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Showing metabocard for Pravastatin (HMDB0005022)
Enzymes
- General function:
- Involved in hydroxymethylglutaryl-CoA reductase (NADPH) activity
- Specific function:
- Transmembrane glycoprotein that is the rate-limiting enzyme in cholesterol biosynthesis as well as in the biosynthesis of nonsterol isoprenoids that are essential for normal cell function including ubiquinone and geranylgeranyl proteins.
- Gene Name:
- HMGCR
- Uniprot ID:
- P04035
- Molecular weight:
- 97475.155
- General function:
- Involved in monooxygenase activity
- Specific function:
- Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. This enzyme contributes to the wide pharmacokinetics variability of the metabolism of drugs such as S-warfarin, diclofenac, phenytoin, tolbutamide and losartan.
- Gene Name:
- CYP2C9
- Uniprot ID:
- P11712
- Molecular weight:
- 55627.365
- General function:
- Involved in GTP binding
- Specific function:
- Isoform B has an accelerated GEF-independent GDP/GTP exchange and an impaired GTP hydrolysis, which is restored partially by GTPase-activating proteins. It is able to bind to the GTPase-binding domain of PAK but not full-length PAK in a GTP- dependent manner, suggesting that the insertion does not completely abolish effector interaction
- Gene Name:
- RAC1
- Uniprot ID:
- P63000
- Molecular weight:
- 21449.9
- General function:
- Involved in CAAX-protein geranylgeranyltransferase acti
- Specific function:
- Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to a cysteine at the fourth position from the C-terminus of proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X. Acts on the Rac1, Rac2, Rap1A and Rap1B proteins. The beta subunit is responsible for peptide-binding.
- Gene Name:
- PGGT1B
- Uniprot ID:
- P53609
- Molecular weight:
- 42367.81
- General function:
- Not Available
- Specific function:
- Retroviral envelope proteins mediate receptor recognition and membrane fusion during early infection. Endogenous envelope proteins may have kept, lost or modified their original function during evolution
- Gene Name:
- Not Available
- Uniprot ID:
- P61568
- Molecular weight:
- 21461.4
Transporters
- General function:
- Involved in transporter activity
- Specific function:
- Mediates the Na(+)-independent transport of organic anions such as pravastatin, taurocholate, methotrexate, dehydroepiandrosterone sulfate, 17-beta-glucuronosyl estradiol, estrone sulfate, prostaglandin E2, thromboxane B2, leukotriene C3, leukotriene E4, thyroxine and triiodothyronine. May play an important role in the clearance of bile acids and organic anions from the liver
- Gene Name:
- SLCO1B1
- Uniprot ID:
- Q9Y6L6
- Molecular weight:
- 76448.0
- General function:
- Involved in ATP binding
- Specific function:
- Mediates hepatobiliary excretion of numerous organic anions. May function as a cellular cisplatin transporter
- Gene Name:
- ABCC2
- Uniprot ID:
- Q92887
- Molecular weight:
- 174205.6