinkMET
    NuGOwiki LinkHMDB00696
    Metagene LinkHMDB00696
    METLIN ID5664
    PubChem Compound6137
    PDB IDMET
    ChEBI ID16643
    References
    Synthesis ReferenceBoy, Matthias; Klein, Daniela; Schroeder, Hartwig. Method for the production and recovery of methionine. PCT Int. Appl. (2005), 34 pp.
    Material Safety Data Sheet (MSDS)Not Available
    General References
    1. Sreekumar A, Poisson LM, Rajendiran TM, Khan AP, Cao Q, Yu J, Laxman B, Mehra R, Lonigro RJ, Li Y, Nyati MK, Ahsan A, Kalyana-Sundaram S, Han B, Cao X, Byun J, Omenn GS, Ghosh D, Pennathur S, Alexander DC, Berger A, Shuster JR, Wei JT, Varambally S, Beecher C, Chinnaiyan AM: Metabolomic profiles delineate potential role for sarcosine in prostate cancer progression. Nature. 2009 Feb 12;457(7231):910-4. Pubmed: 19212411
    2. Shoemaker JD, Elliott WH: Automated screening of urine samples for carbohydrates, organic and amino acids after treatment with urease. J Chromatogr. 1991 Jan 2;562(1-2):125-38. Pubmed: 2026685
    3. Engelborghs S, Marescau B, De Deyn PP: Amino acids and biogenic amines in cerebrospinal fluid of patients with Parkinson's disease. Neurochem Res. 2003 Aug;28(8):1145-50. Pubmed: 12834252
    4. Hagenfeldt L, Bjerkenstedt L, Edman G, Sedvall G, Wiesel FA: Amino acids in plasma and CSF and monoamine metabolites in CSF: interrelationship in healthy subjects. J Neurochem. 1984 Mar;42(3):833-7. Pubmed: 6198473
    5. Peng CT, Wu KH, Lan SJ, Tsai JJ, Tsai FJ, Tsai CH: Amino acid concentrations in cerebrospinal fluid in children with acute lymphoblastic leukemia undergoing chemotherapy. Eur J Cancer. 2005 May;41(8):1158-63. Epub 2005 Apr 14. Pubmed: 15911239
    6. Cynober LA: Plasma amino acid levels with a note on membrane transport: characteristics, regulation, and metabolic significance. Nutrition. 2002 Sep;18(9):761-6. Pubmed: 12297216
    7. Rainesalo S, Keranen T, Palmio J, Peltola J, Oja SS, Saransaari P: Plasma and cerebrospinal fluid amino acids in epileptic patients. Neurochem Res. 2004 Jan;29(1):319-24. Pubmed: 14992292
    8. Kersemans V, Cornelissen B, Kersemans K, Bauwens M, Achten E, Dierckx RA, Mertens J, Slegers G: In vivo characterization of 123/125I-2-iodo-L-phenylalanine in an R1M rhabdomyosarcoma athymic mouse model as a potential tumor tracer for SPECT. J Nucl Med. 2005 Mar;46(3):532-9. Pubmed: 15750170
    9. Alme B, Bremmelgaard A, Sjovall J, Thomassen P: Analysis of metabolic profiles of bile acids in urine using a lipophilic anion exchanger and computerized gas-liquid chromatorgaphy-mass spectrometry. J Lipid Res. 1977 May;18(3):339-62. Pubmed: 864325
    10. Sardharwalla IB, Fowler B, Robins AJ, Komrower GM: Detection of heterozygotes for homocystinuria. Study of sulphur-containing amino acids in plasma and urine after L-methionine loading. Arch Dis Child. 1974 Jul;49(7):553-9. Pubmed: 4851308
    11. Alton KB, Hernandez A, Alvarez N, Patrick JE: High-performance liquid chromatographic determination of N-[2(S)-(mercaptomethyl)-3-(2-methylphenyl)-1-oxopropyl]-L-methionine, the active plasma metabolite of a prodrug atriopeptidase inhibitor (SCH 42495), using a thiol selective (Au/Hg) amperometric detector. J Chromatogr. 1992 Sep 2;579(2):307-17. Pubmed: 1429978
    12. Fischer JL, Lancia JK, Mathur A, Smith ML: Selenium protection from DNA damage involves a Ref1/p53/Brca1 protein complex. Anticancer Res. 2006 Mar-Apr;26(2A):899-904. Pubmed: 16619485
    13. Ditscheid B, Funfstuck R, Busch M, Schubert R, Gerth J, Jahreis G: Effect of L-methionine supplementation on plasma homocysteine and other free amino acids: a placebo-controlled double-blind cross-over study. Eur J Clin Nutr. 2005 Jun;59(6):768-75. Pubmed: 15870821
    14. Hesse A, Heimbach D: Causes of phosphate stone formation and the importance of metaphylaxis by urinary acidification: a review. World J Urol. 1999 Oct;17(5):308-15. Pubmed: 10552150
    15. Harth G, Horwitz MA: Inhibition of Mycobacterium tuberculosis glutamine synthetase as a novel antibiotic strategy against tuberculosis: demonstration of efficacy in vivo. Infect Immun. 2003 Jan;71(1):456-64. Pubmed: 12496196
    16. Takasu A, Shimosegawa T, Shimosegawa E, Hatazawa J, Kimura K, Fujita M, Koizumi M, Kanno I, Toyota T: 11C-methionine uptake to the pancreas and its secretion: a positron emission tomography study in humans. Pancreas. 1999 May;18(4):392-8. Pubmed: 10231845
    17. Ball RO, Courtney-Martin G, Pencharz PB: The in vivo sparing of methionine by cysteine in sulfur amino acid requirements in animal models and adult humans. J Nutr. 2006 Jun;136(6 Suppl):1682S-1693S. Pubmed: 16702340
    18. van de Poll MC, Dejong CH, Soeters PB: Adequate range for sulfur-containing amino acids and biomarkers for their excess: lessons from enteral and parenteral nutrition. J Nutr. 2006 Jun;136(6 Suppl):1694S-1700S. Pubmed: 16702341
    19. Garlick PJ: Toxicity of methionine in humans. J Nutr. 2006 Jun;136(6 Suppl):1722S-1725S. Pubmed: 16702346

    Enzymes

    Gene Name:
    MTR
    Uniprot ID:
    Q99707
    Reactions
    5-Methyltetrahydrofolic acid + Homocysteine unknown Tetrahydrofolic acid + L-Methioninedetails
    Gene Name:
    MTHFR
    Uniprot ID:
    P42898
    Gene Name:
    TAT
    Uniprot ID:
    P17735
    Reactions
    2-Oxo-4-methylthiobutanoic acid + L-Glutamic acid unknown L-Methionine + Oxoglutaric aciddetails
    Gene Name:
    MAT2A
    Uniprot ID:
    P31153
    Reactions
    Adenosine triphosphate + L-Methionine + Water unknown Phosphoric acid + Pyrophosphate + S-Adenosylmethioninedetails
    Phosphoric acid + Pyrophosphate + S-Adenosylmethionine unknown Adenosine triphosphate + L-Methionine + Waterdetails
    Gene Name:
    AS3MT
    Uniprot ID:
    Q9HBK9
    Gene Name:
    INMT
    Uniprot ID:
    O95050
    Gene Name:
    MAT1A
    Uniprot ID:
    Q00266
    Reactions
    Adenosine triphosphate + L-Methionine + Water unknown Phosphoric acid + Pyrophosphate + S-Adenosylmethioninedetails
    Phosphoric acid + Pyrophosphate + S-Adenosylmethionine unknown Adenosine triphosphate + L-Methionine + Waterdetails
    Gene Name:
    MTRR
    Uniprot ID:
    Q9UBK8
    Gene Name:
    CCBL1
    Uniprot ID:
    Q16773
    Reactions
    Se-Methylselenocysteine + 2-Oxo-4-methylthiobutanoic acid unknown Methylselenopyruvate + L-Methioninedetails
    Gene Name:
    MSRA
    Uniprot ID:
    Q9UJ68
    Reactions
    L-Methionine + thioredoxin disulfide + Water unknown Methionine sulfoxide + thioredoxindetails
    Gene Name:
    BHMT
    Uniprot ID:
    Q93088
    Reactions
    Trimethylammonioacetate + Homocysteine unknown Dimethylglycine + L-Methioninedetails
    Gene Name:
    MARS
    Uniprot ID:
    P56192
    Reactions
    Adenosine triphosphate + L-Methionine + tRNA(Met) unknown Adenosine monophosphate + Pyrophosphate + L-methionyl-tRNA(Met)details
    Adenosine triphosphate + L-Methionine + tRNA(Met) unknown Adenosine monophosphate + Pyrophosphate + L-Methionyl-tRNAdetails
    Gene Name:
    GLUL
    Uniprot ID:
    P15104
    Gene Name:
    LIAS
    Uniprot ID:
    O43766
    Reactions
    Protein N(6)-(octanoyl)lysine + Hydrogen sulfide + S-Adenosylmethionine unknown protein N(6)-(lipoyl)lysine + L-Methionine + 5'-Deoxyadenosinedetails
    Protein N6-(octanoyl)lysine + Sulfur donor + S-Adenosylmethionine unknown Protein N6-(lipoyl)lysine + L-Methionine + 5'-Deoxyadenosinedetails
    Octanoyl-[acp] + Sulfur donor + S-Adenosylmethionine unknown Lipoyl-[acp] + L-Methionine + 5'-Deoxyadenosinedetails
    Gene Name:
    MAT2B
    Uniprot ID:
    Q9NZL9
    Reactions
    Phosphoric acid + Pyrophosphate + S-Adenosylmethionine unknown Adenosine triphosphate + L-Methionine + Waterdetails
    Gene Name:
    BHMT2
    Uniprot ID:
    Q9H2M3
    Reactions
    Trimethylammonioacetate + Homocysteine unknown Dimethylglycine + L-Methioninedetails
    Gene Name:
    METAP2
    Uniprot ID:
    P50579
    Gene Name:
    IL4I1
    Uniprot ID:
    Q96RQ9
    Reactions
    L-Methionine + Water + Oxygen unknown 2-Oxo-4-methylthiobutanoic acid + Ammonia + Hydrogen peroxidedetails
    Gene Name:
    CCBL2
    Uniprot ID:
    Q6YP21
    Reactions
    Se-Methylselenocysteine + 2-Oxo-4-methylthiobutanoic acid unknown Methylselenopyruvate + L-Methioninedetails
    Gene Name:
    MSRB2
    Uniprot ID:
    Q9Y3D2
    Reactions
    L-Methionine + oxidized thioredoxin unknown L-methionine R-oxide + reduced thioredoxindetails
    Gene Name:
    MSRB3
    Uniprot ID:
    Q8IXL7
    Reactions
    L-Methionine + oxidized thioredoxin unknown L-methionine R-oxide + reduced thioredoxindetails
    Gene Name:
    MARS2
    Uniprot ID:
    Q96GW9
    Reactions
    Adenosine triphosphate + L-Methionine + tRNA(Met) unknown Adenosine monophosphate + Pyrophosphate + L-methionyl-tRNA(Met)details
    Adenosine triphosphate + L-Methionine + tRNA(Met) unknown Adenosine monophosphate + Pyrophosphate + L-Methionyl-tRNAdetails
    Gene Name:
    MSRB1
    Uniprot ID:
    Q9NZV6
    Reactions
    L-Methionine + oxidized thioredoxin unknown L-methionine R-oxide + reduced thioredoxindetails

    Transporters

    Gene Name:
    SLC16A10
    Uniprot ID:
    Q8TF71